Abstract: A melt-polymerization process is described for the preparation of thermoplastic polyamides and polyesteramides by reaction of the appropriate organic diisocyanate and dicarboxylic acid or difunctional carboxylic acid-terminated polyol. The process, which can be conducted in a batch or continuous manner, comprises the steps of admixing the reactants (preferably in the liquid state), heating the mixed reactants at reaction temperature in a manner such that eliminated carbon dioxide can be vented freely, allowing the reaction to proceed until approximately 25-95 percent (preferably at least 50 percent) of the theoretical carbon dioxide has been eliminated and reducing the resulting intermediate to a powder before completing the reaction by melting, homogenizing, and devolatilizing.

Abstract: A continuous, solvent-free process is described for the preparation of thermoplastic polyamides and polyester-amides by the reaction of the appropriate organic diisocyanate and dicarboxylic acid or difunctional carboxylic acid-terminated polyester.

Abstract: Anomers and asteric mixtures of novel analogs of spectinomycin. Additionally provides novel intermediates and process for preparing spectinomycin and analogs thereof.

Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

Abstract: A silver stain procedure wherein a substance capable of binding silver is treated with a glutaraldehyde solution, an aqueous silver salt solution, a reducing solution and an aqueous carbonate or sulfate solution and kit useful in practicing same.

Abstract: 17.beta.-Difluoromethyl steroids are disclosed which have progestational, antiprogestational activity and which are useful as and male and female contraceptive agents.

Abstract: A process is disclosed for the production of 17-keto-16-methylene steroids (III) from the corresponding readily available 17-keto steroid (I) via a novel intermediate (II).

Abstract: Disclosed are novel compositions comprising blends of at least about 75 percent by weight of a polyesteramide and the balance of the blends comprising a urethane containing ingredient. Optionally, an antioxidant component is present in the blends.The blends display an unexpected level of stability in regard to their tensile properties when exposed to elevated temperatures.The blends find particular utility in the area of hoses, gaskets, seals, etc., used in handling fluids at elevated temperatures.

Abstract: Therapeutic compositions for treating humans and animals comprising, in dosage unit form, a 1-hydroxymethyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine compound of the formula: ##STR1## including the N-oxides esters and pharmacologically acceptable acid addition salts thereof in combination with a pharmaceutical carrier. The compositions are useful as soporifics and provide a process for inducing sleep.

Abstract: Prophylactic and therapeutic methods of treating pseudopregnancy and galactorrhea in mammals with 7.alpha.-methyltestosterones. Also, use of 7.alpha.-methyltestosterones in adjunct treatment of mastitis in mammals.

Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.

Abstract: Disclosed is a 20,21-dihalo steroid (VII) and a steroidal sulfoxide (VIII) as well as processes to produce them. The 20,21-dihalo steroid (VII) and sulfoxide (VIII) are intermediates useful in the preparation of pharmaceutically useful corticoids.

Abstract: Novel pesticidal N-[[[arylformimidoyl]methylamino]thio]-N-substituted sulfonamides are disclosed with novel compositions thereof and methods for their use in controlling invertebrate arthropod pests, particularly insects, mites, and ticks.

Abstract: The present invention provides novel antiatherosclerotic furobenzoxazinones, e.g., 4,9-dimethoxy-4H-furo[3,2-g][1,3]benzoxazin-4-ones. These compounds are structurally and pharmacologically related to khellin and are useful antiatherosclerotic agents.

Abstract: The present invention is a process for the transformation of a 17-keto steroid (II) to a corticoid (XI) which has pharmaceutical utility.

Abstract: Novel copolyamides having the recurring unit ##STR1## are disclosed wherein Ar in the major proportion of the recurring units is m-phenylene and in the corresponding minor proportion (but more than 10 percent) of the recurring units Ar is a phenylene ether having the formula ##STR2## The copolyamides have excellent high temperature resistance but, unlike those polymers in which Ar in the above recurring unit is exclusively m-phenylene, they can be injection molded.

Abstract: Bis(cyclic ureas) are disclosed which have the formula ##STR1## wherein R is ##STR2## and C.sub.n H.sub.2n is ethylene or 1,3-propylene each of which can be substituted by one or more inert substituents.These compounds are useful as masked diisocyanates which, on heating in the presence of a polyol and, optionally, a polyurethane catalyst, give rise to polyurethane resins. Accordingly, they are useful as a component of storage stable compositions which are convertible to polyurethanes upon heating. Such compositions are particularly useful as solvent-less coating compositions. The properties of the above compounds are distinguished in a number of respects from the known bis(cyclic ureas) in which C.sub.n H.sub.2n has 4 or more carbon atoms in the chain between the valencies. Illustratively, the above compounds are more stable on exposure to heat in the absence of catalysts but, in the presence of polyurethane catalysts, react with polyols at a significantly faster rate than the prior art compounds.

Abstract: The present invention relates to novel 2-decarboxy-2-tetrazolyl-6-keto-PG compounds, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same purposes for which prostacyclin is employed.

Abstract: The present invention provides certain substituted-piperazinyl-1,2,4-triazoles which are useful for the treatment of sensitized humans for allergies and anaphylactic reactions.

Abstract: The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.