Patents Assigned to The Washington University
  • Micro-resonator and fiber taper sensor system
    Patent number: 11061025
    Abstract: A micro-resonator and fiber taper based sensing system, which uses mode splitting or frequency shift methods and polarization measurements for particle sensing.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: July 13, 2021
    Assignee: Washington University
    Inventors: Sahin Kaya Ozdemir, Lan Yang
  • Compositions comprising desaminotyrosine and uses thereof to enhance type I interferon stimulation
    Patent number: 11058653
    Abstract: The disclosure provides compositions comprising desaminotyrosine and methods of use thereof in enhancing type I interferon stimulation, epithelial proliferation, and treatment of inflammatory bowel disease.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: July 13, 2021
    Assignee: Washington University
    Inventors: Thaddeus Stappenbeck, Ashley Steed, Gerard Kaiko, George Christophi
  • Method of making trabecular bone
    Patent number: 11060060
    Abstract: Provided herein are methods of producing trabecular bone material, such as trabecular bone or trabecular bone matrix and cells useful in preparing the trabecular bone material.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 13, 2021
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans Affairs, University of Chicago, Washington University
    Inventors: Harry Colbert Blair, Quitterie Larrouture, Irina L. Tourkova, Deborah J. Nelson, Paul Schlesinger
  • PREPARATIVE ELECTROPHORETIC METHOD FOR TARGETED PURIFICATION OF GENOMIC DNA FRAGMENTS
    Publication number: 20210207122
    Abstract: A sample containing particles having high-molecular-weight (HMW) DNA is entrapped in a gel matrix, and the gel matrix is exposed to a lysis reagent configured to release the HMW DNA from the particles. The HMW DNA may be purified by subjecting the gel matrix to an electrophoretic field that removes the HMW DNA from the particles, lysis reagents, and/or other sample constituents, from the gel matrix such that the HMW DNA remains. The gel matrix may be subjected with DNA cleavase reagents configured to cleave at specific DNA sequences within the HMW DNA to liberate defined segments of the DNA as fragments of reduced size. The gel matrix may also be subjected to an electrophoretic field, which moves and separates the DNA fragments from uncleaved DNA of the HMW DNA, which remains substantially immobile. The electrophoretically separated DNA fragments may be isolated from the gel matrix.
    Type: Application
    Filed: November 21, 2016
    Publication date: July 8, 2021
    Applicants: Sage Science, Inc., Washington University
    Inventors: Robi David MITRA, Jeffrey MILBRANDT, Ezra Solomon ABRAMS, Todd J. BARBERA, T. Christian BOLES
  • Methods for Evaluating Angiogenesis
    Publication number: 20210208133
    Abstract: Various methods for isolating cell populations from adipocyte tissue and/or blood and quantifying levels of vascular endothelial growth factor receptors (VEGFR) on the isolated cell populations are provided. Also provided are methods of evaluating or modifying angiogenic therapy in a subject.
    Type: Application
    Filed: November 30, 2020
    Publication date: July 8, 2021
    Applicant: Washington University
    Inventors: Princess Imoukhuede, Yingye Fang
  • Homing agents
    Patent number: 11052163
    Abstract: The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest, such as a biomarker of a disease or disorder.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: July 6, 2021
    Assignee: Washington University
    Inventors: Gregory M. Lanza, Samuel I. Achilefu, Grace Hufang Cui
  • METHODS AND APPARATUS FOR IMPROVING THE IMAGE RESOLUTION AND SENSITIVITY OF WHOLE-BODY POSITRON EMISSION TOMOGRAPHY (PET) IMAGING
    Publication number: 20210196211
    Abstract: A positron emission tomography (PET) technique that can enhance the image resolution and system sensitivity of a clinical PET/CT scanner for imaging a whole body or a target region of a subject is provided. The system includes a detector array and a detector panel. The detector array includes an array of gamma ray detectors defining a field of view of a scanner and configured to detect at least one coincidence event. The detector panel includes an array of gamma ray detectors having a higher intrinsic spatial resolution than the detector array and positioned in closer proximity to a patient table than the detector array. The detector panel is positioned outside the field of view defined by the detector array during at least a portion of scanning by the PET system. The detector panel is configured to detect at least one coincidence event in cooperation with the detector array.
    Type: Application
    Filed: November 27, 2019
    Publication date: July 1, 2021
    Applicant: Washington University
    Inventors: Yuan-Chuan Tai, Joseph O'Sullivan, Ke Li, Qiang Wang
  • Depression brain computer interface for the quantitative assessment of mood state and for biofeedback for mood alteration
    Patent number: 11045134
    Abstract: A brain computer interface (BCI) system includes an electroencephalogram (EEG) headset and a computing device communicatively coupled to the EEG headset. The computing device includes a memory, a processor and a display device. The memory stores instructions that, when executed by the processor, cause the processor to monitor, using the EEG headset, current extrinsic network activity and current intrinsic network activity of a patient, generate a current depression index based on the relationship between the current extrinsic network activity and the current intrinsic network activity, and display, on the display device, a representation of the relationship between the current depression index and a baseline depression index previously generated for the patient.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: June 29, 2021
    Assignee: Washington University
    Inventor: Eric Leuthardt
  • Transvaginal Fast-Scanning Optical-Resolution Photoacoustic Endoscopy
    Publication number: 20210186411
    Abstract: The present disclosure describes a fast-scanning optical-resolution photoacoustic (fsOR-PAE) endoscope for imaging vasculature within tissues in vivo that includes an ultrasonic transducer and a scanning mirror within a lumen of an elongate casing. The scanning mirror is configured to direct the laser pulses from the pulsed laser source to a focal spot outside the casing in a scanning pattern via an imaging window formed in the casing. The scanning mirror is further configured to direct a plurality of photoacoustic signals from the focal spot to the ultrasonic transducer via the imaging window.
    Type: Application
    Filed: December 22, 2020
    Publication date: June 24, 2021
    Applicants: Washington University, California Institute of Technology
    Inventors: Lihong Wang, Konstantin Maslov, Methodius Tuuli, Molly Stout, George Macones, Chiye Li, Junhui Shi, Yuan Qu
  • DOMINANT NEGATIVE SARM1 MOLECULES AS A THERAPEUTIC STRATEGY FOR NEURODEGENERATIVE DISEASES OR DISORDERS
    Publication number: 20210187069
    Abstract: The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegenerative or neurological disease or disorder, pharmaceutical compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 24, 2021
    Applicant: Washington University
    Inventors: Aaron DiAntonio, Jeffrey D. Milbrandt, Daniel Summers, Stefanie Geisler, Xianrong Mao
  • Self-powered sensors for long-term monitoring
    Patent number: 11041764
    Abstract: A sensor system for detecting events is provided. The sensor system includes a sensor and a read-out interface. The sensor includes a transducer and a memory device. The transducer detects an event and generates a sensor signal in response to the event. The memory device includes a floating-gate with a sensing interface coupled to the transducer. The sensing interface has an energy barrier that leaks electrons at a predetermined electron leakage rate through Fowler-Nordheim (F-N) tunneling. The sensor signal alters a geometry of the energy barrier to change the electron leakage rate. The read-out interface is communicatively coupled to the memory device and retrieves data stored on the memory device for analysis. The event and a timestamp of the event are identifiable from the stored data.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 22, 2021
    Assignee: Washington University
    Inventors: Shantanu Chakrabartty, Liang Zhou
  • SYSTEMS, SPHERICAL ROTORS, STATORS, AND METHODS OF USE
    Publication number: 20210181275
    Abstract: Among the various aspects of the present disclosure is the provision of systems and spherical rotors suitable for use in magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and methods of use thereof.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 17, 2021
    Applicant: Washington University
    Inventor: Alexander Barnes
  • QUANTITATIVE DIFFERENTIATION OF TUMOR HETEROGENEITY USING DIFFUSION MR IMAGING DATA
    Publication number: 20210177348
    Abstract: Provided herein are methods for imaging and diagnosing at least one disorder in a patient utilizing diffusion basis spectrum imaging MRI with extended isotropic spectrum (DBSI-EIS). The methods may be used as a tool to image and diagnose heterogeneities within tumors. As a result, different tumor types can be detected, distinguished from one another, and individually quantified without the need to inject exogenous contrast agents.
    Type: Application
    Filed: August 30, 2017
    Publication date: June 17, 2021
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Yong Wang, Gloria Guzman, Qing Wang, Tammie Benzinger
  • COMPOSITIONS COMPRISING A MODIFIED GIcNAc-1-PHOSPHOTRANSFERASE AND METHODS OF USE THEREOF
    Publication number: 20210180035
    Abstract: The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: June 17, 2021
    Applicant: Washington University
    Inventors: Stuart Kornfeld, Lin Liu, Wang Lee, Balraj Doray
  • Foot device
    Patent number: 11033075
    Abstract: A foot engagement device includes a generally U-shaped portion having an inner edge, an outer wall, and a tapered upper surface extending from the inner edge to the outer wall. The upper surface tapers between 1 degree and 45 degrees from the inner edge to the outer wall.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: June 15, 2021
    Assignee: Washington University
    Inventor: Michael D. Weiss
  • Nanohole array based sensors with various coating and temperature control
    Patent number: 11035792
    Abstract: A nanohole array (NHA)-based plasmonic sensor (e.g., gas/condensed phase sensor), their preparation, and their use to detect and analyze samples, especially mixtures of chemicals/bio-chemicals.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: June 15, 2021
    Assignees: The George Washington University, GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE, NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
    Inventors: Yangyang Zhao, Mona Zaghloul, Stephen Semancik, Kurt D. Benkstein
  • SYSTEMS AND METHODS OF PRECISION FUNCTIONAL MAPPING-GUIDED PERSONALIZED NEUROMODULATION
    Publication number: 20210170180
    Abstract: A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.
    Type: Application
    Filed: December 9, 2020
    Publication date: June 10, 2021
    Applicant: Washington University
    Inventors: Nico Dosenbach, Chad Sylvester, Deanna Greene, Scott Marek, Scott Norris, Jarod Roland
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20210171563
    Abstract: The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
    Type: Application
    Filed: November 8, 2018
    Publication date: June 10, 2021
    Applicant: Washington University
    Inventors: Vasilios Kalas, James W. Janetka, Scott Hultgren, Jerry Pinkner, Amarendar Maddirala, Vishnu Damalanka
  • PHOTOACOUSTIC NEAR-INFRARED SPECTROSCOPIC ENDOSCOPY
    Publication number: 20210169414
    Abstract: In various aspects, a photoacoustic endoscopic probe and methods for measuring a hydration of a connective tissue in vivo using the photoacoustic endoscopic probe are disclosed.
    Type: Application
    Filed: December 3, 2020
    Publication date: June 10, 2021
    Applicants: Washington University, California Institute of Technology
    Inventors: Lihong Wang, Konstantin Maslov, Methodius Tuuli, Molly Stout, George Macones, Junhui Shi, Peinan Zhao, Yuan Qu, Peng Hu
  • Oxy-combustion process with modular boiler design
    Patent number: 11029020
    Abstract: A modular boiler system for implementing fuel combustion is provided. The system includes a first boiler and a second boiler of a plurality of boilers, an oxygen input unit, a fuel input unit, a recycled flue gas input unit, and a flue gas separator. The first boiler receives oxygen from the oxygen input unit, fuel from the fuel input unit, and recycled flue gas from the recycled flue gas input unit. The first boiler outputs intra-system flue gas. The flue gas separator separates the intra-system flue gas into a first and second flue gas stream, transfers the first flue gas stream to the second boiler, and transfers the second flue gas stream to a gas cleaning system. The second boiler receives oxygen from the oxygen input unit, fuel from the fuel input unit, and the first flue gas stream from the flue gas separator.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: June 8, 2021
    Assignee: Washington University
    Inventors: Richard Axelbaum, Zhiwei Yang, Akshay Gopan