Abstract: Systems and methods for producing motion-corrected MR images that include an MRI scanner with a plurality of coils in which the plurality of coils is configured to detect a plurality of MR imaging datasets are provided. Each MR imaging dataset includes a plurality of MR signals detected by one coil of the plurality of coils. The system further includes a controller operatively coupled to the MRI scanner that includes at least one processor and a non-volatile memory. The controller further includes an image processing unit configured to receive the plurality of MR imaging datasets associated with the plurality of coils, identify a motion cycle using an automated motion detection method, and to partition the plurality of MR imaging datasets into a plurality of image groups, in which each image group comprises a portion of the plurality of MR imaging datasets associated with one of the phases of the motion cycle.

Abstract: Systems and methods for asset monitoring utilize a network, one or more data servers, one or more asset-monitoring modules, and one or more beacon modules to monitor assets deployed across a facility. The systems and methods are asset-agnostic and are able to provide statistical forecasts and degradation model for each asset monitored. The systems and methods may further apply real-time regression, including Bayesian updating techniques to provide real-time corrections to forecasts and degradation models.

Abstract: A modular pressurized combustion system for flexible energy generation is provided. The system comprises a plurality of pressurized combustion boilers, at least one compressor configured to provide pressurized oxidizer gas to each of the plurality of pressurized combustion boilers in parallel, and at least one feeder configured to provide fuel to each of the plurality of pressurized combustion boilers in parallel. The system further comprises a flue gas input unit configured to provide recycled flue gas to each of the plurality of pressurized combustion boilers in series, at least one pressurized heat recovery unit configured to receive a flue gas output stream from each of the plurality of pressurized combustion boilers, and at least one particle filter configured to filter a flue gas output stream from the pressurized heat recovery unit. The system also comprises an integrated pollutant removal unit.

Abstract: A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.

Abstract: Among the various aspects of the present disclosure is the provision of compositions for and methods of diagnosing, prognosing, and treating diabetes.

Abstract: A diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject is described. The DOT system includes a source subsystem configured to generate optical waves, a probe coupled to the source subsystem and configured to emit the optical waves generated by the source subsystem toward the lesion region and to detect optical waves reflected by the lesion region, a detection subsystem configured to convert the optical waves detected by the probe to digital signals, and a computing device including a processor and a memory. The memory includes instructions that program the processor to receive the digital signals sent from the detection subsystem and perform reconstruction using a depth-regularized reconstruction algorithm combined with a semi-automated interactive convolutional neural network (CNN) for depth-dependent reconstruction of absorption distribution.

Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

Abstract: An improved process for the preparation of nanostructured metal species-based films in a flame aerosol reactor is provided. The present invention also further provides improved nanostructured photo-watersplitting cells, improved dye sensitized solar cells and improved nanostructured p/n junction solar cells.

Abstract: Methods and compositions for producing epidermal growth factor (EGF) in soybean seeds featuring the use of transgenic soybean seeds expressing a seed-specific codon optimized gene encoding of the hEGF protein. Using these methods, the production of hEGF is sufficient and the activity of the EGF protein is comparable to commercially available EGF. The present invention shows the feasibility of using soybean seeds as a biofactory to produce therapeutic agents for a delivery platform, e.g., in a soymilk delivery platform.

Abstract: An arteriovenous graft and methods of reducing the risk of graft thrombosis and extending patency of the arteriovenous graft are provided herein. The arteriovenous graft is operable for attaching to a vein at a venous anastomosis. In some aspects, the arteriovenous graft includes a plurality of grooves at a venous anastomosis end of the arteriovenous graft and the venous anastomoses may be arranged such that the arteriovenous graft and the vein meet at an angle of 30° or less.

Abstract: Characterizing the organization of microbial communities is a formidable challenge given the number of possible interactions between their components. Using a statistical approach initially applied to financial markets, we measured covariance among bacterial taxa in the gut microbiota of healthy members of a Bangladeshi birth cohort sampled monthly from 1-60 months and identified an ‘ecogroup’ composed of 15 co-varying bacterial taxa. A distinct ecogroup configuration is evident by the second postnatal month and develops to a mature form by 21 months. The ‘ecogroup’ provided a concise description of microbiota organization in healthy members of birth cohorts from several low-income countries, a means for monitoring community repair in undernourished children treated with therapeutic foods and serves as a framework for studying emergent characteristics of microbial communities.

Abstract: Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods of treating arthritogenic alphavirus infection and methods of screening.

Abstract: Composite nanostructures having a crumpled graphene oxide shell and a nanoparticle selected from titanium dioxide, silver and magnetite within the shell are disclosed. The nanostructures may be incorporated into a filtration membrane suitable for purifying water for targeted separations and for human consumption.

Abstract: A spiking neural network includes a plurality of neurons implemented in respective circuits. Each neuron produces a continuous-valued membrane potential according to a Growth Transform bounded by an extrinsic energy constraint. The continuous-valued membrane potential is defined as a function of spiking current received from another neuron in the plurality of neurons, and a received electrical current stimulus. The spiking neural network includes a network energy function representing network energy consumed by the plurality of neurons and a neuromorphic framework.

Abstract: The present disclosure provides a system to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein comprising a catalytic domain of an enzyme involved in post-translational protein modification and a targeting domain, and a substrate protein comprising a protein of interest and a sequence that interacts with the targeting domain. The present disclosure also provides polynucleotide sequences encoding fusion proteins and substrate proteins, vectors for expressing polynucleotide sequences, vectors comprising the polynucleotide sequences, and isolated cells comprising said vectors.

Abstract: A coaxial needle having two or more passageways for forming a biomimetic bioprinted blood vessel tubular construct. The coaxial needle has an external needle passageway and an internal needle passageway separated by an internal barrier, and having a nozzle at an end thereof. A bioink is provided flowable through the external needle passageway and a crosslinking solution is provided flowable through the internal needle passageway. The crosslinking solution contacts the bioink as the crosslinking solution and bioink exit the nozzle thereby forming a tubular blood vessel construct.

Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.

Abstract: A method for mapping brain function of a subject includes generating a lesion mask using a search light algorithm based on a plurality of anatomical images of the subject. The plurality of anatomical images are registered with atlas images by nonlinear atlas registration using the generated lesion mask to generate a warping map. A plurality of functional images of the subject are resampled using the warping map to generate a functional map, functional connectivity is computed using the functional map and a multi-layer perceptron.

Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.