Abstract: A system and method for determining the integrity of a sealed container closure assembly wherein the closure is secured to the container by a force applying member and the integrity is determined by converting the force used to secure the closure into a force signal and comparing the force signal to a reference signal, which is reflective of the force used during a closure operation which resulted in seal integrity. The force signal which comprises a series of electrical signals is compared to a series of corresponding reference signals or is a single signal compared to a reference signal at a plurality of points during the closure operation. An indicator is used to indicate when a preselected number of acceptable or non-acceptable comparisons are reached.

Abstract: A single barrel two compartment assembly for medicaments comprising an elongated cylindrical hollow barrel having a normally sealed discharge end, a bypass plunger made of a pliable resilient material having a forward section of a diameter slightly greater than the diameter of the barrel, means defining a seat in the bypass plunger, a plunger rod having a tip engageable in said seat for actuating said bypass plunger axially in said barrel and seal means for sealing the open end of the said barrel remote from said discharge end, said bypass plunger normally dividing said barrel into a first compartment to one side of the bypass plunger for a powder medicament and a diluent compartment on the opposite side of said bypass plunger, actuation of said bypass plunger in one direction creating internal diluent pressure whereby said diluent bypasses the periphery of said plunger to mix with said powder medicament.

Abstract: This invention relates to an overcap for pharmaceutical and similar containers which enables an immediate determination to be made whether or not the container has been tampered with or if an additive has been injected into the containers.

Abstract: A closure for containers having a discharge opening and a finish with means for supporting the closure over the discharge opening comprising a cap portion of generally cup-like form having a top and a depending skirt with means on the interior peripheral surface thereof cooperating with means on the container finish for applying and removing the cap portion; a tamper-evident ring or band connected to the lower terminal edge of said skirt by at least a pair of fracturable bridge means and at least one lug cooperatively associated with at least one cam element below the container finish operable in one direction of movement of the cap portion relative to the container to effect fracturing of the bridge means to separate the tamper-evident ring from the cap portion, said bridge means being oriented in a predetermined manner relative to one another to effect sequential breaking in a given pattern upon relative movement of said cap portion and ring in said one direction.

Abstract: Apparatus for handling a plurality of clad elements of a predetermined configuration formed from a sheet consisting of a layer of an elastomeric material bonded to a layer of inert material and deposited in openings of a die corresponding in number and arrangement to cavities of a mold. The apparatus has a transfer mechanism with a plurality of rods having a pickup face with at least one fluid port. The rods correspond in number and array to the die openings and mold cavities. The fluid port is connected to a source of vacuum to retain a clad element on the pickup face when it engages the element in the die openings and to an air pressure source to discharge the clad element in the cavity of the mold. The apparatus further includes a reciprocating punch having a plurality of punch rods for forming the clad elements from the sheet material and depositing them in the openings of the die. The said die and mold are positioned adjacent one another.

Abstract: A syringe assembly comprising a casing for a medicament or the like having a discharge opening at one end, a diaphragm assembly mounted at said end normally sealing said contents, plunger means movable in said casing and operable upon displacement in one direction to effect increase in pressure in said casing to rupture or displace said diaphragm to permit discharge of the contents of said casing.

Abstract: In a syringe assembly comprising an outer barrel for a powder medicament, an inner barrel telescopically mounted in the outer barrel for diluent, seal means isolating the powder and diluent compartments comprising a plug member made of a resilient material sealingly engaging in the discharge opening of the inner barrel, plunger means mounted on the discharge end of the inner barrel including a hollow plug chamber closed at one end remote from the discharge end of the inner barrel by a wall having a plurality of discharge openings therein, said plug adapted upon pressure buildup in the inner barrel to be displaced axially outwardly into said plug chamber to permit flow of diluent from the inner barrel to the powder compartment.

Abstract: A combination TIP-OFF cap and container closure and sealing means adapted for operative assembly to a container to seal an access opening therein, thereby to seal the contents of the container. The cap comprises an elongated exterior top portion and an open ended skirt depending therefrom and formed integrally therewith. The skirt has a lower edge removably secured to the container adjacent the access opening. The combination TIP-OFF cap and closure sealing means is conjointly operatively connected to and removable from the container as an integrated unit to provide an access to the contents of the container by application of a lateral tilting force against the elongated cap exterior portion at a position remote from the connection of the cap to the container.

Abstract: A venting closure for sealing a pressurized container comprising a stopper member having an elongated stem portion engageable in the discharge opening in the container, an enlarged head portion having a bottom chamber formed in its outer axial end face, a generally disc-like button rotatably mounted in said chamber having means defining a groove overlying a removable cap normally sealing a port in said stopper communicating with the interior head space of said container, vent channel means in said button, rotation of said button operable to displace the means normally sealing said port to establish fluid communication therethrough and permit venting from the head space to the atmosphere through said vent channel means in said button.

Abstract: Disclosed is a method for making articles comprised of a body portion of an elastomeric material having a liner of an inert material covering at least a portion of the peripheral surface of said body portion including the steps of bonding a layer of elastomeric material to one face of a layer of the inert material, positioning the bonded layers in a mold cavity with the layer of inert material contacting at least a portion of the surface of a mold cavity, adding additional amounts of uncured elastomeric material to the mold cavity and curing the elastomeric materials. Also disclosed herein is a system and apparatus for making molded articles as well as the molded articles produced thereby.

Abstract: Disclosed is a method for making articles comprised of a body portion of an elastomeric material having a liner of an inert material covering at least a portion of the peripheral surface of said body portion including the steps of bonding a layer of elastomeric material to one face of a layer of the inert material, positioning the bonded layers in a mold cavity with the layer of inert material contacting at least a portion of the surface of a mold cavity, adding additional amounts of uncured elastomeric material to the mold cavity and vulcanizing the elastomeric materials. Also disclosed herein is a system and apparatus for making molded articles as well as the molded articles produced thereby.

Abstract: Disclosed is a method for making articles comprised of a body portion of an elastomeric material having a liner of an inert material covering at least a portion of the peripheral surface of said body portion including the steps of bonding a layer of elastomeric material to one face of a layer of the inert material, positioning the bonded layers in a mold cavity with the layer of inert material contacting at least a portion of the surface of a mold cavity, adding additional amounts of uncured elastomeric material to the mold cavity and curing the elastomeric materials. Also disclosed herein is a system and apparatus for making molded articles as well as the molded articles produced thereby.

Abstract: A pouring adaptor to be secured to the discharge end of a container or the like comprising a generally cylindrical skirt portion having a bead at its lower terminal edge for detachably securing it to the container finish and a radially inwardly directed top portion which snugly seats on the axial end face of the container. The top portion has a frusto-conical outer face which is outwardly divergent from its inner peripheral edge and a reversely tapered flexible flange which is downwardly divergent from the juncture of the frusto-conical outerface and flange.

Abstract: A stopper assembly for pharmaceutical containers or the like having a pull ring operable between a position flush with the top face of the stopper and an erect position engageable by the finger of the user for removing the stopper from the container. In acccordance with the preferred embodiment, the stopper and pull ring member are separate elements. The stopper which is preferably made of rubber has an annular groove with a locking shoulder to receive an insert ring of the pull ring member of complemetary shape to retain the two in a locked position. A pull ring is connected to a flange of the insert ring by a flexible hinge. The pull ring normally lies in the plane of the insert ring flange flush with the top face of the stopper and may be easily raised to an erect position to receive a finger of the user to enable removal of the stopper from a container by a pulling action.

Abstract: A method and system for making molded articles including a disc from a laminated sheet comprising a layer of elastomeric material and a layer of inert material consisting of the steps of partially cutting at least one disc from sheet material, positioning the sheet over a transfer plate with the partially cut disc in registry with an opening in the transfer plate, severing the disc from the sheet to the opening in the transfer plate, positioning the transfer plate over a mold having at least one cavity therein and transferring the disc from the transfer plate to the bottom of the mold cavity.

Abstract: A composite tip-off type cap, and closure sealing means, operatively connected to a container for closure thereof and sealing of the contents therein. The composite cap includes a narrow elongated exterior top portion, a peripherally enlarged open bottom skirt at the bottom thereof, and a container access opening closure seal means, operatively disposed within the skirt and operatively integrated therewith. The integrated composite cap and closure seal means are conjointly removable from the container, to open the container for access to the liquid therein, by application of a lateral tilting force against the narrow, elongated cap exterior at a position thereof remote from connection of the cap to the container. Removal of the integrated cap and closure seal means from the container is effected without breakage of the material forming the container. The cap and closure seal means act as a unit assembly when being removed.

Abstract: A tip-off cap and closure for a container, for closure thereof, and sealing of the contents therein. The cap includes a narrow elongated exterior top portion, a peripherally enlarged open bottom skirt at the bottom thereof, and a container closure for an access opening, operatively disposed within the skirt and operatively integrated therewith. The integrated cap and closure are conjointly removable from the container, to open the container for access to the liquid therein, by application of a lateral tilting force against the narrow, elongated cap exterior at a position thereof remote from connection of the cap to the container. Removal of the integrated cap and closure seal means from the container is normally effected without breakage of the material forming the container. The cap and closure act as a unit assembly when being removed.

Abstract: A gimbal-type anvil for apparatus for testing in the integrity of a sealed container closure assembly. These assemblies generally comprise a container, a resilient sealing element mounted in the discharge opening in the container and a cup-like cap engaging over the stopper and seating it in place over the discharge opening in the container. The apparatus includes a force applicator for applying an external force to the cap in a direction to further compress the resilient stopper and a microscope to detect initial displacement of the cap relative to the container when the externally applied force exceeds the residual static force in the stopper. The gimbal-type anvil is operatively associated with the force applicator and consists of a housing and at least a pair of annular ring members pivotally connected to the housing about axes transverse to the longitudinal axis of the container closure assembly.

Abstract: A syringe assembly comprising a casing for a medicament or the like having a discharge opening at one end, a diaphragm assembly mounted at said end normally sealing said contents, plunger means movable in said casing and operable upon displacement in one direction to effect increase in pressure in said casing to rupture or displace said diaphragm to permit discharge of the contents of said casing.