Patents Assigned to Thomas GmbH
  • Patent number: 5364646
    Abstract: Pharmaceutical forms of pimobendan for oral administration comprising citric acid, whereby a constant, satisfactory resorption is ensured even when there are major pH fluctuations in the gastrointestinal tract.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: November 15, 1994
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Peter Gruber, Willy Roth, Gottfried Schepky
  • Patent number: 5356577
    Abstract: The invention relates to a process and apparatus for the controlled release of metered quantities of finely divided solids with one or more regulated venturi nozzles for the purpose of applying lubricant or separating compound to the stressed surfaces of pressing tools in tablet making machines or for applying finely divided solids to solid carrier materials particularly in the fields of pharmaceuticals, foodstuffs or catalysts.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: October 18, 1994
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Josef Boldis, Volker I. Glasel, Ekkehard Flaischlen, Gunther M. Voss
  • Patent number: 5312924
    Abstract: The present application relates to the uses of phenylacetic acid benzylamides and new (S)(+)-2-ethoxy-4-[N-[1-2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbon ylmethyl]benzoic acid and the salts thereof, which have valuable pharmacological properties, namely an effect on the intermediate metabolism, but particularly the effect of lowering blood sugar.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: May 17, 1994
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Gerhart Griss, deceased, Robert Sauter, Manfred Reiffen, Eckhard Ruprecht
  • Patent number: 5294626
    Abstract: The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH) They also have an effect on PGE.sub.2 production.
    Type: Grant
    Filed: May 14, 1990
    Date of Patent: March 15, 1994
    Assignee: Dr. Karl Thomas GmbH
    Inventors: Armin Heckel, Josef Nickl, deceased, Rainer Soyka, Wolfgang Eisert, Thomas Muller, Johannes Weisenberger, Christopher Meade, Gojko Muacevic
  • Patent number: 5286736
    Abstract: New pyridyl derivatives of the formula ##STR1## wherein R.sub.1 to R.sub.6, A, X and n are as defined herein, the enantiomers thereof, the cis- and trans-isomers thereof if R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof. The new pyridyl derivatives have antithrombotic activity and thromboxane-mediated activities. The new compounds are also simultaneously thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 -production.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: February 15, 1994
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Rainer Soyka, Wolfgang Eisert, Thomas Mueller, Johannes Weisenberger
  • Patent number: 5276049
    Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: January 4, 1994
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Guenter Linz, Thomas Mueller, Johannes Weisenberger, Wolfgang Eisert
  • Patent number: 5270322
    Abstract: Imidazo[1,2-a]pyridines of the formula ##STR1## wherein R.sub.a to R.sub.e are as defined herein, the enantiomers and the salts thereof, which are useful as angiotensin antagonists and for treating conditions treatable with angiotensin antagonists.
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: December 14, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Uwe Ries, Norbert Hauel, Berthold Narr, Jacques van Meel, Wolfgang Wienen, Michael Entzeroth
  • Patent number: 5232946
    Abstract: The invention relates to new phenylethanolamines of general formula ##STR1## wherein A represents a straight-chained or branched alkylene group,B represents a bond, an alkylene group, a carbonyl or hydroxymethylene group,R.sub.1 represents a hydrogen atom, a halogen atom or a trifluoromethyl group,R.sub.2 represents a hydrogen atom or an amino group,R.sub.3 represents a cyano group, a hydrogen, chlorine or bromine atom andR.sub.4 represents a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group substituted in the end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group,the optical isomers and diastereoisomers and acid addition salts thereof.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: August 3, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Rudolf Hurnaus, Manfred Reiffen, Robert Sauter, Wolfgang Grell, Eckhard Rupprecht
  • Patent number: 5219852
    Abstract: Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: June 15, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Manfred Reiffen, Rudolf Hurnaus, Robert Sauter, Wolfgang Grell, Eckhard Rupprecht
  • Patent number: 5216167
    Abstract: Phenylacetic acid benzylamides having the following general structure ##STR1## wherein the substituents are defined herein, are disclosed, which compounds are hypoglcemic agents.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: June 1, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Gerhart Griss, deceased, Robert Sauter, Manfred Reiffen, Eckhard Rupprecht
  • Patent number: 5188940
    Abstract: A method of determining the total fibrinolytic activity in plasma, is characterized in thata) a quantity of fibrin sufficient to produce turbidity is added to a dilute platelet poor plasma sample or is produced in situ and the time dependent change in turbidity or the time-dependent formation of fibrin cleavage products is measured; orb) a chromogenic plasmin substrate and a quantity of fibrin, fibrinogen cleavage products or an enzyme which produces fibrin in situ, insufficient to produce turbidity, is added to a dilute platelet poor plasma sample and the time dependent color formation is measured.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: February 23, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Jurgen Krause, Walter Haarmann
  • Patent number: 5175158
    Abstract: New diazepinones of formula I ##STR1## wherein the substituents are defined herein, which compounds exhibit favorable effects on heart rate and in view of the absence of inhibitory effects on gastric acid secretion and salivation and the absence of mydriatic effects, are suitable as vagal pacemakers for the treatment of bradycardia and bradyarrhythmia in human and veterinary medicine.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: December 29, 1992
    Assignee: Dr. Karl Thomae, GmbH
    Inventors: Wolfgang Eberlein, Wolfhard Engel, Gunter Trummlitz, Gerhard Mihm, Norbert Mayer, Henri Doods
  • Patent number: 5147882
    Abstract: Cyclophanes of the general formula ##STR1## wherein X.sub.1, X.sub.2, A, R and R.sub.1 to R.sub.4 are as defined herein, the enantiomers, diastereomers and addition salts thereof and, more particularly, for pharmaceutical use, the physiologically acceptable addition salts thereof, which have pharmacological properties such as lowering blood pressure, dilating the coronary blood vessels and a mild heart rate lowering activity, pharmaceutical compositions which contain these compounds and processes for preparing them.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: September 15, 1992
    Assignee: Karl Thomae GmbH
    Inventors: Manfred Psiorz, Volker Trach
  • Patent number: 5135932
    Abstract: The invention relates to new 2-hydroxy-n-propylamines of the formulaR.sub.1 --O--CH.sub.2 --CHOH--CH.sub.2 --NH--A--R.sub.2 (I)whereinR.sub.1, R.sub.2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and .beta.-blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: August 4, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Norbert Hauel, Annerose Mauz, Jacques van Meel, Michael Entzeroth, Rainer Zimmermann, Willi Diederen
  • Patent number: 5120442
    Abstract: There is described a process for the simultaneous chemical and biological elimination of solid and liquid waste and apparatus for performing this process in the form of a loop reactor corresponding to FIG. 1 in conjunction with a specially designed nozzle which ensures an intimate mixing of substrate with air and the spraying-in of oxidizing agents while permitting only a short contact time between the oxidizing agents and the substrate.
    Type: Grant
    Filed: May 16, 1991
    Date of Patent: June 9, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Alfred Kull, Matthias Mather, Hans-Joachim Schmeiss
  • Patent number: 5116986
    Abstract: The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.
    Type: Grant
    Filed: May 7, 1991
    Date of Patent: May 26, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Andreas Bomhard, Joachim Heider, Manfred Psiorz, Norbert Hauel, Berthold Narr, Klaus Noll, Christian Lillie, Walter Kobinger, Willi Diederen
  • Patent number: 5114935
    Abstract: Novel compounds of the general formula ##STR1## which have antitussive activity, wherein R.sub.1 -R.sub.4 are as defined herein.
    Type: Grant
    Filed: August 15, 1990
    Date of Patent: May 19, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Helmut Ballhause, Gunther Engelhardt, Claus A. Landgraf, Norbert Mayer, Willy Roth, Kurt Schumacher, Alex Prox
  • Patent number: 5087625
    Abstract: Disclosed are novel pyridodiazepines. These compounds, as well as certain known 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: February 11, 1992
    Assignees: Boehringer Ingelheim Pharmaceuticals, Inc., Dr. Karl Thomae GmbH
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased, Wolfhard Engel, Vokhard Austel
  • Patent number: 5084449
    Abstract: Disclosed are substituted bis(4-aminophenyl-sulfonees of general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or cycloalkyl; group,R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl,R.sub.3 is nitrile, C.sub.1 -C.sub.3 alkylaminocarbonyl, di C.sub.1 -C.sub.3 alkylaminocarbonyl, C.sub.3 -C.sub.7 N-cycloalkyl-C.sub.1 -C.sub.3 alkylaminocarbonyl C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3, di alkylaminocarbonyl alkoxy, alkylaminosulfonyl, di C.sub.1 -C.sub.3 alkylaminono, diC.sub.1 -C.sub.3 alkylaminosulfonyl, hydroxy C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkylcarbonyl, amino C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy C.sub.1 -C.sub.3 alkyl groupor, when R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 can be hydroxy, hydroxycarbonyl C.sub.1 -C.sub.3 alkoxy or di C.sub.1 -C.sub.3 aminocarbonylalkoxy;or, when R.sub.1 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 cycloalkyl and R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, R.sub.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: January 28, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Joachim K. Seydel, Helmut Pieper, Gerd Kruger, Klaus Noll, Johannes Keck, Uwe Lechner
  • Patent number: 5068325
    Abstract: The present invention relates to new 4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines of general formula II ##STR1## wherein the substituents are defined herein below, which compounds have valuable pharmacological properties, namely selective effects on the dopaminergic system which are achieved by stimulating (predominantly D2) dopamine receptors.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: November 26, 1991
    Assignee: Karl Thomae GmbH
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Manfred Reiffen, Robert Sauter, Ludwig Pichler, Walter Kobinger, Michael Entzeroth, Joachim Mierau, Gunter Schingnitz