Patents Assigned to Thomas Jefferson University
  • Patent number: 11911631
    Abstract: A device having a biocompatible polymer as a body and regularly spaced radiation seeds and regularly spaced magnetic materials disposed of within the body of the biocompatible polymer, or uniformly distributed liquid radiation and magnetic fluid materials within a polymer slab, hollow thick wall polymer shell, or thin wall polymer balloon, as suitable for surgical placement within a resection cavity for treatment of at-risk tissue in the tumor margin with local hyperthermia in combination with radiation and potentially also with chemotherapy and/or immunotherapy that is slowly released from the biocompatible polymer.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: February 27, 2024
    Assignees: Thomas Jefferson University, Drexel University
    Inventors: Paul Stauffer, Voichita Bar-ad, Mark Hurwitz, Adam Luginbuhl, Michele Marcolongo, Dario Rodrigues, David Cognetti, Joseph Curry, Katsiaryna Prudnikova
  • Patent number: 11905563
    Abstract: A method of identifying a subject in need of therapeutic intervention to treat a disease or condi-tion or disease recurrence or disease progression comprising, isolating isomiRs or miRNAs from a sample obtained from the subject; and characterizing the isomiRs or miRNAs and their presence or absence in the sample to identify a signature, wherein when the signature is indicative of a di-agnosis of the disease then treatment of the subject is recommended.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: February 20, 2024
    Assignee: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Patent number: 11873431
    Abstract: An article comprising a luminescent nanoparticle is described, wherein the luminescent nanoparticle is selected from the group consisting of oxide nanoparticles, aluminate nanoparticles, and germanate nanoparticles; and wherein the luminescent nanoparticle is doped with one or more metals or rare-earth elements. A method of making a luminescent nanoparticle is also described, the method comprising the steps of: providing a nanoparticle, wherein the nanoparticle is doped with one or more chemical elements, and heating the nanoparticle to a temperature of between about 1000° C. and about 1200° C. to alter the crystal structure of the nanoparticle and/or to create oxygen vacancies in the nanoparticle.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: January 16, 2024
    Assignee: Thomas Jefferson University
    Inventors: Brian Robert George, Brian Yust, Abdur Rahaman Sk
  • Patent number: 11842491
    Abstract: A method of generating a quantitative characterization of injury presence and status of spinal cord tissue using an adaptive CNN system for use in diagnostic assessment, surgical planning, and therapeutic strategy comprises preprocessing for artifact correction of diffusion based, spinal cord MRI data, training an adaptive CNN system with healthy and abnormal (injured/pathologic) spinal cord images obtained by imaging a population of healthy, typically developed spinal cord subjects and subjects with spinal cord injury, evaluating a novel, diffusion-based MRI image for injury biomarkers using the adaptive CNN system, generating a three-dimensional predictive axonal damage map for quantitative characterization and visualization of the novel, diffusion-based MRI image, and transmitting the sets of healthy and injured spinal cord images back to a central database for continued improvement of the adaptive CNN system training. A system for defining a predictive spinal axonal damage map is also described.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 12, 2023
    Assignee: Thomas Jefferson University
    Inventors: Christopher J. Conklin, Feroze B. Mohamed, Devon M. Middleton, Mahdi Alizadeh
  • Patent number: 11826011
    Abstract: A device and a signal processing method that can monitor human memory performance by recognizing and characterizing high-gamma (65-250 Hz) and beta (14-30 Hz) band oscillations in the left Brodmann Area 40 (BA40) of the brain that correspond with the strength of memory encoding or correct recall. The signal processing method detects high-gamma and beta band oscillations in the electrical signals recorded from left BA40, and quantifies the spectral content, power, duration, onset, and offset of the oscillations. The oscillation's properties are used to classify the subject's memory performance on the basis of a comparison with the subject's prior human memory performance and the properties of the corresponding oscillations. A report of the subject's current memory performance can be utilized in a closed loop brain stimulation device that serves the purpose of enhancing human memory performance.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 28, 2023
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Shennan Aibel Weiss, Zachary Waldman, Michael Sperling
  • Patent number: 11801259
    Abstract: The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: October 31, 2023
    Assignee: Thomas Jefferson University
    Inventors: David W. Andrews, Douglas C. Hooper
  • Patent number: 11767474
    Abstract: A thermal process for carbonizing hemp and reducing particle size, mechanically, by grinding or milling said carbonized hemp materials to generate a precise particle size hemp char and combining the hemp char particles with a polymer into a master batch.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: September 26, 2023
    Assignee: Thomas Jefferson University
    Inventor: Mark Sunderland
  • Patent number: 11759114
    Abstract: An implantable extravascular pressure sensing system includes a cuff including a first brace portion affixed to a second brace portion and defining a longitudinal axis therebetween. The first brace portion defines a fluid chamber, the fluid chamber defining a recessed aperture. A first lateral restraint and a second lateral restraint are disposed between the first brace and the second brace, the first lateral restraint and the second lateral restraint being configured to be displaceable in a direction orthogonal to the longitudinal axis. A diaphragm is coupled to the fluid chamber and sealing the recessed aperture. A fluid is disposed within the fluid chamber for exhibiting a hydraulic pressure in communication with the diaphragm. A pressure sensor is coupled to the first brace portion, the pressure sensor being configured to measure a change in the hydraulic pressure when a force is imparted on the diaphragm.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: September 19, 2023
    Assignees: RTM Vital Signs LLC, Thomas Jefferson University
    Inventors: Josiah Verkaik, Jeffrey I Joseph
  • Patent number: 11751771
    Abstract: An implantable extravascular pressure sensing system including a cuff having a first brace portion, a second brace portion, and a plurality of biasing members movably coupling the first brace portion and the second brace portion to each other, the first brace portion defining a fluid chamber, the fluid chamber defining a recessed aperture, a flexible diaphragm coupled to the fluid chamber and sealing the recessed aperture, a fluid disposed within the fluid chamber for exhibiting a hydraulic pressure in communication with the flexible diaphragm, and a pressure sensor coupled to the first brace portion, the pressure sensor being configured to measure a change in the hydraulic pressure when a force is imparted on the flexible diaphragm.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: September 12, 2023
    Assignees: RTM Vital Signs, LLC, Thomas Jefferson University
    Inventors: Josiah Verkaik, Jeffrey I. Joseph, Noud Van Helmond
  • Publication number: 20230282308
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Application
    Filed: December 15, 2022
    Publication date: September 7, 2023
    Applicant: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Publication number: 20230240585
    Abstract: A device and a signal processing method that can be used with a device to recognize and distinguish a physiological high-frequency oscillation (HFO) from a pathological high-frequency oscillation. The signal processing method detects a physiological HFO in the electrical brain signal one regimen of electrical or optogenetic brain stimulation can be triggered, alternatively if the method detects a pathological HFO associated with epilepsy a different regimen of electrical or optogenetic brain stimulation can be triggered. Thus, the signal processing method can be utilized in a closed loop brain stimulation device that serves the dual purpose of both enhancing memory encoding, consolidation, and recall, or improving cognition, and reducing the probability of a seizure in a patient with epilepsy.
    Type: Application
    Filed: October 14, 2022
    Publication date: August 3, 2023
    Applicant: Thomas Jefferson University
    Inventors: Shennan WEISS, Zachary WALDMAN, Inkyung SONG
  • Patent number: 11715549
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 1, 2023
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Publication number: 20230220457
    Abstract: A method for specifically and efficiently quantifying the expression of targeted RNA variants with specific terminal sequences suitable to identify multiple isoforms bearing complex heterogeneity in terminal sequences by hybridizing a 5?-Dbs-adapter to the 5?-end of target RNAs, wherein the 5?-Dbs-adapter has a stem-loop structure whose protruding 5?-end base-pairs with the 5?-end of target RNAs, and wherein the loop region of 5?-Dbs-adapter contains a base-lacking spacer which will terminate reverse transcription in a subsequent step; hybridizing a 3?db-adapter to the 3?-end of target RNAs, wherein the 3?-db-adapter has a stem-loop structure whose protruding 3?-end base-pairs with the 3?-end of target RNAs; ligating both adapters with target RNAs by RN12 ligation to form a “dumbbell-like” structure; and, amplifying and quantifying the ligation product by RT-PCR.
    Type: Application
    Filed: November 10, 2022
    Publication date: July 13, 2023
    Applicant: Thomas Jefferson University
    Inventors: Yohei KIRINO, Shozo HONDA
  • Patent number: 11666728
    Abstract: A system to provide circadian-friendly lighting for nighttime hospital care comprising a lighting module and a transmitter tag that interface wirelessly wherein the lighting module comprises red-shifted light spectra, which is proven to be less disruptive to melatonin production than current blue-shifted hospital lighting; wherein the light output of the devices is modulated by the proximity of a tag to the device, with light intensity increasing with closer proximity between these two components and decreasing with increased distance, thereby providing hands-free lighting to caregivers in the specific locations where they need light to perform care tasks.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 6, 2023
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Lorenzo Albala, Graham Hale, Tim Bober, Bon Ku, Marcel Botha, Salih Berk Ilhan
  • Patent number: 11660336
    Abstract: The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: May 30, 2023
    Assignee: Thomas Jefferson University
    Inventors: Matthias Johannes Schnell, Christoph Wirblich, Drishya Kurup
  • Patent number: 11578366
    Abstract: The present invention includes a method for analyzing RNA fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of rRNA fragments. The invention also includes diagnosing, identifying or monitoring a disease or condition, and a method for identifying rRNA fragments. The invention also includes diagnosing, identifying or monitoring a glaucoma in a subject in need thereof by characterizing the identity of rRNA or tRNA fragments.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 14, 2023
    Assignee: Thomas Jefferson University
    Inventor: Isidore Rigoutsos
  • Publication number: 20230044615
    Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.
    Type: Application
    Filed: June 30, 2022
    Publication date: February 9, 2023
    Applicants: Thomas Jefferson University, Drexel University
    Inventors: Brian Edward Oeffinger, Margaret A. Wheatley, Rawan Shraim, Purva Vaidya, John Robert Eisenbrey
  • Patent number: 11571483
    Abstract: A modified melanoma cell line capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: February 7, 2023
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Andrew Aplin, Jessica Teh
  • Patent number: 11567065
    Abstract: A method for detecting and quantifying of the frequency of T cells to multiple antigenic peptide epitopes comprising: measuring intracellular Ca2+ signaling in individual T cells that are labeled with Ca2+ sensitive fluorophore; wherein said T cells are placed on the glass bottom of a well-covered with antibodies or other capturing proteins specific for non-stimulatory T cells' surface receptors and wherein a peptide antigens are injected into the well and the peptide binds to MHC molecules on the T-cell surface, wherein an increase in the intracellular concentration of Ca2+ in responding T cells leads to rise in intracellular fluorescence that is detected by fluorescent microscope and wherein the response rate of said detected fluorescence can be utilized to determine the quantity of responding T cells and the efficiency of said cells.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 31, 2023
    Assignee: Thomas Jefferson University
    Inventors: Yuri Sykulev, Nadezhda Anikeyeva, Neal Flomenberg, Dolores Grosso
  • Patent number: RE49477
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: March 28, 2023
    Assignee: Thomas Jefferson University
    Inventors: Andrzej Fertala, Andrzej Steplewski