Patents Assigned to Thomas Jefferson University
  • Publication number: 20210275773
    Abstract: A system to provide circadian-friendly lighting for nighttime hospital care comprising a lighting module and a transmitter tag that interface wirelessly wherein the lighting module comprises red-shifted light spectra, which is proven to be less disruptive to melatonin production than current blue-shifted hospital lighting; wherein the light output of the devices is modulated by the proximity of a tag to the device, with light intensity increasing with closer proximity between these two components and decreasing with increased distance, thereby providing hands-free lighting to caregivers in the specific locations where they need light to perform care tasks.
    Type: Application
    Filed: July 31, 2017
    Publication date: September 9, 2021
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Lorenzo Albala, Graham Hale, Tim Bober, Bon Ku, Marcel Botha, Salih Berk Ilhan
  • Publication number: 20210260066
    Abstract: A method of reducing the severity of radiation induced fibrosis (RIF) by administering to a patient at least a first dose of an MeK inhibitor such as trametinib between 0.01 mg to 2.0 mg, and after said radiation procedure, administering to said patient a further dose of the MeK inhibitor between 0.01 mg and 2.0 mg after the radiation procedure.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 26, 2021
    Applicant: Thomas Jefferson University
    Inventors: Joel ROSENBLOOM, Edward John MACARAK
  • Patent number: 11085045
    Abstract: The present invention provides functional aptamer-comprising tRNA molecules, useful in the study of tRNA and ribosomal activity.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: August 10, 2021
    Assignees: Anima Biotech Inc., Thomas Jefferson University
    Inventors: Iris Alroy, Ya-Ming Hou, Howard Gamper
  • Patent number: 11077133
    Abstract: The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the selective reduction of M2 cells by targeting expression of IGF-1R in these cells. The present disclosure further provides methods for treating cancer and enhancing therapeutic by targeting expression of IGF-1R in M2 cells in patients. The pharmaceutical composition of the present invention is effective when administered systemically to subjects in need thereof. The ease of administration of the pharmaceutical composition facilitates treatment and enhances patient compliance.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: August 3, 2021
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: David W. Andrews, Douglas C. Hooper
  • Patent number: 11071476
    Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 27, 2021
    Assignees: Thomas Jefferson University, RTM Vital Signs LLC
    Inventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
  • Patent number: 11053405
    Abstract: A process for forming a conductive hemp-based ink comprising carbonizing hemp and reducing the particle size of said hemp via a milling process to between 2 and 5 microns, wherein said reduced size hemp particles are combined with at least one aqueous carrier to produce an ink, and wherein said ink is conductive.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: July 6, 2021
    Assignee: Thomas Jefferson University
    Inventor: Mark Sunderland
  • Publication number: 20210194941
    Abstract: A modified melanoma cell line capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.
    Type: Application
    Filed: September 3, 2020
    Publication date: June 24, 2021
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Andrew Aplin, Jessica Teh
  • Patent number: 11041170
    Abstract: The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: June 22, 2021
    Assignees: Thomas Jefferson University, The United States of America, as represented by the Secretary, Department of Health & Human Service, University of Maryland
    Inventors: Reed F. Johnson, Matthias Schnell, Lisa E. Hensley, Christoph Wirblich, Christopher M. Coleman, Matthew B. Frieman
  • Publication number: 20210145347
    Abstract: A device and a signal processing method that can monitor human memory performance by recognizing and characterizing high-gamma (65-250 Hz) and beta (14-30 Hz) band oscillations in the left Brodmann Area 40 (BA40) of the brain that correspond with the strength of memory encoding or correct recall. The signal processing method detects high-gamma and beta band oscillations in the electrical signals recorded from left BA40, and quantifies the spectral content, power, duration, onset, and offset of the oscillations. The oscillation's properties are used to classify the subject's memory performance on the basis of a comparison with the subject's prior human memory performance and the properties of the corresponding oscillations. A report of the subject's current memory performance can be utilized in a closed loop brain stimulation device that serves the purpose of enhancing human memory performance.
    Type: Application
    Filed: June 13, 2018
    Publication date: May 20, 2021
    Applicant: Thomas Jefferson University
    Inventors: Shennan Aibel Weiss, Zachary Waldman, Michael Sperling
  • Publication number: 20210145959
    Abstract: The present disclosure is directed towards chimeric glycoproteins wherein the clip region, a core region, a flap region, and a transmembrane and cytoplasmic domain are defined by starting from the amino terminus of the protein, these domains are comprised of the following amino acid residue ranges: clip, 1 through 40 to 60; core, 40 to 60 through 249 to 281; flap, 249 to 281 through 419 to 459; the transmembrane domain is comprised of amino acids 460 through 480, and the remaining amino acids 481 through 525 comprise the cytoplasmic domain; and wherein the clip, core, flap, transmembrane, and cytoplasmic domain comprise a chimeric combination of at least two lyssavirus, wherein the chimeric glycoprotein is advantageously inserted into a rabies-based vaccine vector.
    Type: Application
    Filed: June 13, 2018
    Publication date: May 20, 2021
    Applicants: Thomas Jefferson University, ICAHN School of Medicine at Mount Sinai
    Inventors: Schnell Matthias, Christine Rettew Fisher, Christoph Wirblich, Gene Tan
  • Patent number: 11006863
    Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: May 18, 2021
    Assignees: Thomas Jefferson University, RTM Vital Signs LLC
    Inventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
  • Patent number: 11000212
    Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: May 11, 2021
    Assignees: Thomas Jefferson University, RTM Vital Signs LLC
    Inventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
  • Patent number: 11000195
    Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: May 11, 2021
    Assignees: Thomas Jefferson University, RTM Vital Signs LLC
    Inventors: Jeffrey I. Joseph, Apurva Jain, Jonathan Goettler, Nance Dicciani, Denise Devine
  • Patent number: 11001897
    Abstract: The present invention relates to systems, devices and methods for diagnosing cancer. In various embodiments, the present invention provides a method for quantifying a 5?-htRNA; a method for quantifying a 3?-htRNA; a method for obtaining a DNA library of 5?-htRNAs and a DNA library of 5?-htRNAs obtained therefrom; and a method for obtaining a DNA library of 3?-htRNAs and a DNA library of 3?-htRNAs obtained therefrom. The invention also teaches a method for determining the presence or absence of a cancer cell in a biological sample; a method of diagnosing cancer in a subject; and a method of prognosing cancer in a subject.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: May 11, 2021
    Assignee: Thomas Jefferson University
    Inventors: Yohei Kirino, Shozo Honda
  • Patent number: 11000191
    Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: May 11, 2021
    Assignees: Thomas Jefferson University, RTM Vital Signs LLC
    Inventors: Jeffrey I Joseph, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
  • Patent number: 10982214
    Abstract: Therapeutic compositions and methods of treatment of the central nervous system, specifically towards hypertension comprising administration of a therapeutic comprising an anti-miR-135a, an anti-miR-miR-376a, or a combination, in the central nervous system effectively attenuates hypertension for up to four weeks provided a single administration.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: April 20, 2021
    Assignee: Thomas Jefferson University
    Inventors: Rajanikanth Vadigepalli, Danielle Decicco, James Schwaber
  • Publication number: 20210077646
    Abstract: A sanitation system may include a sink, a sanitation material dispenser for dispensing material such as soap, and a dryer for either dispensing dryer material such as paper towels or providing heated air. An electronic device may be in communication with one or more of these items, and a sanitation module may operate on the sanitation system. The sanitation module may time a sanitation activity for the sanitation system, such as hand washing. Content may be displayed on the electronic device, and the content may serve to engage or distract the user. The electronic device may be able to identify the individual user and customize the content. The sanitation module may time the sanitation procedure and may accordingly promote a minimum time spent on the sanitation activity. The sanitation system may also be used for monitoring either the sanitation material or the dryer material and automatically order new material when the material is low.
    Type: Application
    Filed: November 30, 2020
    Publication date: March 18, 2021
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Jeffrey Riggio, Robert Neff
  • Patent number: 10927477
    Abstract: A process of forming a fiber comprised of a plurality of bio-char particles, comprising: combining a portion of a polymer with a hemp derivative, said hemp derivative selected form a hemp carbon made by pyrolyzing a quantity of hemp stalk at between 1100-1500° C. to create a char; adding the char to a milling vessel and milling the char for a period of between 1 to 16 hours, and a full spectrum hemp extract, or combinations thereof, wherein the polymer and hemp derivative are extruded to form a fiber.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: February 23, 2021
    Assignees: Thomas Jefferson University, Ecofibre USA Inc.
    Inventors: Mark Sunderland, Jeffrey William Bruner, Lee Benjamin Williams
  • Patent number: 10927304
    Abstract: A thermal process for carbonizing hemp and reducing particle size, mechanically, by grinding or milling said carbonized hemp materials to generate a precise particle size hemp char and combining the hemp char particles with a polymer into a master batch.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: February 23, 2021
    Assignee: Thomas Jefferson University
    Inventor: Mark Sunderland
  • Patent number: 10913900
    Abstract: A thermal process for carbonizing hemp and reducing particle size, mechanically, by grinding or milling said carbonized hemp materials to generate a precise particle size hemp char and combining the hemp char particles with a polymer into a master batch.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: February 9, 2021
    Assignee: Thomas Jefferson University
    Inventor: Mark Sunderland