Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
Type:
Grant
Filed:
August 22, 2019
Date of Patent:
July 27, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
Abstract: A process for forming a conductive hemp-based ink comprising carbonizing hemp and reducing the particle size of said hemp via a milling process to between 2 and 5 microns, wherein said reduced size hemp particles are combined with at least one aqueous carrier to produce an ink, and wherein said ink is conductive.
Abstract: A modified melanoma cell line capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.
Abstract: The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.
Type:
Grant
Filed:
March 31, 2017
Date of Patent:
June 22, 2021
Assignees:
Thomas Jefferson University, The United States of America, as represented by the Secretary, Department of Health & Human Service, University of Maryland
Inventors:
Reed F. Johnson, Matthias Schnell, Lisa E. Hensley, Christoph Wirblich, Christopher M. Coleman, Matthew B. Frieman
Abstract: The present disclosure is directed towards chimeric glycoproteins wherein the clip region, a core region, a flap region, and a transmembrane and cytoplasmic domain are defined by starting from the amino terminus of the protein, these domains are comprised of the following amino acid residue ranges: clip, 1 through 40 to 60; core, 40 to 60 through 249 to 281; flap, 249 to 281 through 419 to 459; the transmembrane domain is comprised of amino acids 460 through 480, and the remaining amino acids 481 through 525 comprise the cytoplasmic domain; and wherein the clip, core, flap, transmembrane, and cytoplasmic domain comprise a chimeric combination of at least two lyssavirus, wherein the chimeric glycoprotein is advantageously inserted into a rabies-based vaccine vector.
Type:
Application
Filed:
June 13, 2018
Publication date:
May 20, 2021
Applicants:
Thomas Jefferson University, ICAHN School of Medicine at Mount Sinai
Inventors:
Schnell Matthias, Christine Rettew Fisher, Christoph Wirblich, Gene Tan
Abstract: A device and a signal processing method that can monitor human memory performance by recognizing and characterizing high-gamma (65-250 Hz) and beta (14-30 Hz) band oscillations in the left Brodmann Area 40 (BA40) of the brain that correspond with the strength of memory encoding or correct recall. The signal processing method detects high-gamma and beta band oscillations in the electrical signals recorded from left BA40, and quantifies the spectral content, power, duration, onset, and offset of the oscillations. The oscillation's properties are used to classify the subject's memory performance on the basis of a comparison with the subject's prior human memory performance and the properties of the corresponding oscillations. A report of the subject's current memory performance can be utilized in a closed loop brain stimulation device that serves the purpose of enhancing human memory performance.
Type:
Application
Filed:
June 13, 2018
Publication date:
May 20, 2021
Applicant:
Thomas Jefferson University
Inventors:
Shennan Aibel Weiss, Zachary Waldman, Michael Sperling
Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
Type:
Grant
Filed:
February 27, 2020
Date of Patent:
May 18, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
Type:
Grant
Filed:
July 24, 2020
Date of Patent:
May 11, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I Joseph, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
Abstract: The present invention relates to systems, devices and methods for diagnosing cancer. In various embodiments, the present invention provides a method for quantifying a 5?-htRNA; a method for quantifying a 3?-htRNA; a method for obtaining a DNA library of 5?-htRNAs and a DNA library of 5?-htRNAs obtained therefrom; and a method for obtaining a DNA library of 3?-htRNAs and a DNA library of 3?-htRNAs obtained therefrom. The invention also teaches a method for determining the presence or absence of a cancer cell in a biological sample; a method of diagnosing cancer in a subject; and a method of prognosing cancer in a subject.
Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
Type:
Grant
Filed:
August 18, 2020
Date of Patent:
May 11, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.
Type:
Grant
Filed:
November 17, 2016
Date of Patent:
May 11, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I. Joseph, Apurva Jain, Jonathan Goettler, Nance Dicciani, Denise Devine
Abstract: Therapeutic compositions and methods of treatment of the central nervous system, specifically towards hypertension comprising administration of a therapeutic comprising an anti-miR-135a, an anti-miR-miR-376a, or a combination, in the central nervous system effectively attenuates hypertension for up to four weeks provided a single administration.
Type:
Grant
Filed:
July 20, 2017
Date of Patent:
April 20, 2021
Assignee:
Thomas Jefferson University
Inventors:
Rajanikanth Vadigepalli, Danielle Decicco, James Schwaber
Abstract: A sanitation system may include a sink, a sanitation material dispenser for dispensing material such as soap, and a dryer for either dispensing dryer material such as paper towels or providing heated air. An electronic device may be in communication with one or more of these items, and a sanitation module may operate on the sanitation system. The sanitation module may time a sanitation activity for the sanitation system, such as hand washing. Content may be displayed on the electronic device, and the content may serve to engage or distract the user. The electronic device may be able to identify the individual user and customize the content. The sanitation module may time the sanitation procedure and may accordingly promote a minimum time spent on the sanitation activity. The sanitation system may also be used for monitoring either the sanitation material or the dryer material and automatically order new material when the material is low.
Abstract: A thermal process for carbonizing hemp and reducing particle size, mechanically, by grinding or milling said carbonized hemp materials to generate a precise particle size hemp char and combining the hemp char particles with a polymer into a master batch.
Abstract: A process of forming a fiber comprised of a plurality of bio-char particles, comprising: combining a portion of a polymer with a hemp derivative, said hemp derivative selected form a hemp carbon made by pyrolyzing a quantity of hemp stalk at between 1100-1500° C. to create a char; adding the char to a milling vessel and milling the char for a period of between 1 to 16 hours, and a full spectrum hemp extract, or combinations thereof, wherein the polymer and hemp derivative are extruded to form a fiber.
Type:
Grant
Filed:
April 27, 2020
Date of Patent:
February 23, 2021
Assignees:
Thomas Jefferson University, Ecofibre USA Inc.
Inventors:
Mark Sunderland, Jeffrey William Bruner, Lee Benjamin Williams
Abstract: A thermal process for carbonizing hemp and reducing particle size, mechanically, by grinding or milling said carbonized hemp materials to generate a precise particle size hemp char and combining the hemp char particles with a polymer into a master batch.
Abstract: Applications of dielectric barrier discharge (DBD) based atmospheric pressure plasma jets are often limited by the relatively small area of treatment due to their 1D configuration. This system generates 2D plasma jets permitting fast treatment of larger targets. DBD evolution starts with formation of transient anode glow, and continues with development of cathode-directed streamers. The anode glow can propagate as an ionization wave along the dielectric surface through and outside of the discharge gap. Plasma propagation is not limited to 1D geometry such as tubes, and can be organized in a form of a rectangular plasma jet, or other 2D or 3D shapes. Also described are a method for generating 2D plasma jets and use of the 2D plasma jets for cancer therapy.
Type:
Application
Filed:
February 20, 2019
Publication date:
January 28, 2021
Applicants:
Drexel University, Thomas Jefferson University
Inventors:
Danil V. DOBRYNIN, Alexander FRIDMAN, Abraham LIN, Vandana MILLER, Adam Snook
Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
Type:
Grant
Filed:
August 19, 2019
Date of Patent:
January 5, 2021
Assignees:
Thomas Jefferson University, RTM Vital Signs LLC
Inventors:
Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
Abstract: A composition of matter comprising an adeno-associated virus (AAV) or other human compatible virus, encoding the gene for Sialidase Neu3, B3Galt4, St3Gal2, or combinations thereof, and a neuron specific promoter, wherein the composition is suitable for administration to a patient comprising injecting the AAV or other human compatible virus into the brain by intracranial stereotaxic injunction; wherein the AAV's encoding for the Sialidase Neu3, B3Galt4, St3Gal2, or combinations thereof enhance and/or normalize levels of GM1 in neurons, providing both therapeutic relief and disease modifying effects in specific areas of the brain relevant to particular neurodegenerative diseases.
Abstract: A sanitation system may include a sink, a sanitation material dispenser for dispensing material such as soap, and a dryer for either dispensing dryer material such as paper towels or providing heated air. An electronic device may be in communication with one or more of these items, and a sanitation module may operate on the sanitation system. The sanitation module may time a sanitation activity for the sanitation system, such as hand washing. Content may be displayed on the electronic device, and the content may serve to engage or distract the user. The electronic device may be able to identify the individual user and customize the content. The sanitation module may time the sanitation procedure and may accordingly promote a minimum time spent on the sanitation activity. The sanitation system may also be used for monitoring either the sanitation material or the dryer material and automatically order new material when the material is low.