Abstract: A method and apparatus for determining a particle criterion to set a predetermined region as the particle criterion in a distribution data of a particles of a specimen and to analyze the specimen based on particles which appear in the predetermined region, includes preparing first fundamental distribution data by accumulating each distribution data of a first specimen group which belongs to a first category, preparing second fundamental distribution data by accumulating each distribution data of a second specimen group which belongs to a second category, calculating a region on the distribution data where peculiar particles exist in the first or second category by comparing the first and second fundamental distribution data and establishing the calculated region as the particle criterion. The region may also be shifted if needed.

Abstract: The present invention relates to an apparatus for automatically analyzing cells in urine using flow cytometry. The present invention includes means for converting scattered-light signals indicative of individual cells in a urine specimen into corresponding pulse signals, means for converting the pulse width of each pulse signal resulting from the aforementioned conversion into cell-diameter data in accordance with known cell diameters, and means for classifying and enumerating various cells in the urine in correlation with each item of cell-diameter data resulting from the conversion.

Abstract: The particle measuring apparatus includes a specimen pipetting section for pipetting a specimen liquid, a reagent dispensing section for dispensing a reagent, a mixing section for receiving the specimen liquid supplied by the specimen pipetting section and the reagent dispensed by the reagent dispensing section and a flow cell for receiving the specimen liquid and the reagent transferred from the mixing section and measuring particles therein; the pipet being so constructed as to be positioned in a first state of picking up the specimen liquid as well as in a second state of supplying the specimen liquid into the mixing section, the mixing section being open when the pipet is in the first state, the mixing section being kept closed by the pipet in the second state so that the reagent dispensed by the reagent dispensing section can press and transfer the specimen liquid in the mixing section out toward the particle measuring section.

Abstract: A method for classifying and counting leukocytes which includes the steps of (i) adding a first reagent used for classifying leukocytes into four groups which contains, (a) at least one ionic surfactant in a sufficient amount to lyse erythrocytes and to damage a part of cell membrane of leukocytes, (b) at least one organic compound having an anionic group in a sufficient amount to bond with a cationic component present in leukocytes to give morphological differences between leukocytes, (c) a nonionic surfactant, and (d) a buffer for adjusting pH, to a part of a blood sample to determine information on the cell size and morphological features in order to classify leukocytes into four groups consisting of three groups corresponding to lymphocytes, mononuclear cells and eosinophils and one group corresponding to neutrophils and basophils; (ii) adding a second reagent used for measuring basophils to another part of the blood sample to determine information on at least the cell size in order to classify basophils,

Abstract: A calculator selects desired data out of a set of data obtained by analyzing a sample, such as blood or urine, and normalizes the selected data with respect to a predetermined level. The normalized values obtained by the calculator may be displayed as values and/or graphs. The graphical display may show a partition line set according to the experiences of the laboratory, so the graph may be quickly understood.

Abstract: A cuvette, to be used for measuring the properties of liquid contained therein by applying a measuring beam of light from a direction intersecting the vertical axis of the cuvette, includes a rectangular or square-outlined portion on the top thereof as viewed in a horizontal cross section, a cylindrical portion below the top portion, and a lower rectangular or square portion provided vertically below the cylindrical portion and having four sides parallel to these of the top rectangular portion, respectively. Thus, the cuvette does not unfavorably rotate when measuring the absorption of light transmitted therethrough. Further, an apparatus for transporting the aforementioned transparent cuvette, accurately controls the position of the cuvette during transportation so that a flat surface thereof can be irradiated with a measuring beam of light.

Abstract: A liquid sampling valve includes a fixed element having a contact surface and a movable element having a contact surface for contacting the contact surface of the fixed element; the fixed element or the movable element having measuring passageways extending to the contact surfaces, the measuring passageways having an opening for receiving and measuring a liquid sample incorporated into the opening; both the fixed element and the movable element being provided with a plurality of cleaning passageways, each having an opening at a location spaced apart from the central part of the contact surface, the location being different from the locations where the openings for the measuring passageways are provided. Movement of the movable element relative to the fixed element into a first state allows for a liquid sample to be filled into the measuring passageway, and movement into the second state allows for the liquid sample filled in the measuring passageway to be conveyed to out of the element.

Abstract: A mixing apparatus, which can prevent possibility of mixing nonuniformity and contamination, employs a small and simple mechanism, and is advantageous with respect to costs. A vessel is gripped and held from the right and left sides by a hand member. The hand member horizontally rotatable by an urging power of a coil spring at the bottom of a support member. A vibration motor comprises a DC coreless motor body and an eccentric weight, the weight being eccentrically mounted to a motor shaft of the motor body. The rotation of the weight allows the motor body to eccentrically rotate, whereby the support member conically revolves and vibrates. The weight has a semicircular cross section. The support member is connected to a mobile member for moving the support member through a resilient member to allow the conical revolution of the support member.

Abstract: A sample liquid containing particles are caused to flow through a transparent flow cell. An image capturing device is used to capture different images for a single particle existing in an image capturing area of the flow cell. The image capturing device further preferably captures different images of the single particle from different directions. Further, the image capturing device can capture different images at different focal positions. The different images can include fluorescence images and chemiluminescence images.

Abstract: A particle analyzer includes a flow cell for enclosing a sample liquid containing particles in a sheathed flow to form a flat flow of the sample liquid; an exciting light source for emitting light for exciting fluorescence to irradiate the particle in the flat flow; a capturing device for capturing a fluorescent image of the particle when the particle reaches a predetermined position of the flat flow, the exciting light source and the capturing device being disposed so that a capturing optical axis of the capturing device is perpendicular to a surface of the flat flow and orthogonal to a light emitting optical axis of the exciting light source; and a shutter device for allowing the capturing device to receive the fluorescence from the particle for a predetermined period of time.

Abstract: Particle measuring apparatus 1 comprising slide plate 3 set between tanks 2a and 2b and having through-holes 8 to 11 passing through slide plate 3 and a pair of electrodes 4a and 4b, wherein through-holes 8 to 11 on slide plate 3 are formed by a group of through-holes with different diameters. When one of the through-holes 8 to 11 is brought to a position corresponding to connective holes 2c and 2d by driving unit 7, particle distribution is measured and analyzed in accordance with the electrical impedance when a sample suspension passes through the through-hole.

Abstract: An apparatus comprises a memory for storing a characteristic pattern for each of a plurality of groups, a discriminant function defining part for selecting at random every combination of two groups of the plurality of groups stored in the memory and defining for every selected combination of two groups a two-group linear discriminant function which provides an optimal borderline bisecting the combination of two groups, a two-group discrimination result calculation part for calculating a two-group discrimination result to which a given sample is attributed for every combination of two groups using the two-group linear discriminant function defined by the discriminant function defining part, a support degree determination part for determining a support degree of the two-group discrimination result obtained by the two-group discrimination result calculation part for every combination of two-groups, and an attribution degree calculation part for calculating attribution degrees indicating to what extent the test d

Abstract: A reagent for analyzing leucocytes comprises (a) at least one ionic surfactant, being either a cationic or an amphoteric surfactant, in an amount sufficient for lysing erythrocytes and causing damage to a part of cell membranes of leucocytes; (b) at least one organic compound having a hydrophobic group and an acidic group which has a negative charge in an aqueous solution in an amount sufficient for a preserving leucocyte morphology by combining with a cationic component in leucocytes; (c) a nonionic surfactant; and (d) a buffer for adjusting pH.

Abstract: A non-invasive blood analyzer includes a light application device for applying light to a detection region of vessels contained in part of the living body, an imaging device for imaging the detection region to which light is applied, a fixing device for relatively fixing the imaging device and the part of the living body; a stabilizing device for stabilizing a focus of the imaging device with respect to the detection region; and an analyzer for analyzing the morphology and/or number of blood cells contained in the detection region by processing images captured with the imaging device, the light application device and the imaging device forming one image with a light application and capturing process during an interval of one ten thousandth to one billionth of a second.

Abstract: A particle analyzing apparatus includes a flow device having a light-transmissive flow cell for allowing subject particles in a sample liquid to flow in a separated state, a laser beam illuminator for illuminating a subject particle flowing in the flow cell with a laser beam and a coherence lowering device for lowering coherence of the laser beam. The particle analyzing apparatus further includes an image capturing device receiving light from the subject particle, for capturing an image of the subject particle and an image processor for processing and analyzing the captured image of the subject particle. By use of the coherence lowering device, both temporal and spatial coherence of the laser beam is lowered. Thus, image quality is improved and a high quality particle image can be obtained which is bright and high in S/N ratio.

Abstract: A dispensing device having a flexible tube provided with a pipetting nozzle at an end, a washing solution supplier supplying washing solution to the flexible tube and the pipetting nozzle, a syringe connected to another end of the flexible tube and a control section for controlling the driving of the syringe. The control section of the present invention includes a syringe driving compensator by which the washing solution is supplied into or discharged out of the syringe in an amount compensate for the variation in the inner volume of the tube caused by reduction in the liquid pressure when the washing solution is transmitted from the washing solution supplier into the flexible tube. The liquid surface of the washing solution contained in the pipetting nozzle is maintained at a constant level by actuating the driving compensator in response to the completion of washing of the pipetting nozzle with the washing solution.

Abstract: A washing apparatus includes a pipet-outer-wall washing member embedding a through-hole in which a pipet is loosely inserted, a supply path for supplying washing solution to the through-hole, and a discharge path for discharging waste liquid from the through-hole. It further includes a pipet-interior washing device which connects to the pipet. A washing solution storage chamber is connected to the supply path in the pipet-outer-wall washing member and to the pipet-interior washing device and a suction device is connected to the discharge path of the washing member. The sucking device is used for sucking-up waste liquid which exits the through-hole at a side wall thereof. A waste liquid storage chamber is connected to the discharge path. Finally, a drive device causes at least one of the washing member and the pipet to move relative to the other to vary the relative position of the washing member versus the pipet to thereby allow for washing of the entire pipet.

Abstract: A blood analyzer system transports blood samples through at least one blood analyzer and an automatic blood smear generator under the control of a preprogrammable controller. Blood samples are stored in containers that identify the blood samples they contain. The containers move through the system mounted in protective racks that permit the reading of the identifications. The results of analysis by one or more blood analyzers in the system determines for each sample individually whether or not to make a blood smear. When a blood smear is to be made, the controller makes the smear thickness of each blood sample consistent with other samples whatever the consistency of the sample to be smeared. If a required sample is not made, a detector sounds an alarm, thereby alerting operators that the system has failed.

Abstract: An apparatus and a method for automatically analyzing specimens are disclosed.