Abstract: An object of the present invention is to provide an antithrombotic agent that has fewer side effects and that is highly effective. The present invention provides an antithrombotic agent comprising (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate represented by Formula (1) as an active ingredient.

Abstract: The object of the invention is to provide a functional thin tube device in which a pump and a liquid drawing device are constituted to be not separate without a sophisticated channel design and to correspond to various applications. A functional thin tube device includes a hollow tubular body, a plurality of vibrating ring bodies mounted as being kept in contact with the tubular body spaced an interval along an axial direction on an outer circumference of the tubular body, and an energy supply means of energy for vibrating the vibrating ring bodies. The energy supply means is constituted to supply energy such that the displacement caused by vibrations is mutually different among the vibrating ring bodies.

Abstract: A method and an apparatus capable of selectively damaging and killing tumor cells includes a step of irradiating tumor cells with a UV pulse flash having continuous emission spectra ranging at least from 230 to 270 nm, outside a living body of a human or a living body of a non-human animal or in a living body of a non-human animal. The UV pulse flash may have an accumulated irradiation amount per unit area that is achieved at a distance of 8 cm from a light source having an integrated output of, for example, 90, 180-7100 or 14200 J.

Abstract: A neutron measurement apparatus 1A includes a neutron detection unit 10, a photodetection unit 20 that detects scintillation light emitted from the neutron detection unit 10, a light guide optical system 15 that guides the scintillation light from the neutron detection unit 10 to the photodetection unit 20, and a shielding member 30 which is located between the neutron detection unit 10 and the photodetection unit 20 for shielding radiation passing in a direction toward the photodetection unit 20. Further, a scintillator formed of a lithium glass material in which PrF3 is doped to a glass material 20Al(PO3)3-80LiF is used as a neutron detection scintillator composing the neutron detection unit 10. Thereby, the neutron detection scintillator and the neutron measurement apparatus which are capable of suitably performing neutron measurement such as measurement of scattered neutrons from an implosion plasma can be realized.

Abstract: The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.

Abstract: It is an object of the present invention to provide an agent for suppressing the replication of HIV, which comprises a human CD4-recognizing antibody.

Abstract: An object of the present invention is to provide a method for diagnosing endometrial cancer by comprehensively analyzing the glycan structures of glycoprotein with the normal endometrium and endometrial cancers (well-differentiated/poorly-differentiated), using the lectin microarray system. The present invention provides a method for diagnosing or determining the state of normal endometrium or endometrial cancer/cancer stages by glycan profiling using a structure of a glycoprotein in a sample as an indicator.

Abstract: An object of the present invention is to provide a novel method for producing a peptide utilizing a ligation reaction in which ligation efficiency is excellent and side reactions to other functional groups in the peptide are hard to occur, in comparison with the conventional native chemical ligation methods utilizing the thiol auxiliary group. The present invention provides a method for producing a peptide which comprises a step of causing a first peptide and a second peptide to react in the presence of a reducing agent to obtain a ligated product of the first peptide and the second peptide, wherein the first peptide contains, at the C-terminal end, an amino acid derivative having a thioester group, and the second peptide contains, at the N-terminal end, a serine or threonine derivative having a thiol auxiliary group.

Abstract: An ionic liquid which is high in ionic conductivity and high in safety without an anxiety of ignition or the like and an electrolyte composition containing the same are provided. The present invention concerns an electrolyte composition for photoelectric conversion device, containing a quaternary phosphonium salt ionic liquid represented by the following formula (1). A viscosity at 25° C. of this ionic liquid is preferably not more than 200 mPa·sec. In the formula (1), it is preferable that the alkoxyalkyl group is a methoxymethyl group, and all of the alkyl groups are an ethyl group. In the formula, R1 represents a linear alkyl group or a branched alkyl group each having from 1 to 6 carbon atoms; R2 represents a methyl group or an ethyl group; n represents an integer of from 1 to 6; and X represents N(SO2CF3)2 or N(CN)2.

Abstract: A magnetic resonance imaging apparatus includes an imaging unit which applies a labeling pulse to invert a spin included in a labeling region within part of a imaging region and then collects a echo signal from a time point when an inversion time has passed from the application of the labeling pulse, and a control unit, the control unit controlling the imaging unit so that the echo signal in the imaging region is collected a plurality of times with variations in the inversion time, the control unit also controlling the imaging unit so that a time ranging from a reference time point within a biological signal obtained from a subject to the application of the labeling pulse is a time determined in accordance with the inversion time.

Abstract: The present invention provides a carbon monoxide removal agent that can be easily administered to a patient by injection or orally. The carbon monoxide removal agent of the present invention contains, as an active ingredient, an inclusion complex in which a cyclodextrin dimer represented by chemical formula (1) below includes a water-soluble metalloporphyrin. (In the formula, m represents either of number 1 or 2 and n represents any of number 1, 2, or 3.

Abstract: Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

Abstract: A dry etching method includes the steps of: supplying process gas to an interior of a vacuum vessel and supplying high-frequency power for plasma generation to an electrode of a plasma generation unit disposed in the vacuum vessel so as to generate plasma; and applying a high-frequency bias voltage to a substrate which is a member to be etched so as to carry out etching of the substrate, wherein the etching is carried out while applying the high-frequency bias voltage in which a self-bias voltage Vdc of a substrate bias voltage is not less than 0 Volts, by adopting a composition using a high-frequency power source for bias which is transformer-coupled to the substrate and a direct current power source for bias which is connected in series to a secondary side of a transformer so as to apply the substrate bias voltage in which a high-frequency voltage and a direct current voltage are superimposed, to the substrate from these power sources via the transformer.

Abstract: A plasma oxidation method includes the steps of: generating oxygen-containing plasma with a process gas containing oxygen; applying a bias voltage to a substrate placed on a stage; and radiating positive ions and negative ions in the oxygen-containing plasma onto the substrate so as to perform plasma oxidation of the substrate while controlling a bias potential of the substrate in such a manner that a maximum value Vmax and a minimum value Vmin of the bias potential and a plasma potential Vp satisfy a following relationship: Vmin<Vp<Vmax.

Abstract: An object of the present invention is to provide a method for synthesizing a peptide thioester by using a compound that can be easily obtained within a relatively short time under conditions in which a side reaction is unlikely to occur. In the present invention, a thioester bond is formed by elongating a peptide chain using N-alkyl cysteine as the C-terminal amino acid according to the Fmoc method, carrying out deprotection, and then causing the peptide bond to undergo N—S transfer to the thiol group of N-alkyl cysteine under weak acidic conditions.

Abstract: An ionic liquid which is high in ionic conductivity and high in safety without an anxiety of ignition or the like and an electrolyte composition containing the same are provided. The present invention concerns an electrolyte composition for photoelectric conversion device, containing a quaternary phosphonium salt ionic liquid represented by the following formula (1). A viscosity at 25° C. of this ionic liquid is preferably not more than 200 mPa·sec. In the formula (1), it is preferable that the alkoxyalkyl group is a methoxymethyl group, and all of the alkyl groups are an ethyl group. In the formula, R1 represents a linear alkyl group or a branched alkyl group each having from 1 to 6 carbon atoms; R2 represents a methyl group or an ethyl group; n represents an integer of from 1 to 6; and X represents N(SO2CF3)2 or N(CN)2.

Abstract: A magnetic resonance imaging apparatus includes an imaging unit which applies a labeling pulse to invert a spin included in a labeling region within part of a imaging region and then collects a echo signal from a time point when an inversion time has passed from the application of the labeling pulse, and a control unit, the control unit controlling the imaging unit so that the echo signal in the imaging region is collected a plurality of times with variations in the inversion time, the control unit also controlling the imaging unit so that a time ranging from a reference time point within a biological signal obtained from a subject to the application of the labeling pulse is a time determined in accordance with the inversion time.

Abstract: The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.

Abstract: A magnetic resonance imaging apparatus includes an imaging unit which applies a labeling pulse to invert a spin included in a labeling region within part of a imaging region and then collects a echo signal from a time point when an inversion time has passed from the application of the labeling pulse, and a control unit, the control unit controlling the imaging unit so that the echo signal in the imaging region is collected a plurality of times with variations in the inversion time, the control unit also controlling the imaging unit so that a time ranging from a reference time point within a biological signal obtained from a subject to the application of the labeling pulse is a time determined in accordance with the inversion time.

Abstract: It is an objective of the present invention to provide a novel peritoneal membrane protecting agent which can effectively suppress deterioration of peritoneal functions in long-term peritoneal dialysis (PD) patients and the like. The present invention provides a peritoneal membrane protecting agent comprising a pyridoxine or a salt thereof, as an active ingredient.