Patents Assigned to TOKUSHIMA UNIVERSITY
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Patent number: 11091517Abstract: The present invention provides peptides having a structure in which portions of a dominant-negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 are replaced by at least two stapling structures. The peptides of the present invention have excellent cell growth inhibiting activity. The cell growth inhibiting activity lasts longer, compared to a single-stapled peptide. Therefore, the peptides of the present invention have a feature suitable for clinical applications in cancer therapy.Type: GrantFiled: July 18, 2018Date of Patent: August 17, 2021Assignees: TOKUSHIMA UNIVERSITY, ONCOTHERAPY SCIENCE, INC.Inventors: Toyomasa Katagiri, Tetsuro Yoshimaru, Takashi Miyamoto, Yasuhide Okamoto
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Publication number: 20210246560Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n +1 valent linker group, n is an integer of 1 or more and 5 or less.Type: ApplicationFiled: June 4, 2020Publication date: August 12, 2021Applicants: CHEMICAL DENSHI CO., LTD., Tokushima UniversityInventors: Shoichi YAMADA, Toshio HYUGA, Hisao NEMOTO
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Patent number: 11000572Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.Type: GrantFiled: November 1, 2019Date of Patent: May 11, 2021Assignee: TOKUSHIMA UNIVERSITYInventors: Akihito Yamamoto, Minoru Ueda, Kohki Matsubara, Akio Suzumura, Koichi Furukawa, Yoshihiro Matsushita, Hirotaka Wakayama, Nobunori Takahashi, Shin Tsunekawa, Takako Izumoto
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Patent number: 10976240Abstract: A concentration measurement device for measuring the concentration of a measured fluid within a measurement cell by detecting transmitted light that has passed through the measurement cell having a light incidence window and a light emission window disposed opposing to each other, comprising a reflected-light detector for detecting reflected light of the light incidence window.Type: GrantFiled: August 9, 2016Date of Patent: April 13, 2021Assignees: TOKUSHIMA UNIVERSITY, FUJIKIN INCORPORATEDInventors: Yoshihiro Deguchi, Masaaki Nagase, Michio Yamaji, Nobukazu Ikeda, Kouji Nishino, Masayoshi Kawashima, Kazuteru Tanaka
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Patent number: 10928303Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.Type: GrantFiled: July 25, 2017Date of Patent: February 23, 2021Assignees: TOKUSHIMA UNIVERSITY, FUJIKIN INCORPORATEDInventors: Yoshihiro Deguchi, Takashi Fukawa, Taiki Hattori, Masaaki Nagase, Kazuteru Tanaka, Kouji Nishino, Nobukazu Ikeda
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Publication number: 20200392464Abstract: An object of the present invention is to provide a method for producing insulin-producing cells having sufficient glucose responsiveness from mesenchymal stem cells, an insulin-producing cell having sufficient glucose responsiveness, a cell structure containing the insulin-producing cell, and a pharmaceutical composition.Type: ApplicationFiled: May 8, 2020Publication date: December 17, 2020Applicants: FUJIFILM Corporation, Tokushima UniversityInventors: Kentaro NAKAMURA, Mitsuo SHIMADA, Tetsuya IKEMOTO
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Publication number: 20200347165Abstract: The present invention provides a vinyl alcohol-vinyl acetate copolymer having excellent solubility and capable of providing a film having high flexibility, high mechanical strength, and high adhesion, and a method for producing a vinyl alcohol-vinyl acetate copolymer. Provided is a vinyl alcohol-vinyl acetate copolymer including a unit of vinyl alcohol and a unit of vinyl acetate, the vinyl alcohol-vinyl acetate copolymer having a triad unit chain ratio TOO of 7.5 or less, where the triad unit chain ratio TOO is obtained using the following formula (1): [ Math .Type: ApplicationFiled: November 14, 2018Publication date: November 5, 2020Applicants: TOKUSHIMA UNIVERSITY, SEKISUI CHEMICAL CO., LTD.Inventors: Koichi UTE, Tomohiro HIRANO, Miyuki OSHIMURA, Yasunari KUSAKA, Yohei NISHIMURA, Misaki SENOO
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Publication number: 20200255474Abstract: The present invention provides peptides having a structure in which portions of a dominant-negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 are replaced by at least two stapling structures. The peptides of the present invention have excellent cell growth inhibiting activity. The cell growth inhibiting activity lasts longer, compared to a single-stapled peptide. Therefore, the peptides of the present invention have a feature suitable for clinical applications in cancer therapy.Type: ApplicationFiled: July 18, 2018Publication date: August 13, 2020Applicants: TOKUSHIMA UNIVERSITY, ONCOTHERAPY SCIENCE, INCInventors: Toyomasa KATAGIRI, Tetsuro YOSHIMARU, Takashi MIYAMOTO, Yasuhide OKAMOTO
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Patent number: 10732099Abstract: A gas analysis device includes a laser light source configured to output a laser beam, an irradiation unit configured to irradiate a measurement region including measurement target gas with the laser beams in plural directions, plural photoreceivers each configured to receive a laser beam having passed through the measurement region and output an electric signal according to intensity of the received laser beam, and an analyzer configured to analyze the physical state of the measurement target gas based on the electric signal output from each photoreceiver. The analyzer sets a function (e.g. two-dimensional polynomial f(X,Y)) representing the physical state (e.g. concentration, temperature) of the target gas at least in the measurement region, and measures the physical state of the target gas by determining a coefficient of each of terms included in the function based on a measured value obtained from the electric signal output from the photoreceiver.Type: GrantFiled: December 20, 2016Date of Patent: August 4, 2020Assignee: Tokushima UniversityInventor: Yoshihiro Deguchi
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Patent number: 10711081Abstract: The present invention provides a vinyl alcohol-vinyl acetate copolymer having excellent solubility and a method for producing a vinyl alcohol-vinyl acetate copolymer. Provided is a vinyl alcohol-vinyl acetate copolymer including a unit of vinyl alcohol and a unit of vinyl acetate, the vinyl alcohol-vinyl acetate copolymer having a randomness value R of 0.5 or higher, the randomness value R being obtained using the following equation (1): R = 1 L A + 1 L O ( 1 ) where LO represents a mean chain length of the unit of vinyl alcohol and LA represents a mean chain length of the unit of vinyl acetate.Type: GrantFiled: May 8, 2017Date of Patent: July 14, 2020Assignees: TOKUSHIMA UNIVERSITY, SEKISUI CHEMICAL CO., LTD.Inventors: Koichi Ute, Tomohiro Hirano, Miyuki Oshimura, Yasunari Kusaka
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Publication number: 20200181579Abstract: A novel tissue usable for a kidney tissue model is provided. A method for producing a kidney-like tissue includes co-culturing a cell group containing mesenchymal stem cells, vascular endothelial cells, and clonal embryonic kidney cells.Type: ApplicationFiled: October 6, 2017Publication date: June 11, 2020Applicant: Tokushima UniversityInventor: Hideharu ABE
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Patent number: 10669310Abstract: The present invention provides peptides containing a structure in which a portion of the dominant negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 is substituted with stapling structure(s). Peptides of the present invention have excellent cell growth inhibitory actions. Furthermore, their cell growth inhibitory actions continue for a longer time than the actions of peptides without stapling structures. Therefore, these peptides have features suitable for clinical applications in cancer therapy.Type: GrantFiled: January 16, 2017Date of Patent: June 2, 2020Assignees: TOKUSHIMA UNIVERSITY, ONCOTHERAPY SCIENCE, INC.Inventors: Toyomasa Katagiri, Takashi Miyamoto, Rie Hayashi
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Patent number: 10638758Abstract: Provided is a novel heterocycle-containing amino acid compound that has a metal uptake ability equivalent to mugineic acids and can be less expensively produced than mugineic acids. Also provided are a fertilizer and a plant growth regulating agent each comprising the novel heterocycle-containing amino acid compound. The present invention is a heterocycle-containing amino acid compound represented by general formula (1): (wherein: R1, R2 and R3 are the same or different and represent a hydrogen atom or a carboxyl-protecting group; R4 represents a hydrogen atom or a hydroxy-protecting group; R5 represents a hydrogen atom or an amino-protecting group; and n is an integer of 1-3) or a salt thereof and use of the same.Type: GrantFiled: November 1, 2016Date of Patent: May 5, 2020Assignees: AICHI STEEL CORPORATION, TOKUSHIMA UNIVERSITYInventors: Kosuke Namba, Yoshiko Murata
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Publication number: 20200129591Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.Type: ApplicationFiled: November 1, 2019Publication date: April 30, 2020Applicant: TOKUSHIMA UNIVERSITYInventors: Akihito YAMAMOTO, Minoru UEDA, Kohki MATSUBARA, Akio SUZUMURA, Koichi FURUKAWA, Yoshihiro MATSUSHITA, Hirotaka WAKAYAMA, Nobunori TAKAHASHI, Shin TSUNEKAWA, Takako IZUMOTO
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Patent number: 10507230Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.Type: GrantFiled: March 28, 2018Date of Patent: December 17, 2019Assignee: TOKUSHIMA UNIVERSITYInventors: Akihito Yamamoto, Minoru Ueda, Kohki Matsubara, Akio Suzumura, Koichi Furukawa, Yoshihiro Matsushita, Hirotaka Wakayama, Nobunori Takahashi, Shin Tsunekawa, Takako Izumoto
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Publication number: 20190271636Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.Type: ApplicationFiled: July 25, 2017Publication date: September 5, 2019Applicants: TOKUSHIMA UNIVERSITY, FUJIKIN INCORPORATEDInventors: Yoshihiro DEGUCHI, Takashi FUKAWA, Taiki HATTORI, Masaaki NAGASE, Kazuteru TANAKA, Kouji NISHINO, Nobukazu IKEDA
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Patent number: 10400226Abstract: Provided is a modified ?-subunit of human ?-hexosaminidase which has the activity derived from the ?-subunit of wild-type human ?-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a ?-subunit of wild-type human ?-hexosaminidase.Type: GrantFiled: October 17, 2013Date of Patent: September 3, 2019Assignees: TOKUSHIMA UNIVERSITY, MEJI PHARMACEUTICAL UNIVERSITYInventors: Koji Ito, Hitoshi Sakuraba, Daisuke Tsuji
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Patent number: 10384998Abstract: To provide a method for producing propionaldehyde directly from glycerol with high yield, gasified glycerol is brought into contact with a silica-type regular mesoporous body. More specifically, gasified glycerol is supplied to a catalyst layer containing a regular mesoporous body while heating the catalyst layer at a temperature ranging from 200 to 800° C. in such a manner that a W/F value can fall within the range from 0.001 to 1000 g·min/ml inclusive wherein W represents an amount (g) of a catalyst and F represents a supply rate (ml/min) of supplied glycerol.Type: GrantFiled: November 28, 2018Date of Patent: August 20, 2019Assignees: Mitsubishi Chemical Corporation, TOKUSHIMA UNIVERSITYInventors: Yuki Kato, Wataru Ninomiya, Shigeru Sugiyama
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Patent number: 10383822Abstract: An object of the present invention is to provide an oxaliplatin-encapsulating liposome aqueous dispersion that has excellent long-term storage stability. The present invention provides an aqueous dispersion of liposomes encapsulating oxaliplatin, the oxaliplatin-encapsulating liposome aqueous dispersion containing 2-morpholinoethanesulfonic acid in an external aqueous phase.Type: GrantFiled: August 9, 2013Date of Patent: August 20, 2019Assignees: TAIHO PHARMACEUTICAL CO., LTD., TOKUSHIMA UNIVERSITYInventors: Yusuke Doi, Tatsuhiro Ishida
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Patent number: 10371630Abstract: An inline concentration meter includes a light source unit emitting mixed light containing at least two wavelengths with a phase difference, a detecting unit including a light incident part for entering the mixed light emitted from the light source unit into a fluid passage of a detector body and at least two light detection parts receiving the mixed light passed through the fluid passage, a computing processor unit conducting frequency analyzes of detection signals of the mixed light output from the respective light detection parts and computing variations of intensities of the detection signals corresponding to absorbances in at least two frequency ranges to compute a concentration of fluid in the fluid passage based on the variations of the intensities of the detection signals, and a recording/displaying unit recording and displaying a value of the fluid concentration computed at the computing processor unit.Type: GrantFiled: July 18, 2014Date of Patent: August 6, 2019Assignees: Tokushima University, Fujikin IncorporatedInventors: Yoshihiro Deguchi, Masaaki Nagase, Nobukazu Ikeda, Michio Yamaji