Patents Assigned to TOKUSHIMA UNIVERSITY
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Patent number: 9651467Abstract: This invention is related to an optical-analysis-type raw material fluid density detector including a detector main body and a light oscillation unit and a light detection unit that are provided on the upper surface or the under surface of the detector main body, in which the detector main body has at least one recess formed in the upper surface and the under surface, a fluid flow path connecting a fluid inlet of the detector main body to the recess, a fluid flow path connecting the recesses to each other, and a fluid flow path connecting the recess to a fluid outlet of the detector main body; the light oscillation unit is disposed in the recess that is closest to the inlet; and light detection units are disposed in the remaining recesses.Type: GrantFiled: April 30, 2014Date of Patent: May 16, 2017Assignees: TOKUSHIMA UNIVERSITY, FUJKIN INCORPORATEDInventors: Yoshihiro Deguchi, Masaaki Nagase, Ryousuke Dohi, Nobukazu Ikeda, Kouji Nishino, Michio Yamaji, Tadayuki Yakushijin
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Patent number: 9540420Abstract: A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises: (a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20); (b) a carboxylvinyl polymer; and, (c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself. The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.Type: GrantFiled: March 1, 2011Date of Patent: January 10, 2017Assignee: TOKUSHIMA UNIVERSITYInventors: Hiroshi Kido, Dai Mizuno
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Patent number: 9463236Abstract: A composition comprising the following composition: an AD vehicle including a synthetic peptide and a lipid, wherein the synthetic peptide includes the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20), a carboxylvinyl polymer and an RSV antigen. The composition has an antibody producing ability which is further higher than that of a conventional mucosal vaccine, hence capable of exerting excellent anti-virus antigen-specific IgA antibody- and IgG antibody-inducing effect in the nasal wash and the serum, respectively, even with an extremely small quantity of an RSV antigen.Type: GrantFiled: August 29, 2012Date of Patent: October 11, 2016Assignee: TOKUSHIMA UNIVERSITYInventors: Hiroshi Kido, Dai Mizuno, Hirotsugu Ueda, Koji Yoshikawa, Keisuke Ohsumi, Nobuyuki Yamamoto, Kenji Sudo
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Patent number: 9409972Abstract: An object of the present invention is to provide a pharmaceutical composition comprising an enzyme-treated human serum which is useful for treatment and prevention of diseases such as a cancer and an infectious disease, and a method of preparing the same. The present invention relates to a method of preparing a pharmaceutical composition comprising an enzyme-treated human serum, comprising a step of bringing the human serum into contact with ?-galactosidase and, to a pharmaceutical composition comprising an enzyme-treated human serum obtained by the preparation method.Type: GrantFiled: February 28, 2014Date of Patent: August 9, 2016Assignees: TOKUSHIMA UNIVERSITY, SAISEI MIRAI CLINICInventors: Yoshihiro Uto, Hitoshi Hori, Toshio Inui, Kentaro Kubo
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Patent number: 9393554Abstract: Provided is a method that produces a saturated aldehyde from a 1,2-alkanediol in high yield. Disclosed is a method for producing a saturated aldehyde from a 1,2-alkanediol in the presence of a regular mesoporous material.Type: GrantFiled: February 4, 2014Date of Patent: July 19, 2016Assignees: TOKUSHIMA UNIVERSITY, MITSUBISHI RAYON CO., LTD.Inventors: Shigeru Sugiyama, Yuuki Katou, Toshiya Yasukawa, Shuji Akihara, Wataru Ninomiya
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Publication number: 20160178517Abstract: A gas analyzing apparatus includes first and second laser sources (11, 12) that output first and second laser lights, a laser controller (14) that controls the first and second laser sources to vary wavelengths of the first and second laser lights in the respective predetermined wavelength ranges, an optical multiplexer (15, 17) that multiplexes the first and second laser lights to transmit the multiplexed laser light to a target gas, an optical receiver (19) that receives the laser light transmitted through the target gas, and an analyzer (23) that analyzes a temperature and/or a concentration of the target gas based on an electric signal output from the optical receiver. While varying the wavelengths of the laser lights, the laser controller (14) controls amplitudes of the first and second laser lights to differ from each other and varies intensities of the first and second laser lights in the opposite direction.Type: ApplicationFiled: August 21, 2014Publication date: June 23, 2016Applicant: Tokushima UniversityInventors: Yoshihiro Deguchi, Takahiro Kamimoto
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Patent number: 9351949Abstract: Provided is a prophylactic/therapeutic agent for influenza viral infection that is effective not only before and at an early stage of infection with influenza virus but also at an intermediate or late stage of the infection and is highly safe for human bodies. A prophylactic/therapeutic drug for influenza viral infection comprising, as active ingredients, 5-aminolevulinic acid (5-ALA), a derivative thereof or a salt of the 5-ALA or the derivative, and an iron compound is prepared. This prophylactic/therapeutic agent can be used for ameliorating (preventing) depression in food consumption, water consumption and body weight, for ameliorating (decreasing) increase in ketone body levels in blood that may otherwise cause ketosis, for ameliorating (preventing) depression in ATP levels in blood, or for ameliorating (increasing) a survival rate and depression in a body surface temperature.Type: GrantFiled: June 3, 2013Date of Patent: May 31, 2016Assignees: SBI Pharmaceuticals Co., Ltd., Tokushima UniversityInventors: Tohru Tanaka, Motowo Nakajima, Kiwamu Takahashi, Takuya Ishii, Hiroshi Kido, Junji Chida, Kazuhiko Yamane
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Patent number: 9278133Abstract: A novel type A botulinum toxin preparation is provided. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. In particular, the medicament of the present invention, as compared to the conventional known botulinum toxin preparations, has rapid efficacy of potential and is less diffusive and thus, having a broader safety margin, may be used as therapeutic medicament for decreasing local, muscle overactivity in a disease with a muscle overactivity.Type: GrantFiled: October 26, 2007Date of Patent: March 8, 2016Assignees: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, TOKUSHIMA UNIVERSITYInventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Yoshitaka Goto, Miho Shinmura, Sachio Okuda, Ryuji Kaji, Shunji Kosaki
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Publication number: 20160061704Abstract: This invention is related to an optical-analysis-type raw material fluid density detector including a detector main body and a light oscillation unit and a light detection unit that are provided on the upper surface or the under surface of the detector main body, in which the detector main body has at least one recess formed in the upper surface and the under surface, a fluid flow path connecting a fluid inlet of the detector main body to the recess, a fluid flow path connecting the recesses to each other, and a fluid flow path connecting the recess to a fluid outlet of the detector main body; the light oscillation unit is disposed in the recess that is closest to the inlet; and light detection units are disposed in the remaining recesses.Type: ApplicationFiled: April 30, 2014Publication date: March 3, 2016Applicants: FUJIKIN INCORPORATED, TOKUSHIMA UNIVERSITYInventors: Yoshihiro DEGUCHI, Masaaki NAGASE, Ryousuke DOHI, Nobukazu IKEDA, Kouji NISHINO, Michio YAMAJI, Tadayuki YAKUSHIJIN
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Publication number: 20160022895Abstract: Provided are a stock solution concentrating device, a stock solution treatment device and a circulation-type treatment device that can prevent the deposition of cells and the like on a filtration member and that can continuously filter and concentrate a stock solution such as pleural and ascitic fluid or blood plasma. The stock solution concentrating device concentrates a stock solution such as pleural and ascitic fluid or blood plasma to form a concentrated solution, and is equipped with: a filter (10) having a filtration member that filters the stock solution; a concentrator (20) to which the filtrate which has been filtered is supplied, and which concentrates the filtrate to form a concentrated solution; and a stock solution supply unit that supplies the stock solution to the filter (10). The stock solution supply unit has a supply amount adjustment function for adjusting the amount of the stock solution supplied to the filter.Type: ApplicationFiled: January 14, 2014Publication date: January 28, 2016Applicants: TAKATORI CORPORATION, TOKUSHIMA UNIVERSITYInventors: Toshiya OKAHISA, Yohsuke KINOUCHI, Tadahiko NAKAGAWA, Satoru YAMAJI, Zenji TANAKA