Patents Assigned to Topera, Inc.
  • Patent number: 10856760
    Abstract: A system for processing cardiac activation information associated with a complex rhythm disorder identifies a location of the heart rhythm disorder by determining activations within cardiac signals obtained at neighboring locations of the heart and arranging the activations to identify an activation trail. The activation trail may define a rotational pattern or radially emanating pattern corresponding to an approximate core of the heart rhythm disorder.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: December 8, 2020
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Sanjiv M. Narayan, Ruchir Sehra
  • Patent number: 10765329
    Abstract: Provided is a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the rotational area profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. Thereafter, an aggregated stability map is generated map based on the plurality of rotational area profile maps, wherein the aggregated stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter level of highest rotation intensity values for that location from corresponding locations of the plurality of rotational area profile maps.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: September 8, 2020
    Assignee: Topera, Inc.
    Inventors: William Robert Macneil, Carey Robert Briggs, Christopher Todd Schuster, Heather A. Drury
  • Publication number: 20200061384
    Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.
    Type: Application
    Filed: September 5, 2019
    Publication date: February 27, 2020
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TOPERA, INC.
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10561369
    Abstract: A system to generate a representation of a rhythm disorder that includes identifying remote or polar sources associated with a cardiac rhythm disorder is disclosed. The system includes generating a representation based on the cardiac information signals received from the sensors by transformation of spline-sensor locations of the catheter to x-y coordinate pairs of locations. A first offset is determined resulting from a perturbation to corresponding x-y coordinate pairs of locations associated with the representation, the first offset displacing coordinate pairs of sensor locations of the representation at least one unit of displacement in a first direction. A remote source associated with a cardiac rhythm disorder is identified when activations associated with the cardiac information signals rotate in sequence at least once, or emanate centrifugally for at least a first time period, the source being identified based on the representation as displaced.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: February 18, 2020
    Assignee: Topera, Inc.
    Inventors: William Robert Macneil, Ruchir Sehra
  • Patent number: 10485438
    Abstract: A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: November 26, 2019
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs
  • Patent number: 10434319
    Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: October 8, 2019
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10398326
    Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance with therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element. A plurality of indexes of progressive rotational activations or progressive focal activations over time is formed. One or more indexes are selected from the plurality of indexes that indicate consistency of the successive rotational activations or the progressive focal activations in relation to a portion of the region of the heart.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: September 3, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRE, TOPERA, INC.
    Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
  • Publication number: 20190239767
    Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.
    Type: Application
    Filed: February 8, 2019
    Publication date: August 8, 2019
    Applicant: Topera, Inc.
    Inventors: Thomas F. Kordis, Ruchir Sehra, Eric T. Johnson, Darrin J. Kent, Robert Ryan Ragland
  • Patent number: 10368764
    Abstract: A system and method to select segments of cardiac signals. Each of a plurality of segments in a first signal is correlated at a plurality of offsets to determine a highest correlation coefficient for each of the plurality of segments in the first signal. Each of a plurality of segments in a second signal is correlated at the plurality of offsets to determine a highest correlation coefficient for each of the plurality of segments in the second signal. A plurality of composite correlation coefficients is generated using highest correlation coefficients for segments of the first signal and segments of the second signal. The segments of the first and second signals are approximately contemporaneous. A set of segments including a segment from the first signal and a segment from the second signal is selected. The set is associated with a highest composite correlation coefficient from the plurality of composite correlation coefficients.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 6, 2019
    Assignee: Topera, Inc.
    Inventors: Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10271786
    Abstract: Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: April 30, 2019
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv Narayan, Carey Robert Briggs
  • Patent number: 10271744
    Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 30, 2019
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10244960
    Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; and a basket assembly including a plurality of flexible splines; an anchor for securably affixing proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a tip for securably affixing the distal portions of the splines; where the tip is recessed within the basket assembly upon radial expansion of the basket assembly.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: April 2, 2019
    Assignee: Topera, Inc.
    Inventors: Thomas F. Kordis, Ruchir Sehra, Eric T. Johnson, Darrin J. Kent, Robert Ryan Ragland
  • Patent number: 10149622
    Abstract: In a system and method of reconstructing cardiac activation information, pairs of cardiac signals obtained from a patient are accessed. The pairs have a first cardiac signal that is common among the pairs and second cardiac signals that are different among the pairs. The first cardiac signal and the second cardiac signals are processed to identify points of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to derivatives of the second cardiac signals. An activation onset time is assigned at a point in the first cardiac signal based on correspondence of the points of change to define a cardiac activation indicating a beat.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: December 11, 2018
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veteran's Affairs
    Inventors: Sanjiv Narayan, Carey Robert Briggs
  • Patent number: 10098560
    Abstract: A system and method are provided to define a driver of a source associated with a cardiac rhythm disorder of a human heart. A plurality of cardiac signals associated with sensors arranged spatially in relation to an area of the heart are processed to determine a sequence of arcs of rotation in relation to the sensors over a time interval. Rotational directions of the arcs of rotation in the sequence are determined. The area of the heart is identified as controlling the source when the rotational directions of the arcs of rotation in the sequence continue in a same rotational direction in excess of a threshold.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: October 16, 2018
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10085655
    Abstract: A system and method are provided for identifying a driver of a source associated with a heart rhythm disorder. Data are accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and determine whether the first region controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 2, 2018
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10070795
    Abstract: An example system and method of defining a rotational source associated with a heart rhythm disorder are disclosed. A plurality of center locations of wave fronts are calculated at a plurality of time points associated with the heart rhythm disorder. A rotational path that connects the plurality of center locations is then determined. Thereafter, a clinical representation that identifies a region of heart tissue associated with the rotational path is generated. The system and method can also determine a likely core associated with the rotational path. A plurality of relative diffusion shapes associated with the plurality of the center locations is calculated. A plurality of intersecting points of a smallest relative diffusion shape and other relative diffusion shapes is determined within the rotational path. A bounded polygon of the intersecting points is defined as the likely core.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: September 11, 2018
    Assignee: Topera, Inc.
    Inventors: William Robert Macneil, Ruchir Sehra
  • Patent number: 10058262
    Abstract: In a system and method of determining regularity associated with a rhythm disorder of a heart, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardiac signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: August 28, 2018
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Carey Robert Briggs, Sanjiv M. Narayan
  • Patent number: 9913615
    Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association among the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: March 13, 2018
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 9895072
    Abstract: A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: February 20, 2018
    Assignee: Topera, Inc.
    Inventors: Thomas F. Kordis, Eric T. Johnson, Phillip C. Burke, Darrin J. Kent, Robert Ryan Ragland
  • Patent number: 9724009
    Abstract: A system and method of locating a source of a heart rhythm disorder are provided in which a first pair of cardiac signals is processed to define a first coefficient associated with variability of the first pair of signals at a first region of the heart. A second pair of cardiac signals is processed to define a second coefficient associated with variability of the second pair of signals at a second region of the heart. Thereafter, the first coefficient of variability is compared to the second coefficient of variability to determine a direction towards the source of the rhythm disorder.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: August 8, 2017
    Assignees: The Regents of the University of California, Topera, Inc., The United State of America as represented by the Department of Veterans Affairs
    Inventors: Sanjiv Narayan, Carey Robert Briggs