Patents Assigned to Toyama Chemical Co., Ltd.
  • THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20160228404
    Abstract: A method for treating the relapsing-remitting or secondary progressive multiple sclerosis at the time of relapse, by administering a benzopyran derivative of the following formula or a salt thereof, where R1 represents an optionally substituted C1-6 alkyl group, one of R2 and R3 represents a hydrogen atom, and the other of R2 and R3 represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group.
    Type: Application
    Filed: April 19, 2016
    Publication date: August 11, 2016
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiichi TANAKA, Kimiko MORIMOTO
  • THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20160228406
    Abstract: A method for inhibiting macrophage migration and a method for treating neuropathic pain, by administering a benzopyran derivative of the following formula, or a salt thereof, where R? represents an optionally substituted C1-6 alkyl group, one of R2 and R3 represents a hydrogen atom, and the other of R2 and R3 represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group.
    Type: Application
    Filed: April 19, 2016
    Publication date: August 11, 2016
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiichi TANAKA, Kimiko MORIMOTO
  • NOVEL HYDROXAMIC ACID DERIVATIVE OR SALT THEREOF
    Publication number: 20160039751
    Abstract: A compound represented by general formula (1) (wherein R1 represents a hydrogen atom, an optionally substituted C1-6 alkyl group or the like; R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group or the like; R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group; R4 represents a hydrogen atom, an optionally substituted C1-6 alkyl group or the like; X1 represents an optionally substituted C2-6 alkynylene group or the like; A represents an optionally substituted bivalent aromatic hydrocarbon group or the like; X2 represents an optionally substituted C1-6 alkylene group or the like; Y1 represents an oxygen atom or the like; and R5 represents a hydrogen atom or the like) or a salt thereof is useful as an antibacterial agent.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Muneo SHOJI, Naomi SUGAYA, Naoko YASOBU
  • THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20150353519
    Abstract: A benzopyran derivative represented by general formula [1], or a salt thereof, is useful in therapeutic or preventive treatment of disease, wherein said therapeutic or preventive treatment is effective because said benzopyran derivative, or salt thereof, binds to MIF, has an MIF inhibitory effect, and inhibits MIF. [In the formula, R1 represents an optionally substituted C1-6 alkyl group, one of R2 and R3 represents a hydrogen atom, and the other of R2 and R3 represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group, or an optionally substituted aryl group.
    Type: Application
    Filed: July 17, 2014
    Publication date: December 10, 2015
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiichi TANAKA, Kimiko MORIMOTO
  • NOVEL AMINE DERIVATIVE OR SALT THEREOF
    Publication number: 20150299189
    Abstract: A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents —COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.
    Type: Application
    Filed: October 30, 2013
    Publication date: October 22, 2015
    Applicants: TOYAMA CHEMICAL CO., LTD., FUJIFILM CORPORATION
    Inventors: Tadashi Tanaka, Yoshitake Konishi, Daisuke Kubo, Masataka Fujino, Issei Doi, Daisuke Nakagawa, Tatsuya Murakami, Takayuki Yamakawa
  • SODIUM SALT OF 6-FLUOR0-3-HYDROXY-2-PYRAZINE CARBOXAMIDE
    Publication number: 20150266831
    Abstract: A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 24, 2015
    Applicant: Toyama Chemical Co., Ltd.
    Inventors: Keiko TAKAKURA, Namika NAKAMATSU, Sakiko TAKESHIMA, Sayuri UEHARA
  • MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE
    Publication number: 20150266832
    Abstract: A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Application
    Filed: June 9, 2015
    Publication date: September 24, 2015
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiko TAKAKURA, Namika NAKAMATSU, Sakiko TAKESHIMA, Takayoshi NAKASHIMA
  • NOVEL HYDROXAMIC ACID DERIVATIVE
    Publication number: 20150225335
    Abstract: Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria.
    Type: Application
    Filed: April 21, 2015
    Publication date: August 13, 2015
    Applicants: TAISHO PHARMACEUTICAL CO., LTD., TOYAMA CHEMICAL CO., LTD.
    Inventors: Hajime TAKASHIMA, Risa TSURUTA, Tetsuya YABUUCHI, Yusuke OKA, Hiroki URABE, Yoichiro SUGA, Masato TAKAHASHI, Fumito UNEUCHI, Hironori KOTSUBO, Muneo SHOJI, Yasuko KAWAGUCHI
  • Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
    Patent number: 9096547
    Abstract: A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 4, 2015
    Assignee: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiko Takakura, Namika Nakamatsu, Sakiko Takeshima, Sayuri Uehara
  • Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
    Patent number: 9090571
    Abstract: A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: July 28, 2015
    Assignee: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiko Takakura, Namika Nakamatsu, Sakiko Takeshima, Takayoshi Nakashima
  • Hydroxamic acid derivative
    Patent number: 9073821
    Abstract: Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: July 7, 2015
    Assignees: TAISHO PHARMACEUTICAL CO., LTD, TOYAMA CHEMICAL CO., LTD.
    Inventors: Hajime Takashima, Risa Tsuruta, Tetsuya Yabuuchi, Yusuke Oka, Hiroki Urabe, Yoichiro Suga, Masato Takahashi, Fumito Uneuchi, Hironori Kotsubo, Muneo Shoji, Yasuko Kawaguchi
  • Method of utilization of combination of benzophenone derivative or salt thereof and immunosuppressing agent, and pharmaceutical composition comprising these components
    Patent number: 9066977
    Abstract: Disclosed are use of a benzophenone derivative represented by general formula (I) or a salt thereof and one or more immunosuppressing agents in combination, and a pharmaceutical composition containing the benzophenone derivative or a salt thereof and one or more immunosuppressing agents. The use and the composition are useful for treatment or prevention of autoimmune diseases and the like. (In the formula, R1 represents an optionally substituted heterocyclic group, a substituted phenyl group or the like; Z represents an alkylene group or the like; R2 represents a carboxyl group, which may be protected by an alkyl group, or the like; R3 represents an optionally protected hydroxyl group or the like; R4 represents an optionally substituted cycloalkyloxy group or the like; and R5 represents a hydrogen atom or the like.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: June 30, 2015
    Assignee: TOYAMA CHEMICAL CO., LTD.
    Inventors: Yukihiko Aikawa, Shunichi Shiozawa
  • Amidine compound or salt thereof
    Patent number: 9045466
    Abstract: An amidine compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: June 2, 2015
    Assignees: TAISHO PHARMACEUTICAL CO., LTD, TOYAMA CHEMICAL CO., LTD.
    Inventors: Tetsuya Tanikawa, Yasunobu Ushiki, Fumihito Ushiyama, Toru Yamaguchi, Naoya Ono, Keiko Yamamoto, Risa Tsuruta, Yasuhiro Tsutsui, Noritomo Fujino, Ayumu Mori
  • Drug containing benzophenone derivative or its salt
    Patent number: 9012482
    Abstract: Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: wherein the each substituent is as defined in the specification, or salts thereof have suppressive effect on RANKL production, suppressive effect on OPG reduction and inhibitory effects on differentiation/activation of osteoclasts, and are extremely useful for treating, for example therapy and/or prevention, of various diseases in which differentiation/activation of osteoclast are involved, such as osteoporosis.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: April 21, 2015
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Yukihiko Aikawa, Kimiko Morimoto, Mari Yamamoto, Shunichi Shiozawa
  • Pharmaceutical composition and method using antifungal agent in combination
    Patent number: 8993603
    Abstract: A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula: (wherein R1 represents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may be substituted; R2 and R3 identically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifungal agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: March 31, 2015
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Nobuhiko Nomura, Hiroshi Nishikawa, Noritomo Fujino
  • METHOD FOR IMPROVING THERAPY FOR AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS
    Publication number: 20150080356
    Abstract: In the present invention, a method using a combination of iguratimod or a salt thereof and one or more immunosuppressants is useful as a method for the treatment of autoimmune diseases, and with this method adverse effects are lessened. A pharmaceutical composition containing this combination is useful for the treatment of autoimmune diseases. This method and pharmaceutical composition are useful for the treatment of more severe autoimmune diseases.
    Type: Application
    Filed: August 29, 2012
    Publication date: March 19, 2015
    Applicant: Toyama Chemical Co., Ltd.
    Inventor: Keiichi Tanaka
  • SUBSTITUTED PYRAZINO[2,3-D]ISOOXAZOLES AS INTERMEDIATES FOR THE SYNTHESIS OF SUBSTITUTED PYRAZINECARBOXAMIDES
    Publication number: 20150051396
    Abstract: The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): wherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(?O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.
    Type: Application
    Filed: October 29, 2014
    Publication date: February 19, 2015
    Applicants: TOYAMA CHEMICAL CO., LTD., FUJIFILM Corporation
    Inventors: Kouki NAKAMURA, Takeshi MURAKAMI, Hiroyuki NAITOU, Naoyuki HANAKI, Katsuyuki WATANABE
  • SOLID PHARMACEUTICAL COMPOSITION CONTAINING 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)ETHOXY)PROPYL)AZETIDIN-3-OL OR SALT THEREOF
    Publication number: 20150045345
    Abstract: This solid pharmaceutical composition is useful as a solid pharmaceutical composition of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol, which is excellently elutable and moldable and is stable in long-term storage, or a salt thereof.
    Type: Application
    Filed: February 21, 2013
    Publication date: February 12, 2015
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Hiroyuki Inaba, Mitsuhiro Nagata
  • SODIUM SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE
    Publication number: 20150038713
    Abstract: A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Applicant: Toyama Chemical Co., Ltd.
    Inventors: Keiko TAKAKURA, Namika Nakamatsu, Sakiko Takeshima, Sayuri Uehara
  • MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE
    Publication number: 20150031885
    Abstract: A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 29, 2015
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiko TAKAKURA, Namika NAKAMATSU, Sakiko TAKESHIMA, Takayoshi NAKASHIMA