Abstract: There is disclosed a cleaning apparatus for a radiation source assembly in a fluid treatment system. The clean apparatus comprises a cleaning sleeve moveable to remove fouling materials from an exterior portion of the radiation source assembly, the cleaning sleeve comprising at least one chamber for receiving a cleaning fluid and a cleaning sleeve inlet in fluid communication with the at least one chamber and a first conduit element for conveying the cleaning fluid to the cleaning sleeve inlet, the first conduit element being configured such that a distal portion of the first conduit element is in fluid communication with the cleaning sleeve inlet and a proximal portion of the first conduit element is disposed outside of fluid being treated in the fluid treatment system.

Abstract: There is described In another of its aspects, the present invention provides a radiation source assembly comprising: (i) an elongate radiation source; (ii) a positioning element connected to a proximal portion of the elongate radiation source; and (iii) a connecting portion secured to a proximal portion of the positioning element and configured to engage a support element to maintain a distal portion of the elongate radiation source in a cantilevered position. The present radiation source assembly is configured such that the distal portion of the radiation source is cantilevered with the respect to the distal portion of the protective sleeve in which it is disposed. This feature obviates the need to use spacers, stops, springs and the like in a distal portion of the protective sleeve to maintain correct position of the radiation source within the protective sleeve.

Abstract: There is disclosed a lamp device including a longitudinal axis, a first elongate electrical connector and a second elongate electrical connector, each of the first elongate electrical connector and the second elongate connector being non-parallel with respect to the longitudinal axis. The present lamp device provides a reliable electric connection on the one hand, yet is relatively inexpensive, uncomplicated and simple to implement on the other hand.

Abstract: There is disclosed a cleaning apparatus for a radiation source assembly in a fluid treatment system. The cleaning system comprises: a cleaning carriage comprising at least one cleaning element for contact with at least a portion of the exterior of the radiation source assembly; a rodless cylinder comprising an elongate housing having a first longitudinal axis; a slidable element disposed on an exterior surface of the elongate housing; and an elongate motive element coupled to the driving element. The slidable element is: (i) coupled to the cleaning carriage, and (ii) magnetically coupled to a driving element disposed within the elongate housing. The elongate motive element has a second longitudinal axis that is oriented in a substantially parallel, non-coaxial relationship with respect to the first longitudinal axis.

Abstract: There is described a fluid treatment system particularly suited for radiation treatment of a flow of fluid (preferably water). The system comprises a fluid treatment zone for receiving a flow of fluid in contact with a surface of the fluid treatment zone. At least one elongate radiation source assembly is disposed in the fluid treatment zone. The elongate radiation source assembly has a longitudinal axis disposed transverse to a direction of fluid flow through the fluid treatment zone. The system further comprises a cleaning apparatus having at least one cleaning element in contact with an exterior surface of the at least one elongate radiation source assembly. A first motive element is provided and is operable to cause relative movement between a distal end of the at least one elongate radiation source assembly and the surface of the fluid treatment zone to define a gap therebetween. A second motive element is provided and is coupled to the cleaning system.

Abstract: The present invention relates to a fluid treatment system comprising: an inlet; an outlet; and a fluid treatment zone disposed between the inlet and the outlet. The fluid treatment zone has disposed therein: (i) an elongate first radiation source assembly having a first longitudinal axis, and (ii) an elongate second radiation source assembly having a second longitudinal axis. The first longitudinal axis and the second longitudinal axis are non-parallel to each other and to a direction of fluid flow through the fluid treatment zone. The present fluid treatment system has a number of advantages including: it can treat large volumes of fluid (e.g.

Abstract: The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject.

Abstract: An excimer radiation lamp assembly. The lamp assembly comprises a radiation emitting region and at least one substantially radiation opaque region. The radiation emitting region comprises a pair of dielectric elements disposed in a substantially coaxial arrangement.

Abstract: There is described a fluid treatment system which may which may be used with radiation sources that do not require a protective sleeve—e.g., excimer radiation sources. An advantage of the present fluid system treatment is that the radiation sources may be removed from the fluid treatment zone without necessarily having to shut down the fluid treatment system, remove the fluid, break the seals which retain fluid tightness, replace/service radiation source and than reverse the steps. Instead, the present fluid treatment system allows for service/replacement of the radiation sources in the fluid treatment zone during operation of the fluid treatment system.

Abstract: A lamp device is disclosed. The lamp device comprises a first electrical connector and a second electrical connector located at a first end portion of the lamp device. The first end portion of the lamp device is received in a receptacle of a first base portion. A first locking portion is included for secunng the first base portion to the first end portion. The present radiation lamp device obviates or mitigates the need to use adhesive and/or polymer insulation/O-rings to achieve electrical connections. Further, the present radiation lamp may be oriented in a vertical orientation without the need to use springs and/or rubber part to support the distal end of the lamp.

Abstract: An optical radiation sensor system having: a housing having a distal portion for receiving radiation from the radiation source and a proximal portion; a sensor element in communication with the proximal portion, the sensor element configured to detect and respond to incident radiation received from the radiation source; and motive structure configured to move the housing with respect to the sensor element between at least a first position and a second position. A radiation pathway is defined between the radiation source and the sensor element when the housing is in at least one of the first position and the second position. Movement of the housing with respect to the sensor element causes a modification of intensity of radiation impinging on the sensor element.

Abstract: There is described a fluid treatment system in which fluid to be treated is impinged under pressure on a radiation emitting surface. The fluid treatment system includes at least one radiation source having a radiation emitting surface and at least one nozzle element having a fluid discharge opening spaced from the radiation emitting surface. The fluid discharge opening is configured to impinge fluid to be treated on to at least a portion of the radiation emitting surface. The fluid treatment system is well suited to treating low transmittance fluid.

Abstract: There is described a fluid treatment system which may which may be used with radiation sources that do not require a protective sleeve—e.g., excimer radiation sources. An advantage of the present fluid system treatment is that the radiation sources may be removed from the fluid treatment zone without necessarily having to shut down the fluid treatment system, remove the fluid, break the seals which retain fluid tightness, replace/service radiation source and than reverse the steps. Instead, the present fluid treatment system allows for service/replacement of the radiation sources in the fluid treatment zone during operation of the fluid treatment system.

Abstract: The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof; and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.

Abstract: There is described an excimer radiation lamp assembly. The lamp assembly comprises: an elongate member having an annular cross-section to define an elongate passageway aligned with a longitudinal axis of the lamp assembly; an electrode element in electrical connection with at least a portion of the elongate passageway; and a cooling element disposed in the elongate passageway, the cooling element being electrically isolated with respect to the electrode element.

Abstract: There is disclosed an ultraviolet radiation device. The device comprises a base portion, a plurality of semiconductor structures connected to the base portion and an ultraviolet radiation transparent element connected to the plurality of semiconductor structures. Preferably: (i) the at least one light emitting diode is in direct contact with the ultraviolet radiation transparent element, or (ii) there is a spacing between the at least one light emitting diode and the ultraviolet radiation transparent element, the spacing being substantially completely free of air. There is also disclosed a fluid treatment system incorporating the ultraviolet radiation device.

Abstract: The P21 protein is used as a medicament in the treatment of cancer. A conjugate comprises a first region comprising the P21 protein, or a homologue or functional fragment thereof; and a second region comprising a translocation factor.

Abstract: There is disclosed a radiation source assembly comprising an elongate radiation emitting outer portion having non-circular cross-sectional shape and an elongate radiation source. A radiation source module and a fluid system incorporating the radiation source assembly are also disclosed. It has been discovered that the use of a non-circular shaped sleeve or outer lamp surface reduces the stress placed on these elements in a fluid treatment system in which the radiation source assemblies are disposed transverse (e.g., orthogonal) to the direction of fluid flow through the fluid treatment zone of the system.

Abstract: There is disclosed an ultraviolet radiation device. The device comprises a base portion, a plurality of semiconductor structures connected to the base portion and an ultraviolet radiation transparent element connected to the plurality of semiconductor structures. Preferably: (i) the at least one light emitting diode is in direct contact with the ultraviolet radiation transparent element, or (ii) there is a spacing between the at least one light emitting diode and the ultraviolet radiation transparent element, the spacing being substantially completely free of air. There is also disclosed a fluid treatment system incorporating the ultraviolet radiation device.

Abstract: There is described a fluid treatment system comprising: (i) a fluid inlet; (ii) a fluid outlet; and (iii) a fluid treatment zone in fluid communication with the fluid inlet and the fluid outlet. The fluid treatment zone comprises a housing within which is disposed a fluid separation section (the separation section may include a single separation device or a combination of two or more similar or disimilar separation devices) and a fluid radiation section in fluid communication with one another. The fluid separation section removes solids in the fluid and the fluid radiation section irradiates the fluid to deactive microorganisms in the fluid. The fluid separation section and the fluid radiation section are configured to have a substantially common fluid flow path which significantly reduces the space or footprint requirement of and/or significantly reduces hydraulic head loss (pressure drops) in the overall fluid treatment system while allowing the two sections to perform their respective functions.