Abstract: The invention relates to a radiation sensor device comprising a housing and a plurality of radiation sensor modules secured to the housing. Each radiation sensor module comprises a radiation sensor arranged to detect radiation incident on the radiation source module. Preferably, each radiation sensor module contains an entire so-called optical train to allow for calibration of the detector (e.g., photodiodes, photoresistors and the like) without disassembling all the components of the module.

Abstract: The present invention is based on the seminal discovery that an antibody or fragment thereof combined with Antennapedia or a fragment thereof, is an effective therapeutic agent. The invention describes the construction of antibody or antibody fragment fused or chemically conjugated with Antennapedia at its carboxyl or its amino terminus (a “cargo-carrier” construct).

Abstract: In one of its aspects, the present invention relates to a fluid treatment system comprising: an inlet; an outlet; a fluid treatment zone disposed between the inlet and the outlet. The fluid treatment zone: (i) comprises a first wall surface and a second wall surface opposed to the first wall surface, and (ii) having disposed therein at least one array of rows of radiation source assemblies. Each radiation source assembly has a longitudinal axis transverse to a direction of fluid flow through the fluid treatment zone and each of the first wall surface and the second wall surface comprises a first fluid deflector element and a second fluid deflector element. The first fluid deflector element projecting into the fluid treatment zone to a greater extent than the second fluid deflector element.

Abstract: The present invention is based on the innovative concept of conjugating a cell-penetrating peptide (CPP), including a protein transduction domain, to a nucleic acid molecule to provide a nucleic acid-protein conjugate exhibiting enhanced cellular uptake. Accordingly, the invention provides a method of producing a cell permeable nucleic acid molecule conjugate nucleic acid including a nucleic acid conjugated with a homeodomain of an antennapedia homeotic transcription factor protein (Antp), or functional fragment thereof. The invention further provides compositions and methods treating a subject using the conjugates produced by the method described herein.

Abstract: The object of the invention is a double-walled chamber for the UV disinfection of liquids, preferably drinking water and/or waste water. It realizes a rectangular and/or square cross-sectional shape of the UV radiation chamber even at higher pressures, whereby the radiation chamber can moreover be provided with a thin-walled configuration and allows an optimal and close arrangement of UV radiators as compared with a round chamber. By applying the inventive idea, the known dead zones at the entrance are completely eliminated and an entrance turbulence is produced which runs simultaneously with the piston flow in the chamber.

Abstract: A process for measuring transmittance of a fluid with first and second radiation wavelengths includes (i) positioning a polychromatic radiation source and a polychromatic radiation sensor in a spaced relationship to define a first thickness of fluid; (ii) detecting a first radiation intensity corresponding to the first wavelength at the first thickness; (iii) detecting a second radiation intensity corresponding to the second wavelength at the first thickness; (iv) altering the first thickness to define a second thickness; (v) detecting a third radiation intensity corresponding to the first wavelength at the second thickness; (vi) detecting a fourth radiation intensity corresponding to the second wavelength at the second thickness; and (vii) calculating radiation transmittance of the fluid in the radiation field from the first radiation intensity, the second radiation intensity, the third radiation intensity and the fourth radiation intensity.

Abstract: An optical radiation sensor system having: a housing having a distal portion for receiving radiation from the radiation source and a proximal portion; a sensor element in communication with the proximal portion, the sensor element configured to detect and respond to incident radiation received from the radiation source; and motive structure configured to move the housing with respect to the sensor element between at least a first position and a second position. A radiation pathway is defined between the radiation source and the sensor element when the housing is in at least one of the first position and the second position. Movement of the housing with respect to the sensor element causes a modification of intensity of radiation impinging on the sensor element.

Abstract: There is disclosed a fluid treatment device comprising a housing for receiving a flow of fluid. The housing comprises a fluid inlet, a fluid outlet, a closed fluid treatment zone disposed between the fluid inlet and the fluid outlet. Disposed in the housing is at least one elongate radiation source assembly having a longitudinal axis disposed in the fluid treatment zone substantially parallel to a direction of the flow of fluid through the housing. The radiation source assembly comprises an elongate radiation source disposed in a protective sleeve to define a substantially annular passageway. The protective sleeve has opposed open ends configured to permit heat to exit the passageway and the housing through at least one of the opposed open ends of the sleeve.

Abstract: There is disclosed an elongate radiation source cartridge. The cartridge comprises: (i) an elongate radiation source assembly having a proximal portion and distal portion, the distal portion of the elongate radiation source assembly being unsupported, (ii) a housing coupled to the proximal portion of the elongate radiation source assembly, and (iii) a power supply disposed within the housing, the power supply in electrical communication with the elongate radiation source assembly (in certain embodiments the power supply is optional). The elongate radiation source assembly and the housing are in substantial alignment with respect to a longitudinal axis of the elongate radiation source cartridge.

Abstract: The object of the invention is a double-walled chamber for the UV disinfection of liquids, preferably drinking water and/or waste water. It realizes a rectangular and/or square cross-sectional shape of the UV radiation chamber even at higher pressures, whereby the radiation chamber can moreover be provided with a thin-walled configuration and allows an optimal and close arrangement of UV radiators as compared with a round chamber. By applying the inventive idea, the known dead zones at the entrance are completely eliminated and an entrance turbulence is produced which runs simultaneously with the piston flow in the chamber.

Abstract: An optical radiation sensor system having: a housing having a distal portion for receiving radiation from the radiation source and a proximal portion; a sensor element in communication with the proximal portion, the sensor element configured to detect and respond to incident radiation received from the radiation source; and motive structure configured to move the housing with respect to the sensor element between at least a first position and a second position. A radiation pathway is defined between the radiation source and the sensor element when the housing is in at least one of the first position and the second position. Movement of the housing with respect to the sensor element causes a modification of intensity of radiation impinging on the sensor element.

Abstract: There is described a fluid treatment system which may which may be used with radiation sources that do not require a protective sleeve—e.g., excimer radiation sources. An advantage of the present fluid system treatment is that the radiation sources may be removed from the fluid treatment zone without necessarily having to shut down the fluid treatment system, remove the fluid, break the seals which retain fluid tightness, replace/service radiation source and than reverse the steps. Instead, the present fluid treatment system allows for service/replacement of the radiation sources in the fluid treatment zone during operation of the fluid treatment system.

Abstract: There is described an excimer radiation lamp assembly. The lamp assembly comprise a radiation emitting region and at least one substantially radiation opaque region. The radiation emitting region comprises a pair of dielectric elements disposed in a substantially coaxial arrangement.

Abstract: There is disclosed a water treatment appliance, particularly for on-the-counter treatment of potable water. The appliance comprises: a base unit comprising a pump, a housing and a cooling unit for chilling water in the housing; a removable water reservoir engageable with the housing; a control panel comprising a water dispensing switch; an outlet for dispensing treated water from the fluid treatment system; and a treatment cartridge removably disposed in the housing. The treatment cartridge comprises a first chamber and a second chamber in communication with one another. The first chamber is in communication with the housing and has disposed therein a filter element. The second chamber is in communication with the outlet and has disposed therein an ultraviolet radiation lamp.

Abstract: An ultraviolet fluid treatment system having feedback control using a kinetic model and a reactor model that interact with one another. The kinetic model uses readily measured fluid properties upstream and downstream of a radiation zone to calculate the conversion of a target contaminant as it passes through the fluid treatment system. This obviates the need to measure the contaminant concentration directly, which generally is too slow to permit real-time control. A reactor model relates system operating cost to system operating parameters, such as electrical power consumption and/or rate of oxidant addition, where applicable. The reactor model is linked to the kinetic model and is used to optimize operating cost by adjusting system operating parameters based on a comparison between the conversion obtained from the kinetic model and the overall treatment objectives. A control center, an ultraviolet fluid treatment apparatus, and a method of treating a fluid are also disclosed.

Abstract: There is described an excimer radiation lamp assembly. The lamp assembly comprises: an elongate member having an annular cross-section to define an elongate passageway aligned with a longitudinal axis of the lamp assembly; an electrode element in electrical connection with at least a portion of the elongate passageway; and a cooling element disposed in the elongate passageway, the cooling element being electrically isolated with respect to the electrode element.

Abstract: The present invention relates to an ultraviolet radiation lamp. The lamp comprises: (i) a substantially sealed cavity comprising a mercury-containing material; and (ii) a heating unit disposed exteriorly with respect to the cavity. The heating unit is disposed in contact with a first portion of the cavity comprising the mercury-containing material. The heating unit has adjustable heat output.

Abstract: There is disclosed an ultraviolet radiation device. The device comprises a base portion, a plurality of semiconductor structures connected to the base portion and an ultraviolet radiation transparent element connected to the plurality of semiconductor structures. Preferably: (i) the at least one light emitting diode is in direct contact with the ultraviolet radiation transparent element, or (ii) there is a spacing between the at least one light emitting diode and the ultraviolet radiation transparent element, the spacing being substantially completely free of air. There is also disclosed a fluid treatment system incorporating the ultraviolet radiation device.

Abstract: There is disclosed a water treatment appliance, particularly for on-the-counter treatment of potable water. The appliance comprises: a base unit comprising a pump, a housing and a cooling unit for chilling water in the housing; a removable water reservoir engageable with the housing; a control panel comprising a water dispensing switch; an outlet for dispensing treated water from the fluid treatment system; and a treatment cartridge removably disposed in the housing. The treatment cartridge comprises a first chamber and a second chamber in communication with one another. The first chamber is in communication with the housing and has disposed therein a filter element. The second chamber is in communication with the outlet and has disposed therein an ultraviolet radiation lamp.

Abstract: The present invention relates to a fluid treatment system comprising: an inlet; an outlet; and a fluid treatment zone disposed between the inlet and the outlet. The fluid treatment zone has disposed therein: (i) an elongate first radiation source assembly having a first longitudinal axis, and (ii) an elongate second radiation source assembly having a second longitudinal axis. The first longitudinal axis and the second longitudinal axis are non-parallel to each other and to a direction of fluid flow through the fluid treatment zone. The present fluid treatment system has a number of advantages including: it can treat large volumes of fluid (e.g.