Abstract: Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro and in vivo methods of quantifying the expression of FAP in a biopsy sample and a mammal, respectively, are also disclosed.
Type:
Grant
Filed:
August 30, 2012
Date of Patent:
March 21, 2017
Assignee:
Trustees of Tufts College
Inventors:
William W. Bachovchin, Hung-sen Lai, Sarah E. Poplawski
Abstract: Aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a first gateway circuit in an optical access network connecting a plurality of end-of-network users to a central node, the first gateway circuit connecting one of the plurality of end-of-network users to the central node via fiber optic data lines. Further, the first gateway circuit is configured and arranged to: relay a first set of data between the end-of-network user and the central node using a packet-switching communication protocol, and relay a second set of data between the end-of-network user and the central node using an optical flow switching communication protocol.
Type:
Grant
Filed:
February 6, 2015
Date of Patent:
March 21, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ahmad R. Dhaini, Marc De Leenheer, Leonid G. Kazovsky, Thomas Shunrong Shen, Shuang Yin, Benjamin A. Detwiler
Abstract: Techniques for coupling light into graphene using a planar photonic crystal having a resonant cavity characterized by a mode volume and a quality factor and at least one graphene layer positioned in proximity to the planar photonic crystal to at least partially overlap with an evanescent field of the resonant cavity. At least one mode of the resonant cavity can couple into the graphene layer via evanescent coupling. The optical properties of the graphene layer can be controlled, and characteristics of the graphene-cavity system can be detected. Coupling light into graphene can include electro-optic modulation of light, photodetection, saturable absorption, bistability, and autocorrelation.
Type:
Grant
Filed:
September 30, 2014
Date of Patent:
March 21, 2017
Assignee:
The Trustees of Columbia University in the City of New York
Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitDynaivity to antigens.
Type:
Grant
Filed:
May 26, 2016
Date of Patent:
March 21, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Qi-Jing Li, Chang-Zheng Chen, Mark M. Davis, Jacqueline Chau
Abstract: Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating subjects at risk of developing IgA neuropathy based on a new seven-SNP genetic risk score. Also provided are screening methods to identify compounds that bind to and reduce the expression or biological activity of a either CFHR1 or CFHR3.
Type:
Grant
Filed:
February 17, 2012
Date of Patent:
March 21, 2017
Assignees:
The Trustees of Columbia University in the City of New York, Yale University
Inventors:
Ali Gharvari, Krzysztof Kiryluk, Richard Lifton
Abstract: A thermally-conductive and mechanically-robust bonding method for attaching a metal nanowire (MNW) array to an adjacent surface includes the steps of: removing a template membrane from the MNW; infiltrating the MNW with a bonding material; placing the bonding material on the adjacent surface; bringing an adjacent surface into contact with a top surface of the MNW while the bonding material is bondable; and allowing the bonding material to cool and form a solid bond between the MNW and the adjacent surface. A thermally-conductive and mechanically-robust bonding method for attaching a metal nanowire (MNW) array to an adjacent surface includes the steps of: choosing a bonding material based on a desired bonding process; and without removing the MNW from a template membrane that fills an interstitial volume of the MNW, depositing the bonding material onto a tip of the MNW.
Type:
Grant
Filed:
August 29, 2016
Date of Patent:
March 21, 2017
Assignees:
Northrup Grumman Systems Corporation, The Board of Trustees of the Leland Stanford Junior University
Inventors:
John A. Starkovich, Edward M. Silverman, Jesse B. Tice, Hsiao-Hu Peng, Michael T. Barako, Kenneth E. Goodson
Abstract: A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
Type:
Grant
Filed:
May 21, 2013
Date of Patent:
March 21, 2017
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
Abstract: A method of making a three-dimensional porous device entails providing a substrate having a conductive pattern on a surface thereof, and depositing a colloidal solution comprising a plurality of microparticles onto the surface, where the microparticles assemble into a lattice structure. Interstices of the lattice structure are infiltrated with a conductive material, which propagates through the interstices in a direction away from the substrate to reach a predetermined thickness. The conductive material spans an area of the surface overlaid by the conductive pattern. The microparticles are removed to form voids in the conductive material, thereby forming a conductive porous structure having the predetermined thickness and a lateral size and shape defined by the conductive pattern.
Type:
Grant
Filed:
January 6, 2011
Date of Patent:
March 21, 2017
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
William P. King, Paul V. Braun, Zhenting Dai, Xindi Yu, Hui Gang Zhang
Abstract: The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formulas (I)-(XXVI) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC.
Type:
Grant
Filed:
September 30, 2011
Date of Patent:
March 21, 2017
Assignee:
Trustees of Boston University
Inventors:
Ulla Hansen, Scott Schaus, Trevor Grant, Joshua Bishop, John Kavouris, Lisa M. Christadore
Abstract: Methods for stopping or slowing bleeding from a wound are provided; these methods include the step of administering a composition comprising a polyphosphate (polyP) to blood from the wound at the site of the wound. Also provided are methods for slowing fibrinolysis and for blocking the action of Tissue Factor Pathway Inhibitor (TFPI) with the use of polyP.
Type:
Grant
Filed:
October 20, 2009
Date of Patent:
March 21, 2017
Assignee:
The Board of Trustees of the University of Illinios
Inventors:
James H. Morrissey, Stephanie A. Smith, Roberto Docampo, Nicola J. Mutch
Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.
Type:
Grant
Filed:
April 12, 2013
Date of Patent:
March 21, 2017
Assignee:
The Trustees of the University of Pennslyvania
Abstract: A scalable, energy efficient process for preparing cellulose nanofibers is disclosed. The process employs treating the cellulosic material with a first mechanical refiner with plates having a configuration of blades separated by grooves, and subsequently treating the material with a second mechanical refiner with plates having a configuration of blades separated by grooves different than the first refiner. The plate configurations and treatment operations are selected such that the first refiner produces a first SEL that is greater than the SEL of the second refiner, by as much as 2-50 fold. An exemplary high first SEL may be in the range of 1.5 to 8 J/m. Paper products made with about 2% to about 30% cellulose nanofibers having a length from about 0.2 mm to about 0.5 mm, preferably from 0.2 mm to about 0.4 mm have improved properties.
Type:
Application
Filed:
May 6, 2015
Publication date:
March 16, 2017
Applicant:
University of Maine System Board of Trustees
Abstract: Strong, light-weight composite laminates are made by impregnating layers of paper with a cellulose nanofiber (CNF) slurry, laying the coated papers up in a plurality of layers or stack, and subjecting the stack to pressure and heat for a period of time sufficient to cause the CNF to impregnate, reinforce, and bond the paper layers into a composite. The resulting composite has impressive mechanical strength and exhibits a substantially homogeneous composition throughout its depth. The composite should have good strength to weight properties, and be recyclable or compostable.
Type:
Application
Filed:
September 8, 2016
Publication date:
March 16, 2017
Applicant:
University of Maine System Board of Trustees
Abstract: According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.
Type:
Application
Filed:
September 20, 2016
Publication date:
March 16, 2017
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Yang Liu, Robert W. Dutton, Roger T. Howe
Abstract: A method of conductively coupling a carbon nanostructure and a metal electrode is provided that includes disposing a carbon nanostructure on a substrate, depositing a carbon-containing layer on the carbon nanostructure, according to one embodiment, and depositing a metal electrode on the carbon-containing layer. Further provided is a conductively coupled carbon nanostructure device that includes a carbon nanostructure disposed on a substrate, a carbon-containing layer disposed on the carbon nanostructure and a metal electrode disposed on the carbon-containing layer, where a low resistance coupling between the carbon nanostructure and metal elements is provided.
Type:
Grant
Filed:
September 7, 2011
Date of Patent:
March 14, 2017
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
Inventors:
Yang Chai, Arash Hazeghi, Kuniharu Takei, Ali Javey, H. S. Philip Wong
Abstract: A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Type:
Grant
Filed:
November 20, 2014
Date of Patent:
March 14, 2017
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Soumitra Roy, James M. Wilson, Luc H. Vandenberghe
Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
Type:
Grant
Filed:
March 4, 2013
Date of Patent:
March 14, 2017
Assignees:
The Board of Trustees of the University of Illinois, Vanquish Oncology, Inc.
Inventors:
Paul J. Hergenrother, Rachel C. Botham, Timothy M. Fan, Mark J. Gilbert, Michael K. Handley, Theodore M. Tarasow
Abstract: An immunization regimen is provided which involves priming with an E1, E4-deleted adenovirus and boosting with an E1-deleted adenovirus. The second administered adenovirus has a capsid of a serotype which is not cross-reactive with the previously administered adenovirus. Further, a product containing the adenoviruses necessary to perform the immunization regimen is provided.
Type:
Grant
Filed:
April 27, 2005
Date of Patent:
March 14, 2017
Assignee:
The Trustees of the University of Pennsylvania
Abstract: A crossed nanobeam structure for strain engineering in semiconductor devices is provided. For example, such a structure can be used for a low-threshold germanium laser. While the photonic crystal nanobeam enables light confinement in a subwavelength volume with small optical loss, another crossing nanobeam induces high tensile strain in the small region where the optical mode is tightly confined. As maintaining a small optical loss and a high tensile strain reduces the required pumping for achieving net optical gain beyond cavity losses, this technique can be used to develop an extremely low-threshold Ge laser source. Moreover, the structure can be easily integrated into electronic and photonic circuits.
Type:
Grant
Filed:
June 23, 2015
Date of Patent:
March 14, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Donguk Nam, Jan A. Petykiewicz, Devanand S. Sukhdeo, Shashank Gupta, Jelena Vuckovic, Krishna C. Saraswat