Patents Assigned to Trustee
  • Hybrid layers for use in coatings on electronic devices or other articles
    Patent number: 9252391
    Abstract: A method for protecting an electronic device comprising an organic device body. The method involves the use of a hybrid layer deposited by chemical vapor deposition. The hybrid layer comprises a mixture of a polymeric material and a non-polymeric material, wherein the weight ratio of polymeric to non-polymeric material is in the range of 95:5 to 5:95, and wherein the polymeric material and the non-polymeric material are created from the same source of precursor material. Also disclosed are techniques for impeding the lateral diffusion of environmental contaminants.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: February 2, 2016
    Assignees: The Trustees of Princeton University, Universal Display Corporation
    Inventors: Prashant Mandlik, Sigurd Wagner, Jeffrey A. Silvernail, Ruiqing Ma, Julia J. Brown, Lin Han
  • Expression vector comprising a nucleotide sequence encoding a light-activated ion channel protein (VChR1) and implantable device thereof
    Patent number: 9249200
    Abstract: Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: February 2, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru
  • Apparatus and method for detecting and identifying microorganisms
    Patent number: 9249446
    Abstract: The present invention is an apparatus for detecting the presence, quantity and identity of one or more microorganisms in a sample and a method for using the same. The apparatus is composed of one or more chambers and a sensing element for sensing microorganisms. In particular embodiments, the sensing element is an array of chemoresponsive dyes deposited on a substrate in a predetermined pattern combination, wherein the combination of the dyes have a distinct and direct spectroscopic, transmission, or reflectance response to distinct analytes produced by the microorganism which is indicative of the presence, quantity and identity of the microorganism.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: February 2, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth S. Suslick, Matthew J. Placek, William B. McNamara, III, Avijit Sen, James R. Carey, Jennifer B. Wilson, Crystal K. Keso
  • Systems and methods for maximizing dissolved gas concentration of a single species of gas from a mixture of multiple gases
    Patent number: 9248415
    Abstract: An apparatus and method for maximizing the dissolved concentration of ozone in a liquid. The apparatus includes a dissolution tank having a pressure vessel configured to contain a treated fluid and at least one gas in a head space above the treated fluid, an inlet configured to permit passage of an untreated fluid into the head space, and an outlet configured to permit passage of the treated fluid out of the vessel; a gas supply system configured to transport the at least one gas to the head space; a fluid supply system configured to provide the untreated fluid to the tank; a bleed-off system for removing gas from the head space so as to maximize the dissolved concentration of the ozone gas in the liquid; and a discharge device configured to pass the treated fluid from the tank into the target liquid.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: February 2, 2016
    Assignees: Board of Trustees of the University of Arkansas, BlueInGreen, LLC
    Inventor: Gregory Scott Osborn
  • OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE
    Publication number: 20160024007
    Abstract: The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Konstantin PETRUKHIN, Christopher CIOFFI, Graham JOHNSON, Nicoleta DOBRI, Emily FREEMAN, Ping CHEN, Michael CONLON, Lei ZHU
  • DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS
    Publication number: 20160024574
    Abstract: This invention provides a process for sequencing nucleic acids using 3? modified deoxynucleotide analogues or 3? modified deoxyinosine triphosphate analogues, and 3? modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.
    Type: Application
    Filed: August 6, 2015
    Publication date: January 28, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Dae Hyun Kim, Jia Guo, Qinglin Meng, Zengmin Li, Huanyan Cao
  • NON-INVASIVE DETERMINATION OF FETAL INHERITANCE OF PARENTAL HAPLOTYPES AT THE GENOME-WIDE SCALE
    Publication number: 20160024579
    Abstract: The present invention provides a method, device and a computer program for haplotyping single cells, such that a sample taken from a pregnant female, without directly sampling the fetus, provides the ability to non-invasively determine the fetal genome. The method can be performed by determining the parental and inherited haplotypes, or can be performed merely on the basis of the mother's genetic information, obtained preferably in a blood or serum sample. The novel device allows for sequence analysis of single chromosomes from a single cell, preferably by partitioning single chromosomes from a metaphase cell into long, thin channels where a sequence analysis can be performed.
    Type: Application
    Filed: September 25, 2014
    Publication date: January 28, 2016
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen R. QUAKE, Hei-Mun C. FAN
  • Stable helical ionic polypeptides
    Patent number: 9243040
    Abstract: The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Hua Lu
  • Systems and methods for monitoring the circulatory system
    Patent number: 9241637
    Abstract: In accordance with embodiments of the present disclosure, a ballistocardiogram (BCG) sensor is used to detect heart and vascular characteristics of a user, and provide a BCG output indicative of the detected cardiovascular characteristics. The BCG output can be used for various purposes, such as detecting arterial aging. Secondary sensors can be used in conjunction with the BCG and can be used to determine the central arterial blood pressure, when used in conjunction with a peripheral blood pressure measurement.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard M. Wiard, Laurent B. Giovangrandi, Gregory T. Kovacs
  • Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
    Patent number: 9243041
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against herpes virus using the vaccines that are provided.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: January 26, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B Weiner, Devon J Shedlock
  • Inhibitors of mitochondrial fission and methods of use thereof
    Patent number: 9243232
    Abstract: The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on dynamin- 1-related protein (Drp1) GTPase activity, binding of Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Xin Qi, Nir Qvit
  • Circuits and methods for implementing a residue amplifier
    Patent number: 9246504
    Abstract: Circuits and methods for implementing a residue amplifier are provided. In some embodiments, circuits for implementing a residue amplifier are provided, the circuits comprising: a first capacitor configured to be charged to an input voltage level and that discharges from the input voltage level to a reference voltage level; a comparator having a first input coupled to the first capacitor, a second input coupled to a reference voltage source, and an output that indicates when the charge on the first capacitor is above the reference voltage level; and a second capacitor configured to be charged to an output voltage based on the output of the comparator.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: January 26, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Junhua Shen, Peter Kinget
  • Method for operating CMUTs under high and varying pressure
    Patent number: 9242273
    Abstract: Capacitive micromachined ultrasonic transducers (CMUTs) in permanent contact mode are provided. Such a CMUT always has its plate in contact with the substrate, even for zero applied electrical bias. This contact is provided by the pressure difference between the environment, and the pressure of the evacuated region between the CMUT plate and substrate. Due to this permanent contact, the electric field in the gap for a given DC bias voltage will be larger, which provides improved coupling efficiency at lower DC bias voltages. Furthermore, in an environment with high and varying pressure, the plate will not shift between the conventional mode and the collapsed mode, but will only be pushed down with varying contact radius. In some embodiments, an electrode shaped as an annulus is employed, so that only the active vibrating part of the CMUT plate sees the applied DC and AC voltages.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Min-Chieh Ho, Mario Kupnik, Butrus T. Khuri-Yakub
  • Pre-charged CMUTs for zero-external-bias operation
    Patent number: 9242274
    Abstract: Capacitive micromachined ultrasonic transducers (CMUTs) having a pre-charged floating electrode are provided. Such CMUTs can operate without an applied DC electrical bias. Charge can be provided to the floating electrode after or during fabrication in various ways, such as injection by an applied voltage, and injection by ion implantation.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Min-Chieh Ho, Mario Kupnik, Butrus T. Khuri-Yakub
  • Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity
    Patent number: 9243037
    Abstract: Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: January 26, 2016
    Assignee: Trustees of Boston College
    Inventors: Jianmin Gao, Fang Wang
  • Facially amphiphilic polymers and oligomers and uses thereof
    Patent number: 9241917
    Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: January 26, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein, Dahui Liu, Jing Yuan, Sungwook Choi
  • Prairie cordgrass () cultivar ‘savoy’ for a bioenergy feedstock production
    Patent number: 9241471
    Abstract: A new synthetic cultivar of prairie cordgrass designated ‘Savoy’ is described. ‘Savoy’ is well adapted to the lower Midwest environment of the United States of America, and has a higher biomass yield potential than presently available commercial prairie cordgrass cultivars, such as ‘Red River’. In particular, compared to ‘Red River’, the cultivar ‘Savoy’ has higher mass per tiller, more leaves per tiller, higher shoot height and longer, wider leaves containing more biomass per leaf.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Dokyoung Lee, Allen Parrish
  • Co-doped titanium oxide foam and water disinfection device
    Patent number: 9242873
    Abstract: A quaternary oxide foam, comprises an open-cell foam containing (a) a dopant metal, (b) a dopant nonmetal, (c) titanium, and (d) oxygen. The foam has the advantages of a high surface area and a low back pressure during dynamic flow applications. The inactivation of Escherichia coli (E. coli) was demonstrated in a simple photoreactor.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jian-Ku Shang, Pinggui Wu, Rong-Cai Xie
  • Time-based digitizer for PET photodetector
    Patent number: 9244179
    Abstract: An integrated circuit in a PET imaging system with a plurality of photo detectors is provided. A plurality of differential transimpedance amplifiers with differential inputs and differential outputs is provided, wherein differential inputs for each differential transimpedance amplifier of the plurality of differential transimpedance amplifiers are electrically connected to a photodetector.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Frances W. Y. Lau, Craig Steven Levin, Mark A. Horowitz, Hwang Ho Choi, Jaeha Kim
  • Nectarine tree named ‘Amoore Sweet’
    Patent number: PP26367
    Abstract: Description and specification of a new and distinct nectarine tree cultivar named ‘Amoore Sweet’ which originated from a hand-pollinated cross of Ark. 699N×Ark. 663CN made in 2001. This new nectarine cultivar can be distinguished by its very firm, non-melting yellow flesh, early-mid season ripening, medium-sized fruits, excellent fruit quality with distinct low-acid nectarine flavor, and resistance to bacterial spot disease.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: February 2, 2016
    Assignee: The Board of Trustees of the University of Arkansas
    Inventor: John Reuben Clark