Patents Assigned to Trustee
  • Chemically defined production of cardiomyocytes from pluripotent stem cells
    Patent number: 9234176
    Abstract: Methods are provided for producing a cardiomyocyte population from a mammalian pluripotent stem cell population. Aspects of the methods include using a Wnt signaling agonist and antagonist, each in minimal media, to modulate Wnt signaling. Also provided are kits for practicing the methods described herein.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Joseph Wu, Robert C. Robbins, Paul W. Burridge
  • Classification of biological tissue by multi-mode data registration, segmentation and characterization
    Patent number: 9235887
    Abstract: A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: January 12, 2016
    Assignees: Elucid Bioimaging, Inc., Rutgers, The State University of New Jersey, Trustees of Boston University, The Trustees of the University of Pennsylvania
    Inventors: Andrew Buckler, Anant Madabhushi, James Hamilton, Shannon Agner, Mark Rosen
  • High throughput system for isolation, growth, and detection of lipid inclusions in bacteria
    Patent number: 9234229
    Abstract: A method of high throughput growth and quantitative analysis of microorganisms is provided that includes providing a microtiter plate growth and gas delivery system having well plates disposed for growth of the microorganisms, and providing a spectroscopic screening system disposed to analyze lipid inclusions of the microorganisms.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric R. Sundstrom, Craig S. Criddle
  • Compounds and anti-tumor NQO1 substrates
    Patent number: 9233960
    Abstract: Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Rahul Palchaudhuri, Elizabeth I. Parkinson
  • Catalysis by metal nanoparticles dispersed within a hierarchically porous carbon material
    Patent number: 9233366
    Abstract: Disclosed are hierarchically porous carbon materials with a plurality of discreet nanoparticles dispersed on their carbon phase. The materials possess a continuous network of pores that spans the porous material, permitting the flow of fluids into and through the material. The porous materials can be used as heterogeneous catalysts.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: January 12, 2016
    Assignee: Board of Trustees of The University of Alabama
    Inventors: Martin G. Bakker, Franchessa Maddox Sayler, Kevin Shaughnessy
  • Moisture-activated self-heating analysis device
    Patent number: 9233368
    Abstract: Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: January 12, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, Changchun Liu, Michael G. Mauk, Robert W. Hart, Xianbo Qiu
  • Graphene hybrid materials, apparatuses, systems and methods
    Patent number: 9236197
    Abstract: Graphene based materials are provided in connection with various devices and methods of manufacturing. As consistent with one or more embodiments, an apparatus includes a graphene sheet and a single-crystal structure grown on the graphene sheet, with the graphene sheet and single-crystalline structure functioning as an electrode terminal. In various embodiments, the single-crystalline structure is grown on a graphene sheet, such as by using precursor particles to form nanoparticles at the distributed locations, and diffusing and recrystallizing the nanoparticles to form the single-crystal structure.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Hailiang Wang
  • Conductor of high electrical current at high temperature in oxygen and liquid metal environment
    Patent number: 9234288
    Abstract: In one aspect, the present invention is directed to apparatuses for and methods of conducting electrical current in an oxygen and liquid metal environment. In another aspect, the invention relates to methods for production of metals from their oxides comprising providing a cathode in electrical contact with a molten electrolyte, providing a liquid metal anode separated from the cathode and the molten electrolyte by a solid oxygen ion conducting membrane, providing a current collector at the anode, and establishing a potential between the cathode and the anode.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: January 12, 2016
    Assignees: Infinium, Inc., The Trustees of Boston University
    Inventors: Adam Clayton Powell, IV, Soobhankar Pati, Stephen Joseph Derezinski, Garrett Lau, Uday B. Pal, Xiaofei Guan, Srikanth Gopalan
  • Non-volatile resistance-switching thin film devices
    Patent number: 9236118
    Abstract: Disclosed herein is a resistive switching device having an amorphous layer comprised of an insulating silicon-containing material and a conducting material. The amorphous layer may be disposed between two or more electrodes and be capable of switching between at least two resistance states. Circuits and memory devices including resistive switching devices are also disclosed, and a composition of matter involving an insulating silicon-containing material and a conducting material comprising between 5 and 40 percent by molar percentage of the composition is disclosed herein as well. Also disclosed herein are methods for switching the resistance of an amorphous material.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: January 12, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: I-Wei Chen, Soo Gil Kim, Albert Chen, Yudi Wang
  • Strongly coupled inorganic-graphene hybrid materials, apparatuses, systems and methods
    Patent number: 9237658
    Abstract: Nanocarbon-based materials are provided in connection with various devices and methods of manufacturing. As consistent with one or more embodiments, an apparatus includes a nanocarbon structure having inorganic particles covalently bonded thereto. The resulting hybrid structure functions as a circuit node such as an electrode terminal. In various embodiments, the hybrid structure includes two or more electrodes, at least one of which including the nanocarbon structure with inorganic particles covalently bonded thereto.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Hailiang Wang, Ming Gong
  • Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha V beta 3 integrin
    Patent number: 9234021
    Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer R. Cochran, Adam Silverman, Douglas Jones, Niv Papo
  • Supramolecular functionalization of graphitic nanoparticles for drug delivery
    Patent number: 9233166
    Abstract: Disclosed are nanoparticles, such as carbon nanotubes or other graphitic sheet materials having extended aromatic surfaces, which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer or adsorption of an amphiphilic molecule to render them stable in suspension. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Zhuang Liu, Xiaolin Li, Xiaoming Sun
  • Minicircle DNA vector preparations and methods of making and using the same
    Patent number: 9233174
    Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhi-Ying Chen, Mark A. Kay
  • Treatment of pulmonary hypertension with leukotriene inhibitors
    Patent number: 9233089
    Abstract: Pulmonary arterial hypertension (PAH) can be prevented in persons susceptible to the diseases and PAH patients can be treated by administering an effective dose of a leukotriene inhibitor. Suitable inhibitors include leukotriene A4 hydrolase (LTA4H) inhibitors, leukotriene B4 receptor (BLT1/BLT2) antagonists, 5-lipoxygenase (5-LO) inhibitors, and 5-lipoxygenase activating protein (FLAP) inhibitors.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark R. Nicolls, Wen Tian, Jayakumar Rajadas
  • Reconfigurable antennas for performance enhancement of interference networks employing interference alignment
    Patent number: 9236955
    Abstract: By using reconfigurable antenna based pattern diversity, an optimal channel can be realized in order to maximize the distance between two subspaces, thereby increasing sum-rate. The inventors show the benefits of pattern reconfigurability using real-world channels, measured in a MIMO-OFDM interference network. The results are quantified with two different reconfigurable antenna architectures. An additional 47% gain in choral distance and 45% gain in sum capacity were achieved by exploiting pattern diversity with IA. Due to optimal channel selection, the performance of IA can also be improved in a low SNR regime.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: January 12, 2016
    Assignees: Drexel University, The Trustees Of The University Of Pennsylvania
    Inventors: Rohit Bahl, Nikhil Gulati, Kapil R. Dandekar, Dwight L. Jaggard
  • MODULATION OF SALTY TASTE PERCEPTION BY ALTERING THE FUNCTION OF BITTER- OR PKD2L1-EXPRESSING TASTE RECEPTOR CELLS
    Publication number: 20160000126
    Abstract: The current invention is in the field of taste and relates to methods and compositions to modulate the perceived taste of saltiness in food or food products where salty taste is desired. The methods and compositions relate to altering the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1-expressing taste receptor cells. The invention also relates to food and food products containing agents and composition that alter the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1-expressing taste receptor cells.
    Type: Application
    Filed: February 12, 2014
    Publication date: January 7, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Yuki OKA, Charles ZUKER
  • DEVICE AND METHOD FOR RAPID ASPIRATION AND COLLECTION OF BODY TISSUE FROM WITHIN AN ENCLOSED BODY SPACE
    Publication number: 20160000991
    Abstract: Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Applicant: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Daniel KRAFT, James HOLE
  • APPARATUS AND METHODS FOR MAKING VESICLES
    Publication number: 20160001290
    Abstract: A microfluidic device includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one waste outlet, at least one vesicle outlet, a flow junction joining the at least one vesicle outlet and the at least one waste outlet in fluid communication, the flow junction having a fluid flow path that is orthogonal to the plane of the substrate, and at least one membrane between the at least one vesicle outlet and the at least one waste outlet configured to intercept a portion of the fluid flow path.
    Type: Application
    Filed: July 2, 2015
    Publication date: January 7, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: David Issadore, Jin A. Ko
  • Methods and compositions for treating or preventing narcotic withdrawal symptoms
    Patent number: 9226918
    Abstract: This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Gary Peltz, David Clark, Lawrence Chu
  • Headrest
    Patent number: D747238
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: January 12, 2016
    Assignee: Roger Thomas Mascull and Elizabeth Jocelyn Mascull as Trustees of the RT and EJ Mascull Family Trust
    Inventor: William George Mascull