Abstract: A peristaltic pump with a removable pump race module has guiding channels for receiving at least a portion of a flexible fluid-carrying tubing and an adjusting device for displacing a flexible inner portion of the removable pump race module to change the compression on the fluid-carrying tubing. The arrangement of the various elements makes it particularly suitable in configurations where compactness and convenience are important considerations.

Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Abstract: Description and specifications of a new and distinct grapevine cultivar which originated from a hand-pollinated cross of Moored (non-patented)×NY 45791 (non-patented, non-released breeding genotype). This new grapevine cultivar can be distinguished by its seedless, pink berries of distinct V. labrusca-like flavor, small compact clusters, distinctly lobed leaves, medium vigor, and healthy plant.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.

Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

Abstract: Techniques for radioablation of sympathetic nerves include positioning a subject on a support in view of a volume imaging system and an ionizing radiation source; and collecting volume image data. Location of a treatment portion of a sympathetic nerve in the subject is determined based on the volume image data. Movement of the source is determined to apply a therapeutic radiation dose to the treatment portion based on the location of the treatment portion and relative location of the source to the volume imaging system. The source is operated to deliver the therapeutic radiation dose. An apparatus includes a mounting structure, an X-ray source and a shield. The source produces an X-ray beam with photon energy above one million electron volts (MeV) and not above six MeV. The shield is mounted in opposition to the source to block the X-ray beam with photon energies not greater than about six MeV.

Abstract: A recessable rotary sliding door handle system provides for comfortable movement of a door or fenestration product with enough durability and strength for everyday use on a large door product. The handle system can include one or two recessable handles with comfortable grips, with balanced weighting to allow the handles to maintain an exposed usable configuration position when swiveled about its axis. In an exposed configuration, the handle is open and accessible for opening and closing a door. In a recessed configuration, the handle is closed to provide a clean appearance and allow the fenestration product to completely pocket within a walled enclosure.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: The invention is directed to binary oligonucleotide probes for nucleic analysis, which probes can be made of DNA or RNA that recognize nucleic acid analytes (both DNA and RNA) with unprecedented high selectivity under mild conditions and are highly sensitive to single nucleotide mismatches (SNP single nucleotide polymorphisms) without PCR amplification. In one group, the binary probes indicate that they have hybridized to a particular nucleic analyte by binding to a molecular beacon that gives off a fluorescent signal. A second group of binary probes bind to a dye such as malachite green, where upon hybridization to analyte the fluorescence of the dye increases dramatically and is easily detected and measured. The new binary probes require only about five minutes at room temperature to generate a detectable signal.

Abstract: The current invention provide a microfluidic valve having a housing that includes a microfluid control port disposed adjacent to a microfluid exhaust port, where a movable rigid material having a first diameter is disposed in the housing between the microfluid control port and the microfluid exhaust port. The housing further includes a microfluid pressure port having a first microfluid pressure. The microfluid pressure port is connected to the microfluid exhaust port by a microfluid valve orifice having a second diameter, where the first diameter is larger than the second diameter, and when a second microfluid pressure is applied to the control port the moveable rigid material closes the microfluid valve orifice, where the first microfluid pressure is greater than the second microfluid pressure.

Abstract: A method of reducing a total number of beam segments in a dose distribution for a radiation therapy field is provided.

Abstract: Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably DNA. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal.

Abstract: The present invention provides a method of reconstructing a tomographic image. In a first step, a tomographic image is forward-projected along a list of geometrical lines in a GPU. This list of geometrical lines may be list-mode event data acquired from a tomographic scanner. Alternatively, the list may be a list of weighted lines derived from a sinogram, a histogram, or a timogram acquired from a tomographic scanner. Next, the list of geometrical lines is back-projected into a 3-dimensional volume using the GPU. The results of the forward- and back-projection are then used to reconstruct the tomographic image, which is then provided as an output, e.g. to make the image available for further processing. Examples of output include storage on a storage medium and display on a display device.

Abstract: Methods and devices are described for the regulation of BMP 2 and 4, TGF-beta 1, 2, and 3, FGF-2, osteocalcin, and alkaline phosphatase mRNA in stem cells via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues containing the stem cells, where the specific and selective fields are generated by application of specific and selective signals to field generating devices disposed with respect to the stem cells so as to facilitate the treatment of diseased or injured bone and other tissues. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and/or other conditions in which BMP 2 and 4, TGF-beta 1, 2, and 3, FGF-2, osteocalcin, and alkaline phosphatase mRNA and/or protein deficiencies in stem cells has been implicated.

Abstract: The present invention provides for compositions comprising carbon nanotubes (CNT) and gold (Au). The present invention further provides methods of manufacture of gold-carbon nanotubes (gCNT). The present invention provides methods of using gCNT for biological application.

Abstract: In a geo-security system, a device receives RF signals from multiple distinct classes of RF communication systems and extracts location-dependent signal parameters. A current geotag is computed from the parameters by fuzzy extractors involving quantization of the parameters and Reed-Solomon decoding to provide a reproducible unique geotag. The current geotag is compared with a stored geotag, and a geo-secured function of the device is executed based on the result of the comparison. The use of multiple signal sources of different types, combined with special fuzzy extractors provides a robust geotag that allows both lower false rejection rate and lower false acceptance rate.

Abstract: A nano electromechanical integrated circuit filter and method of making. The filter comprises a silicon substrate; a sacrificial layer; a device layer including at least one resonator, wherein the resonator includes sub-micron excitable elements and wherein the at least one resonator possess a fundamental mode frequency as well as a collective mode frequency and wherein the collective mode frequency of the at least one resonator is determined by the fundamental frequency of the sub-micron elements.

Abstract: A linker system is provided where a small molecule reactive group, e.g., an activity based probe which binds to certain enzymes at the active site, is linked through an aryl diazo linker to an affinity molecule such as biotin. The reactive group may comprise a number of functionalities known to react with a specific target to be studied. This enables the probe to be exposed to analytes, such as proteins and bind specifically to them to form a complex having an affinity molecule allowing immobilization of the bound analyte on an affinity column or other support, e.g. with streptavidin. Then, the linker is cleaved without causing removal of the affinity group or dissociation of the probe from the analyte. The linker is cleaved under mild reducing conditions, e.g., dithionite. The probe is synthesized along with the linker on a solid support.

Abstract: The present application pertains generally to medical systems and methods for creation of an autologous tissue valves within a mammalian body. In some embodiments, a system for creating an endoluminal valve from a blood vessel wall is provided. The system includes a tubular assembly having a longitudinal axis, a proximal end, a distal portion with a distal end, and a first lumen extending from the proximal end to a distal port located proximate the distal portion. The distal portion can have a supporting surface that extends in a longitudinal direction and is offset from a surface of the tubular assembly proximal the distal port. The system can further include a tissue dissection probe disposed within the first lumen.

Abstract: Systems and methods can mine structured clinical event data in an electronic health record (EHR) system to determine patient outcomes. Mining the structured clinical event data instead of or in addition to mining discharge summaries can increase the accuracy of patient outcome identification. Sophisticated language models can be used to extract outcomes from discharge summaries while also inferring outcomes from cues or hints contained in the structured clinical event data. For example, the clinical event data can include information regarding treatments and medications prescribed by clinicians to specifically manage patient complications; thus, presence or absence of relevant treatments in the clinical event data can provide independent indicators to disambiguate cases where current language processing approaches fail.