Abstract: Described here is an air filter comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter a removal efficiency for PM2.5 of at least 70% when a light transmittance is below 50%. Also described here is an electric air filter comprising a first layer adapted to receive a first electric voltage, wherein the first layer comprises an organic fiber coated with a conductive material. Further described is an air filter for high temperature filtration, comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter has a removal efficiency for PM2.5 of at least 70% at a temperature of a least 70° C.

Abstract: A battery storage system includes a housing defining an opening configured to allow a vehicle travel through the housing, a power supply configured to supply electricity within the housing, a plurality of receptacles positioned within the housing, wherein each of the plurality of receptacles is configured to individually receive a battery of a the vehicle, a battery transportation device configured to selectively couple to the battery of the vehicle in response to the vehicle entering the housing and transport the battery to one of the plurality of receptacles, and a plurality of charging connectors configured to receive the electricity from the power supply and including a first charging connector configured to selectively couple to the battery in response to the battery being received by one of the plurality of receptacles, the first changing connector further configured to provide electricity from the power supply to the battery to charge the battery.

Abstract: A mobile battery charging and swap system includes a housing defining an opening configured to allow a vehicle travel through the housing via the opening and further, a power supply configured to supply electricity within the housing, a battery exchange system configured to selectively couple to a battery of a vehicle in response to the vehicle entering the housing and transport the battery to one of a plurality of receptacles, and a plurality of charging connectors configured to receive the electricity from the power supply and individually provide the electricity to a plurality of batteries including the battery.

Abstract: Systems and methods for spatial graph convolutions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting characteristics for molecules, wherein the method includes performing a first set of graph convolutions with a spatial graph representation of a set of molecules, wherein the first set of graph convolutions are based on bonds between the set of molecules, performing a second set of graph convolutions with the spatial graph representation, wherein the second set of graph convolutions are based on at least a distance between each atom and other atoms of the set of molecules, performing a graph gather with the spatial graph representation to produce a feature vector, and predicting a set of one or more characteristics for the set of molecules based on the feature vector.

Abstract: A vehicle alignment system includes a housing, a tire alignment track configured to receives one or more tires of the vehicle, a battery exchange system configured to selectively couple to the battery of the vehicle in response to the vehicle entering the housing, the battery exchange system comprising a platform configured to translate in a vertical direction between a first position, a second position, and a third position, an alignment pin configured to be received by an alignment aperture in the vehicle as the platform translates in the vertical direction from the first position to the second position, wherein the platform translates in a horizontal direction as the first alignment pin is receive within the tapered alignment aperture, and a locating pin configured to be received by a locating aperture in a battery of the vehicle as the platform translates from the second position to the third position.

Abstract: An attachment system for an electric vehicle includes a battery including a first projection having a head defining a head diameter and a shaft defining a shaft diameter and a battery receptacle including a first plate defining a first slot, a second plate defining a second slot and movable relative to the second plate between a first position and a second position, wherein the first slot and the second slot define an opening configured to receive the head of the first projection, and the second plate is biased towards the first position and configured to translate to the second position in response as the head of the projection passing through the opening such that the battery is secured within the battery receptacle when the head is located within the opening.

Abstract: In an embodiment, the present disclosure pertains to a method of detecting an analyte from vesicles in a sample. In an additional embodiment, the present disclosure pertains to an analyte detection platform. In a further embodiment, the present disclosure pertains to a sensor. In another embodiment, the present disclosure pertains to a method of detecting an analyte from a sample. In an additional embodiment, the present disclosure pertains to a method of lysing vesicles. In a further embodiment, the present disclosure pertains to a vesicle lysis platform.

Abstract: Provided herein, inter alia, are complexes comprising nanoparticles attached to viral proteins or nucleic acids encoding said viral proteins. Methods for making and using said complexes are provided. Compositions including the complexes are contemplated to be useful for treating and/or preventing viral infections.

Abstract: A control system for conducting an election may include a voter client configured to be used by a voter to cast a vote for a candidate, a registrar server, and a moderator server. The moderator server may be configured to obscure the identity of the voter. The registrar server may be configured to randomly assign a ballot to the obscured voter. The registrar server may be configured to encrypt the ballot. The moderator server may be configured to transmit the encrypted ballot to the voter client. The voter client may be configured to decrypt the encrypted ballot to recover the ballot. The voter client, in response to the voter selecting a desired candidate, may be configured to generate a ballot associated with a vote. The voter client may be configured to encrypt the ballot using a public key of the registrar server and a public key of the moderator server.

Abstract: Provided are a diffraction grating device, a method of manufacturing the diffraction grating device, and an optical apparatus including the diffraction grating device. The diffraction grating device includes a diffraction grating arranged on a light reflection substrate. The diffraction grating includes a plurality of diffraction elements, each diffraction element from among the plurality of diffraction elements having a height that causes a destructive interference between first light rays reflected by a top surface therefore and second light rays reflected by a bottom surface thereof, the first and second light rays being incident on the top and bottom surfaces, respectively, at an incidence angle greater than 45°.

Abstract: Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.

Abstract: A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.

Abstract: Systems and methods for structuring unstructured data according to a data object structure that enables fast query look-ups across a variety of space and time dimensions. Furthermore, many embodiments optimize the storage of the data objects using a set of compression techniques that configure the data types used for the data objects based on properties of the stored data. Furthermore, many embodiments provide are able to service query look-up requests without having to deserialize data within the byte stream format as stored in memory by encoding information that provide memory locations for requested data, thereby allowing for the immediate retrieval of the data as it is stored in the persistent memory.

Abstract: Provided herein is an isolated fusion protein comprising a light-responsive domain and a heterologous peptide component. Exposure of the fusion protein to light induces a conformational change in the fusion protein that alters an activity of the fusion protein and the activity is a binding activity selected from an in vitro binding activity, an in vivo extracellular binding activity and an in vivo intracellular binding activity. Also provided are methods of using and identifying the fusion proteins.

Abstract: A system and method for demodulation of a fiber optic interferometric sensor are provided. Another aspect pertains to a system and method employing a single laser to generate multiple quadratic wavelengths to demodulate fiber optic interferometric sensors with approximately sinusoidal fringes. Yet another aspect of the present system and method uses a single frequency laser which is split into multiple paths using a fiber optic coupler, with one path including an intensity modulator and another path including an acousto-optic modulator, whereafter the paths are recombined into a fiber which leads to an interferometric sensor, and the light reflected from the sensor is then directed to a photodetector. A further aspect employs a single frequency laser which is split into multiple paths, with the light in the paths being modulated at different frequencies, whereafter the paths are recombined into a fiber which leads to an interferometric sensor.

Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).

Abstract: A framework for a few-shot learning method is disclosed. In a first part, self-supervision and classification supervision are used to train a feature extractor. An example self-supervision method comprises running grayscale images through an edge filter, normalizing the filtered images, setting the normalized images to ground truth, generating feature-extracted images, using a decoder to reconstruct images from the feature-extracted images, determining a loss between the reconstructed images and the ground truth images, and using the loss to update parameters of the feature extractor. In a second part, a few-shot adaptation process is performed to adapt the model to a novel rapid test kit.

Abstract: The subject invention provides compounds, peptidomimetics, and methods of synthesis thereof. The subject invention provides the synthesis and use of guanidino acids and/or poly guanidino acids not only as vehicles for drug delivery but as toolbox for drug discovery. The peptidomimetic of the subject invention comprises oligo(guanidino acid)s or poly(guanidino acid)s with guanidines as peptide bond surrogates. The incorporation of the guanidine as amide bond surrogates offers significant differences in polarity, hydrogen bonding capability, and acid-base character.

Abstract: An aortic aneurysm carries increasing risk of rupture with growing aneurysm diameter. This condition is typically asymptomatic, so screening and surveillance are essential. Ultrasound and other imaging methods are employed for such monitoring at high accuracy. However, these methods require an expert and are expensive. Aortic aneurysms are considerably under-detected at present and may become even more under-detected in the future as the disease prevalence increases with societal aging. This disclosure present devices that are convenient in use and cost for aortic aneurysm screening and surveillance.

Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.