Abstract: Provided herein are programmable condensate protein systems and nucleic acid constructs encoding the same. The protein system enables modular targeting of proteins of interest. Protein-peptide interaction domains (PPIDs) are incorporated to functionalize engineered condensates with the attributes of the recruited protein, resulting in a modular system that allows for diverse facile and reprogrammable applications, including in enzyme clustering of metabolic pathways. Colocalizing specific metabolic enzymes in these condensates results in functionalized organelles with which can be used to manipulate the output of engineered metabolic pathways for the production of a pharmaceutical precursor.

Abstract: Compositions of matter and devices using those compositions are provided, which can, e.g., impede or restrict the migration of halides from a halide perovskite active layer. The composite material may include n layers of semiconductors, wherein n ? 2. Each layer of semiconductors may contain (i) one or more organic semiconductor layers and one or more inorganic semiconductor layer in contact with the one or more organic semiconductor layers, (ii) one or more composite semiconductor layers, each composite semiconductor layer containing an organic material and inorganic material, or (iii) a combination thereof.

Abstract: Methods and compositions are described for selecting and identifying orthogonal aminoacyl synthetase-tRNA pairs and their use to incorporate unnatural amino acids in a site-specific manner in proteins. Specifically described is a novel E. coli tryptophanyl synthetase-tRNA pair that functions as both an opal and amber suppressor and that incorporates tryptophan analogs into proteins.

Abstract: A method for modeling textile structures using bicontinuous surfaces includes selecting a virtual scaffold of bicontinuous surfaces defining textile fabrication pathways to model spatial relationships between the pathways and yarns in a desired yarn pattern of a textile fabric design. The method further includes constructing a yarn pathway across the bicontinuous surfaces that form the virtual scaffold. The method further includes removing or releasing tension from the virtual scaffold, thereby allowing yarns to relax and determining a physical property of the textile fabric design.

Abstract: The disclosure provides compounds. In certain embodiments, compounds of the disclosure are capable of inhibiting a mammalian SHMT, such as human SMHT1 and/or SHMT2. Compounds of the disclosure have numerous uses.

Abstract: Polypeptide compositions comprising a human immunoglobulin constant region with a modified IgG4 hinge region having an N-terminal deletion of 1, 2, 3, 4, 5 amino acids, relative to a native human IgG4 hinge sequence are provided. In some embodiments the hinge sequence further comprises the amino acid substitution S228P (Eu numbering). Polypeptides comprising the modified sequence optionally comprise a binding moiety specific for an epitope that is present on red blood cells; and can provide for reduced agglutination of hematopoietic cells compared to a comparable polypeptide with a native hinge region.

Abstract: A system for improving radiation tolerance of memory senses an amount of radiation exposure and, based on the sensed amount of radiation exposure, determines whether to perform one or more techniques for mitigating the effects of the radiation exposure. As an example, the system may perform a data refresh operation by re-writing data that has been corrupted by radiation, or the system may adjust the reference voltage used to read memory cells. In another example, the system may perform a fault repair operation by re-programming cells that have erroneously transitioned from a program state to an erase state. The system may selectively perform different radiation-mitigation techniques in a tiered approach based on the sensed amount of radiation in order to limit the adverse effects of the more invasive techniques.

Abstract: A data storage device includes a nonvolatile memory device, a volatile memory device, a data encryption circuit configured to encrypt data outputted from the nonvolatile memory device, a data decryption circuit configured to decrypt encrypted data output from the data encryption circuit and configured to provide the decrypted data to the volatile memory device, and a processor configured to perform a first process that controls installation of a first in-storage program in the data storage device, a second process configured to manage a mapping table storing a relation between a logical address and a physical address of the nonvolatile memory device, and a third process configured to execute the first in-storage program.

Abstract: Human pluripotent stem cells are differentiated in vitro into oligodendro-spheroids comprising oligodendrocytes for use in analysis, screening programs, and the like.

Abstract: A method and device for extracting information from acoustic signals receives acoustic signals by a microphone, processes them in an analog front-end circuit, converts the processed signals from the analog front-end circuit to digital signals by sampling at a rate of less than 1 kHz or more preferably less than 500 kHz; and processes the digital signals by a digital back-end classifier circuit. The analog front-end processing decomposes the received signals into frequency components using a bank of analog N-path bandpass filters having different subband center frequencies.

Abstract: A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.

Abstract: Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets.

Abstract: In an aspect, compositions, methods, and devices described herein provide a safer platform for the ex vivo expansion of cells for immunotherapeutic purposes that eradicates the possibility of having activating substrate transferred into the patient while maintaining and improving upon the level of cell activation and proliferation.

Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

Abstract: Systems and methods for detecting concussions in real-time are provided. An exemplary system of detecting concussions in real time includes an accelerometer to measure acceleration event and generate an accelerometry signal. The system includes a plurality of electrodes to detect an electroencephalogram (EEG) and each of the electrodes can be attached to a top region of the headgear through a flexible shaft. The system further includes a signal processing circuit to amplify, filter and broadcast an electroencephalogram (EEG) signal to a local wireless receiving unit.

Abstract: Systems and methods for generating an enhanced audio signal comprise a trained neural network configured to receive an input audio signal and generate an enhanced target signal, the trained neural network comprising a pre-processing neural network configured to receive a segment of the input audio signal and output an audio classification, the pre-processing neural network including at least one hidden layer comprising an embedding vector, and a noise reduction neural network configured to receive the segment of the input audio signal, and the embedding vector and generate the enhanced target signal. The pre-processing neural network may comprise a target signal pre-processing neural network configured to output a target signal classification and comprising at least one hidden layer comprising a target embedding vector.

Abstract: Subject matter disclosed herein may relate to power converters, and may more particularly relate to multi-stage hybrid power converters, for example.

Abstract: In some embodiments, the present disclosure pertains to a method for capturing alkenes that includes: associating the alkenes with metal-organic frameworks, where the metal-organic frameworks includes one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and oxidizing the metal-organic frameworks, where the oxidizing results in a capturing of the alkenes by the metal-organic frameworks. Additional embodiments of the present disclosure pertain to a system for capturing alkenes that includes: metal-organic frameworks, where the metal-organic frameworks include one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and an alkene feed source associated with the metal-organic frameworks, where the alkene feed source is configured to deliver an alkene feed to the system.

Abstract: According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.

Abstract: A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.