Patents Assigned to Trustees of Dartmouth College
  • Patent number: 10993677
    Abstract: A method for cardiovascular-dynamics correlated imaging includes receiving a time series of images of at least a portion of a patient, receiving a time series of cardiovascular data for the patient, evaluating correlation between the time series of images and the time series of cardiovascular data, and determining a property of the at least a portion of a patient, based upon the correlation. A system for cardiovascular-dynamics correlated imaging includes a processing device having: a processor, a memory communicatively coupled therewith, and a correlation module including machine-readable instructions stored in the memory that, when executed by the processor, perform the function of correlating a time series of images of at least a portion of a patient with a time series of cardiovascular data of the patient to determine a property of the at least a portion of a patient.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: May 4, 2021
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ryan J. Halter, Keith D. Paulsen, Alexander Hartov
  • Publication number: 20210117600
    Abstract: A disclosed circuit prototyping system includes a hardware interface module configured for electronically connecting to a physical electronic device, a virtual circuit design interface to construct a virtual circuit for a plurality of virtual circuit devices including a virtual counterpart of the physical electronic device, and a circuit simulator configured to simulate the virtual circuit including communicating data with the physical electronic device by way of communication with the hardware interface module.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 22, 2021
    Applicant: Trustees of Dartmouth College
    Inventors: Te-Yen WU, Jun GONG, Alemayehu SEYED, Xing-Dong YANG
  • Patent number: 10973589
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: April 13, 2021
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Venkataramanan Krishnaswamy, Richard J. Barth, Jr., Keith D. Paulsen
  • Patent number: 10978504
    Abstract: Some embodiments of the present disclosure are directed to an image sensor pixel that is configured for gateless reset of a floating diffusion. Some embodiments are directed to an image sensor comprising a plurality of pixels, at least one pixel comprising a floating diffusion formed in a semiconductor substrate; a transfer gate configured to selectively cause transfer of photocharge stored in the pixel to the floating diffusion; and a reset drain formed in the semiconductor substrate and spaced away from the floating diffusion by an intervening semiconductor region having a dopant type opposite to the dopant type of the reset drain and the floating diffusion, wherein the reset drain is configured to selectively reset the electrostatic potential of the floating diffusion in response to a voltage pulse applied to the reset drain.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: April 13, 2021
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Eric R. Fossum, Jiaju Ma
  • Patent number: 10973610
    Abstract: A dental drill system with electrical-impedance sensing indicates when a bit of the drill system approaches cortical-cancellous bone, or bone-soft tissue interfaces. The drill system has a dental drill handset having a cannula bearing electrically coupled to a drilling bit, the drilling bit having an electrically insulated portion and an exposed portion. The cannula bearing is coupled to an electrical impedance spectroscopy sensing device configured to measure impedance between the cannula bearing of the dental drill handset and a ground plate, and a processing system uses EIS measurements to distinguish when the bit of the drill system approaches cortical- or cancellous bone, or bone-soft tissue interfaces.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: April 13, 2021
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ryan Halter, Rebecca Butler, Michael Salin
  • Patent number: 10960070
    Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: March 30, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Scripps Research Institute, Trustees of Dartmouth College
    Inventors: Barney Graham, Jason McLellan, Andrew Ward, Robert Kirchdoerfer, Christopher Cottrell, Michael Gordon Joyce, Masaru Kanekiyo, Nianshuang Wang, Jesper Pallesen, Hadi Yassine, Hannah Turner, Kizzmekia Corbett
  • Patent number: 10954315
    Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 23, 2021
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Chenfeng Ke, Qianming Lin
  • Publication number: 20210079134
    Abstract: In an embodiment, the present disclosure pertains to a method of changing the glass transition temperature of a polymer. In some embodiments, the polymer includes at least one hydrazone-containing compound. In general, the methods of the present disclosure include one or more of the following steps of: (1) applying light to the polymer; and (2) thereby changing the glass transition temperature of the polymer. In another embodiment, the present disclosure pertains to a polymer having a light-adjustable glass transition temperature. In some embodiments, the polymer includes at least one hydrazone-containing compound.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 18, 2021
    Applicant: Trustees of Dartmouth College
    Inventors: Ivan Aprahamian, Sirun Yang, Laura L. Jeliazkov, Jared D. Harris
  • Patent number: 10945976
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: March 16, 2021
    Assignees: Io Therapeutics, Inc., Trustees of Dartmouth College
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Patent number: 10940332
    Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: March 9, 2021
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Rongxiao Zhang, Brian William Pogue, Adam K. Glaser, David J. Gladstone, Lesley A. Jarvis, Jacqueline M. Andreozzi, Shudong Jiang, Scott Christian Davis, Johan Jakob Axelsson
  • Patent number: 10933115
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: March 2, 2021
    Assignees: THE TRUSTEES OF DARTMOUTH COLLEGE, KING'S GOLLEGE LONDON
    Inventors: Randolph J. Noelle, Sabrina Ceeraz, Isabelle Lemercier, Elizabeth Nowak, Janet Lines, Li Wang, Mark Spaller
  • Patent number: 10936083
    Abstract: A self-powered module for gesture recognition is presented that utilizes small, low-cost photodiodes for both energy harvesting and gesture sensing. Operating in the photovoltaic mode, photodiodes harvest energy from ambient light. In the meantime, the instantaneously harvested power from individual photodiodes is monitored and exploited as a clue for sensing finger gestures in proximity. Harvested power from all photodiodes is aggregated to drive the whole gesture-recognition module including a micro-controller running the recognition algorithm. A robust, lightweight algorithm is provided to recognize finger gestures in the presence of ambient light fluctuations. Two prototypes are fabricated to facilitate user's interaction with smart glasses and smart watches.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: March 2, 2021
    Assignee: Trustees of Dartmouth College
    Inventors: Yichen Li, Tianxing Li, Ruchir A. Patel, Xing-Dong Yang, Xia Zhou
  • Publication number: 20210029321
    Abstract: Disclosed herein are image apparatuses comprising a frontside surface, a backside surface, a storage region (e.g., a storage node or a floating diffusion node), the storage region being situated closer to the frontside surface than to the backside surface, a storage well situated between the backside surface and the storage region, and a doping region situated between the storage region and the storage well. An impurity type of the doping region is opposite an impurity type of the storage well. A lateral area of the storage well is greater than or equal to a lateral area of the storage region, and no portion of a lateral perimeter of the storage region extends outside of a lateral perimeter of the storage well.
    Type: Application
    Filed: July 25, 2020
    Publication date: January 28, 2021
    Applicant: Trustees of Dartmouth College
    Inventors: Jiaju MA, Eric R. FOSSUM
  • Publication number: 20200405195
    Abstract: In an embodiment, the present disclosure pertains to a method of determining an angular motion in a subject. The method generally includes one or more of the following steps of: (1) applying a wearable system to a body region of the subject; (2) utilizing the wearable system to sense one or more parameters; and (3) correlating the one or more parameters to the angular motion in the subject. In an additional embodiment, the present disclosure pertains to a wearable system for determining angular motion in a subject. Generally, the wearable sensor includes one or more fabrics for sensing one or more parameters of a body region of a subject.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 31, 2020
    Applicant: Trustees of Dartmouth College
    Inventors: Ruibo Liu, Qijia Shao, Siqi Wang, Christina Ru, Devin Balkcom, Xia Zhou
  • Publication number: 20200396404
    Abstract: Some embodiments provide an apparatus and method wherein the non-linearity of the response of a multi-bit QIS is controllable (e.g., selectively variable) by dynamically choosing the bit depth n during A/D conversion, and/or later (i.e., post-conversion) by firmware and/or software.
    Type: Application
    Filed: December 31, 2019
    Publication date: December 17, 2020
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventor: Eric R. Fossum
  • Patent number: 10864248
    Abstract: Compositions and kits including an agent that inhibits the interaction between Disabled-2 and mutant CFTR proteins, optionally in combination with a CFTR corrector, CFTR potentiator, CAL inhibitor, mucolytic, anti-inflammatory agent or a combination thereof are provided as are methods for preventing or treating cystic fibrosis.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: December 15, 2020
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventor: Dean R. Madden
  • Patent number: 10864258
    Abstract: Attenuated Toxoplasma gondii mutants and methods using the same as vaccines in the prevention or treatment pancreatic cancer are provided.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: December 15, 2020
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: David J. Bzik, Barbara A. Fox, Kiah L. Sanders
  • Patent number: 10858439
    Abstract: Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: December 8, 2020
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventor: Randolph J. Noelle
  • Publication number: 20200361976
    Abstract: In an embodiment, the present disclosure pertains to a method of sensing an analyte in a sample by: (1) exposing the sample to an electrode that includes a covalent-organic framework with a plurality of metal-coordinated aromatic units that are linked to one another by aromatic linkers; (2) detecting a change in a property of the electrode; and (3) correlating the change in the property to the presence or absence of the analyte. In an additional embodiment, the present disclosure pertains to said covalent-organic frameworks. Additional embodiments of the present disclosure pertain to methods of making the covalent-organic frameworks.
    Type: Application
    Filed: April 22, 2020
    Publication date: November 19, 2020
    Applicant: Trustees of Dartmouth College
    Inventors: Katherine A. Mirica, Zheng Meng, Robert M. Stolz
  • Patent number: 10840291
    Abstract: Some embodiments provide a color image sensor and color image sampling method that uses multiple-layer pixels and is capable of producing color images without using absorption color filters (e.g., such as employed in conventional CFAs). In accordance with some embodiments of the color image sensor device and color image sampling method, frequency-dependent reflectors are incorporated between the photodetection layers of multiple-layer (e.g., two layer) pixels.
    Type: Grant
    Filed: December 25, 2018
    Date of Patent: November 17, 2020
    Assignee: Trustees of Dartmouth College
    Inventors: Leo Anzagira, Eric R. Fossum