Abstract: In an embodiment, the present disclosure pertains to an electrolyte composition including a plurality of ether-based solvents and at least one sodium-based salt. The plurality of ether-based solvents include at least one acyclic ether and at least one cyclic ether. In a further embodiment, the present disclosure pertains to an energy storage device that includes an electrolyte composition of the present disclosure. In another embodiment, the present disclosure pertains to a method of making the electrolyte compositions of the present disclosure. Such methods generally include one or more of the following steps of mixing a plurality of ether-based solvents and at least one sodium-based salt, and forming the electrolyte composition.

Abstract: Some embodiments provide an image sensor pixel comprising a junction field effect transistor (JFET) and a floating diffusion configured to act as the gate of the JFET. An image sensor may comprise a plurality of pixels, at least one pixel comprising floating diffusion region formed in a semiconductor substrate, a transfer gate configured to selectively cause transfer of photocharge stored in the pixel to the floating diffusion, and a JFET having (i) a source and a drain coupled by a channel region, and (ii) a gate comprising the floating diffusion region.

Abstract: In some embodiments, the present disclosure pertains to a method for capturing alkenes that includes: associating the alkenes with metal-organic frameworks, where the metal-organic frameworks includes one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and oxidizing the metal-organic frameworks, where the oxidizing results in a capturing of the alkenes by the metal-organic frameworks. Additional embodiments of the present disclosure pertain to a system for capturing alkenes that includes: metal-organic frameworks, where the metal-organic frameworks include one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and an alkene feed source associated with the metal-organic frameworks, where the alkene feed source is configured to deliver an alkene feed to the system.

Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

Abstract: In an embodiment, the present disclosure pertains to a method of detecting an analyte from vesicles in a sample. In an additional embodiment, the present disclosure pertains to an analyte detection platform. In a further embodiment, the present disclosure pertains to a sensor. In another embodiment, the present disclosure pertains to a method of detecting an analyte from a sample. In an additional embodiment, the present disclosure pertains to a method of lysing vesicles. In a further embodiment, the present disclosure pertains to a vesicle lysis platform.

Abstract: This invention provides a generalized electronic computer architecture with multiple cores, memory distributed amongst the cores (a core-local memory). This arrangement provides predictable, low-latency memory response time, as well as a flexible, code-supplied flow of memory from one specific operation to another (using an operation graph). In one instantiation, the operation graph consists of a set of math operations, each accompanied by an ordered list of one or more input addresses. Input addresses may be specific addresses in memory, references to other math operations in the graph, or references to the next item in a particular data stream, where data streams are iterators through a continuous block of memory. The arrangement can also be packaged as a PCIe daughter card, which can be selectively plugged into a host server/PC constructed/organized according to traditional von Neumann architecture.

Abstract: A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

Abstract: Provided herein are engineered Coronavirus S proteins, such as engineered SARS-CoV-2 S proteins. In some aspects, the engineered S proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of engineered proteins as diagnostics, in screening platforms and/or in vaccine compositions.

Abstract: Some embodiments provide an apparatus and method wherein the non-linearity of the response of a multi-bit QIS is controllable (e.g., selectively variable) by dynamically choosing the bit depth n during A/D conversion, and/or later (i.e., post-conversion) by firmware and/or software.

Abstract: A method for compressing a digital representation of a stimulus includes encoding the digital representation as a feature vector within a feature space. The method also includes multiplying the feature vector with a Jacobian that maps the feature space to a non-Euclidean perceptual space according to a perceptual system that is capable of perceiving the stimulus. This multiplication generates a perceptual vector within the non-Euclidean perceptual space. The method also includes applying an update operator to the perceptual vector to move the perceptual vector in the perceptual space to an updated vector such that the updated vector has a lower entropy than the perceptual vector. The method also includes rounding the updated vector into a compressed vector that is smaller than the feature vector.

Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

Abstract: Disclosed are infrared (IR) light detectors. The detectors operate by generating hot electrons in a metallic absorber layer on photon absorption, the electrons being transported through an energy barrier of an insulating layer to a metal or semiconductor conductive layer. The energy barrier is set to bar response to wavelengths longer than a maximum wavelength. Particular embodiments also have a pattern of metallic shapes above the metallic absorber layer that act to increase photon absorption while reflecting photons of short wavelengths; these particular embodiments have a band-pass response.

Abstract: A method for controlling a hybrid switched capacitor (SC) converter includes (a) generating control signals for controlling switching devices of the hybrid SC converter, in a manner which regulates one or more parameters of the hybrid SC converter, (b) detecting flying capacitor voltage imbalance in the hybrid SC converter, and (c) in response to detecting flying capacitor voltage imbalance in the hybrid SC converter, generating the control signals in a manner which varies switching state duration of the hybrid SC converter, to move flying capacitor voltage towards balance.

Abstract: Apparatus and method securely transfer first data from a source device to a target device. A wireless signal having (a) a higher speed channel conveying second data and (b) a lower speed channel conveying the first data is transmitted. The lower speed channel is formed by selectively transmitting the wireless signal from one of a first and second antennae of the source device based upon the first data. The first and second antenna are positioned a fixed distance apart and the target device uses a received signal strength indication (RSSI) of the first signal to decode the lower speed channel and receive the first data.

Abstract: Some embodiments provide methods and apparatus for quantum random number generation based on a single bit or multi bit Quanta Image Sensor (QIS) providing single-photon counting over a time interval for each of an array of pixels of the QIS, wherein random number data is generated based on the number of photons counted over the time interval for each of the pixels.

Abstract: Embodiments of the present disclosure pertain to a composition that includes a rotaxane. The rotaxane includes a plurality of macrocyclic rings and a polymer with a molecular weight below 10,000 Da that is covalently appended to one or more sterically hindered molecules. The cavities of the macrocyclic rings are threaded onto the polymer. The plurality of threaded macrocyclic rings include a plurality of different segments that each include a plurality of threaded macrocyclic rings. Each of the plurality of different segments is in the form of a crystalline network. Further embodiments of the present disclosure pertain to methods of forming the rotaxanes by covalently appending one or more sterically hindered molecules onto a polymer and threading a plurality of macrocyclic rings onto the polymer. Additional embodiments of the present disclosure pertain to methods of manufacturing a three-dimensional structure by applying a composition of the present disclosure onto a surface.

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

Abstract: According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes at least two vertically stacked printed circuit boards (PCBs) comprising a top PCB and a bottom PCB. The power converter circuit further includes at least one multiphase coupled inductor placed between the top PCB and the bottom PCB. The top PCB is coupled to the bottom PCB via at least one conductive winding of the multiphase coupled inductor. The power converter circuit further includes at least one circuit module placed above the top PCB and at least one power source placed below the bottom PCB. The multiphase coupled inductor is configured to deliver current vertically from the bottom PCB to the top PCB.