Abstract: In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.

Abstract: Methods of pairing devices wirelessly that include matching received-signal-strength information regarding signal-strength patterns received by differing devices desired to be paired. In some embodiments, signal-strength patterns are based on a user moving an object so as to intentionally create multipath Fresnel-zone propagation disturbances. During pairing, the devices exchange their received-signal-strength information with one another and compare the received-signal-strength information that they receive from another device to the received-signal-strength information that they generated themselves based on the multipath Fresnel-zone propagation disturbances. When the two sets of receive-signal-strength information substantially match one another, the devices determine the presence of a trusted relationship. Methods for assisting with the wireless pairing are also disclosed.

Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.

Abstract: An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.

Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.

Abstract: In an embodiment, the present disclosure pertains to a method of sensing an analyte in a sample by: (1) exposing the sample to an electrode that includes a covalent-organic framework with a plurality of metal-coordinated aromatic units that are linked to one another by aromatic linkers; (2) detecting a change in a property of the electrode; and (3) correlating the change in the property to the presence or absence of the analyte. In an additional embodiment, the present disclosure pertains to said covalent-organic frameworks. Additional embodiments of the present disclosure pertain to methods of making the covalent-organic frameworks.

Abstract: In an aspect, the present disclosure pertains to a method of making a material. Generally, the method includes one or more of the following steps of: (1) placing a mixture having one or more components in a container; and (2) extruding the mixture out of at least one opening of at least one nozzle. In an additional aspect, the present disclosure pertains to a material. In some embodiments, the material includes one or more components. In some embodiments, the one or more components are in the form of a multi-layered structure.

Abstract: In an embodiment, the present disclosure pertains to a method of making a composite. In some embodiments, the method includes applying an external magnetic field to a mixture composed of a plurality of magnetic materials in a container, in which the external magnetic field produces a homogenous and uniform magnetic flux in the container. In some embodiments, the method further includes solidifying the mixture to result in the growth of solvent crystals in the mixture, and subliming a solvent phase of the mixture in the container to thereby form a composite having uniformly aligned magnetic materials. In an additional embodiment, the present disclosure pertains to a composite having uniformly aligned magnetic materials. In some embodiments, a majority of the magnetic materials in the composite are aligned in the same direction.

Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.

Abstract: The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.

Abstract: A system and method for installation of a k-wire through a scaphoid or other fractured bone can include a guide block for accurate trajectory of a k-wire. A support frame for a guide block can be casted and/or secured into place, and a CT scan is obtained, so the fractured bone and the location of the window can be known in the same three-dimensional space. An ideal k-wire trajectory can be plotted through the fractured bone, and a guide block with a lumen can be designed and printed using a three-dimensional printer. The guide block can be inserted into the frame so the lumen aligns with the ideal k-wire trajectory, and a k-wire can be inserted through the lumen into the fractured bone. The net effect would be ideal placement of the k-wire that would facilitate the ultimate insertion of a percutaneous screw to provide fixation of the fractured bone.

Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon’s perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

Abstract: In an embodiment, the present disclosure pertains to an electrolyte composition including a plurality of ether-based solvents and at least one sodium-based salt. The plurality of ether-based solvents include at least one acyclic ether and at least one cyclic ether. In a further embodiment, the present disclosure pertains to an energy storage device that includes an electrolyte composition of the present disclosure. In another embodiment, the present disclosure pertains to a method of making the electrolyte compositions of the present disclosure. Such methods generally include one or more of the following steps of mixing a plurality of ether-based solvents and at least one sodium-based salt, and forming the electrolyte composition.

Abstract: In some embodiments, the present disclosure pertains to a method for capturing alkenes that includes: associating the alkenes with metal-organic frameworks, where the metal-organic frameworks includes one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and oxidizing the metal-organic frameworks, where the oxidizing results in a capturing of the alkenes by the metal-organic frameworks. Additional embodiments of the present disclosure pertain to a system for capturing alkenes that includes: metal-organic frameworks, where the metal-organic frameworks include one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and an alkene feed source associated with the metal-organic frameworks, where the alkene feed source is configured to deliver an alkene feed to the system.

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

Abstract: In an embodiment, the present disclosure pertains to a method of detecting an analyte from vesicles in a sample. In an additional embodiment, the present disclosure pertains to an analyte detection platform. In a further embodiment, the present disclosure pertains to a sensor. In another embodiment, the present disclosure pertains to a method of detecting an analyte from a sample. In an additional embodiment, the present disclosure pertains to a method of lysing vesicles. In a further embodiment, the present disclosure pertains to a vesicle lysis platform.

Abstract: This invention provides a generalized electronic computer architecture with multiple cores, memory distributed amongst the cores (a core-local memory). This arrangement provides predictable, low-latency memory response time, as well as a flexible, code-supplied flow of memory from one specific operation to another (using an operation graph). In one instantiation, the operation graph consists of a set of math operations, each accompanied by an ordered list of one or more input addresses. Input addresses may be specific addresses in memory, references to other math operations in the graph, or references to the next item in a particular data stream, where data streams are iterators through a continuous block of memory. The arrangement can also be packaged as a PCIe daughter card, which can be selectively plugged into a host server/PC constructed/organized according to traditional von Neumann architecture.

Abstract: A method for controlling a hybrid switched capacitor (SC) converter includes (a) generating control signals for controlling switching devices of the hybrid SC converter, in a manner which regulates one or more parameters of the hybrid SC converter, (b) detecting flying capacitor voltage imbalance in the hybrid SC converter, and (c) in response to detecting flying capacitor voltage imbalance in the hybrid SC converter, generating the control signals in a manner which varies switching state duration of the hybrid SC converter, to move flying capacitor voltage towards balance.

Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

Abstract: Embodiments of the present disclosure pertain to a composition that includes a rotaxane. The rotaxane includes a plurality of macrocyclic rings and a polymer with a molecular weight below 10,000 Da that is covalently appended to one or more sterically hindered molecules. The cavities of the macrocyclic rings are threaded onto the polymer. The plurality of threaded macrocyclic rings include a plurality of different segments that each include a plurality of threaded macrocyclic rings. Each of the plurality of different segments is in the form of a crystalline network. Further embodiments of the present disclosure pertain to methods of forming the rotaxanes by covalently appending one or more sterically hindered molecules onto a polymer and threading a plurality of macrocyclic rings onto the polymer. Additional embodiments of the present disclosure pertain to methods of manufacturing a three-dimensional structure by applying a composition of the present disclosure onto a surface.