Abstract: Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.
Type:
Application
Filed:
October 8, 2019
Publication date:
February 13, 2020
Applicant:
Trustees of Dartmouth College
Inventors:
Ryan Chapman, Douglas Wayne Van Citters, Wayne Edward Moschetti, John-Erik Bell
Abstract: Embodiments of the present disclosure pertain to compositions that include: (1) a microalgal co-product; and (2) microalgae whole cells. In some embodiments, the microalgal co-product is derived from Nannochloropsis sp., and the microalgae whole cells include Schizochytrium sp. In some embodiments, the compositions of the present disclosure are completely free of fish oil and fishmeal. Additional embodiments of the present disclosure pertain to methods of cultivating aquatic species by applying the compositions of the present disclosure to a water source that contains the aquatic species. The methods of the present disclosure may be utilized to cultivate numerous aquatic species (e.g., freshwater tilapia) and improve various metabolic parameters in the aquatic species.
Abstract: Embodiments include a device, comprising: a column line; a plurality of pixels; each pixel coupled to the column line; a comparator having an input coupled to the column line and configured to compare a signal from the column line to a threshold; and control logic coupled to the pixels and configured to selectively couple each pixel to the column line after a sampling period for each pixel.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
November 12, 2019
Assignees:
Varex Imaging Corporation, The Trustees of Dartmouth College
Abstract: Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.
Type:
Grant
Filed:
February 17, 2017
Date of Patent:
November 5, 2019
Assignee:
Trustees of Dartmouth College
Inventors:
Ryan Chapman, Douglas Wayne Van Citters, Wayne Edward Moschetti, John-Erik Bell
Abstract: The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.
Type:
Application
Filed:
February 28, 2019
Publication date:
June 27, 2019
Applicants:
New Health Sciences, Inc., Trustees of Dartmouth College
Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.
Type:
Application
Filed:
April 14, 2017
Publication date:
May 2, 2019
Applicant:
Trustees of Dartmouth College
Inventors:
Margaret Ackerman, Casey Hua, Charles Sentman
Abstract: A multiphase composite, formed by freeze-casting, lyophilization, and sintering, has sintered particles forming a scaffold having at least one region of aligned porosity; and a second phase formed in pores of the scaffold. In a particular embodiment, the second phase is a nuclear fuel, in another, the first phase is a nuclear fuel, and in others, both phases are nuclear fuels. In some embodiments, the first phase is a ceramic, and in other embodiments a metal such as stainless steel. In other embodiments, the second phase is a metal, and in other embodiments a ceramic. In some embodiments the second phase is positioned in a subset of pores of the scaffold, at least some additional pores being filled with a third phase. In embodiments, the second phase is also sintered.
Type:
Application
Filed:
March 4, 2014
Publication date:
May 2, 2019
Applicant:
The Trustees of Dartmouth College
Inventors:
Ulrike G.K. Wegst, Philipp Hunger, Todd Allen
Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) a real capacitor, whose value exactly emulates the value of the quantum constant ? termed a Planck capacitor; 2) a ‘quantum admittance’ element, which has no classical equivalent, but which can be emulated by approximately 18 transistors of a coupled transconductor system; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple quantum admittances to each other under the control of an input. We describe how these parts may be composed together to emulate arbitrary two-state and discrete-state quantum or quantum-inspired systems including stochastics, state preparation, probability computations, state amplification, state attenuation, control, dynamics, and loss compensation.
Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ? termed Planck capacitors; 2) a ‘quantum admittance’ element, which can be emulated efficiently via coupled transconductors; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple emulated quantum admittances to each other under the control of an input. We describe a ‘Quantum Cochlea’, a biologically-inspired quantum traveling-wave system with coupled emulated quantum two-state systems for efficient spectrum analysis that uses all of these parts.
Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ? termed Planck capacitors; 2) a ‘quantum admittance’ element, which can be emulated efficiently via coupled transconductors; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple emulated quantum admittances to each other under the control of an input. We describe a ‘Quantum Cochlea’, a biologically-inspired quantum traveling-wave system with coupled emulated quantum two-state systems for efficient spectrum analysis that uses all of these parts.
Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.
Type:
Grant
Filed:
May 28, 2015
Date of Patent:
October 16, 2018
Assignee:
Trustees of Dartmouth College
Inventors:
Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
Abstract: A technique performs a security operation. The technique includes receiving first activity data from a mobile device, the first activity data identifying activity by a user that is currently using the mobile device. The technique further includes receiving second activity data from an electronic wearable apparatus, the second activity data identifying physical activity by a wearer that is currently wearing the electronic wearable apparatus. The technique further includes, based on the first activity data received from the mobile device and the second activity data received from the electronic wearable apparatus, performing an assessment operation that provides an assessment result indicating whether the user that is currently using the mobile device and the wearer that is currently wearing the electronic wearable apparatus are the same person. With such a technique, authentication may be continuous but without burdening the user to repeatedly re-enter a password.
Type:
Grant
Filed:
September 30, 2016
Date of Patent:
May 1, 2018
Assignees:
EMC IP Holding Company LLC, The Trustees of Dartmouth College
Inventors:
Andres D. Molina-Markham, Shrirang Mare, Ronald Peterson, Jr., David Kotz
Abstract: This disclosure relates to preserving a quantum state in a quantum memory. A controller of the quantum memory determines based on a characteristic of noise that causes deterioration of the quantum state a dynamical decoupling base sequence. The duration of the base sequence is shorter than or equal to an access latency time of the quantum memory to allow access to the quantum state within the access latency time. Further, the deterioration of the quantum state is bounded to an upper deterioration limit when the base sequence is repeatedly applied to the quantum system. This provides acceptable access times while simultaneously allowing long term storage of data in the quantum state with low error rates. Repeatedly applying the base sequence to the quantum system will first yield an increasing deterioration but that deterioration will eventually reach the upper limit. As a result, over time the error rates will not exceed that upper limit and the quantum state is stable.
Type:
Grant
Filed:
June 18, 2013
Date of Patent:
April 17, 2018
Assignees:
The University of Sydney, Trustees of Dartmouth College
Inventors:
Michael J. Biercuk, Kaveh Khodjasteh, Lorenza Viola
Abstract: The present invention a method for producing a human immunoglobulin G (IgG) antibody using a prime-boost regime in a Bone Marrow Liver Thymic (BLT) mouse.
Abstract: The present invention includes an expression cassette containing a polynucleotide encoding a polypeptide; and a host cell, transgenic plant (e.g., a dicot or monocot), transformed seed, and transgenic rootstock containing said expression cassette. Methods for desensitizing a plant to endogenous cytokinin; increasing seed, embryo or cotyledon size or weight; increasing the seed yield of a plant; and/or increasing the size of the root or root meristem or formation of lateral or adventitious roots are provided. In some embodiments, expression of the polypeptide is under control of a seed-preferred, embryo-preferred or root-preferred promoter.
Type:
Grant
Filed:
March 18, 2014
Date of Patent:
October 24, 2017
Assignees:
Trustees of Dartmouth College, The University of North Carolina at Chapel Hill
Inventors:
G. Eric Schaller, Hyo-Jung Kim, Joseph Kieber
Abstract: Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.
Abstract: Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.
Type:
Application
Filed:
February 17, 2017
Publication date:
August 24, 2017
Applicant:
Trustees of Dartmouth College
Inventors:
Ryan Chapman, Douglas Wayne Van Citters, Wayne Edward Moschetti, John-Erik Bell