Abstract: Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform 1a3 (ALDH1a3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.

Abstract: Disclosed herein are a spherical-motion average radiant temperature sensor (SMART Sensor) system which can be used in various applications, including but not limited to, informing or controlling HVAC systems in buildings, locating and tracking people or objects, and detecting the release of gases. The system may optionally include the use of sensors other than a non-contacting temperature sensor to improve calculations and determinations made by the system.

Abstract: Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.

Abstract: According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes a plurality of voltage splitting units (VSUs) coupled to a plurality of current splitting units (CSUs). The VSUs are connected to each other in series and the CSUs are connected to each other in parallel. The VSUs each have a fixed voltage conversion ratio and are operated at a lower frequency than the CSUs. The CSUs each have an adjustable voltage conversion ratio and are operated at a higher frequency than the VSUs.

Abstract: Recombinant phages that infect and kill bacterial hosts in response to user-defined inputs are provided. The components that encode the user-defined inputs can be combined, such that multiple inputs are maintained on a single recombinant phage, enabling precise control over the targeting strategy. The phages can be engineered to kill a specific bacterial species or multiple species simultaneously. Recombinant phages can also be engineered to harbor fluorescent and bioluminescent reporter genes that enable them to be used for tracking, detection, and in biosensing applications. Recombinant phages can also be used to lyse bacterial cells that produce recombinant proteins, as a rapid method to enable extraction and high-level purification of potentially valuable and/or industrially important proteins. Systems are provided that can be used to control the activity of a protein of interest, by taking advantage of an interaction between Qtip and a phage repressor protein.

Abstract: According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a next generation core (NGC). The NGC includes an authentication server function (AUSF) configured to determine whether the computing device contains a valid subscriber identity module (SIM) card, and a user plane function (UPF) configured to allow a computing device to connect to the Internet. The architecture further includes a gateway connected to the UPF, the gateway configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access.

Abstract: A system and method for modulating stress granule assembly, utilizing a protein construct that has a cell penetrating protein fused to one or more proteins that can bind with an NTF2-like domain of a G3BP protein. By configuring the protein construct with an appropriate number of proteins that being with NTF2-like domains, stress granule assembly can be upregulated or downregulated as needed to treat patients.

Abstract: A system and method for chat-based studies utilizing a plurality of users may be provided, utilizing at least one chat room processor and a plurality of remote processors. The chat room processors may be configured to receive a chat room template, create a plurality of chat rooms based on the chat room template, assign participants to one chat rooms, provide instructions associated with the chat room when all participants are present, provide questions or prompts at times defined by the chat room template or when conditions defined by the chat room template are met, collect all messages received from each participant, and storing information that includes the message, a time stamp the message was sent and/or received, and at least one unique identification code associated with the participant sending the message.

Abstract: According to various embodiments, a method for reducing heading error in a magnetometer that uses Rb-87 atoms is disclosed. The method includes varying a direction and magnitude of a magnetic field at different spin polarization regimes. According to various embodiments, a magnetometer adapted for reduced heading error is disclosed. The magnetometer includes a multipass cell containing Rb-87 vapor, a pump laser operated in a pulse mode that is synchronous with a Larmor frequency, and two orthogonal probe lasers configured to rotate to vary a direction and magnitude of a magnetic field at different spin polarization regimes.

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.

Abstract: Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform Ia3 (ALDHIa3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.

Abstract: Disclosed herein is the detection of dangerous dielectric materials (explosives) and dangerous non-explosive and/or prohibited items. The detection is based on a broad bandwidth nonlinear radar system, driven by a highly stable optical frequency comb. The disclosed approach allows for the spatial resolution of the interrogated object in complex settings. Detection of dangerous materials and non-explosive chemical prohibited items is disclosed. The chemicals can be identified under clothing, within boxes, or other dielectric enclosures.

Abstract: Disclosed is a portable medical device that can automatically sense the location of a vein and inject a needle to precisely pierce the vein without damaging surrounding tissue. The disclosed device does not require additional assistance for a person to use it on oneself. The disclosed device may optionally employ a basic arm cuff style, and can be used, inter alia, in hospital, military, home infusion, infusion treatment center, emergency response, school, or disaster relief settings.

Abstract: Methods of inducing or controlling particle motion in suspensions and colloids are described. In one aspect, a method of inducing particle motion in a suspension comprises contacting the suspension with a gas phase to establish at least one interface between the gas phase and continuous phase of the suspension. One or more gases of the gas phase are transferred across the interface to provide a solute gradient in the continuous phase, the solute gradient inducing motion of the suspended particles.

Abstract: Metasurfaces and systems including metasurfaces for imaging and methods of imaging are described. In one embodiment, a method for acquiring images by an imaging system comprising a metalens includes: illuminating the metalens; acquiring light passing through the metalens as a first image by an image sensor; and processing the first image into a second image that is a deconvolved version of the first image by a post-processing engine. The metalens includes a plurality of nanoposts carried by a substrate.

Abstract: Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.

Abstract: Systems and methods are provided for reducing power in in-memory computing, matrix-vector computations, and neural networks. An apparatus for in-memory computing using charge-domain circuit operation includes transistors configured as memory bit cells, transistors configured to perform in-memory computing using the memory bit cells, capacitors configured to store a result of in-memory computing from the memory bit cells, and switches, wherein, based on a setting of each of the switches, the charges on at least a portion of the plurality of capacitors are shorted together. Shorting together the plurality of capacitors yields a computation result.

Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.

Abstract: Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated.

Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.