Abstract: The present application provides a method of assaying pyruvate dehydrogenase complex (PDHC) activity in a mammalian cell that expresses human sirtuin 4 (SIRT4) comprising measuring a level of a dihydrolipoyllysine acetyltransferase (DLAT) lipoamide peptide comprising the amino acid sequence TDK[lipoyl]AT in the cell. The present application also demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.

Abstract: When one looks at a face, one cannot help but ‘read’ it: in the blink of an eye, people form reliable impressions of both transient psychological states (e.g., happiness) and stable character traits (e.g., trustworthiness). Such impressions are irresistible, formed with high levels of consensus, and important for social decisions. Disclosed herein is a large-scale data-driven methodology that allows for the easy manipulation of social trait information in hyper-realistic face images. For example, a given face image could be made to look more or less trustworthy by moving a simple slider. Further, this method can not only generate faces, but can ‘read’ faces as well, providing confidence estimates of different social traits for any arbitrary image. The disclosed approach is both fast and accurate, and represents a paradigm shift in facial photo manipulation.

Abstract: The present disclosure relates to iron-containing compounds including a 2,6-diimino(heteroaryl) ligand useful for producing substituted-cyclo-alkanes, such as vinyl cyclobutanes. The present disclosure provides new and improved iron-containing catalysts with enhanced solubility in hydrophobic (nonpolar) solvents.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms, apparatus, and improvements thereof for in-memory computing using charge-domain circuit operation to provide energy efficient, high speed, capacitor-based in-memory computing. Various embodiments contemplate controlling input signal presentation within in-memory computing structures/macros in accordance with predefined or dynamic switch selection criteria to reduce energy consumption associated with charging and/or discharging summing capacitors during reset and evaluation operating modes of multiplying bit-cells (M-BCs).

Abstract: A method for controllably making catalysts with at least one metallic surface state, that includes: a) identifying all the topological insulators in the ICSD, b) calculating the Real Space Invariants of the valence bands for all these topological insulators in order to c) identify in all these topological insulators the Wyckoff Positions where the irreducible Wannier Charge Centers (WCCs) are localized, and then d) selecting as potentially catalytic active compound a topological insulator in which the position of WCCs is not occupied by any atom; e) synthesizing a crystal of the selected potentially catalytic active compound either so that it is grown in a predefined crystallographic direction (characterized by its Miller indices (h,k,l)) which exposes the metallic surface state; or cutting the crystal in a predefined crystallographic direction (characterized by its Miller indices (h,k,l)), so that the metallic surface state is exposed when ( ( { ( h , k , l ) · ( x - X j , y -

Abstract: A method is provided for measuring different flow properties of a fluid. The method includes (a) providing a nanowire, the resistance of the nanowire varying based on temperature changes of the nanowire that reflect values of the different flow properties of the fluid when the nanowire is operated in different modes of operation respectively, such that the nanowire measures different flow properties when operated in different modes of operation respectively, and (b) alternating the nanowire between different modes of operation, measuring different flow properties of the fluid during the different modes of operation, respectively, and using the measurements of one of the flow properties to correct the measurements of another flow property. Other applications are also described.

Abstract: This disclosure provides a system and method for producing ultrasound images based on Full Waveform Inversion (FWI). The system captures acoustic/(an)elastic waves transmitted through and reflected and/or diffracted from a medium. The system performs an FWI process in a time domain in conjunction with an accurate wave propagation solver. The system produces 3D maps of physical parameters that control wave propagation, such as shear and compressional wavespeeds, mass density, attenuation, Poisson's ratio, bulk and shear moduli, impedance, and even the fourth-order elastic tensor containing up to 21 independent parameters, which are of significant diagnostic value, e.g., for medical imaging and non-destructive testing.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.

Abstract: The present disclosure relates, in general, to a fusion protein construct comprising RNase L and a split reporter system, and methods of using the reporter for detecting 2?-5? linked oligoadenylates (2-5A) and double stranded RNA in vivo.

Abstract: Methods for forming a coating over a surface are disclosed. A method includes directing a first source of barrier film material toward a substrate in a first direction at an angle ? relative to the substrate, wherein ? is greater than about 0° and less than about 85°. Additionally, a method of depositing a barrier film over a substrate includes directing a plurality of N sources of barrier film material toward a substrate, each source being directed at an angle ?N relative to the substrate, wherein for each ?N, ? is greater than about 0° and less than about 180°. For at least a first of the ?N, ?N is greater than about 0° and less than about 85°, and for at least a second of the ?N, ?N is greater than about 95° and less than about 180°.

Abstract: Disclosed is a high-throughput transcriptional assay format in Actinomycete bacteria, and Streptomyces spp. in particular, that leverages eGFP, inserted both at a neutral site and inside the biosynthetic cluster of interest, as a read-out for secondary metabolite synthesis. Using this approach, a silent gene cluster in Streptomyces albus J1074 was induced. The cytotoxins etoposide and ivermectin were revealed as potent inducers, allowing the isolation and structural characterization of nearly 20 novel small molecule products of the chosen cluster. One of these molecules is a novel antifungal, while several others inhibit a cysteine protease implicated in cancer. Studies addressing the mechanism of induction by the two elicitors led to the identification of a pathway-specific transcriptional repressor that silences the gene cluster under normal growth conditions.

Abstract: This invention relates generally to the field of quasicrystalline strictures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for pre-selected range of wavelengths propagating in multiple directions.

Abstract: The present invention an electronic inhaler for the delivery of pharmaceuticals through vaporization.

Abstract: A method and system for mass and heat exchange, where water is preferentially absorbed by a non-toxic, non-corrosive liquid desiccant after passing through a hydrophilic, non-porous membrane. Optionally, mixing stages are provided to reduce the surface concentration of water at the desiccant-membrane interface.

Abstract: In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.

Abstract: A system and method for performing novel wind forecasting that is particularly accurate for forecasting over short-term time periods, e.g., over the next 1-5 hours. Such wind forecasting is particularly advantageous in wind energy applications. The disclosed method is anchored in a robust physical model of the wind variability in the atmospheric boundary layer (ABL). The disclosed method approach leverages a physical framework based on the unsteady dynamics of earth's atmosphere, and drives forecasting as a function of previously-observed atmospheric condition data observed at the same location for which a wind forecast is desired.

Abstract: Disclosed is a virtual rating device that associate online ratings with differential time costs by endowing the graphical user interface that solicited ratings from the users with “physics,” including an initial (default) slider position and friction. When ratings are associated with differential time cost, scores correlated more strongly with objective service quality. The differential time costs optimize information when proportional to the deviation from the median score. Correlations between subjective rating scores and objective service performance can be further improved by boosting time costs for reporting extreme scores. The disclosed device lowers the sample size (and therefore costs) required for obtaining reliable, averaged crowd estimates. The disclosed device improves information quality in online rating and feedback systems. By endowing a rating widget with virtual friction to increase the time cost for reporting extreme scores, one can obtain a more reliable crowd estimates of quality.

Abstract: An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.

Abstract: According to various embodiments, a method for generating one or more optimal neural network architectures is disclosed. The method includes providing an initial seed neural network architecture and utilizing sequential phases to synthesize the neural network until a desired neural network architecture is reached. The phases include a gradient-based growth phase and a magnitude-based pruning phase.

Abstract: Operations of a method include receiving a request to enhance a new source audio. Responsive to the request, the new source audio is input into a prediction model that was previously trained. Training the prediction model includes providing a generative adversarial network including the prediction model and a discriminator. Training data is obtained including tuples of source audios and target audios, each tuple including a source audio and a corresponding target audio. During training, the prediction model generates predicted audios based on the source audios. Training further includes applying a loss function to the predicted audios and the target audios, where the loss function incorporates a combination of a spectrogram loss and an adversarial loss. The prediction model is updated to optimize that loss function. After training, based on the new source audio, the prediction model generates a new predicted audio as an enhanced version of the new source audio.