Patents Assigned to Trustees of Princeton University
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Publication number: 20250027231Abstract: Systems and methods for fibrous material manufacturing are provided. The methods include dispensing a first stream of a solution (that includes a crosslinkable material) from first nozzle(s) into a bath containing a liquid (that includes a first material). The first nozzle(s) are submerged in the liquid. The methods include dispensing a second stream from second nozzle(s) also submerged in the liquid. The second stream(s) are configured to elongate and thin the first stream(s). The second stream contain a liquid. The liquid includes a second material, which may be the same, or may be different, form the first material. The methods include forming a fibrous material by crosslinking the crosslinkable material in the first stream (e.g., using a light source to cross-link a photo-crosslinkable material in the stream).Type: ApplicationFiled: July 12, 2024Publication date: January 23, 2025Applicant: The Trustees of Princeton UniversityInventors: Zehao Pan, Janine Nunes, Howard A. Stone
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Publication number: 20250026074Abstract: Disclosed is a method to 3D print materials with defined bacterial communities into controlled, complex 3D structures, and compositions. The technique includes first providing an ink composition that includes a pre-polymer composition and a microorganism, where the pre-polymer composition includes a polymerizable monomer, a cross-linking agent, the photoinitiator, and a solvent. The technique also includes 3D printing a pattern in a hydrogel support matrix using the ink composition where the hydrogel support matrix is in a container. The technique may also include forming a 3D printed engineered living material by curing the 3D printed pattern.Type: ApplicationFiled: November 4, 2022Publication date: January 23, 2025Applicant: The Trustees of Princeton UniversityInventors: Sujit S. DATTA, Rodney PRIESTLEY, Xiaohui XU, Reed Konane BAY
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Publication number: 20250027134Abstract: Described herein is a method of screening for a nuclease with an altered nuclease activity comprising; a) forming a first compartmentalizing reaction comprising a carrier and a variant nuclease template nucleic acid comprising a coding region for a variant nuclease, and amplifying said coding region for said variant nuclease, to obtain variant nuclease encoding nucleic acid; b) forming a second compartmentalizing reaction comprising said variant nuclease encoding nucleic acid, and performing an in vitro transcription and translation reaction to obtain variant nuclease polypeptides; and c) forming a third compartmentalizing reaction comprising said variant nuclease polypeptides, and assaying said variant nuclease polypeptides for the altered nuclease activity of said nuclease.Type: ApplicationFiled: November 15, 2022Publication date: January 23, 2025Applicant: The Trustees of Princeton UniversityInventors: Cameron MYHRVOLD, Gaeun KIM, Jon ARIZTI SANZ, Ryan MCNULTY
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Publication number: 20250028049Abstract: A retroreflector tracking and sensing technique is provided. Systems may include a laser source, optical component(s), and a beam steering component disposed along an optical transmit path. The optical component(s) may be disposed between the laser source and the beam steering component (such as a mirror coupled to an actuator). The systems may include a position-sensitive detector (PSD). The beam steering component, one or more of the optical component(s), and the PSD may be disposed along an optical return path. The optical component(s) in the optical return path may be disposed between the beam steering component and the position-sensitive detector. The PSD may be operably coupled to a position tracking analyzer and an optical sensing analyzer. Electrical signals generated by the PSD may be configured to be used for retroreflector tracking and/or optical sensing.Type: ApplicationFiled: July 19, 2024Publication date: January 23, 2025Applicant: The Trustees of Princeton UniversityInventors: Michael Soskind, Felix Kleemann, Gerard Wysocki
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Publication number: 20250025527Abstract: Compositions are provided that can be used to, e.g., treat or prevent infections caused by Streptococcus suis. The compositions may include one or more threoglucins in a carrier, at a total concentration of threoglucins being at least 1 ?M. The at least one threoglucin may include one or more of threoglucins A-R. Such threoglucins may be produced by, e.g., growing a culture of Streptococcus suis in the presence of niacin, nicotinamide, and/or anabasine.Type: ApplicationFiled: July 19, 2024Publication date: January 23, 2025Applicant: The Trustees of Princeton UniversityInventors: Mohammad R. Seyedsayamdost, Brett C. Covington, Kenzie A. Clark
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Patent number: 12186436Abstract: Hydrophilic molecules such as biologics, which can include peptides, proteins, and other biologically-derived materials, can be used as therapeutic agents in medical applications. They can face administration challenges because of poor membrane permeability and rapid clearance from the blood stream. Methods for the formation of a core-shell-brush nanoparticle from an A-B-C triblock copolymer are set forth. A hydrophilic core can contain the biologic and the C Block of the copolymer. The shell can be comprised of the precipitated B Block, and the A Block can form a stabilizing brush layer. The particles can be assembled by sequential precipitations under defined mixing conditions. Presented herein are methods to tune release based on process parameters during particle assembly and triblock characteristics.Type: GrantFiled: July 19, 2019Date of Patent: January 7, 2025Assignee: The Trustees of Princeton UniversityInventors: Robert K. Prud'homme, Chester E. Markwalter, Robert F. Pagels
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Patent number: 12180149Abstract: Methods of polymer and/or oligomer depolymerization are described herein which, in some embodiments, enable facile polymer and/or oligomer decomposition under mild, non-energy intensive conditions. Briefly, a method of depolymerization comprises providing a reaction mixture comprising a transition metal catalyst, and a polymer or oligomer having a backbone including cyclobutane units, and decomposing the polymer or oligomer to provide diene monomer or alkene monomer.Type: GrantFiled: January 28, 2021Date of Patent: December 31, 2024Assignee: The Trustees of Princeton UniversityInventors: Paul J. Chirik, C. Rose Kennedy, Megan Mohadjer Beromi
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Patent number: 12180400Abstract: In one aspect, organic-inorganic nanoparticle compositions are described herein comprising engineered surfaces which, in some embodiments, reduce non-radiative recombination mechanisms, thereby providing optoelectronic devices with enhanced efficiencies. In some embodiments, a nanoparticle composition comprises a layer of organic-inorganic perovskite nanocrystals, the organic-inorganic perovskite nanocrystals comprising surfaces associated with growth passivation ligands and trap passivation ligands, wherein the growth passivation ligands are larger than the trap passivation ligands and are of size unable to incorporate into octahedral corner sites of the perovskite crystal structure.Type: GrantFiled: October 11, 2019Date of Patent: December 31, 2024Assignee: The Trustees of Princeton UniversityInventors: Barry P. Rand, Zhengguo Xiao
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Patent number: 12176068Abstract: Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels.Type: GrantFiled: March 26, 2019Date of Patent: December 24, 2024Assignees: The Trustees of Princeton University, The Simons Foundation, Inc.Inventors: Jian Zhou, Chandra Theesfeld, Olga G. Troyanskaya
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Publication number: 20240416256Abstract: A process for water, mineral, and/or organics recovery, as well as devices and systems that practice the process, are disclosed. The process may include providing a plurality of evaporator structures, each structure physically separated from the others, and contacting the first end of each evaporator structure with a liquid containing a plurality of materials (such as a solvent and one or more minerals). The process may include allowing capillary forces and siphonic action to draw at least one material of the plurality of materials (which may be, e.g., the solvent, a volatile organic material, and/or a mineral) from the first end towards the second end, and evaporating one or more of the plurality of materials by transferring at least one form of environmental energy (such as solar energy, wind energy, and/or ambient heat of air) directly to each evaporator structure, thereby providing the latent heat of vaporization.Type: ApplicationFiled: November 23, 2022Publication date: December 19, 2024Applicant: The Trustees of Princeton UniversityInventors: Sunxiang ZHENG, Xi CHEN, Zhiyong Jason REN
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Publication number: 20240419946Abstract: Disclosed is a framework called SCouT that employs a Transformer architecture to make counterfactual predictions that can be used in healthcare and other longitudinal decision-making scenarios. The disclosed approach can use longitudinal donors under an intervention to estimate the synthetic counterfactual for other units. The Transformer-based encoder-decoder model uses a causal map, which enables spatial bidirectionality, to autoregressively generate a synthetic control of a target unit.Type: ApplicationFiled: June 14, 2024Publication date: December 19, 2024Applicant: The Trustees of Princeton UniversityInventors: Bhishma Dedhia, Roshini Balasubramanian, Niraj K. Jha
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Publication number: 20240419966Abstract: Systems and methods for tackling a significant problem in data analytics: inaccurate dataset labeling. Such inaccuracies can compromise machine learning model performance. To counter this, label error detection algorithm is provided that efficiently identifies and removes samples with corrupted labels. The provided framework (CTRL) detects label errors in two steps based on the observation that models learn clean and noisy labels in different ways. First, one trains a neural network using the noisy training dataset and obtains the loss curve for each sample. Then, one applies clustering algorithms to the training losses to group samples into two categories: cleanly-labeled and noisily-labeled. After label error detection, one removes samples with noisy labels and retrains the model.Type: ApplicationFiled: June 14, 2024Publication date: December 19, 2024Applicant: The Trustees of Princeton UniversityInventors: Chang Yue, Niraj K. Jha
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Publication number: 20240408050Abstract: Compositions including dihydromyricetin (DHM) and methods for forming them through spray drying.Type: ApplicationFiled: August 22, 2024Publication date: December 12, 2024Applicants: The Trustees of Princeton University, Cheers Health, Inc.Inventors: Robert K. PRUD'HOMME, Brooks POWELL, Vikram PANSARE, Nicholas CAGGIANO, Jie FENG
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Publication number: 20240391502Abstract: Systems and methods are provided trajectory prediction that leverages game-theory to improve coverage of multi-modal predictions. Examples of the systems and methods include obtaining training data including first trajectories for a first plurality of agent devices and first map information of a first environment for a past time horizon and applying the training data to a game-theoretic mode-finding algorithm to generate a mode-finding model for each agent device that predicts modes of the first trajectories. A trajectory prediction model can be trained on the predicted modes as a coverage loss term between predicted modes. Future trajectories can be predicted for a second plurality of agent devices based on applying observed data to the trajectory prediction model. A control signal can then be generated to effectuate an autonomous driving command on an agent device of the second plurality of agent devices based on the predicted future trajectories.Type: ApplicationFiled: October 9, 2023Publication date: November 28, 2024Applicants: Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha, The Trustees of Princeton UniversityInventors: Guy Rosman, Justin Lidard, Oswin So, Yanxia Zhang, Paul M. Drews, Jonathan DeCastro, Xiongyi Cui, Yen-Ling Kuo, John J. Leonard, Avinash Balachandran, Naomi Ehrich Leonard
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Publication number: 20240392350Abstract: Disclosed is DNA valency sorting chromatography, a purification method for separating solutes based on the number of barcoded DNA molecules present on their surface, which can operate using conventional low-pressure chromatography equipment and instrumentation. Solutes can take a variety of forms, including biological macromolecules, polymeric nanoparticles, gold or silver nanospheres, gold nanorods, iron oxide nanoparticles, and semiconducting nanocrystals. In contrast to most existing purification procedures, DNA valency sorting is highly selective for the DNA sequence specifically, rather than the characteristics of the solute as a whole, and uses extremely gentle elution conditions. As a result, it is applicable to a range of solute characteristics, including variable chemical composition, surface charge, and materials with hydrodynamic diameters up to 80 nm, which cannot be purified with a well-defined number of macromolecules by any other existing technique.Type: ApplicationFiled: September 30, 2022Publication date: November 28, 2024Applicant: The Trustees of Princeton UniversityInventors: Haw YANG, Nyssa EMERSON
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Patent number: 12151978Abstract: The present invention relates to granular composite density enhancement, and related methods and compositions. The applications where these properties are valuable include but are not limited to: 1) additive manufacturing (“3D printing”) involving metallic, ceramic, cermet, polymer, plastic, or other dry or solvent-suspended powders or gels, 2) concrete materials, 3) solid propellant materials, 4) cermet materials, 5) granular armors, 6) glass-metal and glass-plastic mixtures, and 7) ceramics comprising (or manufactured using) granular composites.Type: GrantFiled: June 22, 2022Date of Patent: November 26, 2024Assignees: The Trustees of Princeton University, Heavy Metal LLCInventors: Adam Bayne Hopkins, Salvatore Torquato
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Publication number: 20240376554Abstract: A highly reliable and accurate method of assessing bacterial community viability has been developed that allows for the assessment of extremely low biomass samples, which cannot be done with traditional methods, such as qPCR. The method utilizes both PMA and droplet digital PCR (PMA-ddPCR), resulting in very accurate quantification of DNA even at very low abundances. Comparing DNA abundance in untreated samples to DNA abundance in PMA-treated samples allows the calculation of the overall viability of bacteria in any given sample. Further, PMA can be combined with traditional RNA gene sequencing (using gene-specific primers for a target species or strain) to accurately profile, e.g., the human skin microbiome, which has previously been done using traditional sequencing methods alone, but this method allows for a species-level understanding of the viable (and nonviable) components of any complex bacterial community.Type: ApplicationFiled: August 11, 2022Publication date: November 14, 2024Applicant: The Trustees of Princeton UniversityInventors: Ellen ACOSTA, Zemer GITAI
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Publication number: 20240368648Abstract: Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field.Type: ApplicationFiled: July 16, 2024Publication date: November 7, 2024Applicant: The Trustees of Princeton UniversityInventors: Jose L. Avalos, Makoto A. Lalwani, Mark P. Brynildsen
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Publication number: 20240367138Abstract: The approach disclosed herein is a process for non-equilibrium chemical and materials processing using the combination of non-equilibrium plasma, non-equilibrium multi-functional catalysis, a precisely programed heating and quenching (PHQ), and supersonic reaction quenching to dynamically change the chemical equilibrium and increase the yield and selectivity of the products. An important feature of the disclosed approach is to realize an efficient and high selectivity synthesis method of chemicals and materials by using non-chemical equilibrium, non-equilibrium catalysts, and non-equilibrium of excited states via active control of molecule excitation by low temperature hybrid plasma, dynamics of chemical reactions by programed heating and supersonic quenching, and the design of non-equilibrium catalysts by thermal shocks and plasma coupling to enable distributed and electrified chemical synthesis of hydrogen, ammonia, valued carbon and other chemical products at atmospheric conditions.Type: ApplicationFiled: March 31, 2022Publication date: November 7, 2024Applicants: The Trustees of Princeton University, University of Maryland, College ParkInventors: Yiguang JU, Liangbing HU
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Publication number: 20240360576Abstract: Disclosed is a technique for reducing CO2 to oxalate utilizing a copper-free, nickel-enhanced electrocatalyst (such as a nickel-enhanced (Cr2O3)3(Ga2O3) electrocatalyst) that can be used for producing, e.g., 1-butanol, in exceedingly high yields. Disclosed herein are various synthetic methodologies for introducing nickel into the electrocatalysts, and described is the characterization, and optimization of the Ni enhanced electrocatalysts for the reduction of CO2 to 1-butanol with a maximum faradaic efficiency ?max of 64%, at an overpotential of 900 mV (?1.48 V vs Ag/AgCl), and having an onset overpotential of 320 mV. The product selectivity is potential dependent with other C2+ products such as 3-hydroxybutanal, (?max 63%) at an overpotential of 890 mV (?1.4 V vs Ag/AgCl); acetic acid with ?max 18% at an overpotential of 390 mV (?1.0 V vs Ag/AgCl); and acetone with ?max 10% at an overpotential of 620 mV (?1.2 V).Type: ApplicationFiled: April 29, 2024Publication date: October 31, 2024Applicant: The Trustees of Princeton UniversityInventors: Andrew B. Bocarsly, Steven Cronin, Stephanie Dulovic, Kai Filsinger, Josef Lawrence