Patents Assigned to Trustees of Tufts College
  • Patent number: 11219392
    Abstract: A method for determining a hemoglobin saturation of a volume-oscillating vascular compartment in tissue includes receiving data representing measurements of a number of oscillating hemoglobin concentrations from the tissue and determining the hemoglobin saturation of the volume-oscillating vascular compartment to exclude an effect of an oscillating rate of supply of oxygenated blood to a portion of the tissue including removing a first contribution on one or more of the oscillating hemoglobin concentration measurements from at least one of the measurements, the first contribution being phase offset relative to said measurements.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: January 11, 2022
    Assignee: Trustees of Tufts College
    Inventors: Jana M. Kainerstorfer, Sergio Fantini, Angelo Sassaroli
  • Publication number: 20220003798
    Abstract: A method comprises using an atomic-force microscope, acquiring a set of images associated with surfaces, and, using a machine-learning algorithm applied to the images, classifying the surfaces. As a particular example, the classification can be done in a way that relies on surface parameters derived from the images rather than using the images directly.
    Type: Application
    Filed: November 7, 2019
    Publication date: January 6, 2022
    Applicant: Trustees of Tufts College
    Inventors: Igor Sokolov, Milos Miljkovic
  • Patent number: 11198103
    Abstract: A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a thickness of 5 nm to 10 ?m, is formed of an amphiphilic copolymer that contains both charged groups and hydrophobic groups. The support layer has a pore size of 3 nm to 10 ?m, which is larger than the pore size of the polymer layer. Also disclosed is a process of filtering a liquid using the two-layer membrane described above.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: December 14, 2021
    Assignee: Trustees of Tufts College
    Inventors: Ayse Asatekin Alexiou, Ilin Sadeghi
  • Patent number: 11197906
    Abstract: The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: December 14, 2021
    Assignees: On Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical Center
    Inventors: Charles Cohen, Krishna Kumar, Alan S. Kopin, Benjamin N. Harwood, Venkata S. Raman, Pedram Hamrah
  • Patent number: 11188616
    Abstract: An illustrative embodiment includes a method for solving a dynamical system. The method comprises: obtaining multidimensional snapshots representing respective discrete solutions of the dynamical system; storing the multidimensional snapshots within a snapshot tensor having an order of at least three; generating a basis for at least a subspace of a state space of the dynamical system at least in part by performing a decomposition of the snapshot tensor; deriving a reduced order model at least in part by using the basis to project the dynamical system from the state space onto the subspace; and solving the reduced order model of the dynamical system.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: November 30, 2021
    Assignees: International Business Machines Corporation, Trustees of Tufts College, Ramot at Tel Aviv University Ltd.
    Inventors: Lior Horesh, Misha Elena Kilmer, Haim Avron, Jiani Zhang
  • Publication number: 20210363275
    Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents.
    Type: Application
    Filed: July 9, 2021
    Publication date: November 25, 2021
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: CHARLES B. SHOEMAKER, HANPING FENG
  • Patent number: 11174255
    Abstract: Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds having the structures below (I) are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 16, 2021
    Assignees: UNIVERSITY OF HOUSTON SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Gregory Cuny, Sameer Nikhar, Alexei Degterev
  • Patent number: 11161958
    Abstract: Disclosed is a macroporous polymeric hydrogel microsphere that contains polyacrylamide and chitosan. The hydrogel microsphere, having a diameter of 50-250 ?m and an average pore size of 1-60 nm, is capable of transporting biomolecules conjugated to it. Also disclosed is a method of fabricating the microsphere based on a micromolding technique utilizing surface tension-induced droplet formation followed by photo-induced polymerization.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: November 2, 2021
    Assignee: Trustees of Tufts College
    Inventors: Hyunmin Yi, Sukwon Jung, John H. Abel
  • Patent number: 11158091
    Abstract: The present disclosure includes systems and methods for color transfer. The method includes receiving a target image, and determining dominant source colors. The method further includes transforming the target image into a color model including a target luminance component and a target color information component. Additionally, the method includes segmenting the target image into a plurality of target segments based on the target color information component or the target luminance component and extracting dominant target colors from the target image by extracting information for at least one of the dominant target colors from each target segment of the plurality of target segments. Further, the method includes generating a color mapping relationship between the dominant target colors and the dominant source colors, and creating a recolored target image using the color mapping relationship.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 26, 2021
    Assignees: Trustees of Tufts College, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Karen Panetta, Long Bao, Sos Agaian
  • Patent number: 11135209
    Abstract: Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 5, 2021
    Assignees: University of Houston System, Trustees of Tufts College
    Inventors: Gregory Cuny, Chalada Suebsuwong, Alexei Degterev
  • Patent number: 11129921
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: September 28, 2021
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Patent number: 11122995
    Abstract: Disclosed herein are various patient measurement devices having an extendable elongate body and a deployable arm rotatably coupled to the elongate body. The elongate body has a first body comprising a lumen defined along a length of the first body and a second body extendably disposed within the lumen of the first body. The deployable arm is rotatably coupled to an end of the second body and is rotatably movable between a retracted position and a deployed position. Also disclosed are various methods of using the device to take various range-of-motion measurements, other physical capability measurements, and anthropometric measurements.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: September 21, 2021
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventor: Brandon Ness
  • Patent number: 11121334
    Abstract: A field effect transistor having a channel that comprises three-dimensional graphene foam. The subject matter of the invention concerns a three dimensional field-effect transistor having a channel based on graphene foam and the use of ionic liquid as a gate. The graphene foam is made of a three-dimensional network of single and double layer graphene that extends in all the three dimensions. Metal contacts on either end of the graphene foam form the drain and source contacts of the transistor.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: September 14, 2021
    Assignee: Trustees of Tufts College
    Inventors: Sameer Sonkusale, Shideh Kabiri Ameri Abootorabi, Pramod Kumar Singh
  • Patent number: 11110148
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: September 7, 2021
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20210268500
    Abstract: Articles and methods involving fluidic devices are generally provided. In some embodiments, a fluidic device comprises a first layer comprising first and second regions that are disconnected from each other in the first layer and a second layer comprising a channel in fluidic communication with the first and second regions. The device may also comprise a third layer comprising a channel in fluidic communication with the first and second regions. One or more portions of a channel and/or one or more reagents may comprise reagent. In some embodiments, a method comprises flowing two or more fluid samples towards each other through a channel. The fluids may meet at an interface and/or may react at an interface.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 2, 2021
    Applicant: Trustees of Tufts College
    Inventors: Daniel J. Wilson, Charles R. Mace
  • Patent number: 11103686
    Abstract: Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: August 31, 2021
    Assignee: Trustees of Tufts College
    Inventors: Hojatollah Rezaei Nejad, Aydin Sadeqi, Sameer Sonkusale
  • Publication number: 20210263027
    Abstract: Articles and methods involving fluidic devices are generally provided. In some embodiments, a fluidic device comprises a first layer comprising a central region in fluidic communication with an environment external to the fluidic device. The first layer may also comprise a first channel and a second channel in fluidic communication with the central region and extending radially outwards therefrom. The first and second channels may comprises first and second sample regions from which first and second samples can be removed from the fluidic device. In some embodiments, a fluidic device comprises a first layer and a second, filtration layer configured to separate blood cells from plasma positioned between the environment external to the fluidic device and the first layer.
    Type: Application
    Filed: June 19, 2019
    Publication date: August 26, 2021
    Applicant: Trustees of Tufts College
    Inventors: Charles R. Mace, Jessica C. Brooks, Syrena C. Fernandes, Keith Baillargeon
  • Patent number: 11099210
    Abstract: A method of carrying out sub-resonant tapping in an atomic force microscope includes causing a probe that is disposed above a sample to be translated in a direction parallel to a horizontal plane defined by the sample and to oscillate in a vertical direction that is perpendicular to the horizontal plane about an equilibrium line that is separated from the horizontal plane by a vertical offset. As a result, the probe repeatedly taps a surface of the sample. Each tap begins with a first contact of the probe on the surface followed by a progressive increase in force exerted by the sample on the probe until a peak force is attained. The vertical offset is controlled by relying at least in part on a feature other than the peak force as a basis for controlling the vertical offset.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 24, 2021
    Assignee: Trustees of Tufts College
    Inventors: Piers Echols-Jones, William C. Messner, Igor Sokolov
  • Patent number: 11096924
    Abstract: Disclosed are combination therapies including administration of I-DASH inhibitors and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: August 24, 2021
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, Wengen Wu
  • Patent number: 11091563
    Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 17, 2021
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: Charles B. Shoemaker, Hanping Feng