Patents Assigned to Trustees of Tufts College
  • Publication number: 20190293655
    Abstract: Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.
    Type: Application
    Filed: February 27, 2019
    Publication date: September 26, 2019
    Applicant: Trustees of Tufts College
    Inventors: David R. Walt, David M. Rissin
  • Publication number: 20190292688
    Abstract: This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a biopolymer silk fibroin as a base material, patterns an intermediate hydrogel were generated within a deformable mold. Subsequently, mechanical tension was introduced via either hydrogel contraction or mold deformation, and finally a material is reentrapped in this transformed shape via beta-sheet crystallization and critical point drying. Topdown engineered anchorages, cables, and shapes act in concert to mediate precision changes in nanofiber alignment/orientation and a macroscale form of provided nanofibrillar structure. An ability of this technique to engineer large gradients of nano- and micro-scale order, manipulate mechanical properties (such as plasticity and thermal transport), and the in-situ generation of 2D and 3D, multi-tiered and doped, nanofibrillar constructs was demonstrated.
    Type: Application
    Filed: August 1, 2017
    Publication date: September 26, 2019
    Applicant: Trustees of Tufts College
    Inventors: Fiorenzo G. OMENETTO, Peter TSENG
  • Patent number: 10381719
    Abstract: A spiral antenna device includes a plurality of generally polygonal loops. The polygonal loops have respective side counts that decrease progressively as a function of the loop's radial distance from a center of the antenna device. The side count may vary between loops as a multiple of a power of two.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: August 13, 2019
    Assignee: Trustees of Tufts College
    Inventors: Nahid Rahman, Mohammed N. Afsar
  • Patent number: 10351617
    Abstract: Methods, compositions and kits for regulating complement activity or treating a complement activity disorder in a subject using soluble, membrane-independent CD59 protein, methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 16, 2019
    Assignee: Trustees of Tufts College
    Inventors: Rajendra Kumar-Singh, Soibhan M. Cashman, Kasmir Ramo
  • Patent number: 10335519
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: July 2, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Patent number: 10314938
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: June 11, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Patent number: 10285702
    Abstract: A bioresorbable drug-eluting biopolymer suture-free blood vessel anastomosis devices can be deployed to join two blood vessels and resorbed by the body over a predetermined time period after the blood vessel has become joined. The anastomosis device can include a hollow tube that is inserted interconnect the two vessels to be jointed. A non-piercing suture is wrapped around the vessel to secure the anastomosis. The anastomosis device can include hollow tube that extends along an axis from a first end to a second end. The ends can be fitted with elements that facilitate mechanical attachment of the vessel to the anastomosis device and provide for a secure seal.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: May 14, 2019
    Assignees: Trustees of Tufts College, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Rodrigo R. Jose, Waseem K. Raja, David L. Kaplan, Ahmed Ibrahim, Samuel Lin, Abdurrahman Abdurrob
  • Patent number: 10261089
    Abstract: Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: April 16, 2019
    Assignee: Trustees of Tufts College
    Inventors: David R. Walt, David M. Rissin
  • Publication number: 20190099459
    Abstract: Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus Vibrio, for example, cholera caused by V. cholerae, the compositions containing two or more strains of lytic bacteriophage that infect and kill Vibrio cells. The bacteriophage are virulent, which replicate intracellularly and lyse and kill the bacteria. Use of two or more strains in a single treatment, as a result of a rate of mutation of the bacteria to simultaneous resistance to all of the bacteriophage to be so low as to be negligible, reduces appearance of phage-resistant bacteria to statistical negligibility. Normal human microbial flora species were not affected. In alternative embodiments of the method and the composition, antibiotic agents or other treatment agents can be administered with a cocktail of the plurality of bacteriophage strains.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 4, 2019
    Applicant: Trustees of Tufts College
    Inventors: Andrew Camilli, Lynne Cairns, Minmin Yen
  • Patent number: 10241026
    Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: March 26, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David R. Walt, Karri Lynn Michael-Ballard
  • Publication number: 20190083462
    Abstract: This disclosure relates to methods and compositions for addressing conditions of dysbiosis and/or inflammation, such as enteropathy, associated with administration of non-steroidal anti-inflammatory drug (NSAID). The disclosure includes methods comprising administering an effective amount of a tryptophan derived microbiota metabolite (TDMM) to a subject that has also been administered, or is expected to have administered, a NSAID.
    Type: Application
    Filed: March 17, 2017
    Publication date: March 21, 2019
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee, Canaan Whitfield, Noah Cohen
  • Patent number: 10233219
    Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 19, 2019
    Assignees: Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLC
    Inventors: Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
  • Publication number: 20190032014
    Abstract: Disclosed are compositions derived from the commensal microbiota and related methods for inducing and differentiating naive T cells. In some embodiments, the compositions and methods can be selectively used to generate stable regulatory T-cells (Tregs or iTregs) or stabilize such Tregs to prevent inflammatory responses and instead promote antigen tolerance. Alternatively, in other aspects, select compositions can be used to promote pro-inflammatory T cell development, such as through the induced development and stabilization of Th1 and Th7 cells.
    Type: Application
    Filed: March 17, 2017
    Publication date: January 31, 2019
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee
  • Publication number: 20190000885
    Abstract: Aspects of the technology disclosed herein generally (and in part) relates to use of Angiogenin (ANG) for increasing hematopoietic reconstitution of in vivo hematopoietic cells and transplanted hematopoietic cells. Provided herein are methods and compositions useful in treatment of diseases characterized by decreased levels of hematopoietic cells, decreased levels of hematopoietic reconstitution, blood cell deficiency and prevention and treatment of radiation injury. One aspect relates to angiogenin treated hematopoietic cell compositions and methods of their use in stem cell transplantation. Treatment of hematopoietic cells with angiogenin enhances quiescence and reduces proliferative capacity of primitive hematopoietic stem cells while increasing proliferation of myeloid restricted progenitor cells. Another aspect relates to use of ANG in prophylactic and therapeutic treatment methods for radiation injury.
    Type: Application
    Filed: November 29, 2016
    Publication date: January 3, 2019
    Applicants: THE GENERAL HOSPITAL CORPORATION, TUFTS MEDICAL CENTER, INC., TRUSTEES OF TUFTS COLLEGE, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: David SCADDEN, Peter KHARCHENKO, Lev SILBERSTEIN, Guo-fu HU, Kevin GONCALVES
  • Patent number: 10130661
    Abstract: The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: November 20, 2018
    Assignees: President and Fellows of Harvard College, Beth Israel Deaconess Medical Center, Inc., Trustees of Tufts College
    Inventors: Aristidis Veves, David J. Mooney, Jonathan Garlick
  • Patent number: 10124091
    Abstract: Disclosed are compositions including a film enriched with a radioisotope relative to its natural abundance, wherein the film has a thickness of one to ten atomic or molecular layers, decay of the radioisotope comprises emission of electrons, and a majority of the emitted electrons have an energy less than or equal to 700 electron volts (ev). Also disclosed are methods for making the compositions. The compositions can be used in microarrays, nanoarrays, microparticles, nanoparticles, power sources, sensing devices, and medical devices; they may also be used in a method of delivering low-energy electrons to a liquid, solid, molecular layer, or cell.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: November 13, 2018
    Assignee: Trustees of Tufts College
    Inventors: Charles Sykes, Alex Pronschinske, Colin Murphy
  • Patent number: 10115847
    Abstract: A method of preparing a cupric oxide semiconductor. The method includes providing a substrate having a first surface, forming a cuprous oxide layer on the first surface, converting the cuprous oxide layer into a cupric oxide layer via an oxidation reaction, and depositing additional cupric oxide on the cupric oxide layer, which serves as a seed layer, to yield a cupric oxide film, thereby obtaining a cupric oxide semiconductor. Also disclosed are a cupric oxide semiconductor thus prepared and a photovoltaic device including it.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 30, 2018
    Assignee: Trustees of Tufts College
    Inventors: Changqiong Zhu, Matthew Panzer
  • Patent number: 10106588
    Abstract: The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides of the present disclosure include peptides comprising SEQ ID NOs: 1-4 which promote angiogenesis and cell proliferation. Further, the anti-angiogenic compounds of the present disclosure include antisense oligonucleotides that hybridize or are complementary to the polynucleotides of SEQ ID NOs: 5-16, and the like.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: October 23, 2018
    Assignee: Trustees of Tufts College
    Inventor: Ira M. Herman
  • Patent number: 10107804
    Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: October 23, 2018
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David R. Walt, Karri Lynn Michael-Ballard
  • Publication number: 20180258389
    Abstract: In some embodiments, the present invention provides methods including the steps of providing one or more human somatic cells, causing transient increased expression of OCT4, KLF4, SOX2, and cMYC in the somatic cells forming modified somatic cells, providing a plurality of inactivated embryonic fibroblasts, associating the modified somatic cells with the inactivated embryonic fibroblasts in a culture media comprising 20% KO DMEM xeno-free serum replacement and at least 15 ng/ml recombinant bFGF to form human induced neural stem cells.
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Applicant: Trustees of Tufts College
    Inventors: Dana Cairns, David L. Kaplan