Patents Assigned to Trustees of Tufts College
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Patent number: 11547358Abstract: An oxygen sensor for sensing dissolved oxygen concentration in tissue includes an electrochemical sensor comprising first and second conductive threads having proximal sections connected to a potentiostat. The first thread forms a cathode, and the second thread forms an anode.Type: GrantFiled: December 8, 2021Date of Patent: January 10, 2023Assignees: Trustees of Tufts College, DTAMedicalInventors: Sameer Sonkusale, Junfei Xia, Francois Dufay
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Publication number: 20220408702Abstract: The invention relates, in part, to methods to introduce gene alleles of interest into members of a population of a species. The invention also relates to methods to prepare large numbers of organisms comprising one or more introduced alleles of interest in an otherwise wild-type genome.Type: ApplicationFiled: November 20, 2020Publication date: December 29, 2022Applicants: Massachusetts Institute of Technology, Trustees of Tufts CollegeInventors: Kevin Michael Esvelt, Sam Rountree Telford, III
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Patent number: 11536797Abstract: A method localizes a first agent in a network including a number of agents, the number of agents including a number of mobile agents and one or more beacons located at known locations. The method includes performing a procedure including, receiving transmissions from a number of neighboring agents, processing the transmissions to determine information related to a relative location of the first agent and each neighboring agent of the number of neighboring agents, determining, based on the information related to the relative location of the first agent and each neighboring agent, that the first agent is within one or more proximity regions, and updating an estimated location of the first agent based on the information related to a relative location of the first agent and each neighboring agent.Type: GrantFiled: November 6, 2017Date of Patent: December 27, 2022Assignee: Trustees of Tufts CollegeInventors: Sam Safavi, Usman A. Khan
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Patent number: 11531902Abstract: Techniques for generating and managing, including simulating and training, deep tensor neural networks are presented. A deep tensor neural network comprises a graph of nodes connected via weighted edges. A network management component (NMC) extracts features from tensor-formatted input data based on tensor-formatted parameters. NMC evolves tensor-formatted input data based on a defined tensor-tensor layer evolution rule, the network generating output data based on evolution of the tensor-formatted input data. The network is activated by non-linear activation functions, wherein the weighted edges and non-linear activation functions operate, based on tensor-tensor functions, to evolve tensor-formatted input data. NMC trains the network based on tensor-formatted training data, comparing output training data output from the network to simulated output data, based on a defined loss function, to determine an update.Type: GrantFiled: November 13, 2018Date of Patent: December 20, 2022Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, TRUSTEES OF TUFTS COLLEGE, RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Lior Horesh, Elizabeth Newman, Misha E. Kilmer, Haim Avron
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Patent number: 11504303Abstract: A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.Type: GrantFiled: December 21, 2021Date of Patent: November 22, 2022Assignees: TRUSTEES OF TUFTS COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Pamela C. Yelick, Ali Khademhosseini
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Patent number: 11506683Abstract: A method comprises using an atomic-force microscope, acquiring a set of images associated with surfaces, and, using a machine-learning algorithm applied to the images, classifying the surfaces. As a particular example, the classification can be done in a way that relies on surface parameters derived from the images rather than using the images directly.Type: GrantFiled: November 7, 2019Date of Patent: November 22, 2022Assignee: Trustees of Tufts CollegeInventors: Igor Sokolov, Milos Miljkovic
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Patent number: 11484262Abstract: A composite thread includes first and second segments joined to each other. The first segment comprises a functional segment that interacts with an environment of the thread. The second segment communicates information between the first segment and a point external to said composite thread.Type: GrantFiled: July 29, 2016Date of Patent: November 1, 2022Assignee: Trustees of Tufts CollegeInventors: Sameer Sonkusale, Pooria Mostafalu
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Patent number: 11484846Abstract: A graft copolymer including zwitterionic repeat units and hydrophobic repeat units, in which the zwitterionic repeat units constitute 2-60 wt % of the graft copolymer and each of the hydrophobic repeat units is characterized in that a homopolymer formed thereof is miscible with polyvinylidene fluoride, polysulfone, poly ether sulfone, polyvinyl chloride, or polyacrylonitrile, each of the hydrophobic repeat units not being a repeat unit of polyvinylidene fluoride. Also disclosed is a filtration membrane containing such a graft copolymer or a statistical copolymer that includes the same composition of repeat units as the graft copolymer. Further disclosed are methods of preparing the graft copolymer and the filtration membrane.Type: GrantFiled: January 6, 2020Date of Patent: November 1, 2022Assignee: Trustees of Tufts CollegeInventors: Ayse Asatekin Alexiou, Papatya Kaner, Chiara Vannucci
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Patent number: 11447753Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.Type: GrantFiled: May 6, 2020Date of Patent: September 20, 2022Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
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Publication number: 20220280630Abstract: Described herein are vaccine compositions and methods of selecting an antigen or fragment thereof for the preparation of a vaccine composition. The methods and vaccine compositions described herein are based, in part, on the discovery that certain polypeptides not previously identified or considered for potential use as antigens from pathogenic microorganisms (e.g., N. gonorrhoeae) can provoke an immune response in a subject. The methods of identifying and selecting the antigens described herein rely, in part, on approaches that identify polypeptides (e.g., hypothetical proteins) predicted to be immunogenic.Type: ApplicationFiled: July 30, 2020Publication date: September 8, 2022Applicant: Trustees of Tufts CollegeInventors: Paola MASSARI, Caroline GENCO
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Patent number: 11426129Abstract: A method for inferring characteristics of a physiological system includes measuring one or more physiological signals in the physiological system and inferring characteristics of the physiological system from the one or more measured physiological signals using a multiple vascular compartment hemodynamic model, the multiple vascular compartment hemodynamic model defining a relationship between the one or more measured physiological signals and the characteristics of the physiological system. When the one or more measured physiological signals include coherent oscillations at a plurality of frequencies, the method is termed coherent hemodynamics spectroscopy. The multiple vascular compartment hemodynamic model is based on an average time spent by blood in one or more of said vascular compartments and a rate constant of oxygen diffusion.Type: GrantFiled: October 21, 2013Date of Patent: August 30, 2022Assignee: Trustees of Tufts CollegeInventor: Sergio Fantini
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Patent number: 11419901Abstract: A heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768 is used as an immunomodulator. The immunomodulator may be used in combination with an antigen of interest to potentiate or restrain a host immune response toward the selected antigen.Type: GrantFiled: January 23, 2019Date of Patent: August 23, 2022Assignee: Trustees of Tufts CollegeInventors: Caroline Attaro Genco, George Papadopoulos
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Patent number: 11421061Abstract: Disclosed is a statistical copolymer that includes both zwitterionic repeat units and hydrophobic repeat units, and a filtration membrane that contains a selective layer formed of the statistical copolymer. Also disclosed are methods of preparing the above-described filtration membrane.Type: GrantFiled: March 16, 2020Date of Patent: August 23, 2022Assignee: Trustees of Tufts CollegeInventors: Ayse Asatekin Alexiou, Prity Bengani-Lutz
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Publication number: 20220227882Abstract: Provided herein are proteins that inhibit both the metalloprotease activity and disintegrin activity of human wherein the protein comprises an antigen-binding domain that: (i) binds specifically to human ADAM8; and (ii) binds to an epitope within human ADAM8 that includes at least one amino acid within the sequence of SEQ ID NO: 1, nucleic acids, vectors, compositions, and methods of use thereof (e.g., methods of treatment and methods of diagnosing).Type: ApplicationFiled: May 29, 2020Publication date: July 21, 2022Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Gail Sonenshein, Nora Mineva
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Patent number: 11386507Abstract: A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.Type: GrantFiled: September 23, 2019Date of Patent: July 12, 2022Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Trustees of Tufts College, RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Lior Horesh, Osman Asif Malik, Shashanka Ubaru, Misha E. Kilmer, Haim Avron
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Patent number: 11376329Abstract: The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition.Type: GrantFiled: March 11, 2016Date of Patent: July 5, 2022Assignee: Trustees of Tufts CollegeInventors: Jonathan A. Kluge, Fiorenzo G. Omenetto, David L. Kaplan
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Patent number: 11339378Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.Type: GrantFiled: May 6, 2020Date of Patent: May 24, 2022Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts CollegeInventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
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Patent number: 11298443Abstract: The present invention provides, in some embodiments, multi-layer silk compositions including a first layer comprising silk fibroin and keratinocytes, a second layer comprising silk fibroin and fibroblasts, a third layer comprising silk fibroin and adipocytes, and a plurality of nervous system cells, wherein at least some of the plurality of nervous system cells span at least two layers, and methods of making and using the same. In some embodiments, provided methods and compositions further include immune cells and/or endothelial cells.Type: GrantFiled: June 30, 2017Date of Patent: April 12, 2022Assignee: Trustees of Tufts CollegeInventors: David L. Kaplan, Sarah Lightfoot Vidal, Rosalyn Abbott, Siwei Zhao, Dana Cairns, Fiorenzo G. Omenetto
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Patent number: 11298678Abstract: A polymeric hydrogel microparticle that contains polyacrylamide and chitosan, the chitosan uniformly incorporated in a polyacrylamide matrix. The microparticle, having a coefficient variation of 0 to 2% and containing macropores with an average size of 1 to 60 nm, is capable of transporting biomolecules conjugated to it. Also disclosed are a method of fabricating such a microparticle in a micromold via photo-induced radical polymerization and a one-pot method of conjugating biomolecules to polymeric hydrogel microparticles.Type: GrantFiled: March 22, 2017Date of Patent: April 12, 2022Assignee: Trustees of Tufts CollegeInventors: Hyunmin Yi, Eunae Kang, Sukwon Jung, John H. Abel
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Publication number: 20220099678Abstract: Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.Type: ApplicationFiled: October 8, 2021Publication date: March 31, 2022Applicant: Trustees of Tufts CollegeInventors: David R. Walt, David M. Rissin