Patents Assigned to Tuskegee University
-
Patent number: 8936663Abstract: A chemical extractant selected from solutions of K2SO4 and/or Na2SO4 can be used by contacting with untreated broiler litter to selectively and efficiently remove phosphorous from the broiler litter. The broiler litter and extractant solution mixture, after a suitable time, can be separated, such as by filtration. The resulting treated broiler litter is thus significantly lower in P content without being lower by an undesirable amount in more preferred minerals. The treated litter so obtained is suitable for crop soil augmentation. Further, phosphorous can be thereafter precipitated in the form of phytic acid. Since the precipitate is high in mineral content, it can be used for other purposes (e.g., plant food, etc.).Type: GrantFiled: November 22, 2011Date of Patent: January 20, 2015Assignee: Tuskegee UniversityInventor: Kokoasse Kpomblekou-Ademawou
-
Publication number: 20140342366Abstract: The invention relates to a method of determining whether a live microbe, such as bacteria, is present in a test sample.Type: ApplicationFiled: May 15, 2014Publication date: November 20, 2014Applicant: Tuskegee UniversityInventors: Teshome Yehualaeshet, Temesgen Samuel, Woubit Abdela, Tsegaye Habtemariam
-
Patent number: 8883488Abstract: Disclosed are novel primers for use in the molecular detection of food-threat agents and food-borne pathogens. The primers may be used in combination for the rapid, high-throughput screening PCR-based techniques to simultaneously detect multiple food safety biothreat agents. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple high-impact food-borne pathogens simultaneously. Real-time PCR assaying techniques using such primers include microarrays and multiplex single-tube arrays, the latter optionally simultaneously with TaqMan probes.Type: GrantFiled: November 15, 2011Date of Patent: November 11, 2014Assignee: Tuskegee UniversityInventors: Woubit Salah Abdela, Temesgen Samuel-Tulore, Teshome Yehualaeshet
-
Publication number: 20140302515Abstract: Kaiso, a transcriptional regulator with bimodal DNA-binding specificity, is over-expressed in breast cancer cells, and its nuclear localization is correlated with malignant and lymph node metastasis. Depleted expression of Kaiso in those cells results in a significant decrease in basal and EGF-induced cell migration, and this is associated with increased E-cadherin expression. The data reported and described herein provide significant evidence that Kaiso is involved in breast cancer invasion and metastasis. Kaiso nuclear localization is a biomarker that is associated with invasive and metastatic infiltrating ductal breast cancer that may be used to monitor, detect, and/or track the progress of disease in a patient.Type: ApplicationFiled: August 9, 2012Publication date: October 9, 2014Applicant: TUSKEGEE UNIVERSITYInventors: Clayton Yates, Timothy Turner, Jacqueline Jones-Triche
-
Publication number: 20140286868Abstract: Immortalized human cell lines derived from prostate cells are disclosed. Immortalized cells derived from a human epithelial prostate tissue cancer tumor are provided, as well as immortalized cells derived from healthy human epithelial prostate tissue from the same patient. Methods for utilizing such immortalized cell lines for researching, screening, and evaluating antimalignancy therapies and drug candidates are also disclosed.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Applicant: TUSKEGEE UNIVERSITYInventors: Clayton Yates, Timothy Turner
-
Publication number: 20140166766Abstract: A multi-pass gas metal arc weld (“GMAW”) approach is used for in-situ repair of railhead defects. A defect is removed via machining a perpendicular slot or grove in the railhead leaving the web and base unaltered. A sufficient number of GMAW passes are used to fill the slot using a weld material suitable for the particular type of parent steel, and excess weldment can be removed. Optionally, for pearlitic steel rails post-weld heat treatment can be used to cause austenization and/or quenching of the weld. The weld heat inputs and other parameters are controlled to avoid ductile and brittle fracture related morphologies.Type: ApplicationFiled: December 17, 2012Publication date: June 19, 2014Applicant: TUSKEGEE UNIVERSITYInventor: Heshmat AGLAN
-
Publication number: 20140147533Abstract: Embodiments of the present invention relate to the use of tannin-containing wood products in animal feed to improve production efficiency and health of ruminants (e.g., sheep, goats, and cattle) by reducing internal parasite load, reducing methane and ammonia production in the rumen, and decreasing phosphor emissions from fecal waste. Embodiments include a domesticated ruminant feed comprising a condensed tannin. Certain embodiments relate to methods comprising administering condensed tannins to ruminant animals by incorporating pine bark or other suitable condensed tannin-containing wood products into regular animal feed.Type: ApplicationFiled: November 27, 2012Publication date: May 29, 2014Applicant: TUSKEGEE UNIVERSITYInventors: Sandra SOLAIMAN, Byeng Ryel MIN
-
Patent number: 8734775Abstract: Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of newly-formed vessels and resolving of wounds in the later stages of wound healing. Preferred peptides are derived from the ?-helix portion IP-10 (CXCL10) or from IP-9 (CXCL11), are nontoxic, and smaller than naturally occurring peptides, making them useful in therapies against diseases or disease states marked by unwanted angiogenesis, including tumorogenic diseases such as cancers, and in healing of chronic wounds.Type: GrantFiled: August 26, 2011Date of Patent: May 27, 2014Assignees: University of Pittsburgh, Tuskegee UniversityInventors: Cecelia C. Yates-Binder, Jesse Jaynes, Timothy Turner, Alan Wells, Richard J. Bodnar
-
Publication number: 20130219531Abstract: Immortalized human cell lines derived from prostate cells are disclosed. Immortalized cells derived from a human epithelial prostate tissue cancer tumor are provided, as well as immortalized cells derived from healthy human epithelial prostate tissue from the same patient. Methods for utilizing such immortalized cell lines for researching, screening, and evaluating antimalignancy therapies and drug candidates are also disclosed.Type: ApplicationFiled: August 20, 2012Publication date: August 22, 2013Applicant: TUSKEGEE UNIVERSITYInventors: Clayton YATES, Timothy TURNER
-
Patent number: 8461118Abstract: Lytic peptides, including fusion peptides of lytic peptides conjugated with luteinizing hormone-releasing hormone or modified versions thereof to target luteinizing hormone-releasing hormone receptors, are disclosed. The lytic peptides show anti-proliferative activity against human prostate cancer cell lines, but are nontoxic to normal primary human prostate epithelial cells or to bone marrow stromal cells in co-culture. The lytic peptides have specificity for and anti-proliferative activity against prostate cancer tumor cells, and low toxicity for normal prostate cells, making the peptides useful in therapies for prostate cancer.Type: GrantFiled: July 7, 2011Date of Patent: June 11, 2013Assignee: Tuskegee UniversityInventors: Clayton Yates, Jesse Jaynes, Timothy Turner
-
Publication number: 20130131266Abstract: Structured films containing multi-walled carbon nanotubes (“MWCNTs”) have enhanced mechanical performance in terms of strength, fracture resistance, and creep recovery of polyimide (“PI”) films. Preferably, the loadings of MWCNTs can be in the range of 0.1 wt % to 0.5 wt %. The strength of the new PI films dried at 60° C. increased by 55% and 72% for 0.1 wt % MWCNT and 0.5 wt % MWCNT loadings, respectively, while the fracture resistance increased by 23% for the 0.1 wt % MWCNTs and then decreases at a loading of 0.5 wt % MWCNTs. The films can be advantageously be created by managing a corresponding shift in the annealing temperature at which the maximum strength occurs as the MWCNT loadings increase.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicant: TUSKEGEE UNIVERSITYInventor: TUSKEGEE UNIVERSITY
-
Publication number: 20130125599Abstract: A chemical extractant selected from solutions of K2SO4 and/or Na2SO4 can be used by contacting with untreated broiler litter to selectively and efficiently remove phosphorous from the broiler litter. The broiler litter and extractant solution mixture, after a suitable time, can be separated, such as by filtration. The resulting treated broiler litter is thus significantly lower in P content without being lower by an undesirable amount in more preferred minerals. The treated litter so obtained is suitable for crop soil augmentation. Further, phosphorous can be thereafter precipitated in the form of phytic acid. Since the precipitate is high in mineral content, it can be used for other purposes (e.g., plant food, etc.).Type: ApplicationFiled: November 22, 2011Publication date: May 23, 2013Applicant: TUSKEGEE UNIVERSITYInventor: Kokoasse Kpomblekou-Ademawou
-
Publication number: 20130123119Abstract: Disclosed are novel primers for use in the molecular detection of food-threat agents and food-borne pathogens. The primers may be used in combination for the rapid, high-throughput screening PCR-based techniques to simultaneously detect multiple food safety biothreat agents. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple high-impact food-borne pathogens simultaneously. Real-time PCR assaying techniques using such primers include microarrays and multiplex single-tube arrays, the latter optionally simultaneously with TaqMan probes.Type: ApplicationFiled: November 15, 2011Publication date: May 16, 2013Applicant: TUSKEGEE UNIVERSITYInventors: Woubit Salah ABDELA, Temesgen SAMUEL-TULORE, Teshome YEHUALAESHET
-
Publication number: 20130012437Abstract: Lytic peptides, including fusion peptides of lytic peptides conjugated with luteinizing hormone-releasing hormone or modified versions thereof to target luteinizing hormone-releasing hormone receptors, are disclosed. The lytic peptides show anti-proliferative activity against human prostate cancer cell lines, but are nontoxic to normal primary human prostate epithelial cells or to bone marrow stromal cells in co-culture. The lytic peptides have specificity for and anti-proliferative activity against prostate cancer tumor cells, and low toxicity for normal prostate cells, making the peptides useful in therapies for prostate cancer.Type: ApplicationFiled: July 7, 2011Publication date: January 10, 2013Applicant: Tuskegee UniversityInventors: Clayton YATES, Jesse JAYNES, Timothy TURNER
-
Patent number: 5216836Abstract: A hydroponic system for growing sweet potatoes and other root and tuber crops includes a growing channel incorporating a movable root contact/pressure plate assembly. The assembly consists of a flat, rigid PVC plate in which holes for inserting plants are drilled and a flexible vinyl film which is secured along the length of each side edge of the plate, by means of pressure fit connectors. The assembly is secured to the top edges of a growing channel, again by pressure fit connectors. The flexible film suspends the plate near and parallel to the bottom of the growing channel, with the flexibility of the film allowing upward movement of the plate within the channel as the plant roots grow. The assembly provides contact and pressure to the plant roots inside the growing channel thereby promoting enlargement of the roots. This enlargement causes the assembly to move upwardly, thereby maintaining the desired pressure conditions during growth. A suitable nutrient solution is supplied in the growing channel.Type: GrantFiled: June 27, 1989Date of Patent: June 8, 1993Assignee: Tuskegee UniversityInventors: Carlton E. Morris, Philip A. Loretan, Conrad K. Bonsi, Walter A. Hill
-
Patent number: 4860490Abstract: A hydroponic system for growing sweet potatoes and other root and tuber crops includes a growing channel incorporating a movable root contact/pressure plate assembly. The assembly consists of a flat, rigid PVC plate in which holes for inserting plants are drilled and a flexible vinyl film which is secured along the length of each side edge of the plate, by means of pressure fit connectors. The assembly is secured to the top edges of a growing channel, again by pressure fit connectors. The flexible film suspends the plate near and parallel to the bottom of the growing channel, with the flexibility of the film allowing upward movement of the plate within the channel as the plant roots grow. The assembly provides contact and pressure to the plant roots inside the growing channel thereby promoting enlargement of the roots. This enlargement causes the assembly to move upwardly, thereby maintaining the desired pressure conditions during growth. A suitable nutrient solution is suppplied in the growing channel.Type: GrantFiled: February 16, 1988Date of Patent: August 29, 1989Assignee: Tuskegee UniversityInventors: Carlton E. Morris, Philip A. Loretan, Conrad K. Bonsi, Walter A. Hill