Patents Assigned to UAB Research Foundation
  • Patent number: 10893809
    Abstract: A method and system for evaluating physiological properties of a segment of blood vessel is provided. The method includes: acquiring a first measurement and a second measurement respectively at the first point and the second point; obtaining a transfer function configured to produce an output given an input, using the first measurement and the second measurement as the input and the output respectively; and determining the physiological properties of the section of the blood vessel based on the transfer function. The transfer function can be a velocity transfer function based on the blood velocity waveforms, or can be a pressure transfer function based on the blood pressure waveforms. The method and system can be used to non-invasively diagnose PH, COPD, and PA impedance in a pulmonary artery, and to detect a stenosis in a coronary artery.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: January 19, 2021
    Assignees: Auburn University, The UAB Research Foundation
    Inventors: Thomas S. Denney, Jr., Himanshu Gupta, Ankur Gupta
  • Publication number: 20210009633
    Abstract: Provided herein are compositions and methods for protein purification.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 14, 2021
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Dmitry Vassylyev, Norman Patrick Higgins, Marina Vassylyeva, Alexey Vasiliev
  • Patent number: 10870692
    Abstract: Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: December 22, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Max D. Cooper, Brantley R. Herrin, Matthew N. Alder
  • Patent number: 10870883
    Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 22, 2020
    Assignees: University of Washington, The UAB Research Foundation
    Inventors: Jens H. Gundlach, Michael Niederweis, Thomas Z. Butler, Mikhail Pavlenok, Mark A. Troll, Suja Sukumaran
  • Patent number: 10830774
    Abstract: The present invention provides a method of identifying meningitis as either bacterial meningitis or aseptic meningitis in a subject, comprising: a) measuring the amount of complement C3, complement factor B, complement membrane attack complex (MAC) protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 in a cerebrospinal fluid (CSF) sample obtained from the subject; and b) comparing the amount of complement C3, complement factor B, complement MAC protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 measured in (a) with the amount of complement C3, complement factor B, complement MAC protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 measured in a control sample, wherein an amount of complement C3, complement factor B, complement MAC protein, complement C5b, complement C6, complement C7, complement C8, and/or complement C9 measured in (a) that is greater than the amount of complement C3, complement
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: November 10, 2020
    Assignee: UAB Research Foundation
    Inventors: Scott R. Barnum, Theresa N. Schein, James M. Johnston
  • Patent number: 10815212
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 27, 2020
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UAB RESEARCH FOUNDATION
    Inventors: Bill J. Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
  • Publication number: 20200323903
    Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer.
    Type: Application
    Filed: December 9, 2019
    Publication date: October 15, 2020
    Applicants: Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.
    Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
  • Patent number: 10800726
    Abstract: Novel rexinoid compounds are provided herein. Also provided herein are methods of using the compounds to treat disorders, such as metabolic disorders, diabetes, insulin resistance, glucose intolerance, obesity, steatosis, inflammation, and/or cancer.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 13, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Donald D. Muccio, Venkatram Reddy Atigadda, Wayne J. Brouillette, Clinton J. Grubbs, Jeonga Kim
  • Patent number: 10792873
    Abstract: Fastening devices are described. In one example, the fastening devices can be used for a landing string buoyancy solution. The landing string hardware includes a stop collar to be fitted and secured around a drill pipe and stop collar hardware to secure the stop collar together around the drill pipe. The stop collar can be secured at one end of a number of buoyancy modules placed along a longitudinal length of the drill pipe to hold them into place along the drill pipe. The stop collar can be formed from long fiber thermoplastic using extrusion-compression molding. The stop collar hardware includes a bolt having an external thread formed from long fiber thermoplastic and a nut having an internal thread formed from long fiber thermoplastic. Both the stop collar and the stop collar hardware are tested for suitability for the application of holding the buoyancy modules in place under operating conditions.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 6, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Selvum Pillay, Haibin Ning
  • Publication number: 20200305730
    Abstract: A computerized information processing method for evaluating blood vessels is provided. The method includes acquiring a series of sequences of measurements, each at different time points in at least one cardiac cycle and at a different point along a blood vessel segment of a subject, generating corresponding profiles, calculating a transfer function for a subsegment between two selected points along a blood flow direction, and based thereon determining the physiological property of the subsegment. The measurements can contain information of blood velocity or blood pressure. A processing device and system implementing the information processing method are also provided. This approach can be used to evaluate arteries or veins and can be applied in screening, diagnosis, or prognosis of a variety of vascular diseases. For example, when combined with MRI scan, this approach can be used for non-invasively diagnosing pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), etc.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicants: Auburn University, Arcus-Med, LLC, The UAB Research Foundation
    Inventors: Thomas S. DENNEY, JR., Himanshu GUPTA, Ankur GUPTA
  • Patent number: 10779600
    Abstract: In one embodiment, a protective helmet includes an outer shell made of a polyethylene material, wherein the shell is locally deformable when impacted with a strong force and an inner liner provided within the outer shell. A protective helmet comprising: an outer shell made of a polyethylene material, wherein the shell is locally deformable when impacted with a strong force; and an inner liner provided within the outer shell.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: September 22, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Dean Sicking, Benjamin Willis
  • Patent number: 10781237
    Abstract: Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: September 22, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Michael Niederweis, Mikhail Pavlenok
  • Patent number: 10779722
    Abstract: The present disclosure provides an improved method for photobleaching an eye of a subject. The disclosed method may be used in a number of psychophysical test methods, including, but not limited to, measurement of dark adaptation. The improved method for photobleaching involves at least one of the following improvements: (i) the use of a bleaching light emitting a particular wavelength of light or a tailored spectrum of wavelengths; (ii) restricting or otherwise spatially tailoring the region of the retina that is subject to photobleaching; and (iii) utilizing a bleaching light having an intensity that is at or below the intensity of ambient daylight. The present disclosure additionally provides a combination of a photobleaching light and an apparatus to administer a psychophysical test suitable for use in practicing the disclosed methods.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: September 22, 2020
    Assignee: The UAB Research Foundation
    Inventors: John G. Edwards, Gregory R. Jackson
  • Patent number: 10782307
    Abstract: The present disclosure provides a variety of methods based on the determination of cholesterol concentration in remnant lipoprotein and/or the determination of a remnant lipoprotein level in a sample from a subject. Such methods include, but are not limited to, a method of predicting the risk of cardiovascular disease, a method for evaluating a subject for treatment for a cardiovascular disease and a method for determining if a subject is suffering from cardiovascular disease.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: September 22, 2020
    Assignee: The UAB Research Foundation
    Inventor: Krishnaji R. Kulkarni
  • Publication number: 20200292559
    Abstract: Provided herein are methods for assessing risk of infection or cardiovascular disease (CVD) in a subject with an inflammatory disease, e.g., rheumatoid arthritis. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers with or without additional clinical variables to assess infection and CVD risk. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Application
    Filed: March 10, 2020
    Publication date: September 17, 2020
    Applicants: CRESCENDO BIOSCIENCE, INC., UAB RESEARCH FOUNDATION
    Inventors: Kerri FORD, Jeffrey R. CURTIS
  • Patent number: 10759830
    Abstract: The disclosure provides compositions and methods for purification of proteins, including multi-subunit complexes and membrane proteins. Modified colicin-DNAse domains and modified colicin immunity proteins are provided for use in purification methods. Also provided are related nucleic acids, vectors, genetically modified cells and affinity matrices.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: September 1, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Dmitry Vassylyev, Norman Patrick Higgins, Marina Vassylyeva, Alexey Vasiliev
  • Patent number: 10729200
    Abstract: In one embodiment, a tether system for use with a protective helmet worn by a user includes multiple tethers, each tether having a first end adapted to attach to a shell of the protective helmet and a second end adapted to attach to an article worn by the user, wherein the tethers limit movement of the helmet.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: August 4, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Dean Sicking, Blake Feltman, James T. Houston
  • Patent number: 10653747
    Abstract: Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 19, 2020
    Assignees: UAB RESEARCH FOUNDATION, LIPIMETIX DEVELOPMENT, LLC
    Inventors: Gattadahalli M. Anantharamaiah, Dennis Goldberg
  • Patent number: 10653682
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 19, 2020
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Patent number: 10634685
    Abstract: Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {?2) glucose 1 (1?3) glucose 2 (1?3) rhamnose (1?3) ribitol (5?phosphate}. This new serotype may be included in pneumococcal vaccines.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: April 28, 2020
    Assignees: The UAB Research Foundation, Fundacao Oswaldo Cruz
    Inventors: Moon H. Nahm, Jisheng Lin, Angela P. Brandao, Maria Cristina Brandileone