Abstract: The present invention relates to a thermally and cationically curable composition containing triarylcyclopropenylium salts and a solvent that is a Lewis base which contains acidic hydrogen and their use as thermal initiators in polymerization processes. The present invention includes the polymerization of epoxy resins, vinyl ethers and other cationically curable monomers.
Type:
Grant
Filed:
February 12, 2001
Date of Patent:
July 16, 2002
Assignee:
UCB S.A.
Inventors:
Wenqin Zhang, John H. Malpert, Douglas C. Neckers, Dustin B. Martin
Abstract: In order to offer coatings with improved resistance to solvents which can be prepared by cationic polymerization under irradiation, the choice is made of a composition comprising at least one monomer, oligomer or polymer of general formula (I):
in which:
A1 is chosen from polyester blocks, polyurethane blocks, hydrocarbon-comprising backbones of mono- or polycarboxylic acid and addition products of a polycarboxylic acid and of a cycloaliphatic diepoxide,
m is a number from 1 to 6,
R1 is a cycloaliphatic group carrying a hydroxyl group situated in the a position with respect to the oxygen atom to which R1 is bonded,
R2 is a second cycloaliphatic group carrying an oxirane group situated at the chain end, and
B is chosen from one or more covalent bonds, an oxygen atom and linear, branched or cyclic hydrocarbon-comprising radicals.
Type:
Grant
Filed:
July 28, 2000
Date of Patent:
July 9, 2002
Assignee:
UCB, S.A.
Inventors:
Stephan Peeters, Kris Verschueren, Jean-Marie Loutz
Abstract: Use of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy-acetic-acid, an individual optical isomer or a pharmaceutically acceptable salt thereof as an active ingredient for the production of a pharmaceutical composition for the treatment of diseases induced by the respiratory-syncytial-virus.
Type:
Grant
Filed:
April 21, 1999
Date of Patent:
July 2, 2002
Assignee:
UCB S.A.
Inventors:
Brigitte König, Jean-Pierre Rihoux, Wolfgang König
Abstract: Radiation-curable powder compositions, usable as paint or varnish, which comprise a mixture of at least one semi-crystalline polyester containing end methacryloyl groups and of at least one acrylic copolymer containing ethylenically unsaturated groups, these polyesters comprising the reaction products of a glycidyl methacrylate and of a semi-crystalline polyester containing end carboxyl groups.
Type:
Grant
Filed:
April 21, 2000
Date of Patent:
May 7, 2002
Assignee:
UCB S.A.
Inventors:
Luc Moens, Jean-Marie Loutz, Daniel Maetens, Patrick Loosen, Marc Van Kerckhove
Abstract: The invention relates to compositions comprising at least one polymer and at least one plasticizer, in which compositions the polymer is semi-crystalline and exhibits a processing temperature equal to or greater than 220° C., preferably 250° C., and the plasticizer is an aromatic benzenesulphonamide represented by the general formula (I)
in which
R1 represents a hydrogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy group,
X represents a linear or branched C2-C10 alkylene group, or
a cycloaliphatic group, or
an aromatic group,
Y represents one of the groups OH or
R2 representing a C1-C4 alkyl group or an aromatic group, these groups optionally themselves being substituted by an OH or C1-C4 alkyl group.
Type:
Grant
Filed:
November 3, 2000
Date of Patent:
May 7, 2002
Assignee:
UCB, S.A.
Inventors:
August Van Gysel, Jean-Claude Van Overvelt, André Nannan, Pierre Godard, Jean-Jacques Biebuyck, Philippe De Groote
Abstract: Radiation-curable powder compositions, usable as paint or varnish, which comprise a mixture of at least one semi-crystalline polyester containing end methacryloyl groups and of at least one amorphous polyester containing end methacryloyl groups, comprising the reaction products of a glycidyl methacrylate and of a semi-crystalline or amorphous polyester containing end carboxyl groups.
Type:
Grant
Filed:
April 17, 2000
Date of Patent:
April 30, 2002
Assignee:
UCB S.A.
Inventors:
Luc Moens, Jean-Marie Loutz, Daniel Maetens, Patrick Loosen, Marc Van Kerckhove
Abstract: A CD40 signal blocking agent comprising, as an active ingredient, s-triazolo[1,5-a]pyrimidine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof, is disclosed
Type:
Grant
Filed:
November 13, 2000
Date of Patent:
April 9, 2002
Assignee:
UCB S.A.
Inventors:
Pierre Chatelain, Anne Mignot, Mark Taubman, Michel Goldman
Abstract: The present invention is related to a peptidic product comprising the tetrapeptide Acetyl-glutamyl-glutamyl-glutamyl-aspartyl (SEQ ID No:5) associated with a chemical entity that is able to introduce said tetrapeptide into a cell. The present invention is also related to the pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and an effective amount of the peptidic product according to the invention.
Abstract: The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.
Type:
Grant
Filed:
March 8, 2001
Date of Patent:
January 1, 2002
Assignee:
UCB, S.A.
Inventors:
Monique Berwaer, Guy Bodson, Michel Deleers, Charles Dogimont, Domenico Fanara, Jacques Timmermans
Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.
Type:
Grant
Filed:
October 17, 2000
Date of Patent:
November 27, 2001
Assignee:
UCB, S.A.
Inventors:
Gurmit Grewal, Anna Toy-Palmer, Xiong Cai, George Mark Latham
Abstract: Polymeric compositions for the preparation of optical grade materials, and the optical materials prepared thereby, are provided. The compositions include a class of reactive and non-reactive additives, referred to as additive, in combination with a polymer and optionally a diluent. The additives are preferably the reaction product of a thiol containing compound and an unsaturated compound. The additives optimally have a refractive index between about 1.40 and 1.70, and preferably between 1.50 and 1.70; a relatively high Abbe number (between 25 and 60) and minimal color.
Abstract: A container comprising a flexible semi-permeable composite membrane structure is described, as well as its applications. The membrane has a low molecular weight cut-off, comprises a flexible support layer thick enough to give strength to the membrane structure and having a relatively high molecular weight cut-off and, on at least one surface of the said support layer, a second layer having a relatively low molecular weight cut-off and is thin enough to allow a workable flux. Said container may be used for the preparation of rehydrated solute solutions, rehydrated blood or blood substitutes, nutritional solutions, solutions for medical purpose or of pure water.
Type:
Grant
Filed:
February 23, 2000
Date of Patent:
September 25, 2001
Assignee:
UCB, S.A.
Inventors:
Jean-Yves Salviato, Colin Marshall, Darren Nash, Lesley Sealby
Abstract: The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[-bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.
Type:
Grant
Filed:
May 23, 2000
Date of Patent:
July 17, 2001
Assignee:
UCB, S.A.
Inventors:
Monique Berwaer, Guy Bodson, Michel Deleers, Charles Dogimont, Domenico Fanara, Jacques Timmermans
Abstract: The present invention relates to novel substituted [2-(1-piperazinyl)-ethoxy]methyl compounds of formula
in which
R1 represents a —CONH2, —CN, —COOH, —COOM or —COOR3 group, M being an alkali metal and R3 being an alkyl radical having from 1 to 4 carbon atoms; and
R2 represents a hydrogen atom or a group —COR4 or —R5, where R4 is chosen from the groups —OR6 l or —R7, in which
R5 represents an alkyl or alkylaryl radical,
R6 represents a linear or branched alkyl radical having from 1 to 4 carbon atoms, a haloalkyl, alkylaryl, alkylnitroaryl or alkylhaloaryl radical, and
R7 represents a haloalkyl radical,
to a process for the preparation of these compounds, and to their use for the preparation of compounds which are themselves valuable intermediates for the preparation of 2-[2-[4[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid or 2-[2-[4-[bix(4-fluorophenyl)methyl&rs
Type:
Grant
Filed:
March 21, 2000
Date of Patent:
July 3, 2001
Assignee:
UCB, S.A.
Inventors:
Guy Duchene, Michel Deleers, Guy Bodson, Genevieve Motte, Francoise Lurquin
Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.
Type:
Grant
Filed:
May 9, 2000
Date of Patent:
June 26, 2001
Assignee:
UCB, S. A.
Inventors:
Gurmit Grewal, Anna Toy-Palmer, Xiong Cai, George Mark Latham
Abstract: Pressure sensitive adhesives comprised of an aqueous dispersion of a copolymer of acrylic esters obtained in the presence of a crosslinking monomer carrying a functional group are set forth, said copolymer having a glass transition temperature which does not exceed 0° C. The crosslinking monomer is methacrylic anhydride. The resulting adhesive displays improved adhesion and cohesion properties.
Type:
Grant
Filed:
April 21, 1999
Date of Patent:
April 10, 2001
Assignee:
UCB, S.A.
Inventors:
Willy Segers, Jean-Marie Hoebeke, Jean-Marie Loutz
Abstract: The present invention provides methods of treatment utilizing pharmaceutical compositions comprising an effective nicotine agonist amount of epibatidine (1) or a synthetic 7-azabicyclo[2.2.1]-heptane or heptene derivative thereof, and a pharmaceutically acceptable earner, excipient or diluent.
Abstract: An improved process for preparing acrylate esters, methacrylate esters, polyester acrylates or polyester methacrylates by reacting acrylic or methacrylic acid with a monohydroxy containing compound or a polyhydroxy containing compound in the presence of a catalyst and polymerization inhibitor in a reaction vessel, in the presence or absence of a solvent, under microwave energy as a heating source. Advantages of using microwave energy in place of conventional thermal heating include higher temperatures coupled with shorter residence times, reduced production costs, increased capacity, lower energy costs, effective use of raw materials, and solventless processing which is environmentally friendly.
Abstract: Novel substituted [2-(1-piperazinyl)ethoxy]methyl compounds.The present invention related to novel substituted [2-(1-piperazinyl)-ethoxy]methyl compounds of formula ##STR1## in which R.sub.1 represents a --CONH.sub.2, --CN, --COOH, --COOM or --COOR.sub.3 group, M being an alkali metal and R.sub.3 being an alkyl radical having from 1 to 4 carbon atoms; andR.sub.2 represents a hydrogen atom or a group --COR.sub.4 or --R.sub.5, where R.sub.4 is chosen from the groups --OR.sub.6 or --R.sub.7, in whichR.sub.5 represents an allyl or alkylaryl radical,R.sub.6 represents a linear or branched alkyl radical having from 1 to 4 carbon atoms, a haloalkyl, alkylaryl, alkylnitroaryl or alkylhaloaryl radical, andR.sub.
Type:
Grant
Filed:
October 9, 1998
Date of Patent:
October 31, 2000
Assignee:
UCB, S.A.
Inventors:
Guy Duchene, Michel Deleers, Guy Bodson, Genevieve Motte, Francoise Lurquin
Abstract: The present invention relates to a process for preparing (S)- and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide. According to this process, the enantiomeric resolution of the racemic mixture of .alpha.-ethyl-2-oxo-1-pyrrolidineacetamide is carried out by simulated mobile bed chromatography, using at least three columns filled with chiral stationary phase.This process makes it possible to achieve good production efficiency on the industrial scale.
Type:
Grant
Filed:
May 7, 1999
Date of Patent:
September 26, 2000
Assignee:
UCB, S.A.
Inventors:
Emile Cavoy, Michel Hamende, Michel Deleers, Jean-Pierre Canvat, Vincent Zimmermann