Patents Assigned to UCL Business PLC
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Patent number: 10358485Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.Type: GrantFiled: December 12, 2018Date of Patent: July 23, 2019Assignees: Eisai R&D Management Co., Ltd., UCL Business PLCInventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
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Patent number: 10314924Abstract: Methods for treating a human subject who has X-linked Retinitis Pigmentosa (XLRP) or another clinically-defined ophthalmological condition due to a loss-of-function mutation in the gene encoding the retinitis pigmentosa GTPase regulator (RPGR) protein, the method comprising administering to the subject a nucleic acid comprising an adeno-associated viral vector comprising an abbreviated human RPGR cDNA.Type: GrantFiled: July 17, 2015Date of Patent: June 11, 2019Assignees: Massachusetts Eye & Ear Infirmary, UCL Business PLC, The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Michael A. Sandberg, Basil Pawlyk, Alan Finlay Wright, Xinhua Shu, Tiansen Li, Robin Ali
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Patent number: 10309027Abstract: The present invention provides a method for producing a solution of nanosheets, comprising the step of contacting an intercalated layered material with a polar aprotic solvent to produce a solution of nanosheets, wherein the intercalated layered material is prepared from a layered material selected from the group consisting of a transition metal dichalcogenide, a transition metal monochalcogenide, a transition metal trichalcogenide, a transition metal oxide, a metal halide, an oxychalcogenide, an oxypnictide, an oxyhalide of a transition metal, a trioxide, a perovskite, a niobate, a ruthenate, a layered III-VI semiconductor, black phosphorous and a V-VI layered compound. The invention also provides a solution of nanosheets and a plated material formed from nanosheets.Type: GrantFiled: February 16, 2015Date of Patent: June 4, 2019Assignee: UCL Business PLCInventors: Patrick Linden Cullen, Neal Skipper, David Buckley, Christopher Howard
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Publication number: 20190154668Abstract: The invention provides light-emitting compositions, including lasing and fluorescent compositions. The invention particularly relates to programmable biological substrates, which fluoresce and/or lase, and which have a wide variety of different applications. The invention extends to use of the fluorescent compositions and lasing compositions comprising programmable biological substrates in fabricating lasers, and in various biological imaging applications, such as in assays.Type: ApplicationFiled: November 20, 2018Publication date: May 23, 2019Applicant: UCL BUSINESS PLCInventors: John Edward Hales, John Ward, Gabriel Aeppli, Tim Dafforn
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Patent number: 10286092Abstract: The present invention relates to a method of detecting a therapeutic cell expressing a dopamine transporter (DAT) at a central nervous system (CNS) site in a subject, which comprises the administration of a DAT tracer to the subject, wherein the presence of a therapeutic cell which expresses the DAT is determined.Type: GrantFiled: August 25, 2015Date of Patent: May 14, 2019Assignee: UCL Business PLCInventors: Martin Pulé, Adam Badar, Louise Kiru, Mark Lythgoe, Adrien Peters
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Patent number: 10288725Abstract: A method and an apparatus are provided for performing passing sensing using wireless digital communications. The wireless digital communications are frame-based with a predefined frame structure. The method includes receiving a reference signal into to a reference channel, wherein the reference signal comprises a direct version of a radio frequency transmission as part of said wireless digital communications; receiving a surveillance signal into a surveillance channel; detecting and extracting portions of the reference signal corresponding to data transmissions based on said predefined frame structure; extracting portions of the surveillance signal corresponding to the extracted portions of the reference signal; performing a cross-correlation on the extracted portions of the reference signal and the surveillance signal to determine a range-Doppler surface; and providing a real-time display of said range-Doppler surface and/or of information derived therefrom.Type: GrantFiled: October 30, 2014Date of Patent: May 14, 2019Assignee: UCL Business PLCInventors: Bo Tan, Karl Woodbridge, Kevin Chetty
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Publication number: 20190134155Abstract: The invention provides methods and materials for treating a seizure disorder such as epilepsy in a patient which employ a vector encoding a modified receptor, the so-called “DREADD” receptor being characterised by (i) a decreased responsiveness to its endogenous activating ligand (ii) a retained or enhanced responsiveness to an exogenous agonist. The modified receptor is expressed in neurons of a seizure focus in brain of the patient, and an exogenous agonist is administered which activates the modified receptor to reversibly alters the excitability of the neurons in the seizure focus leading to synaptic silencing or other inhibition.Type: ApplicationFiled: January 14, 2019Publication date: May 9, 2019Applicant: UCL BUSINESS PLCInventors: Dennis Kaetzel, Matthew Charles Walker, Stephanie Schorge, Dimitri Michael Kullman
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Publication number: 20190106751Abstract: The invention provides methods for detecting single nucleotide variants in lung cancer, especially stage 3a lung adenocarcinoma and lung squamous cell carcinoma. Additional methods and compositions, such as reaction mixtures and solid supports comprising clonal populations of nucleic acids, are provided.Type: ApplicationFiled: April 17, 2017Publication date: April 11, 2019Applicants: Natera, Inc., UCL BUSINESS PLCInventors: Bernhard ZIMMERMANN, Tudor Pompiliu CONSTANTIN, Raheleh SALARI, Huseyin Eser KIRKIZLAR, Robert Charles SWANTON, Mariam JAMAL-HANJANI, Christopher ABBOSH, Gareth WILSON
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Patent number: 10234467Abstract: Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a pH probe (66) which is connectable to a supply of carbon dioxide (32, 34), as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The control unit (50) monitors changes in pH of the solvent medium (18) and, as appropriate, feeds pH increasing and/or pH reducing gas from the supplies (32, 34, 40) into the chamber (12). The control unit (50) is able to maintain a uniform pH during testing or to provide a dynamically adjustable pH during testing, for example to three or more different pH levels in order to test the performance of a drug carrier at different levels of acidity or alkalinity for example, mimicking the conditions of the gastrointestinal tract.Type: GrantFiled: December 28, 2016Date of Patent: March 19, 2019Assignee: UCL Business PLCInventors: Hamid Ali Merchant, John Andrew Frost, Abdul Waseh Basit
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Patent number: 10226298Abstract: A system and method are provided for using a computer system to assist in planning a trajectory (960A, 960B) for a surgical insertion into a skull. The method comprises providing the computer system with a three-dimensional representation of the skull and of critical objects located within the skull, wherein the critical objects comprise anatomical features to be avoided during the surgical insertion. The method further comprises providing the computer system with a target location (770, 970) for the insertion within the skull. The method further comprises generating by the computer system a first set comprising a plurality of entry points, each entry point (760) representing a surface location on the skull, and each entry point (760) being associated (2D) with a trajectory (960A, 960B) from the entry point (760) to the target location (770, 970).Type: GrantFiled: May 14, 2015Date of Patent: March 12, 2019Assignee: UCL Business PLCInventors: Sebastien Ourselin, Gergely Zombori, Mark Nowell, Rachel Sparks, John Duncan, Roman Rodionov, Andrew McEvoy, Anna Miserocchi, Beate Diehl, Tim Wehner
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Publication number: 20190064099Abstract: A sensor device is provided to sample data from a fluid in a sealed environment. The sensor comprises a housing and a diamond within the housing. The housing is formed such that the device is reversibly insertable into the sealed environment so that the diamond directly interfaces with the sealed environment.Type: ApplicationFiled: March 3, 2017Publication date: February 28, 2019Applicant: UCL Business PLCInventors: Richard B. Jackman, Ralph Jennings-Moors, Alex Pak-Pour-Tabrizi, William Parfitt, Joseph O. Welch
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Publication number: 20190038807Abstract: The present invention relates generally to methods and materials for use in the production of implants, particularly luminal tissue implants, where the implants are engineered by seeding of an acellular scaffold or matrix with muscle cell precursors and fibroblasts, for example injection seeding using particular ratios of cells. The present invention provides methods for producing tissue engineered constructs for implantation into a subject which can utilise novel seeding processes described herein for improved cell engraftment and differentiation. In addition, the invention describes methods for treating an individual by implantation of the engineered constructs or tissues of the invention.Type: ApplicationFiled: September 7, 2016Publication date: February 7, 2019Applicant: UCL BUSINESS PLCInventors: Paolo DECOPPI, Luca URBANI, Anna URCIUOLO
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Patent number: 10184136Abstract: There is disclosed a retroviral vector comprising a primer binding site, a long terminal repeat and an RNA packaging sequence, wherein the RNA packaging sequence is located 3? of the long terminal repeat and no long terminal repeat is located 3? of the RNA packaging sequence such that reverse transcription initiated at the primer binding site does not lead to reverse transcription of the RNA packaging sequence into vector DNA in a target cell. Also described is a host cell, a virion, a pharmaceutical composition, a method and uses including or involving the vector described above. Further, a cell or transgenic animal produced by using the vector is also described.Type: GrantFiled: October 16, 2014Date of Patent: January 22, 2019Assignee: UCL Business PLCInventors: Conrad Vink, Steven Howe
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Publication number: 20190009004Abstract: There is described a multiphasic osteochondral scaffold for osteochondral defect repair, the scaffold comprising a bone phase and a cartilage phase, wherein the bone phase comprises a support matrix and the cartilage phase comprises a polymeric matrix, and the scaffold comprises a non-porous layer between the bone phase and the cartilage phase. Also described is a multiphasic osteochondral scaffold for osteochondral defect repair, the scaffold comprising a bone phase and a cartilage phase, wherein the bone phase comprises a support matrix and the cartilage phase comprises a polymeric matrix, and wherein the support matrix is tapered so that the dimensions of the support matrix are less at the lower end of the support matrix than at the upper end of the support matrix.Type: ApplicationFiled: January 9, 2017Publication date: January 10, 2019Applicant: UCL BUSINESS PLCInventors: Chaozong LIU, Gordon BLUNN
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Patent number: 10174099Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.Type: GrantFiled: June 23, 2017Date of Patent: January 8, 2019Assignees: UCL BUSINESS PLC, AUTOLUS LIMITEDInventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
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Patent number: 10174094Abstract: The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X?, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.Type: GrantFiled: February 17, 2016Date of Patent: January 8, 2019Assignee: UCL Business PlcInventors: Mark Smith, Stephen Caddick, James Baker, Vijay Chudasama
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Patent number: 10172885Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second CARs bind to different antigens, and wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-off inhibitory endodomain.Type: GrantFiled: November 21, 2014Date of Patent: January 8, 2019Assignee: UCL BUSINESS PLCInventors: Martin Pulé, Khai Kong, Shaun Cordoba
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Patent number: 10172886Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second CARs bind to different antigens, wherein the spacer of the first CAR is different to the spacer of the second CAR and wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-off inhibitory endodomain.Type: GrantFiled: November 21, 2014Date of Patent: January 8, 2019Assignee: UCL BUSINESS PLCInventors: Martin Pulé, Khai Kong, Shaun Cordoba
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Publication number: 20180371056Abstract: The present invention relates to a multi-span chimeric antigen receptor (CAR) which comprises: i) at least one extra-cellular antigen binding domain; ii) a plurality of linked transmembrane domains; and iii) at least one intracellular signalling domain.Type: ApplicationFiled: November 11, 2016Publication date: December 27, 2018Applicant: UCL Business PLCInventors: Martin Pulé, Weng-Kit Cheung
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Patent number: 10160794Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising: (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.Type: GrantFiled: October 10, 2014Date of Patent: December 25, 2018Assignee: UCL BUSINESS PLCInventors: Martin Pulé, Kwee Yong, Lydia Lee, Ben Draper