Patents Assigned to UCL Business PLC
  • Imaging apparatus and methods
    Patent number: 9104087
    Abstract: Methods, systems and apparatus for manipulating electromagnetic radiation such as laser beams. A method and apparatus for correcting magnification chromatic aberration utilizes one or more dispersive lenses such that long wavelength components are magnified less than short wavelength components. A telecentric relay is preferred to achieve this aim. Further, the use of polarizers to block the undesired zeroth order components of diffraction emanating from acousto-optic deflectors (AODs) is disclosed. Furthermore, specific designs of AOD including narrow transducer AODs which produce a diverging acoustic wave and AODs having two transducers and a selection switch are disclosed.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: August 11, 2015
    Assignee: UCL Business PLC
    Inventors: Paul Anthony Kirkby, K. M. naga Srinivas Nadella, Robin Angus Silver
  • Method for separating nanomaterials
    Patent number: 9079775
    Abstract: A method for dispersing nanomaterial comprising an electrochemical process, a solution of dispersed nanomaterial, comprising individual charged nanomaterial at a concentration of about 0.1 mgm?1 or more and a solvent and an electrochemical cell are described.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: July 14, 2015
    Assignee: UCL Business PLC
    Inventors: Christopher Howard, Neal Skipper, Milo Shaffer, Sian Fogden
  • INHIBITORS OF NKX2.5 FOR VASCULAR REMODELLING
    Publication number: 20150190391
    Abstract: The invention relates to vascular remodelling, and to the treatment of conditions that are characterised or caused by inappropriate vascular remodelling. The invention also extends to pharmaceutical compositions for use in treating such conditions, and to methods of treatment.
    Type: Application
    Filed: July 18, 2013
    Publication date: July 9, 2015
    Applicant: UCL Business PLC
    Inventors: David John Abraham, Markella Ponticos, Alan Matthew Holmes
  • Article and method of surface treatment of an article
    Patent number: 9044528
    Abstract: An article comprising: a substrate; and over at least part of a surface of said substrate an outer coating of hydroxyapatite and an intermediate bonding layer bonded to said substrate and to said outer coating, wherein a mechanical interlock is present between said substrate and said outer coating.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: June 2, 2015
    Assignee: UCL Business PLC
    Inventors: Minoo Esat, William Bonfield, Mohan Edirisinghe, Jie Huang, Xiang Li
  • Radiation detector
    Patent number: 9012855
    Abstract: A radiation detector includes a scintillator crystal (2) in the form of a slab mounted to be rotated by a drive (4) in a housing (8). A photon detector (6) detects photons emitted by the crystal (2). The crystal (2) is rotated to a number of measurement angles and the radiation emitted by a radiation source determined by counting the photons detected by the photon detector. This is used to determine the direction towards the radiation source.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: April 21, 2015
    Assignee: UCL Business PLC
    Inventor: Robert Speller
  • Quantifying cell death
    Patent number: 9014457
    Abstract: The invention relates to methods of diagnosis, particularly methods of staging and diagnosing neurodegenerative diseases using images of cell death in the eye.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: April 21, 2015
    Assignee: UCL Business PLC
    Inventors: Stephen Moss, Maria Francesca Cordeiro, Steven Dakin
  • Image analysis system and/or method
    Patent number: 8995707
    Abstract: Among other things, a method is disclosed comprising: receiving image data representing an image; processing the data to generate orientation information; processing the data using the orientation information to measure a quantity called local phase in a direction perpendicular to the orientation of a putative vessel; using the phase measurements from three collinear image locations or from two locations to detect the centerline of a symmetric image structure, such as a blood vessel, and to locate a center-point defined by the intersection of the centerline with the line created by the measurement locations.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: March 31, 2015
    Assignee: UCL Business PLC
    Inventors: Jeffrey Ng Sing Kwong, Alistair Richard Fielder, Clare Margaret Wilson
  • TREATMENT OF ACUTE INFLAMMATION IN THE RESPIRATORY TRACT
    Publication number: 20150079105
    Abstract: This invention relates to the field of molecular physiology. Specifically, this invention relates to the prevention and/or treatment of acute inflammation of the respiratory tract, especially acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Levels of CCL7 have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of CCL7 and/or other members of the PAR1-CCL7 axis, or CCL2 can be used to prevent and/or treat these conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Applicant: ucl Business PLC
    Inventors: Rachel Chambers, Paul Mercer, Andrew Williams
  • Synthetic scaffolds and organ and tissue transplantation
    Patent number: 8968401
    Abstract: Articles, compositions, and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. Synthetic scaffolds for growing artificial tissue and organ transplants are also provided.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: March 3, 2015
    Assignee: UCL Business PLC
    Inventor: Alexander M. Seifalian
  • MEASURING SURFACE CURVATURE
    Publication number: 20150059026
    Abstract: A method of measuring surface curvature comprises forming an intensity distribution defined by Fresnel diffraction, wherein said intensity distribution is formed by electromagnetic radiation reflected from a surface, obtaining data for the intensity distribution and determining information relating to the curvature of the surface using the obtained data.
    Type: Application
    Filed: March 28, 2013
    Publication date: February 26, 2015
    Applicant: UCL Business PLC
    Inventors: Rodolfo Hermans, Gabriel Aeppli
  • Materials and Methods Relating to Packaging Cell Lines
    Publication number: 20150023933
    Abstract: Lentiviral packaging cells and methods for producing the same are provided herein. Specifically, lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are provided. Methods for producing lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are described.
    Type: Application
    Filed: February 13, 2013
    Publication date: January 22, 2015
    Applicant: UCL Business PLC
    Inventors: Mary Collins, Yasuhiro Takeuchi, Sean Knight
  • DISPERSION METHOD
    Publication number: 20140377159
    Abstract: A method for producing a solution of dispersed graphenes comprising contacting graphite having a dimension in the a-b plane of 10 ?m or less with an electronic liquid comprising a metal and a polar aprotic solvent, and solutions of dispersed graphenes which may be obtained by such a method are described.
    Type: Application
    Filed: June 26, 2012
    Publication date: December 25, 2014
    Applicant: UCL Business PLC
    Inventors: Christopher Howard, Neal Skipper, Milo Shaffer, Emily Milner
  • Apparatus for performing deep brain stimulation with a high frequency electric field
    Patent number: 8914117
    Abstract: One embodiment of the invention provides a method and apparatus for performing deep brain stimulation with an electromagnetic field. The includes an electrode assembly having multiple electrodes and a phased array system for driving the electrodes to generate the electromagnetic field. By controlling delays within the phased array system, the generated electromagnetic field can be steered to a desired region of the brain.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: December 16, 2014
    Assignee: UCL Business PLC
    Inventors: Virgilio Valente, Andreas Demosthenous, Richard Bayford
  • METHOD FOR OBTAINING MAB-LIKE CELLS AND USES THEREOF
    Publication number: 20140363405
    Abstract: The invention relates to the derivation of mesoangioblast-like (MAB-like) cells from pluripotent cells such as induced pluripotent (IPS) and embryonic stem (ES) cells, to cells obtained thereby and to medical uses of such cells, in particular in the treatment of muscular dystrophies.
    Type: Application
    Filed: January 18, 2013
    Publication date: December 11, 2014
    Applicant: UCL Business PLC
    Inventors: Giulio Cossu, Francesco Saverio Tedesco
  • CYCLOSPORIN CONJUGATES
    Publication number: 20140357569
    Abstract: A conjugate which comprises a cyclosporin moiety of formula (I) linked to one or more mitochondrial targeting groups, or a pharmaceutically acceptable salt thereof: wherein: A represents or, B represents methyl or ethyl, one Of R1 and R1* represents hydrogen and the other represents methyl, R2 represents ethyl or isopropyl, R3 represents hydrogen or methyl, and R4 represents —CH2CH(CH3)CH3, —CH2CH(CH3)CH2CH3, —CH(CH3)CH3 or —CH(CH3)CH2CH3.
    Type: Application
    Filed: February 28, 2014
    Publication date: December 4, 2014
    Applicant: UCL Business PLC
    Inventors: David Selwood, Martin Crompton
  • Electrochemical detection of particulates in a gaseous sample using potentiometric measurements in a gaseous flame electrolyte
    Patent number: 8894837
    Abstract: The present invention provides a method for the detection of particulates in a sample, wherein the particulates are introduced into a plasma and the potential difference between a common electrode and each of a plurality of indicator electrodes is measured. The invention further provides an electrode array and an apparatus which can be used for the potentiometric detection of particulates in a sample.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: November 25, 2014
    Assignee: UCL Business PLC
    Inventors: Dimitrios Sarantaridis, Daren J. Caruana
  • Membrane
    Patent number: 8889179
    Abstract: The invention relates to a membrane for supporting cells, especially retinal pigmented epithelial (RPE) cells. The membrane is useful in the treatment of conditions such as age related macular degeneration. The membrane may also be used to support retinal pigmented epithelial cell precursors and retinal cell derivative cells formed from the differentiation of RPE on the membrane.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: November 18, 2014
    Assignee: UCL Business PLC
    Inventors: Peter Coffey, Lyndon Da Cruz, Karen Cheetham
  • T-cell receptor
    Patent number: 8889141
    Abstract: The present invention provides a T-cell receptor (TCR) which binds to a peptide from latent membrane protein 2 (LMP-2) from the Epstein Barr Virus (EBV) having the amino acid sequence CLGGLLTMV (SEQ ID No. 1) when presented by a major histocampatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a EBV-specific T-cell. The present invention also provides the use of EBV-specific T-cell for cellular immunotherapy.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: November 18, 2014
    Assignee: UCL Business PLC
    Inventors: Hans Stauss, Shao-An Xue, Max Topp
  • PURIFICATION METHOD
    Publication number: 20140311921
    Abstract: A method for removing impurities from a sample of carbon nanotubes wherein the sample is contacted with an electronic liquid comprising a metal and an amine solvent is described.
    Type: Application
    Filed: March 26, 2012
    Publication date: October 23, 2014
    Applicant: UCL Business PLC
    Inventors: Christopher Howard, Neal Skipper, Milo Shaffer, Sian Fogden
  • Synthetic scaffolds and organ and tissue transplantation
    Patent number: 8858631
    Abstract: Articles, compositions, and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. Synthetic scaffolds for growing artificial tissue and organ transplants are also provided.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: October 14, 2014
    Assignee: UCL Business PLC
    Inventor: Alexander M. Seifalian