Abstract: An expression library comprising a repertoire of nucleic acid sequences each encoding at least part of a variable domain of a heavy chain derived from an immunoglobulin naturally devoid of light chains and its use in producing antibodies, particularly fragments thereof, is disclosed. The invention provides a method for preparing antibodies, or fragments thereof, having a specificity for a target antigen which avoids the need for the donor previously to have been immunised with the target antigen.

Abstract: The present invention relates to the field of improving nutritional content and more particularly the isoflavone content in plants. The invention provides a process for increasing the content of the isoflavone daidzein in selected plants, novel plants produced by this process and products derivable therefrom.

Abstract: An expression library comprising a repertoire of nucleic acid sequences cloned from a non-immunised source, each nucleic acid sequence encoding at least part of a variable domain of a heavy chain derived from an immunoglobulin naturally devoid of light chains (VHH) wherein the extent of sequence variability in the library is enhanced compared to the corresponding naïve expression library by introducing mutations in one or more of the complementarity determining regions (CDRs) of the nucleic acid sequences or by generating alternative combinations of CDR and framework sequences not naturally present in the naïve library repertoire. Also disclosed is the use of such a library in preparing antibodies, more particularly antibody fragments.

Abstract: A method for manipulating the production of flavonoids other than anthocyanins in plants by manipulating gene activity in the flavonoid biosynthetic pathway by expressing two or more genes encoding transcription factors for flavonoid biosynthesis, compositions for use in such a method and tomato plants having altered flavonoid levels are disclosed.

Abstract: A process for producing an immunoadsorbant material, a surface of which comprises a molecule which incorporates at least a binding site of an antibody, which process comprises the step of exposing a solid surface of a material to a solution of a molecule which incorporates at least the binding site of an antibody such that the molecule adsorbs onto said surface, characterised in that said molecule is an antibody fragment attached through a covalent chemical bond to a second protein which is not the remainder of the corresponding antibody.

Abstract: Cationic peroxyacids of formula (IV) wherein: R1 is a, optionally substituted, C1-C7 alkyl or alkenyl or alkaryl with a C1-C7 alkyl group; R2 and R3 are each independently a C1-C3 alkyl or C1-C3 substituted alkyl group; n is an integer from 0 to 3; and X− is a surfactant anion selected from alkyl carboxylates; alkyl ether sulphates; alkylbenzene sulphonates; C12-15 primary and C14-18 secondary alkyl sulphates; olefin sulphonates; alkane sulphonates; dialkyl sulphosuccinates; fatty acid ester sulphonates; alkylether sulphonates, alkylether carboxylates, sulphonated alkyl polyglycosides; sulphonated alkanoyl glucose ethers, sulphonated monoglycerol ethers; secondary alkane sulphonates; esterified isethionates; alkyl and dialkyl phosphates; sodium fatty acid sulphonates; and fatty acid soaps. They can be used in bleaching and detergent compositions and in bleach additive products.

Abstract: The invention relates to a method of preparing stable oil in water emulsions wherein a ferulyolated compound is at least partly oxidized during or after formation of the oil in water emulsion.

Abstract: A method for improving the chalky-off taste and/or the homogeneity of a solid, active component in a food product by incorporating in the food product an effective amount, preferably 1 to 70 wt % on food product, of a structured particulate system comprising one or more active components in a matrix in a weight ratio of 1:99 to 99:1 and wherein the mean weight diameter of the particles of the structured particulate system ranges from 25 to 500 microns.

Abstract: A multivalent antigen binding protein comprises a single polypeptide chain comprising, in series, two or more single domain binding units which are preferably heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains. Methods for their production and uses thereof, in particular for diagnosis, immunoassay and purification methods are disclosed.

Abstract: The present invention relates to new macrocyclic bleach catalysts, to formulations comprising these catalysts, as well as bleaching processes which employ these catalysts. These catalysts exhibit unexpected hydrolytic stability, as well as stability against metal abstraction by metal abstracting agents.

Abstract: An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile in the porous carrier when in the moist state, and an unlabelled specific binding reagent which is permanently immobilised in a detection zone on the carrier material, the labelled and unlabelled specific binding reagents being capable of participating in either a sandwich reaction or a competition reaction in the presence of the analyte, in which prior to the application to the device of a liquid sample suspected of containing the analyte, the labelled specific binding reagent is retained in the dry state in a macroporous body, eg.

Abstract: The invention concerns an apparatus for the removal of moisture from particulized, solid food products, comprising; a housing (9); a perforated plate (2), creating two chambers (3, 4) in the housing (1), gas-inlets (5, 6), present below the perforated plate (2); an outlet (8) in the perforated plate (2), provided with a removable plug (9); heating means (15, 18) for the gases. The invention further concerns a process for the removal of moisture from solid, small particles, by subjecting these particles, while in an annular, fluidized bed to a heat treatment for a specific time.

Abstract: The present invention relates to molecules derived from guggulipid extract which are capable of reducing insulin resistance in humans. The invention further relates food compositions and medicaments comprising such molecules which can be used to treat and/or prevent insulin resistance and the symptoms thereof.

Abstract: A method of inhibiting viral infection using a monovalent antigen binding protein comprising a single domain binding unit capable of binding to a virus is described. Preferably the protein is a heavy chain variable domain derived from an immunoglobulin naturally devoid of light chains. Food, pharmaceutical and cosmetic products comprising such proteins are also described together with a method for selecting inhibiting proteins from a large population of mainly containing non-inhibiting, but infectious agent binding fragments.

Abstract: Aliphatic, saturated or unsaturated, straight or branched chain C2-C24 monocarboxylic acids and polyhydric alcohols, particularly glycerol are selectively reached to monoesters in the presence of an enzyme which comprises potato lipid acyl hydrolase. The process can be used too for upgrading technical monoglycerides which contain free fatty acids.

Abstract: The inventon concerns blends of a hydroquinone substituted poly unsaturated fatty acid (as present in Kombo nut oil) or a derivative thereof, which blends comprised:

Abstract: Our invention concerns a mixture of CLA glycerides, and/or CLA-fatty acids and or CLA-alkyl esters and another component, wherein the other component (=component A) is selected for its capacity to alleviate problems related to insulin resistance in mammals, using CLA rich diets and/or foods and/or food supplements using an appropriate in vitro test so that in at least one step of the in vitro test, as described in the text, an improvement in test results is obtained of at least 4% by the blend of the CLA derivative and component A when compared to the CLA derivative only.

Abstract: Pea seeds, produced from peas of the rug3rug3 genotype, substantially lacking plastidial phosphoglucomutase activity which have higher sucrose levels at the end of the vining period and may be vined over and extended period compared to conventional vining varieties are provided. Polynucleootides encoding pea plastidial phosphoglucomutase useful for altering the sucrose and starch content of plants, particularly peas, are also disclosed.

Abstract: Detergent tablets for use in fabric washing are made by mixing: (i) particles which contain non-soap organic surfactant and other materials, especially detergency builder, with (ii) material which is other than soap or organic surfactant and which has a solubility in water of at least 10 gm/liter at 20° C., followed by compacting the mixture into a tablet or a region of a tablet using an applied pressure in a range from 3.0 to 35 MPa. Such a pressure, used with the specified mixture, leads to tablets with good strength which also disintegrates with satisfactory speed.

Abstract: The invention concerns concentrates of ursolic acid or its salts and oleanoic acid, wherein