Abstract: Arrays of spin-valve elements that can be selectively activated to trap, hold, manipulate and release magnetically tagged biological and chemical particles, including molecules and polymers. The spin-valve elements that can be selectively activated and deactivated by applying a momentary applied magnetic field thereto. The spin valve element array can be used for selectively sorting and transporting magnetic particles one particle at a time within the array. As the magnetically tagged particles are held by the spin-valve elements, application of an auxiliary magnetic field can be used to apply tension or torsion to the held particles or to move, e.g. rotate, the trapped particles. The arrays of spin-valve elements can be used in a variety of applications including drug screening, nucleic acid sequencing, structural control and analysis of RNA/DNA and protiens, medical diagnosis, and magnetic particle susceptibility and size homogenization for other medical applications.

Abstract: A dimensional reference system for tomography, including X-ray computed tomography and MRI tomography. The system includes a dimensional reference apparatus that comprises plurality of spheres composed of a material having an X-ray absorption property between approximately +500 Hounsfield units and +1200 Hounsfield units. The spheres are spaced apart at a known distance by support structure/spacer unit that has an X-ray absorption property between approximately ?100 Hounsfield units and +400 Hounsfield units. After an image that incorporates the dimensional reference apparatus and a measurement subject has been reconstructed, the dimensional reference apparatus provides for measurement of the resultant image voxels in three dimensions. Because solid structural elements such as plastic or glass spheres may not be visible in an MRI, an MRI implementation of the apparatus may be disposed in a fluid-tight enclosure along with water, a contrast-enhancing agent and ethanol.

Abstract: A method of predicting the destructive capacity of a tropical cyclone based on a new Wind Destructive Potential (WDP) and Storm Surge Destructive Potential (SDP) scales which provide a manner to rate the severity of hurricanes and typhoons, based on information provided in operational forecast and warning products, experimental wind field products, or gridded numerical weather prediction model outputs. These new scales are formulated to be consistent with the physical mechanism through which tropical cyclones impact coastal communities through wind, storm surges and wave damage.

Abstract: A method and apparatus for aligning, stabilizing and registering two or more structures in one or more dimensional space with picometer-scale precision. Low noise laser light is scattered by at least one or more structure or fiducial marks. One mark may be coupled to each structure to be positioned. The light which has been scattered off the fiducial marks is collected in a photo-sensitive device which enables real-time high-bandwidth position sensing of each structure. One or more of the structures should be mounted on a stage, and the stage can move in either one or more dimensions. The photo-sensitive device generates signals in response to the scattered light received, and the signals are used to modulate the position of the stage in a feedback loop.

Abstract: A highly charged ion modified device is provided that includes a first metal layer or layers deposited on a substrate and an insulator layer, deposited on the first metal layer, including a plurality of holes therein produced by irradiation thereof with highly charged ions. The metal of a further metal layer, deposited on the insulator layer, fills the plurality of holes in the insulator layer.

Abstract: Lossless compression techniques provide efficient compression of hyperspectral satellite data. The present invention combines the advantages of a clustering with linear modeling. A number of visualizations are presented, which help clarify why the approach of the present invention is particularly effective on this dataset. At each stage, the algorithm achieves an efficient grouping of the data points around a relatively small number of lines in a very large dimensional data space. The parametrization of these lines is very efficient, which leads to efficient descriptions of data points. The method of the present invention yields compression ratios that compare favorably with what is currently achievable by other approaches.

Abstract: A laser Doppler vibrometer for vibration measurement that employs active feedback to cancel the effect of large vibration excursions at low frequencies, obviating the need to unwrap phase data. The Doppler shift of a reflective vibrating test object is sensed interferometrically and compensated by means of a voltage-controlled oscillator driving an acousto-optic modulator. For frequencies within the servo bandwidth, the feedback signal provides a direct measurement of vibration velocity. For frequencies outside the servo bandwidth, feedback biases the interferometer at a point of maximal sensitivity, thus enabling phase-sensitive measurement of the high-frequency excursions. Using two measurements, one with a low bandwidth and one with a high bandwidth, more than five decades of frequency may be spanned.

Abstract: An atomic magnetometer that simultaneously achieves high sensitivity, simple fabrication and small size. This design is based on a diverging (or converging) beam of light that passes through an alkali atom vapor cell and that contains a distribution of beam propagation vectors. The existence of more than one propagation direction permits longitudinal optical pumping of atomic system and simultaneous detection of the transverse atomic polarization. The design could be implemented with a micro machined alkali vapor cell and light from a single semiconductor laser. A small modification to the cell contents and excitation geometry allows for use as a gyroscope.

Abstract: The DNA Sampling Hook is a significant improvement on a method of obtaining a tissue sample from a live fish in situ from an aquatic environment. A tissue sample taken from a live fish can be used for DNA analyses, which can identify the species of fish, as well as the unique individual fish. Taking a small tissue sample without bringing the fish to the surface is important as it allows for observing the fish community without harming the individual fish by inducing barotrauma or other stresses associated with bringing a fish up from depth, which can be lethal to the animal. These tissue samples are obtained by hook and line methods and do not capture or traumatize the fish resulting in a non-lethal and non-destructive method of observing fish individuals and species. The DNA Sampling Hook is specifically designed to virtually eliminate a condition called double bites, in which more than one individual fish gives up tissue to the same hook.

Abstract: A method of imaging critical dimensions by measuring the zeroeth order of diffracted light. The method involves providing a target, directing light onto the target so as to cause the target to diffract the light. The zeroeth order of the diffracted light is collected and analyzed to determine structural features of the target. The target can be an article of manufacture, such as a semiconductor device, or a separate target that is provided or fabricated on an article of manufacture. One of at least the wavelength and the angle at which the light is directed onto the target can be scanned. The target can fill all or only a portion of the field of view.

Abstract: A stationary phase for a liquid chromatograph and process for making is provided. The stationary phase material may have a modified base substrate and a fluorinated carboxylic acid covalently bonded thereto through an amide or ester bond. The stationary phase may have a substantially consistent shape selectivity characteristic with an ?TBN/BaP of less than 1 within a temperature range of at least 10-70° C. Advantageously, a fluorinated stationary phase has a shape selectivity characteristic exhibited with an ?TBN/BaP of less than 1 with a mobile phase having up to at least 30% water. A process for making the stationary involves mixing a substrate material or fluorinated carboxylic acid with a reactive alkylsilane linker and at least one organic solvent to form a first solution. The other of the substrate material or fluorinated carboxylic acid is then added to the first solution, or to a product separated from the first solution, to form a second solution.

Abstract: A method and apparatus for detecting slow neutrons by monitoring Lyman alpha radiation produced by the 3He(n,tp) nuclear reaction induced by neutrons incident on a gas cell containing 3He or a mixture of 3He and other atoms and/or molecules. Such a method and/or apparatus includes the use of, for example, liquid 3He and 4He mixtures as a scintillation counter for the sensitive detection of neutrons using Lyman alpha radiation produced by the 3He(n,tp) reaction. The radiation can be detected with high efficiency with an appropriate photo-detector, or alternatively, it can be converted to radiation at longer wavelength by absorption in scintillation materials, with the radiation channeled to a photodetector. Because of the simplicity of the system and the fact that the radiation production mechanisms can be measured and/or calculated independently, the method and/or apparatus also has the potential for service as a calculable absolute detector.

Abstract: A method and device are provided for affinity gradient focusing for directing at least one analyte in a solution containing a pseudostationary phase and located in a channel such as a capillary or a microchannel. The method includes establishing a steady-state spatial gradient in a retention factor of the pseudostationary phase for the at least one analyte. The analyte is caused to be moved within the channel whereby the concentration of the at least one analyte changes at one or more positions along the gradient. The pseudostationary phase is charged and the analyte is either neutral or charged or alternatively, the pseudostationary phase is neutral and the analyte is charged. The device may include a fluid channel, a pseudostationary phase having a retention factor gradient, an electrical current source and a pump system for establishing the bulk flow in the solution in the channel.

Abstract: A system and method are disclosed for producing a source of ions, and particularly, a focused ion beam. The system and method use a magneto-optical trap (MOT) to produce a population of neutral atoms. A laser is then utilized to ionize atoms and produce a population of ions. An extraction element is then used to transfer the ions so that they can be used in a wide array of applications.

Abstract: A system and method for bonding and unbonding of small objects using small adhesive particles. The system and method includes the use of a plurality of optical tweezers to manipulate objects to be bonded and adhesive particles suspended in a fluid. The objects to be bonded (or unbonded) and the adhesive particles are positioned by lower power optical tweezers and then an intense bonding optical tweezer is activated to cause the adhesive to join the objects together (or used to unbond objects).

Abstract: Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.

Abstract: A Gd5Ge2Si2 refrigerant compound is doped or alloyed with an effective amount of silicide-forming metal element such that the magnetic hysteresis losses in the doped Gd5Ge2Si2 compound are substantially reduced in comparison to the hysteresis losses of the undoped Gd5Ge2Si2 compound. The hysteresis losses can be nearly eliminated by doping the Gd5Ge2Si2 compound with iron, cobalt, manganese, copper, or gallium. The effective refrigeration capacities of the doped Gd5Ge2Si2 compound are significantly higher than for the undoped Gd5Ge2Si2 compound.

Abstract: The LED-radiance source is a suitable replacement of lamp-based integrating sphere sources where they are used as stable and uniform radiance sources. The LED-based radiance source includes an array of LEDs having substantially similar radiance output wavelengths and a radiation detector such as a photodiode that detects and monitors radiation directed from the LEDs. Temperature of the LEDs can be controlled by feedback from a photodiode, thereby allowing for control and stabilization of temperature-dependent radiation output.

Abstract: A system and method for using an air collection device to collect a continuous air sample as the device descends through the atmosphere are provided. The air collection device may be one or more coils of thin-walled elongated hollow tubing having a small interior diameter. The thin-walled elongated hollow tubing may be of a substantially nonreactive and nonabsorptive material such as stainless steel. A valve or the like controls the flow of air into and out of the tubing with one of the ends of the tubing closed and the other of the ends open at the beginning or end of the ascent and closed substantially at the end of the descent to seal the continuous air sample in the air collection device. The air collection device may be insulated and have cushioning. Once the continuous air sample is collected in the air collection device, it is analyzed to determine the presence and mole fraction of trace gases at different altitudes in the atmosphere.

Abstract: A method and device are provided for concentrating and separating materials in fluids within a fluidic device having a fluid conduit such as a channel or capillary. The concentration is achieved by balancing the electrophoretic velocity of a material against the bulk flow of fluid in the presence of a temperature gradient. An additive is added to the fluid which interacts with the material and which modifies the normal electrophoretic mobility of the material. Using an appropriate fluid, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity so that the electrophoretic and bulk velocities sum to zero at a unique position along the conduit and the material will be focused at that position. The method and device may be adapted for use with a variety of materials including fluorescent dyes, amino acids, proteins, DNA and to concentrate a dilute material.