Abstract: An extrusion printing process for conductive materials and a conductive material extrusion system. The process includes attaching a counter-electrode to a first side of a substrate. A drive voltage is applied to the counter-electrode and to a conductive material to be extruded onto a second side of the substrate, opposite the first side. The conductive material is extruded onto the second side of the substrate while the drive voltage is being applied to the counter-electrode and conductive material. The conductive material is selected from a metal having a melting point ranging from about ?20° C. to about 150° C.

Abstract: Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.

Abstract: Compositions containing at least one compound of formula I where R1 is a phenolic compound (e.g., simple phenol, creosote, thymol, or carvacrol), and where R2 is a polyamine (e.g., ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA), tetraethylenepentamine (TEPA), hexamethylenediamine (HDA)); and optionally a carrier; the compositions may additionally contain at least one epoxy resin. Methods for killing microorganisms involving contacting the microorganisms with an effective microorganism killing amount of the above composition. Compositions containing at least one compound produced by a method involving reacting phenolic-branched chain fatty acid methyl ester with at least one polyamine.

Abstract: A nonlinear frequency modulated gyroscope includes a degenerate-mode mechanical resonator, positive feedback circuits, a temperature control component, and a gyroscope controller. The degenerate-mode mechanical resonator with two or more modes are coupled via a Coriolis effect. The positive feedback circuits for each mode of the degenerate-mode mechanical resonator include an analog or digital automatic gain control that maintains oscillations of each mode at a constant amplitude. The temperature control component includes a sensor and heating elements. The gyroscope controller is an application-specific integrated circuit, a field programmable gate array, or microcontroller. The degenerate-mode mechanical resonator, the positive feedback circuits, and the temperature control component are subsystems of the nonlinear frequency modulated gyroscope.

Abstract: Immunotherapies, particularly chimeric antigen receptors targeting IL-13R?2 and their use for treating cancer are provided. A single chain fragment variable (scFv) that specifically binds IL-13R?2, chimeric antigen receptors (CARs) including the IL-13R?2 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs are provided. Also provided are methods of treating a subject with cancer, including administering to the subject an immune cell expressing an IL-13R?2 scFv-CAR alone or in combination with other cancer therapies.

Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.

Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

Abstract: Methods of treating a subject with diabetes or Alzheimer's disease with a disclosed insulin isoform or C? polypeptide are provided. Methods of detecting insulin isoforms or C? polypeptides are also provided.

Abstract: A capacitively or inductively driven spiral antenna creates an electric current distribution of a dipole, which generates a sensible magnetic field for various military applications including detecting and pre-detonating improvised explosive devices (IEDs). The antenna includes a dielectric substrate, a spiral antenna, driving elements such as tuning forks or loop, and a coaxial cable that connects to a source terminal. The substrate is a low dielectric loss insulating material to provide support for the antenna. The spiral antenna is tuned to a natural frequency is disposed on the substrate. The coaxial cable extends from the substrate to the source terminal.

Abstract: Provided herein are a Heartland virus vaccine composition including a messenger ribonucleic acid (mRNA) including an open reading frame (ORF) encoding Gn or Gc of Heartland virus, a Heartland virus vaccine composition comprising a messenger ribonucleic acid (mRNA) comprising an open reading frame (ORF) encoding Gn or Gc of Heartland virus fused with human collagen type I alpha 1 (COL1A1) signal peptide, and a method of inducing immune response against Heartland virus by administering an effective amount of the Heartland virus vaccine composition to a subject in need thereof.

Abstract: A two-dimensional quantum light emitting device includes a substrate, two or more monolayers, one or more positive electrodes, and one or more negative electrodes. The substrate grows two or more monolayers on a surface of the substrate. The two or more monolayers have a tunable bandgap ranging from about 477 nm to about 620 nm and have a tunable twist angle. The one or more positive electrodes and the one or more negative electrodes provide a current to an active region of the two or more monolayers and are interdigitated electrodes, non-interdigitated electrodes, piezoelectric electrodes, or a combination thereof that tune the twist angle of the two or more monolayers in-situ.

Abstract: Systems and methods of detecting a vortex made by a travelling object is disclosed. Techniques include positioning a media collector to capture a visual media file of the vortex. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glutamine at position 61 with lysine. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: A connector may couple to a non-cylindrical composite tubing having at least two lateral sides disposed in parallel and an open end. The connector may comprise first and second bonding plates adhered to an inner surface of the two lateral sides via an epoxy adhesive uniformly distributed. The first and second bonding plates may each have a distal lateral face defining a plurality of first threaded holes accessible at the open end of the composite tubing. The connector may also comprise an end plate having a plurality of first and second slotted holes disposed substantially in parallel and each aligned with an associating one of the first threaded holes. The connector may also comprise end plate fasteners loosely inserted through the first and second slotted holes and engaged with the first threaded holes. The end plate may also comprise one or more attachment points.

Abstract: Precision flow restrictors and techniques for manufacturing the same for ion thruster manifolds are disclosed. Flow restricting features are moved out of the manifold base and into separate flow restrictors, allowing a wider range of manufacturing techniques and materials to be applied. Quality control can be performed at the level of the flow restrictors as subcomponents, ensuring that only good parts with ideal flow characteristics make it into the final assembly and improving the yield rate of the final manifold assembly.

Abstract: Systems and methods are provided for interrogating a moving acoustic source using radar and processing data using a selection of motion compensation techniques adapted from synthetic aperture radar (SAR) to remove the effects of linear and nonlinear target motion so that the range-Doppler map retains only vibration information in the Doppler dimension. Vibration and sound waveforms can thus be selectively reproduced at specific ranges directly from the radar baseband waveform, without the need for additional complex analysis or audio processing.

Abstract: Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.

Abstract: A method of making an electrode by providing a mixture of first particles of silver or silver oxide and second particles of an inorganic porogen, molding the mixture, cohering the mixture to form a green body, demolding the green body, heating the green body to form a monolith, to convert any silver oxide to silver, and to fuse the first particles together, and submerging the monolith in a liquid that removes the second particles.

Abstract: Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components.

Abstract: A method and apparatus uses a VLF transmitter, a VLF receiver, and/or a low earth orbit satellite including a rocket engine. A VLF wave transmitted into space is converted to an ambient wave. The ambient wave acts as a signal wave for a whistler traveling wave parametric amplifier. Rocket exhaust is generated in atmospheric plasma. The rocket exhaust includes kinetic energy acting as a Lower Hybrid wave source. The Lower Hybrid wave source produces a Lower Hybrid wave, which acts as a pump wave for the parametric amplifier. Nonlinear mixing of the signal wave and the pump wave in the atmospheric plasma simultaneously parametrically amplifies the ambient wave and generates an idler wave and a parametrically amplified wave. The parametrically amplified wave (1) reduces the density of energetic protons or killer electrons in the Van Allen radiation belt, and (2) improves communications between the VLF transmitter and VLF receiver.