Abstract: The present invention is related to the development of novel compounds and methods for the treatment and/or prevention of malaria. The compounds prevent the formation by the malaria parasite of the plasmodium surface anion channel (PSAC) on the surface of the host cell. The compounds and methods described herein are effective against infection by a wide variety of Plasmodia strains known as the causative agent of malaria.

Abstract: An aspect of the invention provides nucleic acids comprising a nucleotide sequence encoding chimeric antigen receptor (CAR) amino acid constructs. Polypeptides, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CAR constructs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Abstract: Devices, systems and methods are provided for low-power and high-sampling rate of analog signals received from sensors transported by host devices. The devices, systems and methods may be adapted to utilize GPS and PPS signals for synchronization with digitized signals generated based on the sampling of the analog signals that are simultaneously received and processed by multiple channels. Synchronized data packets may be recorded by the disclosed data acquisition systems, and may be further transmitted to host devices and remote devices.

Abstract: Systems and methods for continuous real-time sweat sampling and analysis are disclosed. A sweat collection article and method of collecting sweat from a person's skin using the sweat collection article are provided. The sweat collection article includes: a sweat collecting tube placed adjacent to the person's skin, and at least one piece of flexible material that has an adhesive that adheres the article to the person's skin and is positioned to overlie one end of the tube. The second end of the sweat collecting tube is in fluid communication with an instrument such as a mass spectrometer that analyzes the sweat on a real-time basis. The systems and methods may further include a device for removing salt from the sweat that is arranged so that the sweat is transported to the device prior to being transported to the instrument for analyzing the sweat.

Abstract: Methods and systems to control stacked hexapod platforms for use as tools, which function with both high accuracy and high precision are provided. In some embodiments, the methods and systems include a convergence of modern control theory, and machine learning. Furthermore, some embodiments provide control algorithms to carry out autonomous in-space assembly operations using assemblers. Some embodiments provide methods and systems which combine long-reach low precision manipulators and smaller, high-precision assembler with interchangeable tools.

Abstract: An air purification and recirculation system positioned within an animal rearing/sheltering facility. The system draws untreated air into an elongated air treatment apparatus having a dust scrubbing section, an ammonia scrubbing section, and acid scrubbing section, configured so that the treatment sections are positioned in series. At the end of the air treatment process, the treated air is exhausted back into the animal rearing facility so that the air is circulated within the facility. Acid and water used during the air treatment process are continuously recycled and directed back through the scrubbers in the air treatment apparatus.

Abstract: Disclosed herein are embodiments of a solid support suitable for synthesizing nucleic acid sequences. The solid support may have a structure according to Formula I, where CPG is controlled pore glass, and m, n, x, y, R1 and R2 are as defined herein. Also disclosed are methods for making and using the solid support, kits including solid support, and a universal linker phosphoramidite suitable for use in the solid support.

Abstract: Single-domain antibodies (SAbs) against three Yersinia pestis surface proteins (LcrV, YscF, and F1), nucleic acid sequences encoding the SAbs, and polypeptides comprising two or more SAbs capable of recognizing two or more epitopes and/or antigens. The present invention further includes methods for preventing or treating Y. pestis infections in a patient; methods for detecting and/or diagnosing Y. pestis infections; and devices and methods for identifying and/or detecting Y. pestis on a surface and/or in an environment.

Abstract: Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products.

Abstract: A pegylated, circularly permuted construct of the CapD enzyme (a gamma glutamyl transferase enzyme acting as a hydrolase specific to poly-?-D-glutamic acid) is used to treat anthrax and other bacterial infections, including but not limited to infection with strains that are resistant to available antibiotics.

Abstract: A counter-underwater vehicle apparatus and marker. Moreover, a counter-underwater vehicle apparatus comprising a plurality of entanglement lines; a box configured to contain the plurality of entanglement lines; a suction cup coupled to the box configured to attach the box to a surface of an underwater vehicle; a release mechanism coupled to the box configured to detach the box from a bite plate and release the plurality of entanglement lines; and the bite plate selectively coupled to the release mechanism. Additionally a marker configured to highlight the location of an underwater vehicle, a box configured to contain and release the marker, a suction cup coupled to the box configured to attach to the box a surface of an underwater vehicle, a release mechanism coupled to the box configured to detach the box from a bite plate and release the marker, and the bite plate selectively coupled to the release mechanism.

Abstract: An in-situ bollard tester. The in-situ bollard tester may comprise: a frame, cable, and tensioner. The frame may mount onto a pier and around a bollard to provide structural support for the cable and tensioner. The frame may comprise a pair of base assemblies and a spreader bar. Each of the base assemblies may comprise a support frame and a cantilever arm, and the spreader bar may be coupled to the pair of base assemblies. A pair of jacks are coupled near proximal corners of the base assemblies. The tensioner may comprise a pair of hydraulic arms having first ends coupled near a proximal end of the base assemblies and a linear crossmember coupled to the second ends of the hydraulic arms. The cable may fasten to the bollard, and the tensioner may apply tension to the cable at various load angles in order to test the integrity of the bollard.

Abstract: A composition having the structure of formula I: [R—Ar—(COOH)2]x[Ar—(COOH)3]2-xM32+??(I) is provided where M is Mn, Cu, Co, Fe, Zn, Cd, Ni, or Pt; R is a bromine, nitro, a primary amine, C1-C4 alkyl secondary amine, C1-C4 alkyl oxy, Br—(C1-C4 alkyl), NO2—(C1-C4 alkyl), a mercaptan, and reaction products of any of the aforementioned with acyl chlorides of the formulas: CH3(CH2)mC(O)Cl, or CH3(CH(C1-C4 alkyl)CH2)mC(O)Cl, or CH3(CH2)m-Ph-(CH2)pC(O)Cl, where Ph is a C6 phenyl or C6 phenyl with one or more hydrogens replaced with F, C1-C4 fluoroalkyl, or C1-C4 perfluoroalkyl; m is independently in each occurrence an integer of 0 to 12 inclusive; p is an integer of 0 to 36 inclusive, to form an amide, a thioamide, or an ester; Ar is a 1,3,5-modified phenyl, and 1.4>x>0. A process of synthesis thereof and the use to chemically modify a gaseous reactant are also provided.

Abstract: A coil-on-plug (COP) exciter includes a COP and a housing configured to be coupled to and positioned at least partially between the COP and an engine. The COP exciter also includes an electrode core positioned at least partially within the housing. The electrode core has a first end and a second end. The first end is configured to be coupled to the COP. The COP exciter also includes an electrode tip configured to be coupled to the second end of the electrode core. A voltage is conducted from the COP, through the electrode core, and to the electrode tip, which generates a spark that is configured to energize a first propellant to start the engine.

Abstract: A system and method for securely exchanging information between a server and an endpoint. A firewall and switch may administer connections between the endpoint and the server. The network interface of the server may send and receive information through the firewall and switch. A program task in the sever may set the network interface to be in an “on state” for a predetermined amount of time on a specific date thereby creating an active time transfer window that the network interface can receive communications from the endpoint.

Abstract: A system and method for securely exchanging information between a server and an endpoint. A firewall and switch may administer connections between the endpoint and the server. The network interface of the server may send and receive information through the firewall and switch. A program task in the sever may set the network interface to be in an “on state” for a predetermined amount of time on a specific date thereby creating an active time transfer window that the network interface can receive communications from the endpoint.

Abstract: A system and method for securely exchanging information between a server and an endpoint. A firewall and switch may administer connections between the endpoint and the server. The network interface of the server may send and receive information through the firewall and switch. A program task in the sever may set the network interface to be in an “on state” for a predetermined amount of time on a specific date thereby creating an active time transfer window that the network interface can receive communications from the endpoint.

Abstract: A substrate is printed with front side and back side markings. The front side when viewed with reflected light includes: a first marking printed with a first gradient of two colors; a second marking printed with a second gradient of two colors; a first symbol printed with a third gradient of two colors; a second symbol printed with a fourth gradient of two colors; a third symbol printed with a fifth gradient of two colors; and a fourth symbol printed with a sixth gradient of two colors. The back side when viewed with reflected light includes: a third marking printed with the fourth gradient; a fourth marking printed with the third gradient; a fifth symbol printed with the second gradient; a sixth symbol printed with the first gradient; a seventh symbol printed with the sixth gradient; and an eighth symbol printed with the fifth gradient.

Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.

Abstract: A thermal energy storage (TES) device includes a thermoelectric cooler; and a metallic phase change material (PCM) within the thermoelectric cooler. The PCM may include any of gallium or its alloys, low temperature fusible alloys, and solid metal shape memory alloys. A thermoelectric effect within the PCM is to transport heat in the thermoelectric cooler. The TES device may include a graded oxide layer adjacent to the PCM to serve as a distributed electrical junction in the thermoelectric cooler to create a hot side thermoelectric junction in a bulk volume of the PCM. The graded oxide layer may include ?-IGZO. The TES device may include a high-thermopower corrugated metal foil layer comprising barrier oxides patterned therein. The high-thermopower metal foil layer may be adjacent to the graded oxide layer. The TES device may include a dielectric layer adjacent to the high-thermopower corrugated metal foil layer.