Patents Assigned to United States of America
  • Publication number: 20240124935
    Abstract: Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.
    Type: Application
    Filed: December 27, 2023
    Publication date: April 18, 2024
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Yong-Chen Lu, Peter Fitzgerald, Zhili Zheng, Steven A. Rosenberg
  • Patent number: 11958010
    Abstract: Disclosed is a thermal desorber assembly for desorbing substances collected on a high-volume sampling (HVS) filter. The assembly includes, among other elements, a filter holder for securing a HVS filter within the assembly, a desorber body, and an insulating enclosure. The design of the thermal desorber assembly is such that it can accommodate a variety of different types of HVS filter media. Also described herein is a system comprising the thermal desorber assembly and method of using the assembly.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: April 16, 2024
    Assignees: Signature Science, LLC, Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Joseph A. DiCicco, Paul M. Flanigan, IV, David Perry, John Brady, Barry Smith
  • Patent number: 11958053
    Abstract: A media holder can be used for preparing samples. The media holder can comprise a base, a pair of walls extending upwardly from the base, and a plurality of transverse members positioned on and coupled to a respective upper end of each of the walls. Each of the transverse members can define a receiving slot for receiving at least a portion of a media therein.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: April 16, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Joseph A. DiCicco, Andrew Horan, John Brady
  • Patent number: 11958570
    Abstract: A sandwich cable fairing designed for attachment to cables that are towed at operational speeds by marine vessels. The sandwich cable fairing has a design that combines layers of elastic and damping materials. The fairing dampens the vibration caused when the cable is towed at operational speeds. The outer layers (“bread”) of the fairing are made from a material with a modulus of elasticity that provides a desired amount of stiffness. In the middle of the sandwich cable fairing is damping layer made from a viscoelastic material. The layering of materials allows the fairing to have the flexibility to be crushed by cable equipment while maintaining the requisite stiffness to reducing flapping and the resulting vibration.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: April 16, 2024
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventor: David B Coakley
  • Patent number: 11958747
    Abstract: Disclosed are methods and systems of providing carbon nanotubes decorated with polymer coated metal nanoparticles. Then, annealing the metal coated carbon nanotubes to reduce a quantity of hydrophilic components of the polymer coating.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: April 16, 2024
    Assignees: SRI INTERNATIONAL, UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NASA, BAY SYSTEMS CONSULTING, INC.
    Inventors: Gabriel Iftime, Beomseok Kim, Clinton J. Smith, Eric D. Cocker, Junhua Wei, David Eric Schwartz, Meyya Meyyappan, Rahul Pandey, Yong Zhang
  • Patent number: 11960808
    Abstract: A computer-implemented method for deriving resistance, inductance, and capacitance (RLC) values of an RLC equivalent circuit model associated with a fireset.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: April 16, 2024
    Assignee: The United States of America, as represented by Secretary of the Navy
    Inventors: Ciarra Villa, Gabriel Soto
  • Patent number: 11960710
    Abstract: Ways to provide information via dynamic user interfaces including Dynamic InfoGraphics (DIG) are described. DIG representations may include various elements, such as text, icons and other graphics, tags, links, etc. and may be implemented via various types of displays or operating environments. Users may include, for example, pilots, soldiers, commanders, drivers, game players, etc. Information provided via DIG may include, for instance, data received from various types of sensors, communications received from other parties or resources, calculated or otherwise determined information (e.g., predictions associated with artificial intelligence (AI) resources such as autonomous or semi-autonomous intelligent agents), and/or other appropriate information (e.g., user inputs). The received information may be applied to one or more DIG representations or templates. AI features may be used to predict future actions, paths, goals or targets, etc.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: April 16, 2024
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Regina A. Hartnett
  • Patent number: 11962079
    Abstract: The embodiments include an array in intimate adjacent contact with a substrate foundation. The array has a plurality of radio frequency (RF) witness films overlain on the substrate foundation. Each RF witness film is a unit cell defined in a three-dimensional coordinate frame of reference, and is centered at an origin of the three-dimensional coordinate frame of reference. Each RF witness film in the plurality of RF witness films is equally-spaced from adjacent RF witness films.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: April 16, 2024
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Zachary A. Sechrist, Christopher G. Yelton, Mark B. Moran, Linda F Johnson, Joseph E. Estevez, Gretchen H. Hefley
  • Patent number: 11958841
    Abstract: Benzoxazine compounds, methods of making them, polymers made therefrom and methods of polymerizing the benzoxazines. These renewable benzoxazine monomers and polymers that utilize the variety of building blocks found in renewable plant biomass, demonstrate excellent processability and large temperature windows for processing of resin systems.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: April 16, 2024
    Assignees: Drexel University, The United States of America as represented by The Secretary of the Army
    Inventors: Giuseppe R. Palmese, Santosh K. Yadav, John J. LaScala
  • Patent number: 11959711
    Abstract: A recoilless gun system, comprising a gun assembly and associated ammunition for use with the gun assembly employs an integral barrel and a rear inserted ammunition round. The recoilless gun system may combine a laser initiator and a polymer cased ammunition to enable a lightweight system. In such embodiments, the cartridge case is made from a polymer that resists high pressure before extruding into small gaps.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: April 16, 2024
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Frank Dindl, Kenneth Jones
  • Patent number: 11957453
    Abstract: Various embodiments are directed to systems, apparatus and methods configured for anthropometrics data/measurement acquisition such as for fitment of handguns, hand tools, weapons and the like.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: April 16, 2024
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Jim A. Faughn
  • Patent number: 11959096
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 16, 2024
    Assignees: The Medical College of Wisconsin, Inc., The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services NIH, Office of Technology Transfer
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Patent number: 11959592
    Abstract: A self-adjusting band that includes one or more banding segments, one or more buckling assemblies, a pair of one pin and two links for each buckle assembly, a rotary joint base for each pair of one pin and two links, and a high-load, low-deflection compression spring for each section of the buckle assembly.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: April 16, 2024
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventors: Carl E Lostrom, Gregory A Jaccard
  • Publication number: 20240118372
    Abstract: Disclosed are methods and apparatus for recording time, latitude, longitude, frequency, and amplitude data to ascertain information about the radio frequency (RF) environment (e.g., RF emitter locations), where the apparatus is also easily transportable. The location determination method using this simple hardware solution may occur in two processes or phases: (1) a data collection phase; and (2) a data processing phase, although these two phases may also be combined in time for a real time solution. During the data collection phase, a user may select a desired frequency range and step size for analysis. A software defined radio (SDR) sweeps through the desired frequencies and records the amplitude associated with each frequency. Each of the recorded points are stamped with their time and geolocation (i.e., latitude and longitude coordinates) and processed using amplitude measurements to ascertain the locations of unknown emitters.
    Type: Application
    Filed: July 28, 2023
    Publication date: April 11, 2024
    Applicant: The United States of America, as represented by the Secretary of the Navy
    Inventors: Ryan Loehrlein, Timothy Ringwald, Kimberly Gold, Jeffrey A. Miller
  • Publication number: 20240120201
    Abstract: A technique for selective-area diffusion doping of III-N epitaxial material layers and for fabricating power device structures utilizing this technique. Dopant species such as Mg are introduced into the III-N material layer and are diffused into the III-N material by annealing under stable or metastable conditions. The dopant species can be introduced via deposition of a metal or alloy layer containing such species using sputtering, e-beam evaporation or other technique known to those skilled in the art. The dopant material layer is capped with a thermally stable layer to prevent decomposition and out-diffusion, and then is annealed under stable or metastable conditions to diffuse the dopant into the III-N material GaN without decomposing the surface.
    Type: Application
    Filed: March 31, 2023
    Publication date: April 11, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Travis J. Anderson, Mona A. Ebrish, Alan G. Jacobs, Karl D. Hobart, Francis J. Kub
  • Publication number: 20240115261
    Abstract: A surgical clamp for aligning the margins of incised or wounded tissue has jaws with parallel clamping faces, and a handle for manipulating the clamp to align the margins of the tissue. The jaws are in a normally closed position, however they can be opened by compressing the handle to open the jaws. Prongs project from the inferior surface of the jaws. The clamp is positioned in a desired position over the margins of a wound to be closed, the prongs engage the margins of the wound to be aligned, and the jaws are closed by releasing compressive force on the handle. As the jaws close the prongs help move the tissue into alignment. Suture guide slots through the jaws assist in the placement of precisely placed sutures across the incision. The disclosed surgical clamp is particularly suited for selectively closing and reopening surgical incisions, such as a sclerotomy incision in the eye. Methods are disclosed for using the clamp during intraocular and other surgical or minimally invasive procedures.
    Type: Application
    Filed: July 25, 2023
    Publication date: April 11, 2024
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Vladimir R. Khristov, Steven T. Charles, Juan A. Amaral, Arvydas Maminishkis, Kapil Bharti
  • Publication number: 20240118137
    Abstract: Provided is a gyroscope stabilized gimbal assembly for collecting and timestamping video data and laser measurement data. The assembly can be used on multiple platforms and provides an ISR video camera system and one or more laser measurement devices, including photodetectors, thermopiles, filters, and analog to digital converters. The components are mounted to a bracket that can be installed and removed from the assembly to collect/record measurement data from the devices interacting with the laser beam. A processor collects and records measurement data from the devices interacting with the laser beam and calculates optical power data, irradiance data, and wavelength data. A storage device stores a first set of data comprising video data from said camera system and a second set of data comprising optical power data, irradiance data, and wavelength data, wherein said first and second set of data are timestamped, separated, and not comingled.
    Type: Application
    Filed: May 15, 2023
    Publication date: April 11, 2024
    Applicant: The United States of America, as represented by the Secretary of the Navy
    Inventors: Marshall Mullins, Charles Upton, Tyler Fitzsimmons, Joseph Morris
  • Publication number: 20240118144
    Abstract: Methods providing distributed temperature and strain measurements are disclosed. Brillouin pump laser pulses having a Brillouin pump frequency are coupled into a first end of an optical fiber. Brillouin Stokes and Anti-Stokes probe laser beams are coupled into a second end of the fiber. The Stokes probe laser beam has a Stokes probe frequency. The Anti-Stokes probe laser beam has an Anti-Stokes probe frequency. The Stokes and Anti-Stokes probe frequencies and the pump frequency are included in a Brillouin frequency band. A train of Rayleigh seed pulses are coupled into the fiber. Each of the seed pulses of the train has a respective different frequency included in a Rayleigh frequency band. Frequencies of the Brillouin frequency band are coupled to a Brillouin detector, and Rayleigh backscatter signals are coupled to a Rayleigh detector. Brillouin and Rayleigh detector outputs are used to calculate the measurements. Related sensors are also disclosed.
    Type: Application
    Filed: September 26, 2023
    Publication date: April 11, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Matthew Joseph Murray, Joseph Brady Murray, Hannah Marie Ogden, Brandon F. Redding
  • Publication number: 20240119734
    Abstract: The invention is a system and method for efficient filtering, clustering, tracking and persistent motion detection for event cameras. More particularly, embodiments of the present invention combine compatible asynchronous event filtering and clustering techniques in a computationally efficient way to identify and track objects in the field of view that exhibit persistent motion characteristic of marine vessels, cars, aircraft, and other vehicles while ignoring dynamic background elements that move in a more erratic fashion.
    Type: Application
    Filed: October 11, 2022
    Publication date: April 11, 2024
    Applicant: United States of America as represented by the Secretary of the Navy
    Inventors: Stephanie Lilith Aelmore, Richard Christopher Ordoñez
  • Patent number: D1022461
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 16, 2024
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Shea T. Martin, Peter J Voland, Patrick E. Assef