Abstract: Methods and systems for treating anxiety disorders and disorders with psychotic features include implanting at least one electrode in the patient so as to contact a predetermined region of the brain, coupling the at least one electrode to a signal generating source and transmitting an electrical signal from the source to the predetermined region of the brain through the at least one electrode. In one aspect, the predetermined region of the brain is the amygdala, and more specifically, the basolateral nucleus.
Type:
Application
Filed:
December 2, 2010
Publication date:
November 15, 2012
Applicants:
United States Government Department of Veterans Affairs, The Regents of the Univeristy of California
Inventors:
Jean-Philippe Langevin, Scott E. Krahl, Antonio Alfonso Ferreira Desalles
Abstract: A material distribution measuring device (1) for measuring a reaction distribution or a concentration distribution of a material contained in a solution.
Type:
Grant
Filed:
October 10, 2008
Date of Patent:
October 30, 2012
Assignee:
National Univeristy Corporation Okayama Univeristy
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic Channel length. The present invention also includes a method of using said device for separating at least one cell type.
Abstract: A hybrid powertrain system includes reciprocating free-piston internal combustion engines, each including a linear alternator device configured to generate electric power. A control module determines mechanical and electrical power demands responsive to an operator torque request and a state of charge of an energy storage device. The control module operates the torque machine to generate an output torque responsive to the mechanical power demands and operates the reciprocating free-piston internal combustion engines to generate electric power responsive to the electrical power demands.
Type:
Grant
Filed:
July 16, 2009
Date of Patent:
September 11, 2012
Assignees:
GM Global Technology Operations LLC, The Regents of the Univeristy of Michigan
Inventors:
Paul M. Najt, Tang-Wei Kuo, Rodney B. Rask, Aristotelis Babajimopoulos, Zoran S. Filipi, George Lavoie, Dionissios N. Assanis
Abstract: Object: To provide a thermostable L-ribose isomerase. Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose.
Type:
Grant
Filed:
March 26, 2007
Date of Patent:
July 24, 2012
Assignees:
National University Corporation Kagawa Univeristy, Rare Sugar Production Technical Research Laboratories, LLC., Matsutani Chemical Industry Co., Ltd.
Inventors:
Ken Izumori, Kenji Morimoto, Goro Takata, Masaaki Tokuda, Yoshio Tsujisaka, Kei Takeshita, Keiji Tsusaki, Kazuhiro Okuma
Abstract: The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or portion thereof.
Abstract: A ceramic material has a perovskite structure and is represented by formula of (1?x)ABO3-xYZO3. In the formula, “x” is a real number that is greater than 0 and is less than 1 each of “A,” “B,” “Y,” and “Z” is one or more kinds selected from a plurality of metal ions M other than a Pb ion and alkali metal ions, “A” is bivalent, “B” is tetravalent, “Y” is trivalent or combination of trivalent metal ions, and “Z” is bivalent and/or trivalent metal ions, or a bivalent and/or pentavalent metal ions.
Type:
Grant
Filed:
July 6, 2010
Date of Patent:
June 5, 2012
Assignees:
Denso Corporation, The Univeristy of Tokyo
Abstract: A method of setting a number of iteration counts of iterative decoding, and an apparatus and method of iterative decoding. The iterative decoder including a signal-to-noise ratio (SNR) estimation unit that estimates an SNR of a received signal, an iterative decoding count setting unit that sets a minimum number of iteration counts for the received signal based on the estimated SNR, and a decoding unit that iteratively decodes the received signal using tentative decoding and error check, and selectively performs the error check based on the minimum number of iteration counts.
Type:
Application
Filed:
October 12, 2009
Publication date:
May 24, 2012
Applicant:
Industry-University Cooperation Foundation Hanyang Univeristy
Abstract: One aspect of the present invention is directed to search receptors based on the information of HN signaling pathways in order to find Humanin receptor or Humanin-like polypeptide receptor (HNR), and to reveal a mechanism of promoting or suppressing the intracellular signal transduction for neuroprotecting activity of HN and identify a compound involved in the mechanism. The aspect of the invention is directed to a method for screening of HNR agonist and HNR antagonist, to utilize the screened compound in development of a drug for the treatment of neurodegenerative disease, and to provide an assay system of AD neuronal cell death, and to provide methods for the compulsory expression of HNR gene or knocking-out of intracellular genes.
Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.
Type:
Application
Filed:
August 19, 2009
Publication date:
May 3, 2012
Applicant:
The Regents of the Univeristy of California
Inventors:
Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark A. Eddings, Clifton Kwang-Fu Shen
Abstract: An enhancement mode (E-mode) HEMT is provided that can be used for analog and digital applications. In a specific embodiment, the HEMT can be an AlN/GaN HEMT. The subject E-mode device can be applied to high power, high voltage, high temperature applications, including but not limited to telecommunications, switches, hybrid electric vehicles, power flow control and remote sensing. According to an embodiment of the present invention, E-mode devices can be fabricated by performing an oxygen plasma treatment with respect to the gate area of the HEMT. The oxygen plasma treatment can be, for example, an O2 plasma treatment. In addition, the threshold voltage of the E-mode HEMT can be controlled by adjusting the oxygen plasma exposure time. By using a masking layer protecting regions for depletion mode (D-mode) devices, D-mode and E-mode devices can be fabricated on a same chip.
Type:
Application
Filed:
June 29, 2010
Publication date:
April 26, 2012
Applicant:
Univeristy of Florida Research Foundation Inc.
Inventors:
Chih-Yang Chang, Fan Ren, Stephen John Pearton
Abstract: Disclosed is a lithium-sulfur polymer battery having a anode and a cathode separated by an electrolyte formed by a membrane containing a solution of a lithium salt in aprotic organic solvents with the addition of lithium sulfide and/or lithium polysulfides until saturation, this solution being trapped in a polymer matrix.
Type:
Application
Filed:
April 8, 2010
Publication date:
April 19, 2012
Applicant:
IUCF-HYU (Industry-University Cooperation Foundation Hanyang Univeristy)
Abstract: Positive contrast localization of magnetic (e.g. superparamagnetic) particles in vivo or in vitro by means of SWIFT-MRI using the imaginary component of MR image data in combination with an anatomic reference image derived from the real or magnitude component.
Type:
Application
Filed:
April 1, 2010
Publication date:
April 19, 2012
Applicant:
Regents of the Univeristy of Minnesota
Inventors:
Curtis A. Corum, Djaudat S. Idiyatullin, Steen Moeller, Michael G. Garwood
Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
Type:
Application
Filed:
November 22, 2011
Publication date:
April 19, 2012
Applicant:
The Board of Trustees of the Leland Standford Junior Univeristy
Inventors:
Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Rene A. Reijo-Pera, Barry Behr
Abstract: A copper line having self assembled monolayer for use in ULSI semiconductor devices and methods of making the same are presented. The copper line includes an interlayer dielectric, a self-assembled monolayer, catalytic particles on the monolayer, and a copper layer on the monolayer with the catalytic particles. The method includes the steps of forming an interlayer dielectric on a semiconductor substrate having a metal line forming region; forming a self-assembled monolayer on the metal line forming region; adsorbing catalytic particles on the self-assembled monolayer; forming using an electroless process a copper seed layer on the self-assembled monolayer having the catalytic particles adsorbed thereto; and forming a copper layer on the copper seed layer to fill in the metal line forming region.
Type:
Application
Filed:
December 1, 2011
Publication date:
March 29, 2012
Applicants:
IUCF-HYU (Industry-Univeristy Cooperation Foundation Hanyang University), Hynix Semiconductor Inc.
Inventors:
Seung Jin YEOM, Jae Hong KIM, Sung Goon KANG, Won Kyu HAN
Abstract: Disclosed are a luminescence biotin-transition metal complex conjugate and a method of amplifying signals using the same. More particularly, disclosed herein are a luminescence biotin-transition metal complex conjugate comprising an energy acceptor and biotin, and optionally an energy donor and a method of amplifying signals using the biotin-transition metal complex conjugate using intramolecular energy transfer. The luminescence biotin-transition metal complex conjugate using a transition metal probe provides a phosphorescence detection system capable of improved sensitivity.
Type:
Grant
Filed:
February 12, 2009
Date of Patent:
February 28, 2012
Assignees:
Samsung Electronics Co., Ltd., Seoul National Univeristy Industry Foundation
Inventors:
Tae-hyuk Kwon, Jong-chul Kwon, Jong-in Hong
Abstract: The present invention includes methods of influencing the sex chromosome ovulated by a female bird and altering the sex ratio in avian offspring by altering the exposure of an ovulating female bird to one or more stress hormones.
Abstract: The present invention provides for up- and down-regulation of cellular autophagy, e.g., for treating cancer or neurological disease. The invention results, in part, from discovery of two novel proteins, ATG14L (previously called “BISC”) and Rubicon (previously called “BIRC”), which bind to a Class III phophatidylinositol 3?-kinase (PI3K)/Vps34-Beclin 1 autophagic complex. ATG14L and Rubicon each regulate autophagic activity in an opposing manner. ATG14L and Rubicon can be used, for example, to increase/decrease autophagic activity, to increase/decrease PI3K/Vps34 kinase activity, and in so doing, treat diseases and disorders, such as cancer, neurodegenerative disease, stroke, metabolic disease, and age-related disease. ATG14L can increase autophagic activity and PI3K/Vps34 kinase activity; and Rubicon can decrease autophagic activity and PI3K/Vps34 kinase activity.
Type:
Application
Filed:
March 11, 2011
Publication date:
February 16, 2012
Applicants:
The Rockefeller Univeristy, Mount Sinai School of Medicine of New York University
Abstract: A moisture-curable, silane-modified oil is disclosed. The silane-modified oil includes an unsaturated oil having at least one unsaturated aliphatic hydrocarbon chain per molecule of the unsaturated oil, and at least one hydrolysable silyl group grafted to the unsaturated aliphatic hydrocarbon chain. The silane-modified oil has a degree of unsaturation that is substantially similar that of the unsaturated oil. A process for forming the moisture-curable, silane-modified oil according to the disclosure includes reacting the unsaturated oil with an unsaturated hydrolysable silane in the presence of a free radical initiator. Also disclosed is a cured silane-modified oil which includes the reaction product of the silane-modified oil and water. Compositions according to the disclosure have relatively low viscosities (facilitating their application to a substrate) and have relatively high levels of silane grafting (resulting in non-leaching cured compositions with a high gel content).
Type:
Grant
Filed:
October 6, 2008
Date of Patent:
February 7, 2012
Assignees:
Board of Trustees of Michigan State Univeristy, Bioplastic Polymers and Composites, LLC
Inventors:
Ramani Narayan, Daniel Graiver, Kenneth W. Farminer, Madhusudhan Srinivasan