Abstract: A oil-in-water curcumin nanoemulsion that includes curcumin dissolved in at least one miscible solvent and encapsulated in an oil core, wherein the oil core also comprises a stabilizer, wherein the oil core forms an organic phase which is dispersed in an aqueous solvent, and wherein the oil core is selected from a pharmaceutically acceptable oil. A method of manufacturing an oil-in-water curcumin nanoemulsion includes dissolving the curcumin in at least one miscible solvent; encapsulating the curcumin in the oil core to produce an organic phase solution; adding the stabilizer to the organic phase solution; dispersing the organic phase solution in the aqueous solvent; and evaporating the mixture. A method of preventing metastatic cancer using an oil-in-water curcumin nanoemulsion by administering an amount of the nanoemulsion topically to an area of an excised primary tumor, and monitoring any reincidence of metastatic cancer in the excised primary tumor area.

Abstract: The present invention presents a sequence of the AAV/UPR-plus virus, a genetic treatment method and its use in the treatment of neurodegenerative diseases, such as Parkinson's and Huntington's diseases, among others, as presented in the in vitro studies shown in FIG. 14/17.

Abstract: The present invention relates to the field of genetic engineering, preferably the expression of recombinant proteins (RP). In particular, the invention relates to a promoter and variants thereof having an equal function and more than 90% sequence identity. The promoter comprises a fragment of 1147 base pairs (bp) of a first promoter, promoter of the ?-actin gene of the Cricetulus griseus genome, enriched in cytosine-guanine dinucleotides (RegCG). The first promoter can be upstream of a second promoter, cytomegalovirus (CMV) promoter. The invention also relates to vectors, transfected cellular lines and a method for producing RP in mammal cells that have been transfected with vectors containing said promoter or variants thereof.

Abstract: In one aspect, provided herein is a nanocarrier composition for formulating a hydrophilic and aromatic low molecular-weight drug (HALMD), the composition comprising: an aromatic polymer; and a hydrophilic and aromatic low molecular-weight drug (HALMD); wherein the aromatic polymer has a positive or negative charge or is a zwitterion, and the hydrophilic and aromatic low molecular-weight drug (HALMD) has an opposing positive or negative charge or is a zwitterion; and wherein the composition has a size of between 50-400 nm and optionally, a zeta potential of from +100 to ?100 mV. A method for preparing the nanocarrier composition, as well as pharmaceutical compositions and therapeutic uses thereof, are also disclosed.

Abstract: This invention presents a sequence of the virus AAV/XBP1s-HA, method and its use in the improvement of cognitive functions, of memory and of learning, as presented in the in vivo studies in FIG. 12/17 right panel.

Abstract: The present invention provides pyrimidine-isoquinolin-quinone derivatives of formula I, their salts, isomers, pharmaceutically acceptable tautomers; pharmaceutical composition; preparation procedure; and their use in the treatment of bacterial and resistant bacterial diseases, such as methicillin-resistant Staphylococcus aureus (MRSA), intermediate vancomycin-resistant Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), vancomycin-resistant Enterococcus spp. (VRE), Enterococcus faecalis, Emerging Staphylococcus aureus with resistance to linezolid and/or bacterial strains not susceptible to daptomycin. Where the radicals R1, R2, R3, R4 and R5 are as defined in the work specifications of the present invention.

Abstract: The invention relates to a bactericide composition based on bacteriophages for the control of black plague in plants or parts thereof, preferably walnuts, a preparation method and application. The invention provides methods for the isolation, propagation and application of bacteriophages against phytopathogens affecting trees/plants that are of commercial interest for their fruit, flowers etc., for the prevention, treatment or reduction of signs, in particular, for Xanthomonas A. pv juglandis in walnuts.

Abstract: The present invention relates to a system for the production of carbon nanotubes from carbonaceous matter, preferably, plastic waste and solar energy; Method of production.

Abstract: A peptide sequence of a guide protein for the production of a peptide of interest; a peptide sequence that has a similarity of at least 90% to SEQ. ID. NO 1; a nucleotide sequence encoding the guide protein; an expression vector comprising the nucleotide sequence; a host cell that expresses a fusion protein comprising a peptide of interest; a method of production of a peptide of interest, comprising the steps of A) constructing an expression vector; B) inserting the expression vector into a host cell; C) expressing the fusion protein, culturing the host cell in a culture medium; D) recovering the accumulated fusion protein in the host cell; E) cleaving the fusion protein; F) purifying the peptide of interest.

Abstract: The invention relates to a magneto-centrifugal flotation cell for ore concentration which reduces water consumption. A disadvantage of conventional flotation cells is the use of a large amount of water, some flotation cells requiring at least 60% water. The present invention uses ore pulp with increased density and viscosity, owing to the application of an axial magnetic field, wherein the Lorentz force, which is the force exerted by an electromagnetic field that receives a charged particle or an electrical current, can be used. The solution is a cell which, in addition to the forces that usually act on conventional flotation cells, uses external forces which, in principle, produce synergy in the separation of ore particles that have different gravitational and magnetic properties.

Abstract: Vaccines of preferential administration via mucous membranes, for the control of viral diseases generated by infectious agents that use heparan sulfate (HS) as a cellular receptor consisting of an immunogenic formulation for veterinary use, comprising an antigen whose cellular receptor is heparan sulfate (HS), a vehicle for oral, intranasal or parenteral administration, wherein said vehicle corresponds to D-glucosamine and functionalized N-acetyl-D-glucosamine biopolymers, with sulfur atoms, and/or functionalized chitosan biopolymer, with sulfur atoms, and where the antigen is microencapsulated by said types of functionalized biopolymers.

Abstract: The invention is an ex vivo method for early detection of acute kidney injury in critical patients, which includes the measurements of fibroblast growth factor 23 (FGF23), klotho (KL) and erythropoietin (EPO) as biomarkers. These measurements are obtained from a venous blood sample or urine, and allow the determination of the following indicators: 1=([FGF23]p×[EPO]p); 2=([FGF23]p/[Klotho]p); 3=([EPO]p)/[Klotho]p); 4=([FGF23]p×[EPO]p)/[Klotho]p); where [X]p is defined as the plasma level of a specific molecule (X) which includes fibroblast growth factor 23 (FGF23), klotho (KL) or erythropoietin (EPO). If the value of the indicator 1, 2, 3, 4 or two or more thereof, is equal or higher than a cut-off point (10 U), the indicator and/or indicators allow the identification of patients with high risk of developing AKI, with a high sensitivity/specificity.

Abstract: The present invention concerns a new biomaterial used to manufacture antimicrobial dental devices, intended to control the growth of microorganisms in the oral cavity. These include removable dentures (RD) with copper nanoparticles technology and antimicrobial properties against dental pathogens, such as: Candida albicans, a pathogen responsible for denture stomatitis; Pathogenic Streptococcus mutans, responsible for the initiation and progression of caries formation; and Staphylococcus aureus, which causes periprosthetic infections. This removable dental material allows for the production of a new dental device to prevent and/or control oral infections caused by said pathogens, such as denture stomatitis, secondary caries, periodontal diseases, among others.

Abstract: The present invention relates to an antibacterial composition which, when applied to the surface of a tooth, allows remineralisation of the enamel to occur, said composition having very low toxicity for human use. When applied, the composition leaves no stains and does not alter the visible colour characteristics of the teeth to which it has been applied.

Abstract: This patent concerns a compact and portable system for real-time detection and location of electromagnetic emissions in the spectrum used by mobile devices (cell phones and Wi-Fi/Bluetooth devices). The principle of detection and location is based on phased array technology, which enables the synthesis of a directional radiation beam that can be electrically controlled in terms of both its shape and direction. This technology is used primarily in military and astronomical applications. The device also includes localization and control algorithms. This device will allow for detecting and locating electromagnetic emissions by means of an antenna beam scan within a field of view of 80×80 degrees. Once the detection and location have been established, the results are overlaid to a visual image captured by a video camera.

Abstract: The present invention relates to a method for removing dyes from textile effluents and other organic substances using nanocomposites based on zinc hydroxides and carboxylic acids capable of adsorbing and degrading. More specifically, the present invention consists of a method to generate new zinc hydroxide-based materials, which allows removal and degradation of methylene blue and other organic compounds from wastewater from industrial effluents, particularly those from textile industry.

Abstract: Vaccines of preferential administration via mucous membranes, for the control of viral diseases generated by infectious agents that use heparan sulfate (HS) as a cellular receptor consisting of an immunogenic formulation for veterinary use, comprising an antigen whose cellular receptor is heparan sulfate (HS), a vehicle for oral, intranasal or parenteral administration, wherein said vehicle corresponds to D-glucosamine and functionalized N-acetyl-D-glucosamine biopolymers, with sulfur atoms, and/or functionalized chitosan biopolymer, with sulfur atoms, and where the antigen is microencapsulated by said types of functionalized biopolymers.

Abstract: The present invention presents a sequence of the AAV/UPR-plus virus, a genetic treatment method and its use in the treatment of neurodegenerative diseases, such as Parkinson's and Huntington's diseases, among others, as presented in the in vitro studies shown in FIG. 14/17.

Abstract: A new and distinct variety of nectarine tree named ‘Andes Nec-5’ with high vigor, which produces a nectarine with a slow pulp softening rate during the last two weeks before a commercial harvest, the nectarine has a high postharvest life potential, the nectarine is round, symmetrical, it is white in flesh color and most of the nectarine surface is covered by 90 to 100% red blush, and the nectarine has a balanced acid/sweet flavor.

Abstract: A new and distinct variety of nectarine tree named ‘Andes Nec-6’ with medium vigor, which produces a nectarine with a slow pulp softening rate during the last two weeks before a commercial harvest, the nectarine has a high postharvest life potential, the nectarine is broad elliptic, moderately asymmetric, the nectarine has white flesh and the surface of its skin is cream yellow with 70 to 80% of its skin being covered by mottled red blush, and the nectarine has a balanced acid/sweet flavor.