Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Grant
Filed:
June 6, 2022
Date of Patent:
April 22, 2025
Assignees:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPUBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, Maria Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
April 24, 2024
Publication date:
March 27, 2025
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Gérman Adrian Galliussi López, Mária Pia Garat Nuñez
Abstract: A hybrid graphene material and a filter capable of retaining, in whole or in part, polyaromatic hydrocarbons, carbonyl and other smoke compounds from tobacco products or industrial processes, having as adsorbent substances activated carbon and graphene materials, both supported by the same matrix and in the same filter compartment, which may or may not be attached to another conventional filter compartment of cellulose acetate fibers or similar polymer, and a method for manufacturing such material.
Type:
Grant
Filed:
March 3, 2020
Date of Patent:
March 18, 2025
Assignees:
COMPANIA INDUSTRIAL DE TABACOS MONTE PAZ S.A., UNIVERSIDAD DE LA REPUBLICA
Inventors:
Tomás Bense Candela, Magela María Banchero Isasmendi, Eleuterio Francisco Umpiérrez Vázquez, Cristina Rufener, Juan Pablo Villanueva, Helena Pardo, Ricardo Faccio, Alvaro Mombrú
Abstract: The invention relates to self-assembling multimeric recombinant proteins composed of a plurality of polypeptide subunits, and a plurality of immunogens derived from the Bm86 protein of Tick, and their applications for preventing, and controlling Tick infestations in a subject. The invention also relates to methods for engineering and producing the self-assembling multimeric recombinant proteins.
Type:
Application
Filed:
September 12, 2024
Publication date:
March 13, 2025
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Matias Machado, Agustin Correa, Janaina Joselin Lasalvia, Maria Soledad Valledor, Oscar Correa, Laura Decia, Uruguaysito Benavides, Alejandra Navratil, Nahuel Santana
Abstract: This invention relates to the use of nitroalkene derivatives for the treatment of neurodegenerative conditions in mammals in which neuroinflammation is a contributing factor, such as in amyotrophic lateral sclerosis (ALS).
Type:
Application
Filed:
December 1, 2023
Publication date:
November 28, 2024
Applicants:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPÚBLICA
Inventors:
Luis Barbeito, Emiliano Trias, Sofia Ibarburu, Carlos Batthyány, Carlos Escande, Gloria Virginia López, Williams Arturo Porcal Quinta, Mariana Ingold, Lucia Colella
Abstract: A method of estimating speech intelligibility is disclosed. The method comprises the steps of providing at least a first time-dependent signal derived from a first auditory stimulus and a corresponding first measured EEG response; comparing at least part of the first signal with at least part of the first measured EEG response in order to determine a signal-response latency difference; comparing the signal-response latency difference to a reference value; and deriving a measure of speech intelligibility based on the comparison of the signal-response latency difference and the reference value.
Type:
Application
Filed:
October 2, 2020
Publication date:
February 15, 2024
Applicants:
Katholieke Universiteit Leuven, Universidad de la Republica
Inventors:
Francisco Cervantes Constantino, Tom Francart, Jonas Vanthornhout
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
March 29, 2023
Publication date:
November 2, 2023
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Gérman Adrian Galliussi López, Mária Pia Garat Nuñez
Abstract: The invention relates to methods for improving abiotic stress tolerance (and/or yield) in plants, including enhanced drought tolerance. It discloses nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing the same, and methods of using the same for increasing abiotic stress tolerance (and/or yield).
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
April 4, 2023
Assignees:
INSTITUTO NACIONAL DE INVESTIGACION AGROPECUARIA, UNIVERSIDAD DE LA REPUBLICA, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS, ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRES
Inventors:
Julio Omar Borsani Cambón, Esteban Casaretto De Gregorio, Juan Pablo Gallino Malcuori, Andrea Luciana Fleitas Belamendia, Maria Victoria Bonnecarrère Martinez, Atilio Pedro Castagnaro, Esteban Mariano Pardo, Sabina Vidal Macchi
Abstract: The invention comprises a device and method to estimate the elasticity of soft elastic solids from surface wave measurements. The method is non-destructive, reliable and repeatable. The final device is low-cost and portable. It is based in audio-frequency shear wave propagation in elastic soft solids. Within this frequency range, shear wavelength is centimeter sized. Thus, the experimental data is usually collected in the near-field of the source. Therefore, an inversion algorithm taking into account near-field effects was developed for use with the device. Example applications are shown in beef samples, tissue mimicking materials and in vivo skeletal muscle of healthy volunteers.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
January 24, 2023
Assignee:
UNIVERSIDAD DE LA REPUBLICA
Inventors:
Nicolás Benech, Gustavo Grinspan, Sofía Aguiar, Carlos Negreira
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Application
Filed:
June 6, 2022
Publication date:
September 22, 2022
Applicants:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPÚBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, Maria Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
August 2, 2022
Assignees:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPÚBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
March 30, 2021
Publication date:
July 15, 2021
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Gérman Adrian Galliussi López, Mária Pia Garat Nuñez
Abstract: This invention relates to the use of nitroalkene derivatives for the treatment of neurodegenerative conditions in mammals in which neuroinflammation is a contributing factor, such as in amyotrophic lateral sclerosis (ALS).
Type:
Application
Filed:
October 26, 2020
Publication date:
April 29, 2021
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Luis Barbeito, Emiliano Trías, Sofía Ibarburu, Carlos Batthyány, Carlos Escande, Gloria Virginia López, Williams Arturo Porcal Quinta, Mariana Ingold, Lucia Colella
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Application
Filed:
December 23, 2020
Publication date:
April 15, 2021
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Grant
Filed:
August 7, 2019
Date of Patent:
February 2, 2021
Assignees:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPUBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
September 20, 2019
Publication date:
May 21, 2020
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Application
Filed:
January 17, 2020
Publication date:
May 14, 2020
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Grant
Filed:
October 16, 2017
Date of Patent:
January 21, 2020
Assignees:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Application
Filed:
August 7, 2019
Publication date:
November 28, 2019
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Application
Filed:
December 27, 2017
Publication date:
June 27, 2019
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella