Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
Type:
Application
Filed:
September 26, 2013
Publication date:
June 26, 2014
Applicants:
INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FACULTAD DE MEDICINA UNIVERSIDAD DE LA REPUBLICA, INSTITUTO DE INVESTIGACIONES SIOL. CLEM. ESTASLE
Inventors:
Luis BARBEITO, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
Abstract: A process of preparing magnetic graphitic materials from graphite in a second container (3) that reacts with one of more transition metal oxide and in a first container (2) at a volume ratio of 1:1, in a closed reactor (1), heated up to a temperature between 600° C. and the melting temperature of the transition oxide (s) for 6 to 36 hours, under a pressure of 10 atmospheres with the help of a transfer inert gas through an inlet (5) and vacuum between 10?2 torr to 10?7 torr through an outlet (6), obtaining at the end of the process a graphitic material with long-lasting magnetic properties at room temperature. The material obtained exhibits a complex structure, with pores, bunches, pilings and edges of exposed graphenes and finds application in nanotechnology, magnetic images in medical science, applications in communication, electronics, sensors, even biosensors, catalysis or separation of magnetic materials.
Type:
Grant
Filed:
November 16, 2011
Date of Patent:
November 6, 2012
Assignees:
Universidade Federal de Sao Carlos, Universidad de la Republica
Inventors:
Fernando Manuel Araujo Moreira, Helena Pardo Minetti, Alvaro Washington Mombru Rodriguez
Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving a chronic pain and/or neuron loss.
Type:
Application
Filed:
July 23, 2007
Publication date:
March 4, 2010
Applicants:
Institut Pasteur, Instituto De Investigaciones Biol. Clem. Estable, Facultad De Medicina, Universidad De La Republica, Centre National De La Recherche Scientifique
Inventors:
Luis Barbeito, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
Abstract: A process of preparing magnetic graphitic materials from graphite in a second container (3) that reacts with one of more transition metal oxide and in a first container (2) at a volume ratio of 1:1, in a closed reactor (1), heated up to a temperature between 600° C. and the melting temperature of the transition oxide (s) for 6 to 36 hours, under a pressure of 10 atmospheres with the help of a transfer inert gas through an inlet (5) and vacuum between 10?2 torr to 10?7 torr through an outlet (6), obtaining at the end of the process a graphitic material with long-lasting magnetic properties at room temperature. The material obtained exhibits a complex structure, with pores, bunches, pilings and edges of exposed graphenes and finds application in nanotechnology, magnetic images in medical science, applications in communication, electronics, sensors, even biosensors, catalysis or separation of magnetic materials.
Type:
Application
Filed:
June 15, 2005
Publication date:
October 2, 2008
Applicants:
UNIVERSIDAD FEDERAL DE SÃO CARLOS, UNIVERSIDAD DE LA REPÚBLICA
Inventors:
Fernando Manuel Araujo Moreira, Helena Pardos Minetti, Alvaro Washington Mombru Rodriguez