Patents Assigned to UNIVERSITÉ DE BRETAGNE OCCIDENTALE
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Patent number: 11903982Abstract: Pseudomonas aeruginosa (PA) leads to chronic respiratory infections especially in patients with cystic fibrosis patients and chronic obstructive pulmonary disease (COPD), characterized by a high morbidity. After screening Lactobacilli coming from CF expectorations, on their capacity to inhibit two Pseudomonas aeruginosa (PA) virulence factors (elastase, pyocyanin), the inventors evaluated the effect of intranasal administration of Lactobacilli on PA murine pneumonia. The primary outcome was the bacterial lung load 24 hours after PA induced pneumonia. To understand the role of Lactobacillus, the chemokines, the pro and anti-inflammatory BAL rates were also measured. The administration of Lactobacilli cocktail 18 h prior the PA lung infection decreases significantly the lung bacterial load at 24 h post-infection. Although the mechanisms need to be deeply explored, an immunomodulation effect may be involved, notably through the recruitment of neutrophils.Type: GrantFiled: May 10, 2022Date of Patent: February 20, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ETABLISSEMENT FRANCAIS DU SANG (EFS), UNIVERSITE DE BRETAGNE OCCIDENTALE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BRESTInventors: Rozenn Le Berre, Marie-Sarah Fangous, Gwenaelle Le Blay, Geneviève Hery-Arnaud, Rosyne Lagrafeuille
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Publication number: 20240008951Abstract: A computer-implemented method and a system for providing anatomical landmarks of a subject's body part using a set of measures previously acquired by an ultrasound device including at least one fiducial marker and an imaging sensor. Also, a non-transitory computer readable medium including instructions which, when the program is executed by a computer, cause the computer to carry out the method.Type: ApplicationFiled: November 17, 2021Publication date: January 11, 2024Applicants: CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Guillaume DARDENNE, Hoel LETISSIER, Jérôme OGOR, Eric STINDEL
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Publication number: 20230287031Abstract: New glycolipids derivatives of Formula (I) and their use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels. Also, pharmaceutical compositions including compounds of Formula (I) for use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels.Type: ApplicationFiled: July 16, 2021Publication date: September 14, 2023Applicants: UNIVERSITÉ DE BRETAGNE OCCIDENTALE, UNIVERSITÉ DE TOURS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Paul Alain JAFFRES, Hélène COUTHON, Charlotte SEVRAIN, Alicia BAUDUIN, Christophe VANDIER, Aurélie CHANTÖME, Delphine FONTAINE
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Publication number: 20220378320Abstract: A method for measuring respiratory parameters of a subject using a range imaging sensor, wherein the method includes: receiving from the range imaging sensor at least one raw image of at least one portion of the torso of the subject, wherein each point of the raw image represents the distance between the range imaging sensor and the subject; generating a surface image of at least one portion of a surface of the torso of the subject by surface interpolation of the raw image; estimating a respiratory signal as a function of time calculated as the spatial average, in a given region of interest (ROI) defined on the torso of the subject, of the differences between the depth values of the surface image at a given time and the depth values of a reference surface image; and estimating a lung volume.Type: ApplicationFiled: September 18, 2020Publication date: December 1, 2022Applicants: CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST, UNIVERSITÉ DE BRETAGNE OCCIDENTALEInventors: Dimitris VISVIKIS, Erwan L'HER, Souha NAZIR
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Patent number: 11458118Abstract: Activating transcription factor 6 (ATF6) is involved in cystic fibrosis transmembrane conductance regulator (CFTR) repression and understanding this inhibitory mechanism is of great interest to develop a therapeutic approach based on UPR regulation. Using site-1 protease (S1P) inhibitor (e.g. PF-429242) the inventors showed that both membrane localization and function of F508del-CFTR are partially restored. Accordingly, the present invention relates to a method of treating a disease associated with reduced CFTR function in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a S1P inhibitor.Type: GrantFiled: April 20, 2018Date of Patent: October 4, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE BRETAGNE OCCIDENTALE, ETABLISSEMENT FRANÇAIS DU SANG (EFS), CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BRESTInventors: Pascal Trouve, Claude Ferec, Mathieu Kerbiriou, Florentin Huguet
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Publication number: 20220279814Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.Type: ApplicationFiled: July 31, 2020Publication date: September 8, 2022Applicants: SPECIALITES PET FOOD, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT POLYTECHNIQUE DE BORDEAUX, ABYSS INGREDIENTS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER, INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENTInventors: Fabienne GUERARD, Cloé OROY, Anne LEPOUDERE, Mathilde CHATAIGNER, Patrick ALLAUME, Anne-Laure DINEL, Corinne JOFFRE, Véronique PALLET, Fabienne LE GRAND
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Patent number: 11364271Abstract: Pseudomonas aeruginosa (PA) leads to chronic respiratory infections especially in patients with cystic fibrosis patients and chronic obstructive pulmonary disease (COPD), characterized by a high morbidity. After screening Lactobacilli coming from CF expectoration, on their capacity to inhibit two Pseudomonas aeruginosa (PA) virulence factors (elastase, pyocyanin), the inventors evaluated the effect of intranasal administration of Lactobacilli on PA murine pneumonia. The primary outcome was the bacterial lung load 24 hours after PA induced pneumonia. To understand the role of Lactobacillus, the chemokines, the pro and anti-inflammatory BAL rates were also measured. The administration of Lactobacilli cocktail 18 h prior the PA lung infection decreases significantly the lung bacterial load at 24 h post-infection. Although the mechanisms need to be deeply explored, an immunomodulation effect may be involved, notably through the recruitment of neutrophils.Type: GrantFiled: April 19, 2019Date of Patent: June 21, 2022Assignees: INSERM, Etablissement Français Du Sang (EFS), Université De Bretagne Occidentale, Centre Hospitalier Regional et Universitaire de BrestInventors: Rozenn Le Berre, Marie-Sarah Fangous, Gwenaelle Le Blay, Geneviève Hery-Arnaud, Rosyne Lagrafeuille
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Patent number: 11248261Abstract: The present invention relates to the identification of a novel allele of the RHD gene associated with a weak D phenotype and the kits and methods for detecting this allele.Type: GrantFiled: March 7, 2018Date of Patent: February 15, 2022Assignees: ETABLISSEMENT FRANCAIS DU SANG, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), NATIONAL INSTITUTE OF IMMUNOHAEMATOLOGY, UNIVERSITE DE BRETAGNE OCCIDENTALE (UBO)Inventors: Yann Fichou, Swati Kulkarni
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Patent number: 11155553Abstract: Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.Type: GrantFiled: June 28, 2018Date of Patent: October 26, 2021Assignees: GUERBET, UNIVERSITE DE BRETAGNE OCCIDENTALE, Centre national de la recherche scientifiqueInventors: Raphaël Tripier, Olivier Rousseaux, Mariane Le Fur, Maryline Beyler, Olivier Fougère, Gwladys Nizou
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Patent number: 11065408Abstract: A method for controlling the delivery of a breathing gas to a patient. The method comprises: delivering a flow of breathing gas to a patient, the breathing gas having a breathing gas flowrate and a fraction of inspired oxygen; measuring an oxygen saturation level of the patient; determining a respiratory rate of the patient; automatically adjusting the fraction of inspired oxygen of the breathing gas based on the measured oxygen saturation level of the patient and a breathing gas flowrate set-point; and automatically adjusting the breathing gas flowrate set-point based on the determined respiratory rate of the patient.Type: GrantFiled: October 4, 2016Date of Patent: July 20, 2021Assignees: UNIVERSITÉ LAVAL, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, OXY'NOV INCInventors: Francois Lellouche, Erwan L'Her, Benoit Gosselin, Quang-Thang Nguyen
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Publication number: 20210161887Abstract: The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Ar1 and Ar2 may be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Y1 and Z1 are independently CH or NRc+, provided that al least one of Y1 and Z1 is NRc+ and at least one of Y1 and Z1 is CH, and Ra, Rb, Rc, X2? and L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.Type: ApplicationFiled: April 3, 2019Publication date: June 3, 2021Applicants: Universite de Bretagne Occidentale, Centre Hospitalier Regional Universitaire de Brest, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Institut Curie, Université de Paris, Univ Paris XIII Paris-Nord Villetaneuse, Universite Paris-SaclayInventors: Marc Blondel, Alicia Quillevere, Cécile Voisset, Maria José Lista, Robin Fahraeus, Chrysoula Daskalogianni, Rodrigo Prado-Martins, Marie-Paule Teulade-Fichou, Anton Granzhan, Claire Beauvineau, Oksana Reznichenko
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Patent number: 10981912Abstract: A macrocycle compound of general formula (X) in which Y1 represents a C(O)OH group or a group of formula (II)Type: GrantFiled: October 21, 2019Date of Patent: April 20, 2021Assignees: GUERBET, UNIVERSITE DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Mariane Le Fur, Raphaël Tripier, Olivier Rousseaux, Maryline Beyler
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Publication number: 20210017180Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NORMALE SUPÉRIEURE DE LYON, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1), UNIVERSITÉ DE BRETAGNE OCCIDENTALEInventors: Nadège HAMON, Maryline BEYLER, Raphaël TRIPIER, Olivier MAURY, Janah SHAYA
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Patent number: 10772930Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.Type: GrantFiled: March 27, 2018Date of Patent: September 15, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALEInventors: Florie Desriac, Yannick Fleury, Patrick Le Chevalier, Delphine Destoumieux, Matthieu Simon
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Patent number: 10711001Abstract: The present invention relates to compounds, ligands, and/or complexes that are useful in medical imaging and/or in therapy, especially in cancer treatment. The present invention also relates to a pharmaceutical composition comprising said compounds, ligands, and/or complexes that are useful for medical imaging, targeting, and/or treatment of cancers. The present invention also relates to a process for preparing these compounds, ligands, and/or complexes.Type: GrantFiled: December 23, 2016Date of Patent: July 14, 2020Assignees: GUERBET, UNIVERSITE DE BRETAGNE OCCIDENTALE, CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Mariane Le Fur, Raphaël Tripier, Olivier Rousseaux, Maryline Beyler
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Patent number: 10676492Abstract: Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of synthesis for the compounds of formula (II), from unsaturated amphiphilic compounds of general formula (I). Further disclosed is the use of the compounds of general formula (II) and of the lipoplexes obtained by formulation of the compounds of general formula (II) for applications, particularly transfection, in which improved fusion properties are desired.Type: GrantFiled: September 23, 2016Date of Patent: June 9, 2020Assignees: UNIVERSITÉ DE BRETAGNE OCCIDENTALE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BRESTInventors: Paul-Alain Jaffrès, Hélène Couthon-Courvès, Damien Afonso, Tristan Montier, Tony Le Gall
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Patent number: 10576224Abstract: A method is provided for detecting the presence of an anomaly within an observed physical signal. The observed signal includes an addition of a physical disturbance signal and a reference signal. The anomaly is relative to a change in the behavior of the reference signal compared with a first tolerance value. Such a method includes: determining a time span having at least one moment of interest; detecting the presence of the anomaly within the observed physical signal during the time span by conducting a hypothesis test using the first tolerance value, a first rate of tolerated false alarms, and data obtained from processing the observed signal.Type: GrantFiled: March 22, 2013Date of Patent: March 3, 2020Assignees: UNIVERSITE DE BRETAGNE OCCIDENTALE, INSTITUT MINES-TELECOMInventors: Francois Lellouche, Erwan L'Her, Dominique Pastor, Quang-Thang Ngyuen
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Patent number: 10434199Abstract: Chelates resulting from the complexation of picolinate cross-bridged cyclams of formula (I), wherein n and the substituents L1-L4 and R1-R5 are as defined, with metallic cations. Picolinate cross-bridged cyclam ligands of formula (I), the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents are also described.Type: GrantFiled: November 12, 2014Date of Patent: October 8, 2019Assignees: UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Raphael Tripier, Zakaria Halime
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Patent number: 10425431Abstract: A method for processing an intrusion in a communication network including a plurality of node equipment, including a current node, which: discovers of a neighborhood of the current node, including assigning a resilience group to the neighboring node, according to at least one piece of information representative of a resilience level of the neighboring node to at least one type of attack; detecting an intrusion affecting at least one suspect node of the neighborhood of the current node; establishing a consensus concerning the at least one suspect node in a neighborhood by counting a number of resilience groups having detected the intrusion in the neighborhood of the suspect node and a total number of resilience groups represented in the neighborhood of the suspect node; and deciding to change a status of the suspect node based on a result of the consensus by comparison of both numbers.Type: GrantFiled: September 30, 2015Date of Patent: September 24, 2019Assignees: B<>COM, UNIVERSITE DE BRETAGNE OCCIDENTALE, INSTITUT MINES TELECOMInventors: David Espes, Nora Cuppens
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Publication number: 20180214509Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.Type: ApplicationFiled: March 27, 2018Publication date: August 2, 2018Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALEInventors: Florie DESRIAC, Yannick FLEURY, Patrick LE CHEVALIER, Delphine DESTOUMIEUX, Matthieu SIMON