Abstract: An insulating glazing having at least two panels made of transparent or semi-transparent material is provided. At least one of these panels is a luminescent solar concentrator.
Type:
Application
Filed:
October 28, 2019
Publication date:
December 16, 2021
Applicants:
UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA, GLASS TO POWER S.P.A.
Inventors:
Francesco MEINARDI, Sergio BROVELLI, Francesco BRUNI, Marina GANDINI
Abstract: Oligosaccharides are for use in the treatment of neurodegenerative diseases of the central nervous system, in particular Parkinson's disease, and to pharmaceutical compositions including one or more of the oligosaccharides.
Abstract: A detection system (101, 101b) of enteric diseases in animals includes a sensor device (102) having suction (103) for suctioning air from the animals' environment (11, 12). A sensor is (104) configured to determine information about the type and concentration of smelling molecules in the air and further configured to emit a signal representative of the information of smelling molecules. A transmission device (105) is configured to convey the signal representative of smelling molecules. A self-learning processing device (108) is configured to receive and process the signal representative of smelling molecules, and to detect a risk of enteric diseases in the animals associated with the information about the type and concentration of the smelling molecules. A signaling device (111) is configured to report to a user (10) the risk of enteric diseases in the animals, before the enteric diseases arise. A relative method detects enteric diseases in animals.
Type:
Grant
Filed:
June 8, 2017
Date of Patent:
July 20, 2021
Assignee:
UNIVERSITA' DEGLI STUDI DI MILANO
Inventors:
Marcella Guarino, Valentina Ferrante, Guido Grilli, Federica Borgonovo, Lorenzo Ferrari, Andrea Giovanni Pastori, Ilaria Fontana, Emanuela Tullo, Paolo Guffanti
Abstract: Process for the plasma surface treatment under vacuum of a fabric, nonwoven fabric or paper material for obtaining materials to be used for the filtration and separation of two immiscible liquids.
Type:
Grant
Filed:
May 3, 2017
Date of Patent:
June 22, 2021
Assignee:
Universita' degli Studi Di Milano-Bicocca
Abstract: The present invention relates to new synthetic molecules with agonist activity of human Toll-like Receptor 4 (TLR4), compositions comprising them and uses thereof for the treatment of diseases in which it is useful to induce or increase an immune response. The compounds have general formula (1), wherein R1 is a saturated C8-C16 aliphatic chain having a =0 on C1, said chain being free from —OH substituents on C3, wherein R2 is a saturated C8-C16 aliphatic chain having a ?O on C1, said chain being free from —OH substituents on C3, wherein R3 is a saturated C8-C16 aliphatic chain having a ?O on C1, said chain being free from —OH substituents on C3; wherein R4 is a hydrogen atom (H) or a phosphate group (PO42?).
Type:
Application
Filed:
November 5, 2018
Publication date:
February 25, 2021
Applicant:
UNIVERSITA DEGLI STUDI DI MILANO - BICOCCA
Abstract: Process for the plasma surface treatment under vacuum of a fabric, nonwoven fabric or paper material for obtaining materials to be used for the filtration and separation of two immiscible liquids.
Type:
Application
Filed:
May 3, 2017
Publication date:
November 19, 2020
Applicant:
Universita' degli Studi Di Milano-Bicocca
Abstract: The present disclosure relates to delta-2-tubulin and its use as a biomarker for determining if a subject is at risk of developing peripheral neuropathy or if a subject has developed peripheral neuropathy. The present disclosure further relates to methods for the treatment of peripheral neuropathy in a subject and assays for identifying compounds that can be used to treat and/or prevent peripheral neuropathy.
Type:
Application
Filed:
May 27, 2020
Publication date:
October 22, 2020
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA
Inventors:
Francesca Bartolini, Maria Elena Pero, Guido Cavaletti
Abstract: The present invention refers to an antibody able to recognize and bind to an epitope comprised in a sequence of human Migration Stimulating Factor (MSF), and that doesn't recognize and bind human Fibronectin 1 (hFn1) and to uses in diagnostic methods and therapy.
Type:
Application
Filed:
September 19, 2018
Publication date:
September 10, 2020
Applicants:
HUMANITAS MIRASOLE S.P.A., UNIVERSITA' DEGLI STUDI DI MILANO
Inventors:
Alberto MANTOVANI, Barbara BOTTAZZI, Ilaria LAFACE, Antonio INFORZATO, Tamara GULIC
Abstract: The present invention relates to at least one modulator of PP2A or at least one modulator of PP2A-like phosphatase or at least one modulator of PP2A and PP2A-like phosphatase or a combination of said modulators for use in the treatment of a disease characterized by an alteration in the DNA damage response. The present invention also relates to a method to identify a subject to be treated with a PP2A modulator comprising detecting in the genome of said patient a mutation in PP2A.
Type:
Application
Filed:
May 21, 2018
Publication date:
May 28, 2020
Applicants:
UNIVERSITÀ DEGLI STUDI DI MILANO, ISTITUTO EUROPEO DI ONCOLOGIA S.R.L., IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Abstract: Disclosed are a colloidal coating dispersion containing electrochromic polymer particles, a method for manufacturing the colloidal coating dispersion, the use of the colloidal coating dispersion for depositing at least one electrochromic layer on a substrate, and an article including a layer deposited from the colloidal coating dispersion.
Type:
Application
Filed:
November 8, 2019
Publication date:
May 21, 2020
Applicants:
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V., Università degli Studi di Milano - Bicocca
Inventors:
Sven MACHER, Uwe POSSET, Luca BEVERINA, Mauro SASSI, Marco SCHOTT
Abstract: It is described a method for realizing catalytically active electrochemical electrodes with maximized surface area. In the method, InGaN is deposited epitaxially in form of a thin layer on a Silicon substrate exposing a (111) crystal fac, thus forcing the InGaN electrode material to grow exposing a catalytically active surface. The substrate is then removed, the InGaN layer is made into fragments and these are transferred onto a conductive support with one-, two- or three-dimensional structure which can be a wire, a two-dimensional conductive foil which, possibly folded, or a three-dimensional conductive fabric, sponge or cage-like structure. It is thus possible to obtain an InGaN-based electrode with increased surface area and exposing surfaces with high catalytic activity.
Type:
Grant
Filed:
March 14, 2017
Date of Patent:
May 5, 2020
Assignee:
UNIVERSITÁ DEGLI STUDI DI MILANO BICOCCA
Abstract: The present invention regards a solid master elastomeric composition (masterbatch, MB) comprising silicate fibres with needle-shaped morphology of nanometric size, characterised by high fibre content and uniformity, a process advantageous for the preparation thereof and its use in manufacturing tyres for vehicles. Advantageously the present elastomeric composition allows minimising the drawbacks associated with the handling of the powdery fibres in the manufacturing of compounds for tyres, without altering the final performances thereof.
Type:
Application
Filed:
December 18, 2017
Publication date:
March 26, 2020
Applicants:
PIRELLI TYRE S.p.A., POLITECNICO DI MILANO, UNIVERSITA' DEGLI STUDI DI MILANO BICOCCA
Inventors:
Luciano TADIELLO, Valeria Rosaria CIPOLLETTI, Luca GIANNINI, Thomas HANEL, Maurizio GALIMBERTI, Roberto SCOTTI, Barbara DI CREDICO, Franca MORAZZONI, Massimiliano D'ARIENZO, Irene TAGLIARO
Abstract: The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or Parkinson's disease that can be treated by modulation of certain protein kinases. Compounds of formula (I) can be used for treatment of patients who do not respond to kinase inhibition therapy that comprises currently available medications.
Type:
Grant
Filed:
December 14, 2015
Date of Patent:
July 2, 2019
Assignees:
EUDENDRON S.R.L., UNIVERSITA' DEGLI STUDI DI MILANO
Inventors:
Mauro Angiolini, Fabio Zuccotto, Anna Bernardi, Francesco Airaghi
Abstract: The present invention relates to novel molecules suitable to the use in the separation/removal of carbon dioxide from gaseous mixtures as liquid-phase carbon dioxide absorbers and suitable to allow the subsequent release of the absorbed carbon dioxide in form of different ionic liquids, preferentially a glycine salt with choline hexanoate, ester between glycine and hexanoic alcohol (hexyl glycinate) and glycerol ester with glycine and hexanoic acid. The present invention also relates to a method and a plant for the capture of carbon dioxide from gaseous mixtures by using an absorber for carbon dioxide in liquid phase with a heating jacket.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
December 4, 2018
Assignee:
UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
Inventors:
Maurizio Filippo Acciarri, Simona Olga Binetti, Bruno Vodopivec, Maurilio Giuseppe Meschia
Abstract: New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.
Type:
Grant
Filed:
October 2, 2014
Date of Patent:
July 3, 2018
Assignee:
UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
Inventors:
Massimo Masserini, Francesca Re, Giulio Sancini, Gianluigi Forloni, Mario Salmona
Abstract: The inventors have made the surprising discovery that when ceramide production is upregulated in the infarct and at-risk areas upon reperfusion injury in the heart, such upregulation is effected through the de novo ceramide synthesis pathway. Upon treatment of cardiac tissues subject to reperfusion injury with a specific inhibitor of the novo ceramide synthesis pathway (myriocin), the inventors have determined that the inhibition of such pathway not only reduces the inflammation of the interested area, but most surprisingly reduces infarct size, ameliorates cardiac contractility and activates cell detoxification and survival programs. There is thus provided an inhibitor of de novo ceramide synthesis pathway, particularly myriocin, for the treatment of cardiac reperfusion injury.
Type:
Grant
Filed:
January 16, 2017
Date of Patent:
March 27, 2018
Assignees:
UNIVERSITA' DEGLI STUDI DI MILANO, POLICLINICO SAN DONATO S.P.A.
Inventors:
Riccardo Ghidoni, Paola Signorelli, Luigi Anastasia
Abstract: Chemical compounds are provided which act on GPR17 receptors and are useful in the treatment or amelioration of chronic and/or acute neurodegenerative diseases, such as multiple sclerosis, inflammatory diseases, pathologies involving the immune system, cardiovascular diseases, and renal diseases.
Type:
Grant
Filed:
May 9, 2012
Date of Patent:
January 30, 2018
Assignees:
UNIVERSITA′ DEGLI STUDI DI MILANO, FONDAZIONE ITALIANA SCLEROSI MULTIPLA—FISM ONLUS
Inventors:
Maria Pia Abbracchio, Mario Alberto Battaglia, Ivano Eberini, Marta Fumagalli, Chiara Parravicini, Cristina Sensi, Paola Zaratin
Abstract: Disclosed are polymers with a complex branched structure (star- or tree-shaped) obtainable by polymerizing a bifunctional type AB monomer and/or type AA+BB monomers in the presence of: a) one or more polyamine and/or a polyacid and/or a polyalcohol and/or more generally a compound (such as POSS) having at least three functional groups such as amino, carboxylic acid or hydroxyl functions; b) one or more phosphorus containing molecules reacting with only one reactive group during the polymerization; c) optionally one or more organic acid and/or an amine and/or an alcohol having one or two functional groups.
Type:
Grant
Filed:
December 14, 2011
Date of Patent:
November 21, 2017
Assignee:
UNIVERSITA' DEGLI STUDI DI MILANO
Inventors:
Giuseppe Di Silvestro, Yuan Cuiming, Marco Ortenzi, Hermes Farina, Tommaso Lugato, Luca Basilissi
Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.
Type:
Grant
Filed:
April 14, 2014
Date of Patent:
October 24, 2017
Assignee:
Universitá Degli Studi di Milano-Bicocco
Inventors:
Antonio Maria Pesenti, Nicolo Antonino Patroniti
Abstract: The present invention relates to an extracorporeal circuit for CO2 removal from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and in that wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane.
Type:
Application
Filed:
July 31, 2015
Publication date:
August 10, 2017
Applicant:
UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA
Inventors:
Antonio Maria Pesenti, Alberto Zanella, Domenico Salerno, Nicolò Antonino Patroniti, Francesco Mantegazza