Patents Assigned to Universität Hamburg
-
Publication number: 20150361124Abstract: A method for producing phosphate-bridged nucleoside conjugates, in particular poly- or oligonucleosides. In the method, an immobilized cyclosaligenyl derivative of a nucleoside, nucleotide, poly- or oligonucleotide, poly- or oligonucleoside, or an analog thereof, is synthesized, and the subsequent reaction with a nucleophile yields the desired phosphate-bridged nucleoside conjugate, which may subsequently be released from the solid phase.Type: ApplicationFiled: January 22, 2013Publication date: December 17, 2015Applicant: Universitaet HamburgInventors: Ivo Sarac, Chris Meier
-
Patent number: 8871516Abstract: The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the LTR of proviral DNA of a retrovirus inserted into the genome of a host cell and is useful as means for excising the provirus from the genome of the host cell. The present invention further relates to an in vitro-method of optimising the treatment of a retroviral infection of a subject and to the use of tailored recombinases for the preparation of pharmaceutical compositions for reducing the viral load in a subjected infected by a retrovirus.Type: GrantFiled: January 3, 2008Date of Patent: October 28, 2014Assignees: Technische Universität Dresden, Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V., Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität HamburgInventors: Joachim Hauber, Frank Buchholz, Ilona Hauber, Francis A Stewart, Indrani Sarkar
-
Patent number: 8742094Abstract: The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.Type: GrantFiled: May 6, 2010Date of Patent: June 3, 2014Assignee: Universitaet HamburgInventors: Chris Meier, Viktoria Caroline Tonn
-
Patent number: 8688387Abstract: The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, the method comprising the steps of: (a) determining the dehydration of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bond energy, and (c) further adding the change in the free enthalpy of the interacting partners upon their interaction. The obtained results can be used for the prediction if and to what extent two molecules of various origin fit to each other.Type: GrantFiled: February 6, 2012Date of Patent: April 1, 2014Assignees: Bayer CropScience AG, Universitaet HamburgInventors: Gudrun Lange, Robert Klein, Juergen Albrecht, Matthias Rarey, Ingo Reulecke
-
Publication number: 20140042269Abstract: A drive system for driving control surfaces of an aircraft includes at least one drive unit, at least one main shaft connectable to the at least one drive unit and at least two adjusting units for each control surface to be driven. Each adjusting unit includes a differential, two rotary actuators and an adjustment lever. The differential has at least one input means and two output means and is adapted to transfer torque from the at least one input means to the two output means. The input means is connectable to the main shaft, the two rotary actuators each have a rotation input means and a motion output means. The rotation input means is connectable to one of the output means of the differential each and the adjustment lever is connected to the motion output means of both rotary actuators.Type: ApplicationFiled: August 8, 2013Publication date: February 13, 2014Applicants: TECHNISCHE UNIVERSITAET HAMBURG-HARBURG, AIRBUS OPERATIONS GMBHInventors: Tanno Zantz, David Arriola, Stefan Benischke, Frank Thielecke
-
Patent number: 8629265Abstract: The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method a nucleophile is first dissolved in a non-aqueous solvent and dried, and a cyclosaligenyl phosphate compound is subsequently added to the solution.Type: GrantFiled: August 6, 2009Date of Patent: January 14, 2014Assignee: Universitaet HamburgInventors: Chris Meier, Saskia Wolf, Svenja Warnecke
-
Publication number: 20130139749Abstract: A method for crystallizing a substance dissolved in a solvent, including the following steps: introducing a solvent volume containing the substance into a chamber having a preset temperature, humidity, and gas composition, adding a predetermined volume of a precipitant to the solvent volume containing the substance, allowing the solvent to evaporate while simultaneously observing structural changes in the solvent volume containing the substance and the precipitant by means of dynamic light scattering, detecting weight changes and determining the molarities, making an association with the location in the phase diagram on the basis of the DLS measurement and the results of the molarity determination, allowing a predetermined number of crystal nuclei to form by adding solvent or adding precipitant, putting the solvent volume containing the substance and the precipitant into a metastable state by adding solvent and/or protein solution or by allowing the concentration of the dissolved substance to decrease by alloType: ApplicationFiled: June 30, 2011Publication date: June 6, 2013Applicants: UNIVERSITAET HAMBURG, UNIVERSITAET ZU LUEBECKInventors: Christian Betzel, Rolf Hilgenfeld, Dierk Hilterhaus, Thomas Klupsch, Peter Muehlig, Karsten Dierks, Arne Meyer
-
Publication number: 20130020735Abstract: A method for milling long fibre reinforced composite plastics having at least one unidirectional top layer using a rotating milling tool, wherein work piece and tool are moved in an advancing movement parallel to the work piece cutting face relative to each other, and wherein there is an edge fibre separation angle on the work piece of 0°??edge?90°, and the blade of the tool mills the component edge in synchronization.Type: ApplicationFiled: January 7, 2011Publication date: January 24, 2013Applicants: TECHNISCHE UNIVERSITÄT HAMBURG-HARBURG, TUTECH INNOVATION GMBHInventors: Wolfgang Hintze, Dirk Hartmann, Christoph Schütte
-
Patent number: 8350022Abstract: The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.Type: GrantFiled: April 3, 2009Date of Patent: January 8, 2013Assignee: Universitaet HamburgInventors: Chris Meier, Jens O. Thomann
-
Publication number: 20120202699Abstract: The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, the method comprising the steps of: (a) determining the dehydration of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bond energy, and (c) further adding the change in the free enthalpy of the interacting partners upon their interaction. The obtained results can be used for the prediction if and to what extent two molecules of various origin fit to each other.Type: ApplicationFiled: February 6, 2012Publication date: August 9, 2012Applicants: UNIVERSITAET HAMBURG, BAYER CROPSCIENCE AGInventors: Gudrun Lange, Robert Klein, Juergen Albrecht, Matthias Rarey, Ingo Reulecke
-
Publication number: 20120116067Abstract: The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.Type: ApplicationFiled: May 6, 2010Publication date: May 10, 2012Applicant: UNIVERSITAET HAMBURGInventors: Chris Meier, Viktoria Caroline Tonn
-
Publication number: 20110137023Abstract: The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method a nucleophile is first dissolved in a non-aqueous solvent and dried, and a cyclosaligenyl phosphate compound is subsequently added to the solution.Type: ApplicationFiled: August 6, 2009Publication date: June 9, 2011Applicant: Universitaet HamburgInventors: Chris Meier, Saskia Wolf, Svenja Warnecke
-
Publication number: 20110028705Abstract: The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.Type: ApplicationFiled: April 3, 2009Publication date: February 3, 2011Applicant: UNIVERSITAET HAMBURGInventors: Chris Meier, Jens O. Thomann
-
Publication number: 20100285548Abstract: The process according to the invention for the microbial production of a specific product and methane comprises the following steps: a) the production in a bioreactor (2, 10) of a specific product from a specific substrate using a specific organism, the producer, wherein during the production of this product metabolites such as e.g. low-molecular alcohols, aldehydes and acids, hydrogen and CO2, which may inhibit the production of the product, are obtained; and b) the production of methane by means of a methanogen, wherein in the production of the methane at least one metabolite is decomposed and by this means removed from the bioreactor (2, 10) and its energy is made usable.Type: ApplicationFiled: October 8, 2008Publication date: November 11, 2010Applicants: AGRAFERM TECHNOLOGIES AG, TECHNISCHE UNIVERSITÄT HAMBURG-HARBURG, TUTECH INNOVATION GMBHInventors: Hans Friedmann, An-Ping Zeng
-
Publication number: 20100273664Abstract: The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, said method comprising the steps of: (a) determining the dehydration (?Gdehydration) of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bond energy (?H-bond), and (c) further adding the change in the free enthalpy of the interacting partners upon their interaction. The obtained results can be used for the prediction if and to what extent two molecules of various origin fit to each other.Type: ApplicationFiled: October 20, 2007Publication date: October 28, 2010Applicants: BAYER CROPSCIENCE AG, UNIVERSITAET HAMBURGInventors: Gudrun Lange, Robert Klein, Juergen Albrecht, Matthias Rarey, Ingo Reulecke
-
Publication number: 20090018809Abstract: The invention relates to the field of bioinformatics and in particular of biomolecular computing (‘DNA computing’). “Computational genes” comprising nucleic acids are provided which, via autonomous spontaneous self-assembly, can be produced in vivo by means of a biomolecular finite automaton.Type: ApplicationFiled: February 23, 2007Publication date: January 15, 2009Applicants: Technische Universitaet Hamburg-Harburg (Technical University Hamburg-Hraburg), Tutech Innovation GmbHInventors: Karl-Heinz Zimmermann, Zoya Ignatova, Israel Marck Martinez-Perez
-
Patent number: 6834150Abstract: An optical waveguide has a core, wherein the core is doped with laser-active ions, and also additionally doped with Ce.Type: GrantFiled: June 19, 2001Date of Patent: December 21, 2004Assignees: Robert Bosch GmbH, Universitaet HamburgInventors: Frank Heine, Robert Lange, Thomas Schwander, Bernd Michael Dicks, Klaus Petermann
-
Patent number: 6755893Abstract: In a method for the separation of supercritical gas from substances dissolved in the gas with a membrane through which the gas passes while the substances dissolved in the gas is retained, a pore-free membrane of a polymer perfluoro-2,2-diemthyl-1,3-dioxole is used as a membrane in the separation process.Type: GrantFiled: December 26, 2002Date of Patent: June 29, 2004Assignee: Technische Universität Hamburg-HarburgInventors: Klaus-Victor Peinemann, Michael Schossig, Lorenza Sartorelli, Walter Kulcke, Gerd Brunner