Abstract: The Invention relates to a medical device (1) for oral procedures, particularly for use in oral intubation and fixation procedures, comprising at least one protective device (2) for teeth, the protective device (2) comprising the a rigid support component (3), and at least one push button (4), arranged at the support component (3), wherein each of the at least one the push button (4) comprises a rigid surface (42) that is facing towards the teeth, when the medical device (1) is applied orally, wherein the support component (3) is configured such that each of the at least one push button (4) is displaceable separately relative to the support component (3) between a first position and a second position.

Abstract: The invention relates to a device for determining a parameter for the diagnostics of hydrocephalus and other disorders of intracranial pressure, wherein information about the volume elasticity is obtained from a pressure signal or another characteristic signal which contains information about the pressure or the volume composition in the skull. The characteristic parameter determined according to the invention is the ratio of the amplitude of a modulating wave in the processed characteristic signal to the amplitude of the modulated wave in the course of the pulse amplitude of the modulated wave of the processed characteristic signal.

Abstract: An implantable pump system can deliver blood within the body of a patient, with a blood pump which delivers a fluid in an axial direction. The blood pump can include a rotatingly drivable rotor as well as a pump casing surrounding the rotor, as well as a support tube, in which the pump casing is arranged and held, wherein an annular gap is formed between the support tube and the pump casing. An almost physiological blood flow is rendered possible in this manner, by way of the combination of a flow through the pump casing on the one hand, and the annular gap on the other hand.

Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.

Abstract: A device for repair surgery of cylindrical organs, particularly of ruptured tendons, is configured as a tubular sheath (T) made of a mesh of elastic fibers formed by electrospinning a biocompatible and biodegradable polymer. The tubular sheath has a Young elasticity modulus of about 0.1 to about 4 MPa and a strain at break of about 50 to about 1,000%, and it has a first wall surface and a second wall surface substantially parallel thereto, with said first wall surface being comparatively smooth (WS) and said second wall surface being comparatively rough (WR). According to the invention, the elastic fibers comprise first fibers consist of polymer in neat form and second fibers consist of polymer with an admixture of a therapeutic agent for stimulating regrowth processes of a predetermined cylindrical organ.

Abstract: The invention relates to computation of optical flow using event-based vision sensors.

Abstract: The invention relates to a method for preparing a polymer scaffold that comprises the steps of providing a piece of a fabric of filaments of a first biodegradable or biocompatible polymer, applying a coating of a second polymer to said arrangement of filaments, and stretching the piece along its axis of longitudinal extension, thereby obtaining an aligned microfibrillar scaffold. The invention further relates to a method for providing an artificial tissue, and to a microfibrillar scaffold of aligned filaments obtained by the method of the invention.

Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.

Abstract: A dental implant includes an anchoring region (12) for anchoring in a bone, which preferably includes a thread (14) for screwing in the bone, and a fastening region (22) for attaching a supra-construction, wherein an abutment region (16) adjoins the anchoring region (12), the abutment region (16) having a guide structure with a plurality of outwardly projecting ridges (18) provided thereon, and preferably, grooves (20) being formed between the ridges (20). The guide structure of the anchoring region (12) allows a better osseointegration and counteracts peri-implant bone loss.

Abstract: Disclosed embodiments relate to a membrane closure device (100) for closing a perforation in a membrane (10), comprising: a patch guiding mechanism (110) for guiding at least one expandable patch (120) to a perforation site (12) of a membrane (10); and a fastener delivery mechanism (130, 330) for delivering a fastener (140) to the perforation site (12) and for fastening the at least one expandable patch by the fastener (140) to the membrane (10) to seal the perforation in the membrane (10) by the at least one expandable patch (120).

Abstract: A method of imaging single molecules, comprises the steps of: a) providing an assembly comprising a carrier substrate having a substrate face with an aperture, the aperture being covered with a receiving layer attached to the substrate face, the receiving layer being substantially transparent for low-energy electrons with a kinetic energy of 5 to 1,000 eV; b) depositing single molecules onto said receiving layer by means of soft-landing electrospray ion deposition, whereby a single molecule loaded receiving layer is formed; c) acquiring an in-line low-energy electron transmission pattern of said single molecule loaded receiving layer; and d) applying a reconstruction procedure to said electron transmission pattern to obtain at least one image of a single molecule on said single molecule loaded receiving layer. The above steps a) to c) are conducted under vacuum conditions.

Abstract: A band-pass filter is described comprising a first first-order filter stage comprising a first resistor characterized by a first impedance and connected to a first node, referred to as a filter input node, and, through a second node to a first reactive component connected to a third node, the first impedance being such that a first current therethrough is dependent on the difference between the voltages at the first and second nodes; and a second first-order filter stage comprising a second resistor characterized by a second impedance and connected to the second node, and, through a fourth node, to a second reactive component connected to a fifth node. The second impedance is such that a second current therethrough is dependent on the negative of the sum of the voltages at the second and fourth nodes. The band-pass filter further comprises summing means for summing the voltages at the second and fourth nodes to output a voltage at a sixth node.

Abstract: The invention relates to a method for identifying and quantifying a polypeptide from a library of polypeptides. The method comprises the steps of: 1—providing a polypeptide library and a detection tag library, 2—generating a nested library comprising the polypeptides and the detection tags, 3—sequencing the nested library, 4—selecting a member of the nested library in one or several selection steps that are independent of a physical genotype-phenotype linkage, 5—isolating the detection tag from the selected polypeptide, 6—identifying and quantifying the detection tag by mass spectrometry, 7—obtaining the sequence of the selected polypeptide. The invention also relates to a collection of polypeptides, a collection of detection tags, and a collection of plasmid vectors.

Abstract: A recurrent neural network including an input layer, a hidden layer, and an output layer, wherein the hidden layer includes hybrid memory cell units, each of the hybrid memory cell units including a first memory cells of a first type, the first memory cells being configured to remember a first cell state value fed back to each of gates to determine a degree to which each of the gates is open or closed, and configured to continue to update the first cell state value, and a second memory cells of a second type, each second memory cell of the second memory cells including a first time gate configured to control a second cell state value of the second memory cell based on phase signals of an oscillatory frequency, and a second time gate configured to control an output value of the second memory cell based on the phase signals, and each second memory cell of the second memory cells being configured to remember the second cell state value.

Abstract: A magnetic resonance (MR) apparatus comprises magnet means for generating a main magnetic field in a sample region, encoding means for generating encoding magnetic fields superimposed to the main magnetic field, RF transmitter means for generating MR radiofrequency fields, driver means for operating said encoding means and RF transmitter means to generate superimposed time dependent encoding fields and radiofrequency fields according to an MR sequence for forming images or spectra; and acquisition means for acquiring an MR signal from said object. The magnet means comprise a primary magnetic field source providing a static magnetic field B0 and at least one secondary magnetic field source providing an adjustable magnetic field B?.

Abstract: A convolution processing apparatus and method are disclosed. The convolution processing apparatus may include a controller configured to load a pixel of an input image and skip a process associated with the pixel in response to a value of the loaded pixel being 0, a filter bank including at least one filter and configured to extract at least one kernel element corresponding to the pixel from the at least one filter based on an index of the pixel and an input channel of the pixel, and a multiplier-accumulator (MAC) configured to perform a convolution operation based on the value of the pixel and a value of the at least one kernel element and accumulatively store an operation result of the convolution operation, the operation result corresponding to an output image.

Abstract: A biological heart valve replacement, particularly for pediatric patients, comprises a tubular segment (A) comprising a proximal end (Ep), a distal end (Ed) and a central portion (Pc) arranged between said proximal and distal ends and defining a longitudinal direction of the valve. The valve further comprises at least one inner leaflet (C) attached in hinge-like manner to a connection zone (F) at an inner wall (W) region of said central portion, each one of said inner leaflets being movable between a closing position and an opening position of the valve. In order to provide growth adaptability, the tubular segment comprises at least one tubular growth zone (B; B1,B2) configured as a longitudinal strip made of a growth-adaptive biomaterial, with the remainder of the tubular segment being made of a non-growth-adaptive biomaterial.

Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.

Abstract: A processor-implemented neural network method includes acquiring connection weight of an analog neural network (ANN) node of a pre-trained ANN; and determining, a firing rate of a spiking neural network (SNN) node of an SNN, corresponding to the ANN node, based on an activation of the ANN node which is determined based on the connection weight. and the firing rate is also determined based on information indicating a timing at which the SNN node initially fires.

Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysll, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity