Patents Assigned to Universität Zürich
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Patent number: 10227308Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.Type: GrantFiled: February 27, 2017Date of Patent: March 12, 2019Assignees: HOFFMANN-LA ROCHE INC., EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRCIH, UNIVERSITÄT ZÜRICHInventors: Simon M. Ametamey, Juergen Fingerle, Luca Gobbi, Uwe Grether, Ahmed Haider, Thomas Hartung, Linjing Mu, Leo Nicholls, Mark Rogers-Evans, Christoph Ullmer
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Publication number: 20190070340Abstract: A device for repair surgery of cylindrical organs, particularly of ruptured tendons, is configured as a tubular sheath (T) made of a mesh of elastic fibers formed by electrospinning a biocompatible and biodegradable polymer. The tubular sheath has a Young elasticity modulus of about 0.1 to about 4 MPa and a strain at break of about 50 to about 1'000%, and it has a first wall surface and a second wall surface substantially parallel thereto, with said first wall surface being comparatively smooth (WS) and said second wall surface being comparatively rough (WR). According to the invention, the elastic fibers comprise first fibers consist of polymer in neat form and second fibers consist of polymer with an admixture of a therapeutic agent for stimulating regrowth processes of a predetermined cylindrical organ.Type: ApplicationFiled: February 10, 2017Publication date: March 7, 2019Applicants: UNIVERSITAET ZUERICH, ETH ZURICHInventors: Johanna BUSCHMANN, Olivera EVROVA, Viola VOGEL
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Publication number: 20190062784Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.Type: ApplicationFiled: March 21, 2018Publication date: February 28, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Daniel D. Pinschewer, Lukas Flatz, Andreas Bergthaler, Rolf Zinkernagel
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Patent number: 10213297Abstract: Various inserts, called shapers and spacers, are provided for controlling tissue engineered heart valve (TEHV) leaflet geometry during culture. These inserts will prevent TEHV leaflet retraction during culture, be able to control the leaflet geometry during culture, enable culturing TEHV leaflets with a larger coaptation area, control the height of the coaptation area, maintain TEHV leaflet curvatures, and/or enable possibilities to culture TEHV leaflets in open configuration.Type: GrantFiled: September 24, 2014Date of Patent: February 26, 2019Assignees: UNIVERSITAET ZUERICH, TECHNISCHE UNIVERSITEIT EINDHOVENInventors: Bart Sanders, Sandra Vossen-Loerakker, Anita Driessen-Mol, Simon Philipp Hoerstrup, Franciscus Petrus Thomas Baaijens
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Publication number: 20190050720Abstract: The present invention concerns a method of programming an analogue electronic neural network comprising a plurality of layers of somas. Any two consecutive layers of somas are connected by a matrix of synapses. The method comprises: applying test signals to inputs of the neural network; measuring at a plurality of measurement locations in the neural network responses of at least some somas and synapses to the test signals; extracting from the neural network, based on the responses, a first parameter set characterising the behaviour of the at least some somas; carrying out a training of the neural network by applying to a training algorithm the first parameter set and training data for obtaining a second parameter set; and programming the neural network by using the second parameter set. The invention also relates to the neural network and to a method of operating it.Type: ApplicationFiled: February 17, 2017Publication date: February 14, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Jonathan Jakob Moses BINAS, Daniel Lawrence NEIL
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Patent number: 10195310Abstract: The invention relates to a device and a method for compressing a hydrogel layer (H), wherein a separate piston (600) that is designed to be connected to a second component (400) of the device in a releasable manner in an operating mode of the device, particularly by means of a latching connection, presses along a compression direction (C) against said hydrogel layer (H) residing on a membrane bottom (501) of a graft frame (500) so as to compress the hydrogel layer (H) between the piston (600) and the membrane bottom (501).Type: GrantFiled: June 27, 2014Date of Patent: February 5, 2019Assignee: UNIVERSITÄT ZÜRICHInventor: Ernst Reichmann
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Publication number: 20190035616Abstract: A method of imaging single molecules, comprises the steps of: a) providing an assembly comprising a carrier substrate having a substrate face with an aperture, the aperture being covered with a receiving layer attached to the substrate face, the receiving layer being substantially transparent for low-energy electrons with a kinetic energy of 5 to 1,000 eV; b) depositing single molecules onto said receiving layer by means of soft-landing electrospray ion deposition, whereby a single molecule loaded receiving layer is formed; c) acquiring an in-line low-energy electron transmission pattern of said single molecule loaded receiving layer, said single molecule loaded receiving layer. The above steps a) to c) are conducted under vacuum conditions.Type: ApplicationFiled: June 29, 2016Publication date: January 31, 2019Applicant: UNIVERSITAET ZUERICHInventors: Jean-Nicolas LONGCHAMP, Hans-Werner FINK, Conrad ESCHER
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Publication number: 20190020331Abstract: A band-pass filter is described comprising a first first-order filter stage comprising a first resistor characterised by a first impedance and connected to a first node, referred to as a filter input node, and, through a second node to a first reactive component connected to a third node, the first impedance being such that a first current therethrough is dependent on the difference between the voltages at the first and second nodes; and a second first-order filter stage comprising a second resistor characterised by a second impedance and connected to the second node, and, through a fourth node, to a second reactive component connected to a fifth node. The second impedance is such that a second current therethrough is dependent on the negative of the sum of the voltages at the second and fourth nodes. The band-pass filter further comprises summing means for summing the voltages at the second and fourth nodes to output a voltage at a sixth node.Type: ApplicationFiled: January 5, 2017Publication date: January 17, 2019Applicant: UNIVERSITÄT ZÜRICHInventors: Minhao YANG, Shih-Chii LIU
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Publication number: 20190016797Abstract: The present invention relates to antibodies binding to human interleukin-2 (hIL-2). The invention more specifically relates to humanized antibodies specifically binding a particular epitope of hIL-2 and, when bound to this epitope, displaying a unique capability of inhibiting binding of hIL-2 to CD25.Type: ApplicationFiled: January 11, 2017Publication date: January 17, 2019Applicants: Novartis AG, Universität ZürichInventors: Natalia Arenas-Ramirez, Iwan Beuvink, Onur Boyman, Barbara Brannetti, Andreas Katopodis, Simone Popp, Catherine Regnier, Chao Zou
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Patent number: 10144765Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.Type: GrantFiled: December 21, 2017Date of Patent: December 4, 2018Assignees: POLYPHOR LTD., UNIVERSITAET ZUERICHInventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Publication number: 20180336466Abstract: A sensor transformation attention network (STAN) model including sensors configured to collect input signals, attention modules configured to calculate attention scores of feature vectors corresponding to the input signals, a merge module configured to calculate attention values of the attention scores, and generate a merged transformation vector based on the attention values and the feature vectors, and a task-specific module configured to classify the merged transformation vector is provided.Type: ApplicationFiled: March 5, 2018Publication date: November 22, 2018Applicants: SAMSUNG ELECTRONICS CO., LTD., UNIVERSITAET ZUERICHInventors: Stefan BRAUN, Daniel NEIL, Enea CEOLINI, Jithendar ANUMULA, Shih-Chii LIU
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Patent number: 10133334Abstract: An event-based sensor is provided and may include a sensor configured to generate an event signal that includes identification information that relates to an active pixel that detects an event from among a plurality of sensing pixels, a determiner configured to determine whether the event signal is to be filtered based on a predetermined condition, and an outputter configured to output the event signal based on a result of the determination.Type: GrantFiled: September 23, 2015Date of Patent: November 20, 2018Assignees: SAMSUNG ELECTRONICS CO., LTD., UNIVERSITAET ZUERICHInventors: Hongjie Liu, Chenghan Li, Christian Brandli, Shih-Chii Liu, Tobi Delbruck
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Patent number: 10032498Abstract: A memory cell unit and a recurrent neural network including memory cell units are provided. The memory cell unit includes a first time gate configured to control a cell state value of the memory cell unit, based on a phase signal of an oscillatory frequency, and a second time gate configured to control an output value of the memory cell unit, based on the phase signal.Type: GrantFiled: November 9, 2016Date of Patent: July 24, 2018Assignees: SAMSUNG ELECTRONICS CO., LTD., UNIVERSITAET ZUERICHInventors: Daniel Neil, Shih-Chii Liu, Michael Pfeiffer
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Patent number: 9999770Abstract: A device including a cochlear implant electrode array and an apparatus configured to sense a phenomenon of fluid in a cochlea, wherein the apparatus and the electrode array are a single unit.Type: GrantFiled: November 6, 2014Date of Patent: June 19, 2018Assignees: Cochlear Limited, Universität ZürichInventors: Joris Walraevens, Pieter Wiskerke, Francesca Paris, Alexander Huber, Lukas Prochazka, Dominik Obrist
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Publication number: 20180150721Abstract: A convolution processing apparatus and method are disclosed. The convolution processing apparatus may include a controller configured to load a pixel of an input image and skip a process associated with the pixel in response to a value of the loaded pixel being 0, a filter bank including at least one filter and configured to extract at least one kernel element corresponding to the pixel from the at least one filter based on an index of the pixel and an input channel of the pixel, and a multiplier-accumulator (MAC) configured to perform a convolution operation based on the value of the pixel and a value of the at least one kernel element and accumulatively store an operation result of the convolution operation, the operation result corresponding to an output image.Type: ApplicationFiled: April 28, 2017Publication date: May 31, 2018Applicants: SAMSUNG ELECTRONICS CO., LTD., UNIVERSITAET ZUERICHInventors: Hesham MOSTAFA, Aimar ALESSANDRO
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Publication number: 20180127467Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activityType: ApplicationFiled: December 21, 2017Publication date: May 10, 2018Applicants: UNIVERSITAET ZUERICH, POLYPHOR LTD.Inventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Publication number: 20180121802Abstract: A neural network conversion method and a recognition apparatus that implements the method are provided. A method of converting an analog neural network (ANN) to a spiking neural network (SNN) normalizes first parameters of a trained ANN based on a reference activation that is set to be proximate to a maximum activation of artificial neurons included in the ANN, and determines second parameters of an SNN based on the normalized first parameters.Type: ApplicationFiled: June 23, 2017Publication date: May 3, 2018Applicants: SAMSUNG ELECTRONICS CO., LTD., UNIVERSITAET ZUERICHInventors: Bodo RUCKAUER, Iulia-Alexandra LUNGU, Yuhuang HU, Michael PFEIFFER
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Patent number: 9944952Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.Type: GrantFiled: March 14, 2016Date of Patent: April 17, 2018Assignee: Universität ZürichInventors: Daniel D. Pinschewer, Lukas Flatz, Andreas Bergthaler, Rolf Zinkernagel
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Patent number: 9943583Abstract: The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.Type: GrantFiled: December 2, 2014Date of Patent: April 17, 2018Assignees: UNIVERSITÄT ZÜRICH, SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE, VIROMETIX AGInventors: Arin Ghasparian, Armando Zuniga, Nina Geib, Marco Tamborini, Maja Jud, Gerd Pluschke, Aniebrys Marrero Nodarse, John Anthony Robinson
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Publication number: 20180042702Abstract: An implant, particularly a dental implant is provided, having an anchoring region (12) for anchoring in a bone, which preferably includes a thread (14) for screwing in the bone, and a fastening region (22) for attaching a supra-construction, wherein an abutment region (16) adjoins the anchoring region (12), the abutment region (16) having a guide structure with a plurality of outwardly projecting ridges (18) provided thereon, and preferably, grooves (20) being formed between the ridges (20). The guide structure of the anchoring region (12) allows a better osseointegration and counteracts periimplant bone loss.Type: ApplicationFiled: March 3, 2016Publication date: February 15, 2018Applicants: UNIVERSITAET BASEL, UNIVERSITAET ZUERICHInventor: Stefan Bernd STUEBINGER