Abstract: A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.
Type:
Grant
Filed:
March 7, 2018
Date of Patent:
April 23, 2024
Assignee:
Technische Universität Braunschweig Korperschaft Des Offentlichen Rechts
Inventors:
Sönke Fündling, Frederik Steib, Andreas Waag
Abstract: A process for obtaining a tannin extract isolated from whole grape seeds is provided. The process is performed in as a one-pot reaction and in a single extraction step, wherein the seeds are processed without grinding or milling. Also provided is a tannin extract with improved antioxidant and light fastness properties obtained from whole grape seeds that includes a mixture of tannins and non-tannins, in which the content of tannins or polyphenols is higher than 50%. Ise, the tannin extract isolated from whole grape seeds can include a coloring agent.
Abstract: The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.
Type:
Grant
Filed:
September 16, 2022
Date of Patent:
April 23, 2024
Assignees:
Massachusetts Institute of Technology, Universität Zürich
Inventors:
Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Madeleine Henley, Beat W. Schaefer, Marco Wachtel
Abstract: Immobilization and magnetic extraction of pathogens and pathogen components The application describes a method for reducing the concentration of pathogens and/or pathogen components in an aqueous or body fluid sample. Specifically, the method relates to incubating the sample with superparamagnetic iron-based particles attached to a target binding peptide and immobilising the superparamagnetic iron-based particles with a magnetic field and thereby separating the pathogen-bound and/or pathogen component-bound superparamagnetic iron-based particles from the sample. Furthermore, the application relates to a method for identifying pathogens in an aqueous or body fluid sample a use of superparamagnetic iron-based particles for reducing the concentration of pathogens and/or pathogen components in an aqueous or body fluid sample. In addition, a use of superparamagnetic iron-based particles for identifying pathogens in an aqueous or body fluid sample is disclosed.
Abstract: In a method of controlling a lithography-based additive manufacturing device capable of manufacturing a three-dimensional component from a plurality of volume elements, a check is made to determine whether the volume elements are entirely within the three-dimensional virtual model by identifying at least first and second boundary points of the volume element or virtual model in x-y planes spaced apart in the z-direction, and the volume element in question is provided for the manufacturing process only if it is within the model with respect to the first and second boundary points.
Abstract: The present invention relates to a method of diagnosing bladder cancer in an individual. Further, the present invention relates to a method of determining the course of bladder cancer in an individual. Furthermore, the present invention relates to a kit for diagnosing bladder cancer in an individual or determining the course of bladder cancer in an individual.
Abstract: A method for monitoring and visualizing a patient's medical condition, wherein a graphical representation of the patient comprising a body having at least a torso and a head, as well as particularly two legs and two arms, is displayed using a display device, wherein said displayed graphical representation comprises at least one region which is allocated to at least one or several provided (e.g. measured and/or determined) patient monitoring quantities, and wherein the appearance of the at least one region is altered in real-time when the at least one patient monitoring quantity to which said at least one region is allocated changes.
Type:
Grant
Filed:
August 23, 2021
Date of Patent:
April 16, 2024
Assignee:
Universität Zürich
Inventors:
David Tscholl, Christoph Nothiger, Patrick Neubauer
Abstract: The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
Type:
Grant
Filed:
June 29, 2022
Date of Patent:
April 16, 2024
Assignees:
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN, FORSCHUNGSVERBUND BERLIN E.V.
Inventors:
Heinrich Leonhardt, Jonas Helma, Dominik Schumacher, Christian Hackenberger
Abstract: An implantable electrical connector arrangement electrically connects a first electrical component and a second electrical component. The connector arrangement includes a first connector having a first terminal and a first coupling electrode connected to the first terminal and a second connector having a second terminal and a second coupling electrode connected to the second terminal. The first connector and the second connector are connectable to each other such that the first terminal and the second terminal are capacitively connectable via the first coupling electrode and the second coupling electrode in a connected state. A defined separation gap is formed between the first coupling electrode and the second coupling electrode in the connected state.
Type:
Grant
Filed:
May 18, 2021
Date of Patent:
April 16, 2024
Assignee:
Albert-Ludwigs-Universität Freiburg
Inventors:
Patrick Kiele, Cristian Pasluosta, Thomas Stieglitz
Abstract: A method and an apparatus (15) for computer-implemented determination of physical properties of a porous layer (1) present on a surface of a substrate. The physical properties include at least a layer thickness (d) of the layer, a porosity (p) of the layer and a roughness (r) of the layer at an interface (9) with the substrate supporting the layer. The method includes recording a reflectance curve (39) concerning light (25) irradiated onto the porous layer within a wavelength range in which the porous layer is largely transparent, setting a predetermined roughness start value, setting a porosity start value based on knowledge concerning a manufacturing process for forming the porous layer, setting a layer thickness start value based on an evaluation of periodic fluctuations of reflectance intensities within the recorded reflectance curve, and determining the physical properties of the porous layer by computer-implemented fitting of the recorded reflectance curve using a non-linear least squares method.
Type:
Application
Filed:
January 29, 2021
Publication date:
April 11, 2024
Applicant:
UNIVERSITÄT KONSTANZ
Inventors:
Gabriel MICARD, Yves Patrick BOTCHAK MOUAFI, Barbara TERHEIDEN
Abstract: A method for determining a concentration of a target gas in blood of a human or animal animate being. The method includes the steps of: generating electromagnetic excitation radiation having a carrier frequency, wherein the carrier frequency is selected such that the target gas and an absorbing gas absorb the excitation radiation, modulating an amplitude or the carrier frequency of the excitation radiation with a modulation frequency, illuminating an absorption path superficial to a skin of the animate being with the excitation radiation, generating a sound wave by an absorption of the excitation radiation in the absorption gas, and detecting at least one of an amplitude and a phase of the sound wave as a measure of a concentration of the target gas on the absorption path. Also provided is a photoacoustic sensor for determining a concentration of a target gas in blood of a human or animal animate being.
Type:
Application
Filed:
January 28, 2022
Publication date:
April 11, 2024
Applicants:
Albert-Ludwigs-Universität Freiburg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Inventors:
Johannes KAPP, Katrin SCHMITT, Christian WEBER, Jürgen WÖLLENSTEIN, Hassan YASSINE
Abstract: The invention relates to a combination medicament for treatment of malignant neoplastic disease. The combination medicament comprises an IL-12 polypeptide having a biological activity of IL-12 or a nucleic acid expression vector comprising a sequence encoding such IL-12 polypeptide, and a non-agonist blockade of T-cell inhibitory molecules, including non-agonist LAG-3 ligand, non-agonist TIM-3 ligand, non-agonist BLTA ligand, non-agonist TIGIT ligand, non-agonist VISTA ligand, non-agonist B7/H3 ligand, non-agonist CTLA-4 ligand or non-agonist PD-1 ligand, particularly an anti-CTLA-4 or anti-PD-1 immunoglobulin G.
Abstract: The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.
Type:
Grant
Filed:
October 9, 2018
Date of Patent:
April 9, 2024
Assignees:
MEDIZINISCHE HOCHSCHULE HANNOVER, TWINCORE ZENTRUM FÜR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH, TECHNISCHE UNIVERSITÄT DRESDEN
Inventors:
Daniel Todt, Sibylle Haid, Martin Wetzke, Gesine Hansen, Chris Lauber, Lars Kaderali, Thomas Pietschmann
Abstract: A radar assembly and a method for operating the radar assembly is disclosed, where a first frequency comb generator is arranged in the transmitting unit between the first oscillator and the transmitting antenna and a second frequency comb generator is arranged in the receiving unit between the second oscillator and the first mixer. On the transmitter side a first frequency comb generator is controlled with the first oscillator frequency in order to generate a primary signal containing a plurality of frequency components, on the receiver side a second frequency comb generator is controlled with a second oscillator frequency in order to generate an output signal containing a plurality of frequency components, the output signal generated in such a way is mixed with a third oscillator frequency, and the intermediate frequency is generated by mixing the received reflected signal with the mixed signal.
Abstract: Described herein is a genetically modified plant or non-human animal having reduced expression of an endogenous target gene.
Type:
Application
Filed:
January 27, 2022
Publication date:
April 4, 2024
Applicants:
UNIVERSITAT AUTÒNOMA DE BARCELONA, HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
Inventors:
Maria Fátima BOSCH TUBERT, Verónica JIMENEZ CENZANO, Miquel GARCIA MARTINEZ, Estefanía CASANA LORENTE, Martin Matthias HRABE DE ANGELIS, Gerhard Kurt Herbert PRZEMECK, Anna-Lena AMEND
Abstract: A heat exchanger comprises a base, and a plurality of deformable fins connected to a surface of the base. Some deformable fins have a free end configured to move away from the surface of the base as a function of a local temperature increase of the base. The deformable fins are distributed on the surface of the base to be exposed to a coolant flowing over the surface of the base, wherein a distribution of the deformable fins on the surface of the base is non-uniform.
Type:
Grant
Filed:
March 1, 2019
Date of Patent:
April 2, 2024
Assignees:
UNIVERSITAT DE LLEIDA, SOCPRA SCIENCES ET GENIE S.E.C.
Inventors:
Luc Frechette, Jérôme Barrau, Montserrat Vilarrubi Porta
Abstract: The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
April 2, 2024
Assignee:
UNIVERSITÄT ZÜRICH
Inventors:
Simon Hoerstrup, Benedikt Weber, Anna Mallone
Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.
Abstract: A method for transferring objects includes providing a medium in a reservoir, the medium containing objects; providing a substrate having an acceptor surface, the acceptor surface facing an opening of the reservoir; determining a first target focus point in the medium; and generating a first laser pulse or first laser pulse train focused onto the first target focus point. Pulse intensity of the first laser pulse or pulse train at the first target focus point and/or pulse duration of the first laser pulse or pulse train is/are chosen to generate a droplet of the medium ejected towards the acceptor surface. A center wavelength of the first laser pulse or pulse train is larger than 500 nm, larger than 650 nm, or between 0.9 ?m and 1.35 ?m. The first target focus point is determined relative to the position of at least one object of the objects.
Type:
Grant
Filed:
December 19, 2019
Date of Patent:
April 2, 2024
Assignees:
Hochschule für angewandte Wissenschaften München, Universität Regensburg—Universitätsklinikum
Inventors:
Jun Zhang, Heinz Paul Huber, Hauke Clausen-Schaumann, Stefanie Sudhop, Denitsa Docheva
Abstract: The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123.